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Gene: Eed (embryonic ectoderm development) Rattus norvegicus

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Symbol:

Eed

Name:

embryonic ectoderm development

RGD ID:

1309782

Description:

Enables chromatin binding activity. Involved in negative regulation of transcription by RNA polymerase II and spinal cord development. Predicted to be located in cytosol; nucleus; and sex chromatin. Predicted to be part of ESC/E(Z) complex and chromatin silencing complex. Used to study transient cerebral ischemia. Orthologous to human EED (embryonic ectoderm development); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; amphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC293104; polycomb protein EED

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EED (embryonic ectoderm development)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Eed (embryonic ectoderm development)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Eed (embryonic ectoderm development)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EED (embryonic ectoderm development)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EED (embryonic ectoderm development)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Eed (embryonic ectoderm development)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EED (embryonic ectoderm development)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EED (embryonic ectoderm development)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Eed (embryonic ectoderm development)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TBX21 (T-box transcription factor 21)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	EED (embryonic ectoderm development)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Eed (embryonic ectoderm development)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	eed (embryonic ectoderm development)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	esc	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	escl	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mes-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	eed	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	153,280,419 - 153,307,537 (-)	NCBI		GRCr8
mRatBN7.2	1	143,867,875 - 143,895,008 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	143,867,875 - 143,894,974 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	151,808,615 - 151,835,700 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	158,985,009 - 159,012,094 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	151,858,916 - 151,886,001 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	154,189,252 - 154,216,340 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	154,189,260 - 154,216,340 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	160,493,753 - 160,520,834 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	146,563,961 - 146,591,042 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	146,642,345 - 146,669,450 (-)	NCBI
Celera	1	142,108,258 - 142,135,298 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eed	Rat	Kidney Reperfusion Injury		ISO	RGD:1320307	155631277	mRNA:altered expression:kidney (mouse)	RGD
Eed	Rat	transient cerebral ischemia		IDA		9588303		RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eed	Rat	autism spectrum disorder		ISO	RGD:1320306	8554872	ClinVar Annotator: match by term: Autism spectrum disorder	ClinVar	PMID:25741868
Eed	Rat	Cohen-Gibson Syndrome		ISO	RGD:1320306	8554872	ClinVar Annotator: match by term: Cohen-Gibson syndrome \| ClinVar Annotator: match by term: EED-related condition	ClinVar	PMID:17576681\|PMID:25741868\|PMID:27193220\|PMID:27868325\|PMID:28119537\|PMID:28229514\|PMID:28475857\|PMID:28492532\|PMID:30858506\|PMID:9536098
Eed	Rat	exudative vitreoretinopathy 1		ISO	RGD:1320306	8554872	ClinVar Annotator: match by term: Exudative vitreoretinopathy 1	ClinVar	PMID:21097938\|PMID:21681106
Eed	Rat	genetic disease		ISO	RGD:1320306	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:17576681\|PMID:28492532\|PMID:9536098
Eed	Rat	hereditary breast ovarian cancer syndrome		ISO	RGD:1320306	8554872	ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndrome	ClinVar	PMID:25741868
Eed	Rat	intellectual disability		ISO	RGD:1320306	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eed	Rat	Nerve Sheath Neoplasms		ISO	RGD:1320306	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:25240281
Eed	Rat	neurilemmoma		ISO	RGD:1320306	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:25119042

