GPR6 (G protein-coupled receptor 6) - Rat Genome Database
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Gene: GPR6 (G protein-coupled receptor 6) Homo sapiens
Analyze
Symbol: GPR6
Name: G protein-coupled receptor 6
RGD ID: 737528
HGNC Page HGNC
Description: Predicted to have sphingosine-1-phosphate receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of metabolic process; and sphingosine-1-phosphate receptor signaling pathway. Predicted to localize to cytoplasm and plasma membrane; INTERACTS WITH aflatoxin B1; benzo[a]pyrene; folic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G-protein coupled receptor 6; sphingosine 1-phosphate receptor GPR6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6109,978,256 - 109,980,718 (+)EnsemblGRCh38hg38GRCh38
GRCh386109,978,311 - 109,980,720 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376110,299,459 - 110,301,923 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366110,406,991 - 110,408,616 (+)NCBINCBI36hg18NCBI36
Build 346110,406,989 - 110,408,615NCBI
Celera6111,046,984 - 111,048,609 (+)NCBI
Cytogenetic Map6q21NCBI
HuRef6107,866,913 - 107,868,538 (+)NCBIHuRef
CHM1_16110,562,682 - 110,565,146 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:7832990   PMID:12477932   PMID:12649592   PMID:14574404   PMID:15489334   PMID:16344560   PMID:20677014   PMID:21873635   PMID:22487033   PMID:28514442   PMID:32046081  


Genomics

Comparative Map Data
GPR6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6109,978,256 - 109,980,718 (+)EnsemblGRCh38hg38GRCh38
GRCh386109,978,311 - 109,980,720 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376110,299,459 - 110,301,923 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366110,406,991 - 110,408,616 (+)NCBINCBI36hg18NCBI36
Build 346110,406,989 - 110,408,615NCBI
Celera6111,046,984 - 111,048,609 (+)NCBI
Cytogenetic Map6q21NCBI
HuRef6107,866,913 - 107,868,538 (+)NCBIHuRef
CHM1_16110,562,682 - 110,565,146 (+)NCBICHM1_1
Gpr6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391040,945,973 - 40,948,286 (-)NCBIGRCm39mm39
GRCm381041,069,977 - 41,072,290 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1041,069,977 - 41,072,285 (-)EnsemblGRCm38mm10GRCm38
MGSCv371040,790,299 - 40,791,390 (-)NCBIGRCm37mm9NCBIm37
MGSCv361040,758,908 - 40,759,999 (-)NCBImm8
Celera1041,965,591 - 41,966,682 (-)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1022.08NCBI
Gpr6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02045,813,169 - 45,815,940 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2045,813,169 - 45,815,940 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02047,518,790 - 47,521,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2045,290,688 - 45,293,459 (-)NCBICelera
Cytogenetic Map20q12NCBI
Gpr6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541134,781,598 - 34,783,926 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541134,781,598 - 34,783,926 (+)NCBIChiLan1.0ChiLan1.0
GPR6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16111,825,742 - 111,828,202 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v06107,783,260 - 107,785,662 (+)NCBIMhudiblu_PPA_v0panPan3
GPR6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1266,720,606 - 66,723,157 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11266,721,466 - 66,723,153 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gpr6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365645,935,216 - 5,937,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1175,979,360 - 75,982,036 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2185,202,296 - 85,204,602 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11363,909,222 - 63,911,725 (-)NCBI
ChlSab1.1 Ensembl1363,909,793 - 63,910,881 (-)Ensembl
Gpr6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249161,042,193 - 1,045,191 (+)NCBI

Position Markers
RH70579  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376110,301,357 - 110,301,582UniSTSGRCh37
Build 366110,408,050 - 110,408,275RGDNCBI36
Celera6111,048,043 - 111,048,268RGD
