Sox8 (SRY-box transcription factor 8)

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Gene: Sox8 (SRY-box transcription factor 8) Rattus norvegicus

Analyze

Symbol:

Sox8

Name:

SRY-box transcription factor 8

RGD ID:

1309072

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of morphogenesis of an epithelium; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including astrocyte fate commitment; negative regulation of photoreceptor cell differentiation; and positive regulation of macromolecule metabolic process. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human SOX8 (SRY-box transcription factor 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC302993; SRY (sex determining region Y)-box 8; SRY box 8; SRY-box containing gene 8; transcription factor SOX-8

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	14,584,829 - 14,589,818 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	14,584,829 - 14,589,818 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	19,325,192 - 19,330,186 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	18,814,064 - 18,819,058 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	14,313,375 - 14,318,361 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	14,932,348 - 14,937,336 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	14,932,348 - 14,937,336 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	14,745,882 - 14,750,870 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	14,818,955 - 14,823,943 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	14,819,838 - 14,823,749 (-)	NCBI
Celera	10	14,255,730 - 14,260,718 (-)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

46, XY Disorders of Sex Development (ISO)

epilepsy (ISO)

familial Mediterranean fever (ISO)

Fanconi anemia (ISO)

genetic disease (ISO)

idiopathic generalized epilepsy (ISO)

peripheral nervous system disease (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

tuberous sclerosis 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

5-azacytidine (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP,ISO)

all-trans-retinoic acid (ISO)

atrazine (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bortezomib (ISO)

butanal (ISO)

camptothecin (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

CU-O LINKAGE (ISO)

cyclosporin A (ISO)

dinophysistoxin 1 (ISO)

dioxygen (ISO)

disodium selenite (ISO)

disulfiram (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

folic acid (ISO)

genistein (ISO)

hydrogen peroxide (ISO)

manganese(II) chloride (EXP)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

nickel atom (ISO)

panobinostat (ISO)

paracetamol (EXP)

paraquat (ISO)

pentanal (ISO)

phenylmercury acetate (ISO)

pioglitazone (ISO)

propanal (ISO)

Ptaquiloside (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sunitinib (ISO)

thimerosal (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adipose tissue development (ISO,ISS)

astrocyte fate commitment (ISO)

biological_process (ND)

cell fate commitment (ISO,ISS)

cell maturation (ISO)

DNA-templated transcription (ISO)

enteric nervous system development (IBA,ISO,ISS)

fat cell differentiation (ISO,ISS)

in utero embryonic development (ISO,ISS)

male gonad development (ISO,ISS)

metanephric nephron tubule formation (ISO,ISS)

morphogenesis of a branching epithelium (ISO,ISS)

morphogenesis of an epithelium (IBA)

negative regulation of apoptotic process (ISO,ISS)

negative regulation of DNA-templated transcription (ISO,ISS)

negative regulation of myoblast differentiation (ISO,ISS)

negative regulation of photoreceptor cell differentiation (ISO)

negative regulation of transcription by RNA polymerase II (IBA)

neural crest cell development (IBA)

neural crest cell migration (ISO,ISS)

oligodendrocyte differentiation (ISO,ISS)

osteoblast differentiation (ISO,ISS)

peripheral nervous system development (IBA,ISO,ISS)

positive regulation of branching involved in ureteric bud morphogenesis (ISO,ISS)

positive regulation of DNA-templated transcription (ISO,ISS)

positive regulation of gene expression (ISO)

positive regulation of gliogenesis (ISO,ISS)

positive regulation of kidney development (ISO,ISS)

positive regulation of osteoblast proliferation (ISO,ISS)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of DNA-templated transcription (ISO)

regulation of hormone levels (ISO,ISS)

renal vesicle induction (ISO,ISS)

retina development in camera-type eye (ISO,ISS)

retinal rod cell differentiation (ISO,ISS)

Sertoli cell development (ISO,ISS)

signal transduction (ISO,ISS)

skeletal muscle cell differentiation (ISO)

spermatogenesis (ISO,ISS)

ureter morphogenesis (ISO,ISS)