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eed	Rat	Cohen-Gibson Syndrome		ISO	RGD:1320306	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eed	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:1320307	6480464	Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of EED mRNA]	CTD	PMID:22206623
Eed	Rat	1,2-dimethylhydrazine	decreases expression	ISO	RGD:1320307	6480464	1,2-Dimethylhydrazine results in decreased expression of EED mRNA	CTD	PMID:22206623
Eed	Rat	17alpha-ethynylestradiol	multiple interactions	ISO	RGD:1320307	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EED mRNA	CTD	PMID:17942748
Eed	Rat	17alpha-ethynylestradiol	increases expression	ISO	RGD:1320307	6480464	Ethinyl Estradiol results in increased expression of EED mRNA	CTD	PMID:17942748
Eed	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1320307	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EED mRNA	CTD	PMID:17942748
Eed	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of EED mRNA	CTD	PMID:34747641
Eed	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1320307	6480464	Tetrachlorodibenzodioxin affects the expression of EED mRNA	CTD	PMID:21570461
Eed	Rat	2,4-dinitrotoluene	affects expression	EXP		6480464	2,4-dinitrotoluene affects the expression of EED mRNA	CTD	PMID:21346803
Eed	Rat	aflatoxin B1	increases expression	ISO	RGD:1320307	6480464	Aflatoxin B1 results in increased expression of EED mRNA	CTD	PMID:19770486
Eed	Rat	aflatoxin B1	decreases methylation	ISO	RGD:1320306	6480464	Aflatoxin B1 results in decreased methylation of EED gene	CTD	PMID:27153756
Eed	Rat	amiodarone	increases expression	ISO	RGD:1320306	6480464	Amiodarone results in increased expression of EED mRNA	CTD	PMID:19774075
Eed	Rat	amphetamine	increases expression	EXP		6480464	Amphetamine results in increased expression of EED mRNA	CTD	PMID:30779732
Eed	Rat	arsane	increases expression	ISO	RGD:1320307	6480464	Arsenic results in increased expression of EED protein	CTD	PMID:22843710
Eed	Rat	arsenic atom	increases expression	ISO	RGD:1320307	6480464	Arsenic results in increased expression of EED protein	CTD	PMID:22843710
Eed	Rat	azoxystrobin	increases expression	ISO	RGD:1320306	6480464	azoxystrobin results in increased expression of EED mRNA	CTD	PMID:33512557
Eed	Rat	benzene	increases expression	ISO	RGD:1320306	6480464	Benzene results in increased expression of EED mRNA	CTD	PMID:19162166
Eed	Rat	benzo[a]pyrene	increases expression	EXP		6480464	Benzo(a)pyrene results in increased expression of EED mRNA	CTD	PMID:21839799
Eed	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1320306	6480464	Benzo(a)pyrene results in increased expression of EED mRNA	CTD	PMID:32234424
Eed	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1320307	6480464	Benzo(a)pyrene results in increased expression of EED mRNA	CTD	PMID:19770486\|PMID:22228805
Eed	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	RGD:1320306	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EED mRNA	CTD	PMID:19150397
Eed	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of EED mRNA	CTD	PMID:25181051\|PMID:30816183\|PMID:34947998
Eed	Rat	bisphenol A	decreases expression	ISO	RGD:1320307	6480464	bisphenol A results in decreased expression of EED mRNA	CTD	PMID:33221593\|PMID:36508816
Eed	Rat	bisphenol A	decreases expression	ISO	RGD:1320306	6480464	bisphenol A results in decreased expression of EED mRNA	CTD	PMID:29275510
Eed	Rat	bisphenol A	increases methylation	ISO	RGD:1320307	6480464	bisphenol A results in increased methylation of EED gene; bisphenol A results in increased methylation more ...	CTD	PMID:30841672\|PMID:36508816
Eed	Rat	copper atom	multiple interactions	ISO	RGD:1320306	6480464	[Disulfiram binds to Copper] which results in decreased expression of EED mRNA	CTD	PMID:24690739
Eed	Rat	copper(0)	multiple interactions	ISO	RGD:1320306	6480464	[Disulfiram binds to Copper] which results in decreased expression of EED mRNA	CTD	PMID:24690739
Eed	Rat	copper(II) sulfate	decreases expression	ISO	RGD:1320306	6480464	Copper Sulfate results in decreased expression of EED mRNA	CTD	PMID:19549813
Eed	Rat	coumestrol	increases expression	ISO	RGD:1320306	6480464	Coumestrol results in increased expression of EED mRNA	CTD	PMID:19167446
Eed	Rat	coumestrol	multiple interactions	ISO	RGD:1320306	6480464	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of EED mRNA; [Coumestrol co-treated with resveratrol] more ...	CTD	PMID:19167446
Eed	Rat	cyclosporin A	decreases expression	ISO	RGD:1320306	6480464	Cyclosporine results in decreased expression of EED mRNA	CTD	PMID:20106945
Eed	Rat	cyclosporin A	affects expression	ISO	RGD:1320306	6480464	Cyclosporine affects the expression of EED mRNA	CTD	PMID:25562108
Eed	Rat	DDE	increases expression	ISO	RGD:1320306	6480464	Dichlorodiphenyl Dichloroethylene results in increased expression of EED mRNA	CTD	PMID:38568856
Eed	Rat	disulfiram	multiple interactions	ISO	RGD:1320306	6480464	[Disulfiram binds to Copper] which results in decreased expression of EED mRNA	CTD	PMID:24690739
Eed	Rat	dorsomorphin	multiple interactions	ISO	RGD:1320306	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Eed	Rat	Enterolactone	multiple interactions	ISO	RGD:1320306	6480464	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of EED mRNA	CTD	PMID:19167446
Eed	Rat	enzalutamide	multiple interactions	ISO	RGD:1320306	6480464	[enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to more ...	CTD	PMID:32805266
Eed	Rat	enzalutamide	decreases expression	ISO	RGD:1320306	6480464	enzalutamide results in decreased expression of EED protein	CTD	PMID:32805266