Cytogenetic Map6q21UniSTS
HuRef6107,867,972 - 107,868,197UniSTS
GeneMap99-GB4 RH Map6460.02UniSTS
RH46833  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376110,302,003 - 110,302,155UniSTSGRCh37
Build 366110,408,696 - 110,408,848RGDNCBI36
Celera6111,048,689 - 111,048,841RGD
Cytogenetic Map6q21UniSTS
HuRef6107,868,618 - 107,868,770UniSTS
GeneMap99-GB4 RH Map6460.02UniSTS
NCBI RH Map61406.9UniSTS
STS-U18549  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376110,301,416 - 110,301,656UniSTSGRCh37
Build 366110,408,109 - 110,408,349RGDNCBI36
Celera6111,048,102 - 111,048,342RGD
Cytogenetic Map6q21UniSTS
HuRef6107,868,031 - 107,868,271UniSTS
GeneMap99-GB4 RH Map6459.4UniSTS
D6S2092  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376110,301,448 - 110,301,749UniSTSGRCh37
Build 366110,408,141 - 110,408,442RGDNCBI36
Celera6111,048,134 - 111,048,435RGD
Cytogenetic Map6q21UniSTS
HuRef6107,868,063 - 107,868,364UniSTS
Gpr6  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376110,301,046 - 110,301,327UniSTSGRCh37
Build 366110,407,739 - 110,408,020RGDNCBI36
Celera6111,047,732 - 111,048,013RGD
HuRef6107,867,661 - 107,867,942UniSTS
UniSTS:486089  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376110,300,198 - 110,301,479UniSTSGRCh37
Celera6111,046,884 - 111,048,165UniSTS
HuRef6107,866,813 - 107,868,094UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:475
Count of miRNA genes:232
Interacting mature miRNAs:267
Transcripts:ENST00000275169, ENST00000414000
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage
High
Medium 56 548 17
Low 3 2 227 6 3 1364 15 45 1 5
Below cutoff 814 668 311 75 365 38 1003 598 1062 31 609 382 38 1 253 605

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000275169   ⟹   ENSP00000275169
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6109,979,113 - 109,980,201 (+)Ensembl
RefSeq Acc Id: ENST00000414000   ⟹   ENSP00000406986
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6109,978,256 - 109,980,718 (+)Ensembl
RefSeq Acc Id: NM_001286099   ⟹   NP_001273028
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386109,978,311 - 109,980,720 (+)NCBI
HuRef6107,866,074 - 107,868,538 (+)NCBI
CHM1_16110,562,682 - 110,565,146 (+)NCBI
Sequence:
RefSeq Acc Id: NM_005284   ⟹   NP_005275
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386109,978,311 - 109,980,720 (+)NCBI
GRCh376110,299,459 - 110,301,923 (+)NCBI
Build 366110,406,991 - 110,408,616 (+)NCBI Archive
Celera6111,046,984 - 111,048,609 (+)RGD
HuRef6107,866,074 - 107,868,538 (+)NCBI
CHM1_16110,562,682 - 110,565,146 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005275   ⟸   NM_005284
- Peptide Label: isoform b
- UniProtKB: P46095 (UniProtKB/Swiss-Prot),   F1DAM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273028   ⟸   NM_001286099
- Peptide Label: isoform a
- UniProtKB: P46095 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000406986   ⟸   ENST00000414000
RefSeq Acc Id: ENSP00000275169   ⟸   ENST00000275169
Protein Domains
G_PROTEIN_RECEP_F1_2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q21-23.2(chr6:108944899-132067720)x1 copy number loss See cases [RCV000051196] Chr6:108944899..132067720 [GRCh38]
Chr6:109266102..132388860 [GRCh37]
Chr6:109372795..132430553 [NCBI36]
Chr6:6q21-23.2		 pathogenic
GRCh38/hg38 6q16.3-21(chr6:102356502-111049879)x1 copy number loss See cases [RCV000134806] Chr6:102356502..111049879 [GRCh38]
Chr6:102804377..111371082 [GRCh37]
Chr6:102911070..111477775 [NCBI36]
Chr6:6q16.3-21		 pathogenic
GRCh38/hg38 6q21-22.1(chr6:107370141-115827482)x1 copy number loss See cases [RCV000138006] Chr6:107370141..115827482 [GRCh38]
Chr6:107691345..116148646 [GRCh37]
Chr6:107798038..116255339 [NCBI36]
Chr6:6q21-22.1		 pathogenic
GRCh38/hg38 6q21(chr6:109780913-110202309)x1 copy number loss See cases [RCV000140325] Chr6:109780913..110202309 [GRCh38]
Chr6:110102116..110523512 [GRCh37]
Chr6:110208809..110630205 [NCBI36]
Chr6:6q21		 uncertain significance
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3 copy number gain See cases [RCV000139729] Chr6:74382807..142040500 [GRCh38]
