Plekhh2 (pleckstrin homology, MyTH4 and FERM domain containing H2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Plekhh2 (pleckstrin homology, MyTH4 and FERM domain containing H2) Chinchilla lanigera
Analyze
Symbol: Plekhh2
Name: pleckstrin homology, MyTH4 and FERM domain containing H2
RGD ID: 8932881
Description: ENCODES a protein that exhibits actin binding (ortholog); INVOLVED IN negative regulation of actin filament depolymerization (ortholog); ASSOCIATED WITH genetic disease (ortholog); Lynch syndrome (ortholog); FOUND IN cortical actin cytoskeleton (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; pleckstrin homology domain-containing family H member 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,825,499 - 10,919,901 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544110,818,982 - 10,921,224 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plekhh2Chinchillagenetic disease  ISOPLEKHH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
Plekhh2ChinchillaLynch syndrome  ISOPLEKHH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasmsClinVarPMID:28492532


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plekhh2Chinchillanegative regulation of actin filament depolymerization involved_inISOPlekhh2 (Mus musculus)9068941 PMID:22832517UniProtPMID:22832517

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plekhh2Chinchillacortical actin cytoskeleton located_inISOPlekhh2 (Mus musculus)9068941 PMID:22832517UniProtPMID:22832517
Plekhh2Chinchillacytoplasm located_inISOPLEKHH2 (Homo sapiens)9068941 PMID:22832517LIFEdbGO_REF:0000054 and PMID:22832517
Plekhh2Chinchillacytosol located_inISOPLEKHH2 (Homo sapiens)9068941 HPAGO_REF:0000052
Plekhh2Chinchillalamellipodium located_inISOPLEKHH2 (Homo sapiens)9068941 PMID:22832517UniProtPMID:22832517
Plekhh2Chinchillanuclear body located_inISOPLEKHH2 (Homo sapiens)9068941 HPAGO_REF:0000052
Plekhh2Chinchillanucleoplasm located_inISOPLEKHH2 (Homo sapiens)9068941 HPAGO_REF:0000052
Plekhh2Chinchillaplasma membrane located_inISOPLEKHH2 (Homo sapiens)9068941 PMID:22832517HPAGO_REF:0000052 and PMID:22832517

Molecular Function

  