Eed	Rat	fipronil	decreases expression	EXP		6480464	fipronil results in decreased expression of EED mRNA	CTD	PMID:34044035
Eed	Rat	folic acid	multiple interactions	ISO	RGD:1320307	6480464	Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of EED mRNA]	CTD	PMID:22206623
Eed	Rat	formaldehyde	increases expression	ISO	RGD:1320306	6480464	Formaldehyde results in increased expression of EED mRNA	CTD	PMID:23649840
Eed	Rat	ivermectin	decreases expression	ISO	RGD:1320306	6480464	Ivermectin results in decreased expression of EED protein	CTD	PMID:32959892
Eed	Rat	leflunomide	decreases expression	ISO	RGD:1320306	6480464	leflunomide results in decreased expression of EED mRNA	CTD	PMID:28988120
Eed	Rat	methapyrilene	increases expression	EXP		6480464	Methapyrilene results in increased expression of EED mRNA	CTD	PMID:30467583
Eed	Rat	methotrexate	affects response to substance	ISO	RGD:1320306	6480464	EED protein affects the susceptibility to Methotrexate	CTD	PMID:16217747
Eed	Rat	methyl methanesulfonate	increases expression	ISO	RGD:1320306	6480464	Methyl Methanesulfonate results in increased expression of EED mRNA	CTD	PMID:23649840
Eed	Rat	methylmercury chloride	increases expression	ISO	RGD:1320306	6480464	methylmercuric chloride results in increased expression of EED mRNA	CTD	PMID:28001369
Eed	Rat	morphine	increases expression	ISO	RGD:1320307	6480464	Morphine results in increased expression of EED mRNA	CTD	PMID:33891991
Eed	Rat	N-methyl-N-nitrosourea	affects response to substance	ISO	RGD:1320307	6480464	EED protein affects the susceptibility to Methylnitrosourea	CTD	PMID:11803473
Eed	Rat	ozone	multiple interactions	ISO	RGD:1320307	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ...	CTD	PMID:34911549
Eed	Rat	paracetamol	increases expression	ISO	RGD:1320306	6480464	Acetaminophen results in increased expression of EED mRNA	CTD	PMID:22230336
Eed	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1320307	6480464	[perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of EED mRNA	CTD	PMID:36331819
Eed	Rat	quinolin-8-ol	decreases expression	ISO	RGD:1320306	6480464	Oxyquinoline results in decreased expression of EED mRNA	CTD	PMID:21632981
Eed	Rat	resveratrol	multiple interactions	ISO	RGD:1320306	6480464	[Coumestrol co-treated with Resveratrol] results in increased expression of EED mRNA; [Plant Extracts co-treated with more ...	CTD	PMID:19167446\|PMID:23557933
Eed	Rat	resveratrol	decreases expression	ISO	RGD:1320307	6480464	resveratrol results in decreased expression of EED protein	CTD	PMID:25505154
Eed	Rat	SB 431542	multiple interactions	ISO	RGD:1320306	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Eed	Rat	sodium arsenite	increases expression	ISO	RGD:1320307	6480464	sodium arsenite results in increased expression of EED mRNA	CTD	PMID:35364107
Eed	Rat	tetrachloromethane	increases expression	ISO	RGD:1320307	6480464	Carbon Tetrachloride results in increased expression of EED mRNA	CTD	PMID:27339419
Eed	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of EED mRNA	CTD	PMID:34492290
Eed	Rat	titanium dioxide	decreases methylation	ISO	RGD:1320307	6480464	titanium dioxide results in decreased methylation of EED gene	CTD	PMID:35295148
Eed	Rat	valproic acid	decreases expression	ISO	RGD:1320306	6480464	Valproic Acid results in decreased expression of EED mRNA	CTD	PMID:23179753
Eed	Rat	valproic acid	increases expression	ISO	RGD:1320306	6480464	Valproic Acid results in increased expression of EED mRNA	CTD	PMID:26272509
Eed	Rat	valproic acid	multiple interactions	ISO	RGD:1320306	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eed	Rat	cellular response to leukemia inhibitory factor	acts_upstream_of_or_within	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	cellular response to leukemia inhibitory factor	acts_upstream_of_or_within	ISO	RGD:1320307	1624291	PMID:20439489	RGD	PMID:20439489
Eed	Rat	facultative heterochromatin formation	involved_in	ISO	RGD:1320307	1624291	PMID:20064375, PMID:20064376	RGD	PMID:20064375\|PMID:20064376
Eed	Rat	facultative heterochromatin formation	involved_in	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	genomic imprinting	acts_upstream_of_or_within	ISO	RGD:1320307	1624291	MGI:1856856 PMID:12627233	RGD	PMID:12627233
Eed	Rat	genomic imprinting	acts_upstream_of_or_within	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	heterochromatin formation	involved_in	IBA	FB:FBgn0000588\|FB:FBgn0032391\|MGI:95286\|PANTHER:PTN000028944\|UniProtKB:Q6ZJW8\|UniProtKB:Q6ZJX0	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Eed	Rat	negative regulation of transcription by RNA polymerase II		IDA		9588305		RGD
Eed	Rat	negative regulation of transcription by RNA polymerase II	acts_upstream_of_or_within	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	negative regulation of transcription by RNA polymerase II	acts_upstream_of_or_within	ISO	RGD:1320307	1624291	MGI:88174 PMID:17107999, PMID:24105743	RGD	PMID:17107999\|PMID:24105743
Eed	Rat	negative regulation of transcription by RNA polymerase II	involved_in	IBA	MGI:95286\|PANTHER:PTN000028944\|RGD:1309782	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Eed	Rat	oligodendrocyte differentiation	acts_upstream_of_or_within	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	oligodendrocyte differentiation	acts_upstream_of_or_within	ISO	RGD:1320307	1624291	PMID:28041882	RGD	PMID:28041882
Eed	Rat	regulation of adaxial/abaxial pattern formation	acts_upstream_of_or_within	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	regulation of adaxial/abaxial pattern formation	acts_upstream_of_or_within	ISO	RGD:1320307	1624291	MGI:88174 PMID:17107999	RGD	PMID:17107999
Eed	Rat	spinal cord development		IEP		9491842		RGD