Cellular Component

cellular_component (ND)

cytoplasm (ISO,ISS)

nucleus (IBA,ISO)

transcription regulator complex (ISO)

Molecular Function

cis-regulatory region sequence-specific DNA binding (ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,ISO)

DNA-binding transcription factor binding (ISO)

molecular_function (ND)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO,ISS)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:10662550	PMID:10684944	PMID:11564878	PMID:11875113	PMID:12732652	PMID:12782625	PMID:15056615	PMID:15102707	PMID:15572147	PMID:15590666	PMID:15753123	PMID:15893981
PMID:16582099	PMID:16790476	PMID:17084361	PMID:18342849	PMID:18512230	PMID:19124014	PMID:19286648	PMID:19490914	PMID:21212101	PMID:22147266	PMID:22344693

Genomics

Comparative Map Data

Sox8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	14,584,829 - 14,589,818 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	14,584,829 - 14,589,818 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	19,325,192 - 19,330,186 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	18,814,064 - 18,819,058 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	14,313,375 - 14,318,361 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	14,932,348 - 14,937,336 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	14,932,348 - 14,937,336 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	14,745,882 - 14,750,870 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	14,818,955 - 14,823,943 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	14,819,838 - 14,823,749 (-)	NCBI
Celera	10	14,255,730 - 14,260,718 (-)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

SOX8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	981,770 - 986,979 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	16	981,770 - 986,979 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	1,031,770 - 1,036,979 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	971,809 - 976,980 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	971,808 - 976,979	NCBI
Celera	16	1,240,025 - 1,245,196 (+)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	957,907 - 962,880 (+)	NCBI		HuRef
CHM1_1	16	1,030,757 - 1,035,928 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	992,564 - 997,779 (+)	NCBI		T2T-CHM13v2.0

Sox8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	25,784,865 - 25,789,666 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	25,784,866 - 25,789,660 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	25,565,893 - 25,570,686 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	25,565,892 - 25,570,686 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	25,702,838 - 25,707,631 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	25,293,493 - 25,298,286 (-)	NCBI		MGSCv36	mm8
Celera	17	26,098,173 - 26,102,970 (-)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	12.69	NCBI

Sox8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	16,236,232 - 16,241,152 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	16,236,286 - 16,241,093 (-)	NCBI	ChiLan1.0	ChiLan1.0

SOX8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	16	982,054 - 988,955 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

SOX8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	39,667,941 - 39,672,716 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	39,668,232 - 39,672,638 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	40,934,797 - 40,938,267 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	40,013,265 - 40,016,735 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	40,012,061 - 40,016,696 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	39,689,658 - 39,693,126 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	39,662,326 - 39,665,795 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	40,141,148 - 40,144,618 (-)	NCBI		UU_Cfam_GSD_1.0

Sox8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	112,030,848 - 112,034,806 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	127,703 - 132,704 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936501	128,386 - 132,648 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SOX8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	40,825,157 - 40,830,736 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	40,825,151 - 40,830,085 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SOX8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	877,988 - 883,278 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	878,217 - 881,662 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	30,224,976 - 30,232,103 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sox8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624913	1,759,548 - 1,764,344 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624913	1,759,460 - 1,764,242 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sox8
9 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	197
Count of miRNA genes:	146
Interacting mature miRNAs:	167
Transcripts:	ENSRNOT00000025494
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	17245662	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	19233348	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6154182	15990232	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat

Markers in Region

D10Rat198

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	14,590,726 - 14,590,940 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	14,938,245 - 14,938,458	NCBI	Rnor6.0
Rnor_5.0	10	14,751,779 - 14,751,992	UniSTS	Rnor5.0
RGSC_v3.4	10	14,824,851 - 14,825,065	RGD	RGSC3.4
RGSC_v3.4	10	14,824,852 - 14,825,065	UniSTS	RGSC3.4
RGSC_v3.1	10	14,824,795 - 14,825,180	RGD
Celera	10	14,261,627 - 14,261,840	UniSTS
FHH x ACI Map	10	6.75	RGD
FHH x ACI Map	10	6.75	UniSTS
Cytogenetic Map	10	q12	UniSTS