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:22301074   PMID:30032202  



Plekhh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,825,499 - 10,919,901 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544110,818,982 - 10,921,224 (+)NCBIChiLan1.0ChiLan1.0
PLEKHH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38243,637,260 - 43,767,987 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl243,637,260 - 43,767,987 (+)EnsemblGRCh38hg38GRCh38
GRCh37243,864,399 - 43,995,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36243,717,951 - 43,848,630 (+)NCBINCBI36Build 36hg18NCBI36
Build 34243,776,097 - 43,906,776NCBI
Celera243,703,213 - 43,833,863 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef243,600,415 - 43,731,823 (+)NCBIHuRef
CHM1_1243,794,022 - 43,924,517 (+)NCBICHM1_1
T2T-CHM13v2.0243,642,678 - 43,773,318 (+)NCBIT2T-CHM13v2.0
Plekhh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391784,819,303 - 84,929,571 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1784,819,323 - 84,929,566 (+)EnsemblGRCm39 Ensembl
GRCm381784,511,895 - 84,622,143 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1784,511,895 - 84,622,138 (+)EnsemblGRCm38mm10GRCm38
MGSCv371784,911,235 - 85,021,482 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361784,420,221 - 84,530,455 (+)NCBIMGSCv36mm8
Celera1788,877,452 - 88,989,118 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.02NCBI
Plekhh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,783,179 - 15,893,479 (-)NCBIGRCr8
mRatBN7.2610,032,837 - 10,132,081 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl610,032,660 - 10,140,794 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx610,328,232 - 10,428,034 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,637,621 - 10,737,423 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0610,155,943 - 10,253,050 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.067,784,743 - 7,895,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,793,735 - 7,893,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.067,731,647 - 7,830,438 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.467,887,555 - 7,986,077 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.167,887,554 - 7,986,077 (+)NCBI
Celera69,753,640 - 9,852,005 (-)NCBICelera
Cytogenetic Map6q12NCBI
PLEKHH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21282,655,725 - 82,784,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A82,659,697 - 82,788,358 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A43,723,791 - 43,852,380 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A44,570,356 - 44,700,272 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A44,570,356 - 44,700,272 (+)Ensemblpanpan1.1panPan2
PLEKHH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,113,659 - 46,226,259 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,114,348 - 46,224,363 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1045,975,843 - 46,087,889 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01046,992,023 - 47,104,761 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1046,992,060 - 47,103,049 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11046,700,351 - 46,813,125 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01046,990,837 - 47,103,309 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01047,173,714 - 47,286,463 (+)NCBIUU_Cfam_GSD_1.0
Plekhh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,724,758 - 36,840,159 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365088,153,122 - 8,268,779 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365088,153,367 - 8,268,760 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,709,059 - 96,833,410 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1396,707,397 - 96,833,431 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,783,515 - 102,863,985 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11463,488,305 - 63,617,146 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1463,488,773 - 63,609,021 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604548,277,182 - 48,402,709 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekhh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473825,123,506 - 25,239,175 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473825,122,843 - 25,240,304 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000006559   ⟹   ENSCLAP00000006452
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544110,825,499 - 10,919,901 (+)Ensembl
RefSeq Acc Id: XM_005390924   ⟹   XP_005390981
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544110,819,328 - 10,921,224 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005390925   ⟹   XP_005390982
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544110,819,327 - 10,921,224 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005390927   ⟹   XP_005390984
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544110,819,471 - 10,921,224 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005390928   ⟹   XP_005390985
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544110,818,982 - 10,921,224 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005390929   ⟹   XP_005390986
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544110,819,471 - 10,921,224 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005390930   ⟹   XP_005390987
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544110,819,824 - 10,921,224 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005390931   ⟹   XP_005390988
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544110,819,326 - 10,918,587 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005390932   ⟹   XP_005390989
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544110,819,325 - 10,905,922 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005390933   ⟹   XP_005390990
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544110,819,324 - 10,902,474 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013517541   ⟹   XP_013372995
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544110,819,328 - 10,921,224 (+)NCBI
Sequence:
RefSeq Acc Id: XR_262069
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544110,819,326 - 10,918,573 (+)NCBI
Sequence:
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: XP_005390985   ⟸   XM_005390928
- Peptide Label: isoform X3
- UniProtKB: A0A8C2UVL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005390990   ⟸   XM_005390933
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_005390988   ⟸   XM_005390931
- Peptide Label: isoform X5
- UniProtKB: A0A8C2UVL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005390989   ⟸   XM_005390932
- Peptide Label: isoform X6
- UniProtKB: A0A8C2UVL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005390981   ⟸   XM_005390924
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UVL9 (UniProtKB/TrEMBL)
- Sequence:
FERM   MyTH4   PH



1 to 32 of 32 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000004558 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000006559 ENTREZGENE
  ENSCLAT00000006559.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  1.25.40.530 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  MyTH4_dom UniProtKB/TrEMBL
  MyTH4_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
NCBI Gene Plekhh2 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 2 UniProtKB/TrEMBL
  PLEKHH PROTEIN UniProtKB/TrEMBL
Pfam FERM_M UniProtKB/TrEMBL
  MyTH4 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RA_2 UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  MYTH4 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  MyTH4 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
UniProt A0A8C2UVL9 ENTREZGENE, UniProtKB/TrEMBL
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Plekhh2  pleckstrin homology, MyTH4 and FERM domain containing H2    pleckstrin homology domain containing, family H (with MyTH4 domain) member 2  Symbol and/or name change 5135510 APPROVED