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eed	Rat	chromatin silencing complex	part_of	ISO	RGD:1320307	1624291	PMID:26658965	RGD	PMID:26658965
Eed	Rat	chromatin silencing complex	part_of	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	cytosol	located_in	IEA	UniProtKB:O75530\|ensembl:ENSP00000263360	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	cytosol	located_in	ISO	RGD:1320306\|UniProtKB:O75530-1\|UniProtKB:O75530-2\|UniProtKB:O75530-3	1624291		RGD	GO_REF:0000052
Eed	Rat	ESC/E(Z) complex	part_of	ISO	RGD:1320306	1624291	PMID:15385962, PMID:20075857, PMID:23104054, PMID:23273982	RGD	PMID:15385962\|PMID:20075857\|PMID:23104054\|PMID:23273982
Eed	Rat	ESC/E(Z) complex	part_of	IEA	UniProtKB:O75530\|ensembl:ENSP00000263360	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	ESC/E(Z) complex	part_of	IBA	FB:FBgn0000588\|FB:FBgn0032391\|MGI:95286\|PANTHER:PTN000028944\|UniProtKB:O75530	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Eed	Rat	ESC/E(Z) complex	part_of	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	ESC/E(Z) complex	part_of	ISO	RGD:1320307	1624291	PMID:20064375, PMID:20064376, PMID:20144788, PMID:22438827, PMID:31451685	RGD	PMID:20064375\|PMID:20064376\|PMID:20144788\|PMID:22438827\|PMID:31451685
Eed	Rat	nucleoplasm	located_in	ISO	RGD:1320306\|UniProtKB:O75530-1\|UniProtKB:O75530-2\|UniProtKB:O75530-3	1624291		RGD	GO_REF:0000052
Eed	Rat	nucleoplasm	located_in	IEA	UniProtKB:O75530\|ensembl:ENSP00000263360	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	nucleus	located_in	ISO	RGD:1320307	1624291	PMID:11555636, PMID:17107999, PMID:18483221, PMID:19796622, PMID:22573614, PMID:9584197	RGD	PMID:11555636\|PMID:17107999\|PMID:18483221\|PMID:19796622\|PMID:22573614\|PMID:9584197
Eed	Rat	nucleus	located_in	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	pronucleus	located_in	ISO	RGD:1320307	1624291	PMID:12900441	RGD	PMID:12900441
Eed	Rat	pronucleus	located_in	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	sex chromatin	located_in	ISO	RGD:1320307	1624291	PMID:15525528	RGD	PMID:15525528
Eed	Rat	sex chromatin	located_in	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eed	Rat	chromatin binding		IDA		9588305		RGD
Eed	Rat	chromatin binding	enables	ISO	RGD:1320307	1624291	PMID:16687444, PMID:24105743	RGD	PMID:16687444\|PMID:24105743
Eed	Rat	chromatin binding	enables	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	enzyme activator activity	enables	ISO	RGD:1320307	1624291	MGI:1856856 PMID:15916951, PMID:17997413	RGD	PMID:15916951\|PMID:17997413
Eed	Rat	enzyme activator activity	enables	IEA	UniProtKB:O75530\|ensembl:ENSP00000263360	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	enzyme activator activity	enables	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	enzyme activator activity	enables	ISO	RGD:1320306	1624291	PMID:15385962, PMID:28229514	RGD	PMID:15385962\|PMID:28229514
Eed	Rat	identical protein binding	enables	ISO	RGD:1320306	1624291	UniProtKB:O75530 PMID:11124122	RGD	PMID:11124122
Eed	Rat	identical protein binding	enables	IEA	UniProtKB:O75530\|ensembl:ENSP00000263360	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	methylated histone binding	enables	ISO	RGD:1320307	1624291	PMID:17107999	RGD	PMID:17107999
Eed	Rat	methylated histone binding	enables	IEA	UniProtKB:Q921E6\|ensembl:ENSMUSP00000102853	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Eed	Rat	nucleosome binding	contributes_to	IBA	FB:FBgn0000588\|PANTHER:PTN000028944	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Eed	Rat	protein binding		IPI	RGD:619754	9588303		RGD
Eed	Rat	protein binding	enables	ISO	RGD:1320307	1624291	PR:O09106\|PR:P22227\|PR:P70351\|PR:Q00899\|PR:Q3TTC2\|PR:Q61188\|PR:Q923W1\|UniProtKB:Q02395\|UniProtKB:Q61188\|UniProtKB:Q61188-1\|UniProtKB:Q62315\|UniProtKB:Q7TNS8 PMID:12900441, PMID:12943661, PMID:17107999, PMID:17937919, PMID:17997413, PMID:20064375, PMID:20064376, PMID:20075857, PMID:21530438, PMID:22094255, PMID:23180766, PMID:9584197, PMID:9742080	RGD	PMID:12900441\|PMID:12943661\|PMID:17107999\|PMID:17937919\|PMID:17997413\|PMID:20064375\|PMID:20064376\|PMID:20075857\|PMID:21530438\|PMID:22094255\|PMID:23180766\|PMID:9584197\|PMID:9742080
Eed	Rat	protein binding	enables	ISO	RGD:1320306,UniProtKB:O75530-2	1624291	UniProtKB:G5E9A7\|UniProtKB:O60260-5\|UniProtKB:O60333-2\|UniProtKB:P28799\|UniProtKB:P35240\|UniProtKB:P37840\|UniProtKB:P40337-2\|UniProtKB:Q13148\|UniProtKB:Q15910-2\|UniProtKB:Q7Z699\|UniProtKB:Q8WXH2\|UniProtKB:Q92800-2\|UniProtKB:Q9Y3C5 PMID:32296183, PMID:32814053	RGD	PMID:32296183\|PMID:32814053
Eed	Rat	protein binding	enables	ISO	RGD:1320306	1624291	UniProtKB:O43189\|UniProtKB:P26358\|UniProtKB:P49368\|UniProtKB:P63244\|UniProtKB:Q15022\|UniProtKB:Q15156\|UniProtKB:Q15910\|UniProtKB:Q16531\|UniProtKB:Q8IXJ9\|UniProtKB:Q92800\|UniProtKB:Q92833-1\|UniProtKB:Q9JJY3\|UniProtKB:Q9NY59\|UniProtKB:Q9UBC3\|UniProtKB:Q9Y232\|UniProtKB:Q9Y6K1 PMID:16357870, PMID:17041588, PMID:17560333, PMID:20075857, PMID:20080539, PMID:20211142, PMID:20543829, PMID:21078963, PMID:22009739, PMID:22094255, PMID:22439931, PMID:22897849, PMID:23238014, more ...	RGD	PMID:16357870\|PMID:17041588\|PMID:17560333\|PMID:20075857\|PMID:20080539\|PMID:20211142\|PMID:20543829\|PMID:21078963\|PMID:22009739\|PMID:22094255\|PMID:22439931\|PMID:22897849\|PMID:23238014\|PMID:24981860\|PMID:26496610\|PMID:27705803\|PMID:28229514\|PMID:29628311\|PMID:30021884\|PMID:33961781\|PMID:34591612\|PMID:35016035
Eed	Rat	transcription corepressor binding	enables	ISO	RGD:1320306	1624291	UniProtKB:Q96JN0 PMID:29628311	RGD	PMID:29628311
Eed	Rat	transcription corepressor binding	enables	IEA	UniProtKB:O75530\|ensembl:ENSP00000263360	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Pathway Annotations Click to see Annotation Detail View