Chr6:75092523..142361637 [GRCh37]
Chr6:75149243..142403330 [NCBI36]
Chr6:6q13-24.1		 pathogenic
GRCh38/hg38 6q16.1-22.31(chr6:96609994-122161548)x1 copy number loss See cases [RCV000139465] Chr6:96609994..122161548 [GRCh38]
Chr6:97057870..122482694 [GRCh37]
Chr6:97164591..122524393 [NCBI36]
Chr6:6q16.1-22.31		 pathogenic
GRCh38/hg38 6q21(chr6:107445281-110547907)x1 copy number loss See cases [RCV000141382] Chr6:107445281..110547907 [GRCh38]
Chr6:107766485..110869110 [GRCh37]
Chr6:107873178..110975803 [NCBI36]
Chr6:6q21		 pathogenic
GRCh38/hg38 6q21-22.31(chr6:106503719-125781219)x1 copy number loss See cases [RCV000141587] Chr6:106503719..125781219 [GRCh38]
Chr6:106951594..126102365 [GRCh37]
Chr6:107058287..126144058 [NCBI36]
Chr6:6q21-22.31		 pathogenic
GRCh38/hg38 6q16.3-21(chr6:103279465-113934239)x1 copy number loss See cases [RCV000142287] Chr6:103279465..113934239 [GRCh38]
Chr6:103727340..114255403 [GRCh37]
Chr6:103834033..114362096 [NCBI36]
Chr6:6q16.3-21		 pathogenic
GRCh38/hg38 6q16.3-22.31(chr6:100054889-120488154)x1 copy number loss See cases [RCV000143227] Chr6:100054889..120488154 [GRCh38]
Chr6:100502765..120809300 [GRCh37]
Chr6:100609486..120850999 [NCBI36]
Chr6:6q16.3-22.31		 pathogenic
GRCh37/hg19 6q21(chr6:109564793-112223595)x1 copy number loss See cases [RCV000447293] Chr6:109564793..112223595 [GRCh37]
Chr6:6q21		 uncertain significance
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687)x1 copy number loss See cases [RCV000445666] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q21(chr6:110080484-110472732)x1 copy number loss See cases [RCV000510562] Chr6:110080484..110472732 [GRCh37]
Chr6:6q21		 uncertain significance
GRCh37/hg19 6q16.1-22.1(chr6:95549951-116684929)x1 copy number loss not provided [RCV000682693] Chr6:95549951..116684929 [GRCh37]
Chr6:6q16.1-22.1		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_001286099.1(GPR6):c.564G>T (p.Ala188=) single nucleotide variant not provided [RCV000967006] Chr6:109979631 [GRCh38]
Chr6:110300834 [GRCh37]
Chr6:6q21		 benign
NM_001286099.1(GPR6):c.28-9C>T single nucleotide variant not provided [RCV000965352] Chr6:109979086 [GRCh38]
Chr6:110300289 [GRCh37]
Chr6:6q21		 benign
GRCh37/hg19 6q21(chr6:109564694-112232351)x1 copy number loss not provided [RCV001007557] Chr6:109564694..112232351 [GRCh37]
Chr6:6q21		 uncertain significance
GRCh37/hg19 6q16.3-22.1(chr6:101296547-117004249)x3 copy number gain Microcephaly [RCV001251053] Chr6:101296547..117004249 [GRCh37]
Chr6:6q16.3-22.1		 pathogenic
GRCh37/hg19 6q21(chr6:110288308-110768384)x3 copy number gain not provided [RCV001259394] Chr6:110288308..110768384 [GRCh37]
Chr6:6q21		 uncertain significance
GRCh37/hg19 6q16.1-21(chr6:98949950-114533905)x1 copy number loss Deletion 6q16 q21 [RCV001263224] Chr6:98949950..114533905 [GRCh37]
Chr6:6q16.1-21		 pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4515 AgrOrtholog
COSMIC GPR6 COSMIC
Ensembl Genes ENSG00000146360 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000275169 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000406986 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000275169 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000414000 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000146360 GTEx
HGNC ID HGNC:4515 ENTREZGENE
Human Proteome Map GPR6 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR_3/6/12_orphan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2830 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2830 ENTREZGENE
OMIM 600553 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28904 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR6ORPHANR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPRORPHANR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E7EP76_HUMAN UniProtKB/TrEMBL
  F1DAM6 ENTREZGENE, UniProtKB/TrEMBL
  GPR6_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B4DHS9 UniProtKB/Swiss-Prot
  J3KQR3 UniProtKB/Swiss-Prot
  Q17RJ7 UniProtKB/Swiss-Prot
  Q5SYL0 UniProtKB/Swiss-Prot