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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2457
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: CHEBI:39175
Term: thiacloprid
Definition: A nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin-2-ylidene group which in turn is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen.
Chemical ID: MESH:C417209
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1affects expressionISOCYP19A1 (Homo sapiens)6480464CTDthiacloprid affects the expression of CYP19A1 mRNAPMID:29701941
Cyp19a1increases activityISOCYP19A1 (Homo sapiens)6480464CTDthiacloprid results in increased activity of CYP19A1 proteinPMID:26464060 PMID:28750898
Cyp19a1increases expressionISOCYP19A1 (Homo sapiens)6480464CTDthiacloprid results in increased expression of CYP19A1 mRNAPMID:26464060
Cyp19a1multiple interactionsISOCYP19A1 (Homo sapiens)6480464CTD1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects the reaction [thiacloprid affects the expression of CYP19A1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [thiacloprid affects the expression of CYP19A1 mRNA]PMID:29701941
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