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eed	Rat	histone modification pathway		ISO	RGD:1320306	9479059		RGD
Eed	Rat	histone modification pathway		ISO	RGD:1320306	9479058		RGD

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Cohen-Gibson Syndrome (ISO)

exudative vitreoretinopathy 1 (ISO)

genetic disease (ISO)

hereditary breast ovarian cancer syndrome (ISO)

intellectual disability (ISO)

Kidney Reperfusion Injury (ISO)

Nerve Sheath Neoplasms (ISO)

neurilemmoma (ISO)

transient cerebral ischemia (IDA)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

aflatoxin B1 (ISO)

amiodarone (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

azoxystrobin (ISO)

benzene (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

DDE (ISO)

disulfiram (ISO)

dorsomorphin (ISO)

Enterolactone (ISO)

enzalutamide (ISO)

fipronil (EXP)

folic acid (ISO)

formaldehyde (ISO)

ivermectin (ISO)

leflunomide (ISO)

methapyrilene (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

morphine (ISO)

N-methyl-N-nitrosourea (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

quinolin-8-ol (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to leukemia inhibitory factor (IEA,ISO)

facultative heterochromatin formation (IEA,ISO)

genomic imprinting (IEA,ISO)

heterochromatin formation (IBA)

negative regulation of transcription by RNA polymerase II (IBA,IDA,IEA,ISO)

oligodendrocyte differentiation (IEA,ISO)

regulation of adaxial/abaxial pattern formation (IEA,ISO)

spinal cord development (IEP)

Cellular Component

chromatin silencing complex (IEA,ISO)

cytosol (IEA,ISO)

ESC/E(Z) complex (IBA,IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

pronucleus (IEA,ISO)

sex chromatin (IEA,ISO)

Molecular Function

chromatin binding (IDA,IEA,ISO)

enzyme activator activity (IEA,ISO)

identical protein binding (IEA,ISO)

methylated histone binding (IEA,ISO)

nucleosome binding (IBA)

protein binding (IPI,ISO)

transcription corepressor binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi.	Gu L, etal., J Neuroinflammation. 2013 Sep 3;10:109. doi: 10.1186/1742-2094-10-109.
4.	SET for life: biochemical activities and biological functions of SET domain-containing proteins.	Herz HM, etal., Trends Biochem Sci. 2013 Dec;38(12):621-39. doi: 10.1016/j.tibs.2013.09.004. Epub 2013 Oct 20.
5.	Epigenetic control of female puberty.	Lomniczi A, etal., Nat Neurosci. 2013 Mar;16(3):281-9. doi: 10.1038/nn.3319. Epub 2013 Jan 27.
6.	Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes.	Metsuyanim S, etal., Stem Cells. 2008 Jul;26(7):1808-17. doi: 10.1634/stemcells.2007-0322. Epub 2008 May 8.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put.	Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
10.	Polycomb group proteins are essential for spinal cord development.	Wang C, etal., Front Biosci (Landmark Ed). 2010 Jun 1;15:1018-22.

Additional References at PubMed

PMID:9584197	PMID:11124122	PMID:11555636	PMID:12477932	PMID:12627233	PMID:12900441	PMID:15385962	PMID:15525528	PMID:15916951	PMID:16687444	PMID:17107999	PMID:17997413
PMID:18483221	PMID:19796622	PMID:20064375	PMID:20064376	PMID:20075857	PMID:20144788	PMID:20439489	PMID:22438827	PMID:22573614	PMID:23104054	PMID:23273982	PMID:24105743
PMID:26658965	PMID:28041882	PMID:28229514	PMID:31451685	PMID:33479437

Genomics

Comparative Map Data

Eed
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	153,280,419 - 153,307,537 (-)	NCBI		GRCr8
mRatBN7.2	1	143,867,875 - 143,895,008 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	143,867,875 - 143,894,974 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	151,808,615 - 151,835,700 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	158,985,009 - 159,012,094 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	151,858,916 - 151,886,001 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	154,189,252 - 154,216,340 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	154,189,260 - 154,216,340 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	160,493,753 - 160,520,834 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	146,563,961 - 146,591,042 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	146,642,345 - 146,669,450 (-)	NCBI
Celera	1	142,108,258 - 142,135,298 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

EED
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	86,244,753 - 86,287,615 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	86,201,212 - 86,279,807 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	85,955,795 - 85,989,852 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	85,633,463 - 85,667,429 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	85,633,462 - 85,667,426	NCBI
Celera	11	83,265,529 - 83,300,439 (+)	NCBI		Celera
Cytogenetic Map	11	q14.2	NCBI
HuRef	11	82,243,000 - 82,278,147 (+)	NCBI		HuRef
CHM1_1	11	85,841,580 - 85,875,590 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	86,186,227 - 86,228,460 (+)	NCBI		T2T-CHM13v2.0

Eed
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	89,603,862 - 89,630,184 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	89,603,862 - 89,630,191 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	89,954,654 - 89,980,976 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	89,954,654 - 89,980,983 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	97,103,164 - 97,129,486 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	89,829,868 - 89,857,005 (-)	NCBI		MGSCv36	mm8
Celera	7	87,275,683 - 87,302,613 (-)	NCBI		Celera
Cytogenetic Map	7	D3	NCBI
cM Map	7	50.42	NCBI