Sox8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	14,587,949 - 14,589,086 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	14,935,468 - 14,936,604	NCBI	Rnor6.0
Rnor_5.0	10	14,749,002 - 14,750,138	UniSTS	Rnor5.0
RGSC_v3.4	10	14,822,075 - 14,823,211	UniSTS	RGSC3.4
Celera	10	14,258,850 - 14,259,986	UniSTS
Cytogenetic Map	10	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									43		8
Low	2	16	2	2	1	2	5	8	31	14	27	1	5
Below cutoff	1	26	27	11	18	11	3	3		16	6	10	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000025494 ⟹ ENSRNOP00000025494

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	14,584,829 - 14,589,818 (-)	Ensembl
Rnor_6.0 Ensembl	10	14,932,348 - 14,937,336 (-)	Ensembl

RefSeq Acc Id:

NM_001106989 ⟹ NP_001100459

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	14,584,829 - 14,589,818 (-)	NCBI
Rnor_6.0	10	14,932,348 - 14,937,336 (-)	NCBI
Rnor_5.0	10	14,745,882 - 14,750,870 (-)	NCBI
RGSC_v3.4	10	14,818,955 - 14,823,943 (-)	RGD
Celera	10	14,255,730 - 14,260,718 (-)	RGD

Sequence:

show sequence

GCCTCAGTTGAGGAATCAGGCTGCGGGGCGCCTGGCCCACGTGGTGCGGAGGGTGGGGCGGGGT
CCGCAGTCTTCTTTGGATTAGGGGCGGGGCAAACAAACTCCGCCTCGGGGAGGACGCGCCTGCC
AACCCGGACCCGGAGGGGCGGGGTTTCGGCCGCGTTTTAAAGAAACTTGTTGCGGGTCCCAGAA
CTGAGACTGAGCTGCAGCGGCAGAGGAGCGGTTGCTGGGCTCCTGCGGTGAGGACAAAGATTGG
GCCCTGCGTGGCAACCTTGGATTCCAGAGTGTCCGTCCACAGAGTGACCGGGCGCGACCCCTGC
GTCCATCCCCACTGAGCGCTTCTCCGCGCGTGGCCCCGATGCTGGACATGAGTGAGGCCCGCGC
CCAGCCGCCCTGCAGCCCGTCTGGCACTGCTAGCTCCATGTCACACGTGGAGGATTCAGACTCC
GACGCGCCACCGTCGCCCGCGGGATCAGAGGGCTTGGGCCGCGCGGGGGGCGGCGGCCGAGGGG
ATACCGCTGAGGCAGCAGACGAACGCTTCCCAGCCTGCATCCGTGATGCCGTGTCGCAGGTGCT
TAAGGGCTATGACTGGAGTCTGGTGCCTATGCCGGTGCGCGGCGGCGGTGGCGGCACACTCAAG
GCCAAGCCACACGTGAAGCGGCCCATGAATGCCTTCATGGTGTGGGCACAGGCGGCGCGCCGCA
AGCTGGCGGACCAGTACCCGCATCTCCATAACGCAGAGCTCAGCAAGACCCTGGGCAAGCTGTG
GCGCTTGCTGAGTGAAAGCGAGAAGCGGCCATTCGTGGAGGAGGCCGAGAGGCTCCGTGTGCAG
CACAAGAAGGACCACCCAGATTACAAATACCAGCCGAGGAGAAGGAAGAGTGTGAAAACCGGCC
GGAGCGACTCGGACTCTGGTACTGAACTGGGCCACCACCCTGGTGGTCCCATGTACAAAACGGA
CACAGTGCTAGGTGATGCACACCGCCACAGCGACCACACAGGCCAGACCCATGGGCCACCCACC
CCACCCACCACCCCCAAGACGGACCTGCACCAGGCCAGCAATGGAAGCAAGCAAGAGCTAAGGC
TGGAAGGGCGCCGCCTGGTGGACAGCGGGCGCCAGAACATCGACTTCAGCAATGTGGACATCTC
CGAGCTCAGCAGCGAGGTTATCAGTAACATGGATACCTTCGATGTCCACGAGTTTGACCAGTAC
