Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Plekhh2 | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Plekhh2 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of PLEKHH2 mRNA | CTD | PMID:17942748 | Plekhh2 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Plekhh2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLEKHH2 mRNA | CTD | PMID:17942748 | Plekhh2 | Rat | 17beta-estradiol | multiple interactions | ISO | PLEKHH2 (Homo sapiens) | 6480464 | EGF protein inhibits the reaction [Estradiol results in decreased expression of PLEKHH2 mRNA] | CTD | PMID:24758408 | Plekhh2 | Rat | 17beta-estradiol | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of PLEKHH2 mRNA | CTD | PMID:24758408 | Plekhh2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Plekhh2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLEKHH2 mRNA | CTD | PMID:17942748 | Plekhh2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PLEKHH2 mRNA | CTD | PMID:33387578 | Plekhh2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PLEKHH2 mRNA | CTD | PMID:34747641 | Plekhh2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PLEKHH2 mRNA | CTD | PMID:27913140 | Plekhh2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Plekhh2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLEKHH2 mRNA | CTD | PMID:21570461 | Plekhh2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Plekhh2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PLEKHH2 mRNA | CTD | PMID:19933214 | Plekhh2 | Rat | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | decreases expression | EXP | | 6480464 | Puromycin Aminonucleoside results in decreased expression of PLEKHH2 protein | CTD | PMID:20588063 | Plekhh2 | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Plekhh2 (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of PLEKHH2 mRNA | CTD | PMID:25172293 | Plekhh2 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Plekhh2 (Mus musculus) | 6480464 | bisphenol S results in increased expression of PLEKHH2 mRNA | CTD | PMID:30951980 | Plekhh2 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Plekhh2 (Mus musculus) | 6480464 | bisphenol S affects the methylation of PLEKHH2 gene | CTD | PMID:31683443 | Plekhh2 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | PLEKHH2 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of PLEKHH2 gene | CTD | PMID:31601247 | Plekhh2 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PLEKHH2 mRNA | CTD | PMID:24780913 | Plekhh2 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of PLEKHH2 mRNA | CTD | PMID:31881176 | Plekhh2 | Rat | aflatoxin B1 | affects methylation | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the methylation of PLEKHH2 intron | CTD | PMID:30157460 | Plekhh2 | Rat | Aflatoxin B2 alpha | increases methylation | ISO | PLEKHH2 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of PLEKHH2 intron | CTD | PMID:30157460 | Plekhh2 | Rat | all-trans-retinoic acid | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PLEKHH2 mRNA | CTD | PMID:33167477 | Plekhh2 | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PLEKHH2 mRNA | CTD | PMID:35163327 | Plekhh2 | Rat | aristolochic acid A | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PLEKHH2 mRNA | CTD | PMID:33212167 | Plekhh2 | Rat | atrazine | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Atrazine results in increased expression of PLEKHH2 mRNA | CTD | PMID:22378314 | Plekhh2 | Rat | benzo[a]pyrene | increases methylation | ISO | Plekhh2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of PLEKHH2 exon and Benzo(a)pyrene results in increased methylation of PLEKHH2 intron | CTD | PMID:27901495 | Plekhh2 | Rat | benzo[a]pyrene | affects methylation | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PLEKHH2 3' UTR and Benzo(a)pyrene affects the methylation of PLEKHH2 promoter | CTD | PMID:27901495 | Plekhh2 | Rat | benzo[e]pyrene | increases methylation | ISO | PLEKHH2 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of PLEKHH2 intron | CTD | PMID:30157460 | Plekhh2 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of PLEKHH2 mRNA | CTD | PMID:31163220 | Plekhh2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PLEKHH2 mRNA | CTD | PMID:25181051 and PMID:30816183 | Plekhh2 | Rat | bisphenol A | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PLEKHH2 mRNA | CTD | PMID:36232920 | Plekhh2 | Rat | bisphenol A | increases expression | ISO | Plekhh2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PLEKHH2 mRNA | CTD | PMID:30951980 | Plekhh2 | Rat | bisphenol F | increases expression | ISO | Plekhh2 (Mus musculus) | 6480464 | bisphenol F results in increased expression of PLEKHH2 mRNA | CTD | PMID:30951980 | Plekhh2 | Rat | cadmium atom | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Cadmium results in decreased expression of PLEKHH2 mRNA | CTD | PMID:24376830 | Plekhh2 | Rat | chlorpyrifos | decreases expression | ISO | Plekhh2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of PLEKHH2 mRNA | CTD | PMID:37019170 | Plekhh2 | Rat | choline | multiple interactions | ISO | Plekhh2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PLEKHH2 gene | CTD | PMID:20938992 | Plekhh2 | Rat | cisplatin | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of PLEKHH2 mRNA | CTD | PMID:27392435 | Plekhh2 | Rat | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of PLEKHH2 mRNA | CTD | PMID:26033743 | Plekhh2 | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of PLEKHH2 mRNA | CTD | PMID:26033743 | Plekhh2 | Rat | curcumin | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Curcumin results in increased expression of PLEKHH2 mRNA | CTD | PMID:18421014 | Plekhh2 | Rat | cyclosporin A | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PLEKHH2 mRNA | CTD | PMID:25562108 | Plekhh2 | Rat | diclofenac | decreases expression | ISO | Plekhh2 (Mus musculus) | 6480464 | Diclofenac results in decreased expression of PLEKHH2 mRNA | CTD | PMID:35537566 | Plekhh2 | Rat | dimethylarsinic acid | decreases expression | EXP | | 6480464 | Cacodylic Acid results in decreased expression of PLEKHH2 mRNA | CTD | PMID:37567419 | Plekhh2 | Rat | dimethylarsinous acid | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | dimethylarsinous acid results in decreased expression of PLEKHH2 mRNA | CTD | PMID:23487506 | Plekhh2 | Rat | dorsomorphin | multiple interactions | ISO | PLEKHH2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Plekhh2 | Rat | doxorubicin | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PLEKHH2 mRNA | CTD | PMID:29803840 | Plekhh2 | Rat | entinostat | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | entinostat results in increased expression of PLEKHH2 mRNA | CTD | PMID:27188386 | Plekhh2 | Rat | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of PLEKHH2 mRNA | CTD | PMID:30307764 | Plekhh2 | Rat | folic acid | multiple interactions | ISO | Plekhh2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PLEKHH2 gene | CTD | PMID:20938992 | Plekhh2 | Rat | fulvestrant | multiple interactions | ISO | PLEKHH2 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of PLEKHH2 gene | CTD | PMID:31601247 | Plekhh2 | Rat | L-methionine | multiple interactions | ISO | Plekhh2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PLEKHH2 gene | CTD | PMID:20938992 | Plekhh2 | Rat | methapyrilene | increases methylation | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of PLEKHH2 intron | CTD | PMID:30157460 | Plekhh2 | Rat | methylmercury chloride | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PLEKHH2 mRNA | CTD | PMID:28001369 | Plekhh2 | Rat | nickel atom | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Nickel results in decreased expression of PLEKHH2 mRNA | CTD | PMID:24768652 | Plekhh2 | Rat | nickel sulfate | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of PLEKHH2 mRNA | CTD | PMID:22714537 | Plekhh2 | Rat | paracetamol | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PLEKHH2 mRNA | CTD | PMID:22230336 and PMID:29067470 | Plekhh2 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PLEKHH2 mRNA | CTD | PMID:33387578 | Plekhh2 | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of PLEKHH2 mRNA | CTD | PMID:32680482 | Plekhh2 | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PLEKHH2 mRNA | CTD | PMID:35163327 | Plekhh2 | Rat | phenethyl isothiocyanate | decreases expression | EXP | | 6480464 | phenethyl isothiocyanate results in decreased expression of PLEKHH2 mRNA | CTD | PMID:17616710 | Plekhh2 | Rat | phenylmercury acetate | multiple interactions | ISO | PLEKHH2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLEKHH2 mRNA | CTD | PMID:27188386 | Plekhh2 | Rat | SB 431542 | multiple interactions | ISO | PLEKHH2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Plekhh2 | Rat | silicon dioxide | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of PLEKHH2 mRNA and Silicon Dioxide results in decreased expression of PLEKHH2 mRNA | CTD | PMID:25895662 and PMID:28425640 | Plekhh2 | Rat | silver atom | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Silver results in increased expression of PLEKHH2 mRNA | CTD | PMID:26014281 | Plekhh2 | Rat | silver(0) | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Silver results in increased expression of PLEKHH2 mRNA | CTD | PMID:26014281 | Plekhh2 | Rat | sodium arsenite | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of PLEKHH2 mRNA | CTD | PMID:22714537 | Plekhh2 | Rat | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of PLEKHH2 mRNA | CTD | PMID:19281266 | Plekhh2 | Rat | testosterone | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of PLEKHH2 mRNA | CTD | PMID:33359661 | Plekhh2 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of PLEKHH2 mRNA | CTD | PMID:31150632 | Plekhh2 | Rat | trichostatin A | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of PLEKHH2 mRNA | CTD | PMID:24935251 and PMID:27188386 | Plekhh2 | Rat | trichostatin A | affects expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | trichostatin A affects the expression of PLEKHH2 mRNA | CTD | PMID:28542535 | Plekhh2 | Rat | trovafloxacin | decreases expression | ISO | Plekhh2 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of PLEKHH2 mRNA | CTD | PMID:35537566 | Plekhh2 | Rat | valproic acid | affects expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PLEKHH2 mRNA | CTD | PMID:25979313 | Plekhh2 | Rat | valproic acid | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PLEKHH2 mRNA | CTD | PMID:19101580 more ... | Plekhh2 | Rat | valproic acid | multiple interactions | ISO | PLEKHH2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLEKHH2 mRNA | CTD | PMID:27188386 | Plekhh2 | Rat | vorinostat | increases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | vorinostat results in increased expression of PLEKHH2 mRNA | CTD | PMID:27188386 | Plekhh2 | Rat | zoledronic acid | decreases expression | ISO | PLEKHH2 (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of PLEKHH2 mRNA | CTD | PMID:24714768 | |