Eed
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	6,659,055 - 6,685,530 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	6,659,144 - 6,685,530 (-)	NCBI	ChiLan1.0	ChiLan1.0

EED
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	87,159,183 - 87,197,608 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	88,210,050 - 88,248,464 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	81,295,068 - 81,330,321 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	84,902,330 - 84,937,906 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	84,902,330 - 84,937,906 (+)	Ensembl	panpan1.1		panPan2

EED
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	13,260,062 - 13,289,511 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	13,260,002 - 13,289,337 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	13,125,575 - 13,155,433 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	13,442,739 - 13,472,602 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	13,442,743 - 13,472,368 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	13,228,555 - 13,258,431 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	13,300,989 - 13,331,006 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	13,357,756 - 13,387,545 (-)	NCBI		UU_Cfam_GSD_1.0

Eed
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	72,451,606 - 72,483,821 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	14,051,045 - 14,083,570 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	14,050,731 - 14,082,410 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EED
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	20,123,857 - 20,158,816 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	20,123,077 - 20,158,747 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	22,382,548 - 22,417,549 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EED
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	77,496,266 - 77,531,439 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	77,496,086 - 77,531,499 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	48,194,395 - 48,229,592 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eed
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624845	3,679,096 - 3,712,176 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624845	3,679,163 - 3,712,153 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Eed
155 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	53
Count of miRNA genes:	42
Interacting mature miRNAs:	51
Transcripts:	ENSRNOT00000024082
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	121767634	166767634	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	123350408	182418476	Rat
9590300	Scort16	Serum corticosterone level QTL 16	4.39	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	103111621	148111621	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	57336763	151090257	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	115585465	172949803	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	48963584	144267916	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
152025232	Bw192	Body weight QTL 192	3.93		body mass (VT:0001259)		1	117917486	196963478	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	90508614	173018436	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
61346	Rf2	Renal disease susceptibility QTL 2	3.7		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	1	99267916	144267916	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
2317833	Alcrsp19	Alcohol response QTL 19	12.4	0.001	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	100979852	145979852	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	131763437	159756369	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
631206	Niddm40	Non-insulin dependent diabetes mellitus QTL 40			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	136745990	163747690	Rat
1641897	Alcrsp1	Alcohol response QTL 1			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	100979852	145979852	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
9685799	Bp375	Blood pressure QTL 375			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121833674	166833674	Rat
9685802	Bp376	Blood pressure QTL 376			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	126540680	171540680	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	87580395	150700247	Rat
61370	Mcs3	Mammary carcinoma susceptibility QTL 3	2.15		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	102268556	147268556	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	123350408	182418476	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
631496	Bp97	Blood pressure QTL 97	3.08		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	106047847	151047847	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
2303591	Gluco41	Glucose level QTL 41	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	102168504	147168504	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94494440	172949803	Rat
2313060	Bss71	Bone structure and strength QTL 71	2.6	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	1	118944747	163944747	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
724550	Thym3	Thymus enlargement QTL 3	7.82	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
71118	Thym1	Thymus enlargement QTL 1	10.17	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	136830018	181830018	Rat
61399	Tcat1	Tongue tumor resistance QTL 1	3.3		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)	1	99267916	144267916	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	92948896	144267916	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	168883176	Rat
8694370	Bw154	Body weight QTL 154	8.91	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	1	103111621	148111621	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
1354623	Rf46	Renal function QTL 46	3.8		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	1	102813953	151162766	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350408	181759564	Rat
152025212	Bw190	Body weight QTL 190	5.7		body mass (VT:0001259)		1	123556856	196963478	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	123350408	182418476	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106278	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006229664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024082 ⟹ ENSRNOP00000024082

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	143,867,878 - 143,894,958 (-)	Ensembl
Rnor_6.0 Ensembl	1	154,189,260 - 154,216,340 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114221 ⟹ ENSRNOP00000093078

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	143,867,875 - 143,894,269 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115575 ⟹ ENSRNOP00000096570

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	143,867,917 - 143,894,958 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117476 ⟹ ENSRNOP00000085082

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	143,867,879 - 143,894,974 (-)	Ensembl

RefSeq Acc Id:

NM_001106278 ⟹ NP_001099748

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	153,280,419 - 153,307,500 (-)	NCBI
mRatBN7.2	1	143,867,875 - 143,894,958 (-)	NCBI
Rnor_6.0	1	154,189,259 - 154,216,340 (-)	NCBI
Rnor_5.0	1	160,493,753 - 160,520,834 (-)	NCBI
RGSC_v3.4	1	146,563,961 - 146,591,042 (-)	RGD
Celera	1	142,108,258 - 142,135,298 (-)	RGD

Sequence:

show sequence

CAATTGCGGACGAAACGTCTGGGCAAGGAAGGGGGTGAGGGAGCAGCCCTTTGAGTTCCGCCTC
CTCTCTAGGCGCTGGTGGGGAAGGGGGACTAGGAAACCCTGCCCTCTGAGCCAGCAGGTCCGAC
GCCTCGGTGCAAAGTGCCGAGAGGGCGGCGGGAAAACCGCCCGCCGGGACCAGGGGACGGGAAG
CAGCCAGGAAGCCGTACGGGAGGGCGCGCGCGCGCGCGCCCCTTTTTCAGCAGTGTGGCGGGGT
CGCACGCACGCCCGCCTCGGCGGCTGGGCGCGATTTGCGACAGTGGGGGGAGCGGCGGCGGTGG
CGGTGCCGGCAGCTTTGCGGCAGGCTCCGGCCGGGCGTGCTTGACGGCGGTGTGGCGGAGGCCC
CGCCCGAGGCGGCAAGAACCTGGAGGGAGGCGGAGGAATATGTCTGAGAGGGAAGTGTCGACTG
CGCCGGCGGGAACAGACATGCCGGCGGCCAAGAAGCAGAAGTTGAGCAGCGACGAGAACAGCAA
CCCGGACCTCTCGGGAGACGAGAATGACGATGCTGTCAGTATCGAGAGTGGCACAAACACAGAA
CGCCCGGACACACCCACAAATACACCAAATGCACCAGGAAGGAAAAGCTGGGGAAAGGGAAAAT
GGAAGTCGAAGAAATGCAAATATTCTTTCAAATGTGTGAACAGCCTCAAGGAAGATCACAACCA
GCCATTGTTTGGAGTTCAGTTTAACTGGCACAGTAAAGAAGGAGATCCTCTGGTGTTTGCAACT
GTGGGAAGCAACAGAGTAACCTTATATGAATGCCATTCTCAAGGGGAAATACGGTTATTGCAGT
CCTATGTAGATGCTGATGCAGATGAAAACTTTTACACTTGTGCATGGACCTATGATAGCAACAC
CAGCCACCCTCTGCTAGCAGTTGCTGGATCTAGAGGCATAATAAGAATAATTAATCCTATAACA
ATGCAGTGTATAAAGCACTATGTTGGCCATGGGAATGCTATCAATGAGCTGAAATTCCACCCAC
GAGACCCAAACCTTCTCCTGTCAGTAAGTAAAGATCATGCTTTACGATTATGGAATATCCAAAC
AGACACTCTTGTGGCAATATTCGGAGGTGTGGAAGGGCACAGAGATGAAGTGCTGAGTGCTGAT
TATGATCTTTTGGGTGAAAAAATAATGTCCTGTGGTATGGATCACTCTCTTAAACTGTGGAGAA
TCAACTCAAAGAGAATGATGAATGCGATTAAGGAATCTTACGATTATAACCCAAACAAAACTAA
CAGGCCATTTATTTCCCAGAAAATCCACTTTCCTGATTTTTCTACCAGAGACATACATAGGAAT
TATGTTGATTGTGTACGATGGTTAGGCGATTTGATACTTTCCAAGTCTTGTGAAAATGCCATTG
TATGCTGGAAACCTGGCAAAATGGAGGATGATATAGATAAAATTAAACCTAGTGAGTCTAATGT
GACTATTCTTGGGCGATTTGATTACAGCCAGTGTGACATTTGGTACATGAGGTTTTCTATGGAT
TTCTGGCAAAAGATGCTTGCATTGGGCAATCAGGTTGGCAAACTGTATGTTTGGGATTTAGAAG
TAGAAGATCCTCATAAAGCCAAATGCACAACACTGACCCATCATAAATGTGGCGCTGCTATTCG
ACAAACCAGTTTTAGCAGGGATAGCAGCATCCTCATAGCTGTCTGCGATGATGCCAGCATTTGG
CGTTGGGATCGACTTCGATAAACTATTTTTCCCTAGTAAAAATTAGAATATGTTGTCTGTGTAA
AATAGAATTAATGTATCTTGCTAGCAAAGGGACTAGAGCATTTAGACTTGTCTTTCAGCATCCG
ATCAGGCTGAGCTGAATGTAGTGGTGTTTACATTGTTTACATTCTTTGTACTGTCTTCCTGCTC
AGACTTTACTGCTTTTAATAAAAATTTATTTTTGTAAAGCTGTGTTATTTTTATTGTGATGGAA
ACAAACTGGAAGAAATAAAGTTATACCATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006229664 ⟹ XP_006229726

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	153,280,735 - 153,307,537 (-)	NCBI
mRatBN7.2	1	143,867,875 - 143,895,006 (-)	NCBI
Rnor_6.0	1	154,189,252 - 154,216,119 (-)	NCBI
Rnor_5.0	1	160,493,753 - 160,520,834 (-)	NCBI

Sequence:

show sequence

GCGCGCGCGCCCCTTTTTCAGCAGTGTGGCGGGGTCGCACGCACGCCCGCCTCGGCGGCTGGGC
GCGATTTGCGACAGTGGGGGGAGCGGCGGCGGTGGCGGTGCCGGCAGCTTTGCGGCAGGCTCCG
GCCGGGCGTGCTTGACGGCGGTGTGGCGGAGGCCCCGCCCGAGGCGGCAAGAACCTGGAGGGAG
GCGGAGGAATATGTCTGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCGGCGGCC
AAGAAGCAGAAGTTGAGCAGCGACGAGAACAGCAACCCGGACCTCTCGGGAGACGAGAATGACG
ATGCTGTCAGTATCGAGAGTGGCACAAACACAGAACGCCCGGACACACCCACAAATACACCAAA
TGCACCAGGAAGGAAAAGCTGGGGAAAGGGAAAATGGAAGTCGAAGAAATGCAAATATTCTTTC
AAATGTGTGAACAGCCTCAAGGAAGATCACAACCAGCCATTGTTTGGAGTTCAGTTTAACTGGC
ACAGTAAAGAAGGAGATCCTCTGGTGTTTGCAACTGTGGGAAGCAACAGAGTAACCTTATATGA
ATGCCATTCTCAAGGGGAAATACGGTTATTGCAGTCCTATGTAGATGCTGATGCAGATGAAAAC
TTTTACACTTGTGCATGGACCTATGATAGCAACACCAGCCACCCTCTGCTAGCAGTTGCTGGAT
CTAGAGGCATAATAAGAATAATTAATCCTATAACAATGCAGTGTATAAAGCACTATGTTGGCCA
TGGGAATGCTATCAATGAGCTGAAATTCCACCCACGAGACCCAAACCTTCTCCTGTCAGTAAGT
AAAGATCATGCTTTACGATTATGGAATATCCAAACAGACACTCTTGTGGCAATATTCGGAGGTG
TGGAAGGGCACAGAGATGAAGTGCTGAGTGCTGATTATGATCTTTTGGGTGAAAAAATAATGTC
CTGTGGTATGGATCACTCTCTTAAACTGTGGAGAATCAACTCAAAGAGAATGATGAATGCGATT
AAGGAATCTTACGATTATAACCCAAACAAAACTAACAGGCCATTTATTTCCCAGAAAATCCACT
TTCCTGATTTTTCTACCAGAGACATACATAGGAATTATGTTGATTGTGTACGATGGTTAGGCGA
TTTGATACTTTCCAAGTCTTGTGAAAATGCCATTGTATGCTGGAAACCTGGCAAAATGGAGGAT
GATATAGATAAAATTAAACCTAATGCTTGCATTGGGCAATCAGGTTGGCAAACTGTATGTTTGG
GATTTAGAAGTAGAAGATCCTCATAAAGCCAAATGCACAACACTGACCCATCATAAATGTGGCG
CTGCTATTCGACAAACCAGTTTTAGCAGGGATAGCAGCATCCTCATAGCTGTCTGCGATGATGC
CAGCATTTGGCGTTGGGATCGACTTCGATAAACTATTTTTCCCTAGTAAAAATTAGAATATGTT
GTCTGTGTAAAATAGAATTAATGTATCTTGCTAGCAAAGGGACTAGAGCATTTAGACTTGTCTT
TCAGCATCCGATCAGGCTGAGCTGAATGTAGTGGTGTTTACATTGTTTACATTCTTTGTACTGT
CTTCCTGCTCAGACTTTACTGCTTTTAATAAAAATTTATTTTTGTAAAGCTGTGTTATTTTTAT
TGTGATGGAAACAAACTGGAAGAAATAAAGTTATACCATATCTTCTT

hide sequence

RefSeq Acc Id:

XM_039105860 ⟹ XP_038961788

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	153,280,475 - 153,306,914 (-)	NCBI
mRatBN7.2	1	143,867,875 - 143,894,339 (-)	NCBI

RefSeq Acc Id:

XM_039105864 ⟹ XP_038961792

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	153,280,475 - 153,307,537 (-)	NCBI
mRatBN7.2	1	143,867,875 - 143,895,008 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099748	(Get FASTA)	NCBI Sequence Viewer
	XP_006229726	(Get FASTA)	NCBI Sequence Viewer
	XP_038961788	(Get FASTA)	NCBI Sequence Viewer
	XP_038961792	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68872	(Get FASTA)	NCBI Sequence Viewer
	EDM18565	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024082
	ENSRNOP00000024082.6
	ENSRNOP00000085082.1
	ENSRNOP00000093078
	ENSRNOP00000093078.1
	ENSRNOP00000096570.1

RefSeq Acc Id:

NP_001099748 ⟸ NM_001106278

- UniProtKB:

B5DF02 (UniProtKB/TrEMBL), F1LMC5 (UniProtKB/TrEMBL), A0A8I6A2I3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPG
RKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHS
QGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNA
INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM
DHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLIL
SKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG
KLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR

hide sequence

RefSeq Acc Id:	XP_006229726 ⟸ XM_006229664
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6AQZ9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPG RKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHS QGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNA INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM DHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLIL SKSCENAIVCWKPGKMEDDIDKIKPNACIGQSGWQTVCLGFRSRRSS hide sequence

Ensembl Acc Id:

ENSRNOP00000024082 ⟸ ENSRNOT00000024082

RefSeq Acc Id:	XP_038961792 ⟸ XM_039105864
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A2I3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038961788 ⟸ XM_039105860
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AJ96 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000093078 ⟸ ENSRNOT00000114221

Ensembl Acc Id:

ENSRNOP00000096570 ⟸ ENSRNOT00000115575

Ensembl Acc Id:

ENSRNOP00000085082 ⟸ ENSRNOT00000117476

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DF02-F1-model_v2	AlphaFold	B5DF02	1-441	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690185

Promoter ID:

EPDNEW_R710

Type:

multiple initiation site

Name:

Eed_1

Description:

embryonic ectoderm development

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	154,216,356 - 154,216,416	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309782	AgrOrtholog
BioCyc Gene	G2FUF-58545	BioCyc
Ensembl Genes	ENSRNOG00000017509	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024082	ENTREZGENE
	ENSRNOT00000024082.7	UniProtKB/TrEMBL
	ENSRNOT00000114221	ENTREZGENE
	ENSRNOT00000114221.1	UniProtKB/TrEMBL
	ENSRNOT00000115575.1	UniProtKB/TrEMBL
	ENSRNOT00000117476.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	PcG_WD-repeat	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:293104	UniProtKB/TrEMBL
NCBI Gene	293104	ENTREZGENE
PANTHER	POLYCOMB PROTEIN	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PhenoGen	Eed	PhenoGen
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017509	RatGTEx
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	WD40_like	UniProtKB/TrEMBL
UniProt	A0A8I6A2I3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AJ96	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AQZ9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8J8YPE2_RAT	UniProtKB/TrEMBL
	B5DF02	ENTREZGENE, UniProtKB/TrEMBL
	F1LMC5	ENTREZGENE
UniProt Secondary	F1LMC5	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Eed	embryonic ectoderm development	Eed_predicted	embryonic ectoderm development (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Eed_predicted	embryonic ectoderm development (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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