TTACCCCTCAATGGCCACTCAGCCCTGGCCACTGAGCCCAGCCAGGCCACTGCCTCTGGCTCCT
ATGGAGGCGCTTCCTACTCCCACTCCGGTGCAACTGGCATAGGCGCATCCCCTGTGTGGGCCCA
CAAGGGAGCTCCCTCGGCCTCAGCCTCGCCCACAGAGGCAGGACCCCTTCGGCCACATATCAAG
ACGGAGCAGCTGAGTCCCAGCCATTACAACGACCAGTCACACGGCTCACCCGGCCGTGCCGACT
ATGGCTCCTACAGCGCCCAGGCCAGTGTCACCACGGCTGCCTCGGCCACAGCTGCCAGCTCTTT
CGCCAGCGCACAGTGTGACTACACTGACCTGCAGGCTTCCAACTACTACAGCCCCTACCCTGGC
TACCCTCCCAGCCTCTATCAATACCCTTACTTCCATTCATCCCGCCGGCCCTATGCCTCGTCAC
TGCTCAATGGGCTCTCCATGCCCCCCGCACACAGCCCCAGCAGCAACTGGGACCAGCCTGTGTA
CACCACCCTGACCCGGCCCTGAGGCTGCTGCACCCTGGAGGACGCAGCGTCCACGAAGTATAGC
CAGGTCTTTGAGTTCTTCCAGAAGTGTACTTGGTGGAGGGTAGAGGCAGCCGGCACGGCCTCAC
TCCGTCAAGTGCCTGCTGAATGTGCAGGAAACCAGGCTCTGTCACCTTGTATCCCTTTGCCTCT
GGATATCCAAACTTCTGCCAGGGGACAGAGTTCTCTTTCCCCCCTCTTCTCTCTCTGAGGTGAC
TGGTGATTTCTGAAACAGCCATTCTGTTGCTCTCGGTTTGGATAAGTGTGCACCAGCTCCTGAG
TTTTGCATCTCGGTAGATAAGAAGATCGCTACACCTAAGGACAAAGAGAGAAGGGGCTTCAGGT
CCTTACCAGCCCAGCCGAGAACTCCCTGGAACCAAGGGATGCTGTTCCCATGGTGAAAGCATGA
AAGCACATCTGTGGATGCTCCAGGATACATCCACCCAGGGATCCCTTGGGACCGATGTGCGATG
GAGGCTTTCTCATTACCACAGGTCTTTCCCAGCAAGGTTTGGCTGAGACGAACACTTTCCGTGT
TTATTTTTATTTTTTTTTTGTTATTTTTATTTTAAGGCTTAAACATGTTTGTTTTTGAAAGGTG
TTGAAGACGTATTTATGTTCTGTTATTATTTTATCTTTAATTAATGAAGTAATTTGTGCAGAGA
GTAGAGTTTAAGACAAAACGAACGTCGGGAAGCTTGTTTTTGTAAAGGGCAGGAGGGAGGTGGC
CAGGCACCCCCTGCAGCATCTCCTGGCTCTGCCTTTGGATGTCCCTGGAGGCCTCCACCAGGCA
CAGGAGAAAGTGATCGACCTCTTGGGGTCTGGTTAGAACAAAAAGCCCAGCACCAGCATCGGGG
TTGGGCATTGGAAGGCAGGGACAGCATCTCTGCCCTCGGTGGTGCCAAGCGGCAGAAGACAGAA
TCTCCTGCAGGCTGGCAGCTGCAGAACCACGATAATCTTGGCTCTTTGGCACCAGGCGCTGCTT
ACCGAGCTGCGGAAGGAGAGCCTCCCCCACTAACCTGCCTAGGTTCCTAGTTAGAGAGTAACAT
CCACCCGCTTCGCCGCCCGCTTCGCAGTGTGCTGAGTGTGTAACCAGCGACTTCACGGAAACTT
GTGCCTTGGAGACTTTGTATATTTACTCACTCTTGAGAAGTTTTGCTTCTTTTTAATTTTTCTA
CTTTTCCTACCTTTTTCTAGAGGGGAAAAAAATCTTCCTTTTTTTTTTTTTTCTTTCAGCATCT
CTCCTTCCGGGGGTGGGGGTGGGAGCCACAGCAAACTCATTTTTAATGCAGTCATTTTTTTTTT
TTTTTTTTGGCGTTGAATTCAGAAAGACATTCGCTGTCCTTTACCTACTGTGTTTCGTTACTTT
CTGACCAGGCAATGCTAACTTTTGTACAGATCGATTTGATAAAATTTAAAAAAAGAAAAACAAA
GAACAAAACAAAACAAAAAAGCCCAATGCCTTTTATCTACTTGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100459	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM03938	(Get FASTA)	NCBI Sequence Viewer
	EDM03939	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001100459 ⟸ NM_001106989

- UniProtKB:

D3ZR96 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLDMSEARAQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGGGGRGDTAEAADERFPAC
IRDAVSQVLKGYDWSLVPMPVRGGGGGTLKAKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAE
LSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKTGRSDSDSGTELGHH
PGGPMYKTDTVLGDAHRHSDHTGQTHGPPTPPTTPKTDLHQASNGSKQELRLEGRRLVDSGRQN
IDFSNVDISELSSEVISNMDTFDVHEFDQYLPLNGHSALATEPSQATASGSYGGASYSHSGATG
IGASPVWAHKGAPSASASPTEAGPLRPHIKTEQLSPSHYNDQSHGSPGRADYGSYSAQASVTTA
ASATAASSFASAQCDYTDLQASNYYSPYPGYPPSLYQYPYFHSSRRPYASSLLNGLSMPPAHSP
SSNWDQPVYTTLTRP

hide sequence

RefSeq Acc Id:

ENSRNOP00000025494 ⟸ ENSRNOT00000025494

Protein Domains

HMG box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZR96-F1-model_v2	AlphaFold	D3ZR96	1-463	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309072	AgrOrtholog
BioCyc Gene	G2FUF-25773	BioCyc
Ensembl Genes	ENSRNOG00000018841	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000025494	ENTREZGENE
	ENSRNOP00000025494.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025494	ENTREZGENE
	ENSRNOT00000025494.5	UniProtKB/TrEMBL
Gene3D-CATH	1.10.30.10	UniProtKB/TrEMBL
InterPro	HMG_box_dom_sf	UniProtKB/TrEMBL
	HMG_superfamily	UniProtKB/TrEMBL
	Sox_N	UniProtKB/TrEMBL
KEGG Report	rno:302993	UniProtKB/TrEMBL
NCBI Gene	302993	ENTREZGENE
PANTHER	PTHR45803:SF2	UniProtKB/TrEMBL
	SOX100B	UniProtKB/TrEMBL
Pfam	HMG_box	UniProtKB/TrEMBL
	Sox_N	UniProtKB/TrEMBL
PhenoGen	Sox8	PhenoGen
PROSITE	HMG_BOX_2	UniProtKB/TrEMBL
SMART	HMG	UniProtKB/TrEMBL
Superfamily-SCOP	HMG-box	UniProtKB/TrEMBL
UniProt	D3ZR96	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-05	Sox8	SRY-box transcription factor 8	Sox8	SRY box 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-11-12	Sox8	SRY box 8	Sox8	SRY (sex determining region Y)-box 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-18	Sox8	SRY (sex determining region Y)-box 8	Sox8	SRY-box containing gene 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Sox8	SRY-box containing gene 8	Sox8_predicted	SRY-box containing gene 8 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Sox8_predicted	SRY-box containing gene 8 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD