Gbp4 (guanylate binding protein 4)

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Gene: Gbp4 (guanylate binding protein 4) Rattus norvegicus

Analyze

Symbol:

Gbp4

Name:

guanylate binding protein 4

RGD ID:

1310579

Description:

Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Predicted to be involved in cellular response to tumor necrosis factor; defense response to Gram-positive bacterium; and defense response to protozoan. Predicted to act upstream of or within adhesion of symbiont to host; cellular response to interferon-beta; and cellular response to type II interferon. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and perinuclear region of cytoplasm. Orthologous to several human genes including GBP7 (guanylate binding protein 7); INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Gbp3; guanylate nucleotide binding protein 3; guanylate nucleotide binding protein 4; guanylate-binding protein 4; guanylate-binding protein 4-like; LOC100911495; LOC310917

RGD Orthologs

Human

Mouse

Bonobo

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	231,304,910 - 231,318,883 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	231,305,244 - 231,318,879 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	239,078,909 - 239,092,524 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	236,973,203 - 236,986,820 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	231,836,590 - 231,850,207 (+)	NCBI	Rnor_WKY
Rnor_6.0	2	248,249,232 - 248,263,104 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	248,249,468 - 248,263,168 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	266,777,820 - 266,791,543 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	240,495,963 - 240,509,393 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	240,453,144 - 240,495,609 (+)	NCBI
Celera	2	223,352,892 - 223,366,524 (+)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

1,3-dinitrobenzene (EXP)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

4,4'-diaminodiphenylmethane (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

benzoates (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

cholesterol (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclophosphamide (ISO)

cytarabine (ISO)

dibenz[a,h]anthracene (ISO)

diclofenac (ISO)

dimethylarsinic acid (ISO)

dioxygen (EXP,ISO)

disulfiram (ISO)

doxorubicin (ISO)

endosulfan (EXP)

fulvestrant (ISO)

gentamycin (EXP)

lipopolysaccharide (ISO)

methyl methanesulfonate (ISO)

methylarsonic acid (ISO)

N-nitrosodimethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

PCB138 (ISO)

pentachlorophenol (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

progesterone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP,ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

tremolite asbestos (ISO)

trichloroethene (EXP)

tungsten (ISO)

valproic acid (ISO)

zidovudine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (ISO)

adhesion of symbiont to host (ISO)

cellular response to interferon-beta (ISO)

cellular response to lipopolysaccharide (ISO)

cellular response to tumor necrosis factor (ISO)

cellular response to type II interferon (ISO)

cytolysis in another organism (ISO)

defense response to bacterium (ISO)

defense response to Gram-positive bacterium (IBA,ISO)

defense response to protozoan (IBA,ISO)

positive regulation of pyroptosis (ISO)

Cellular Component

cytoplasmic vesicle (ISO)

cytosol (ISO)

Golgi apparatus (ISO)

nucleus (ISO)

perinuclear region of cytoplasm (ISO)

plasma membrane (ISO)

Molecular Function

GTP binding (IBA)

GTPase activity (IBA)

identical protein binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:18025219	PMID:21551061

Genomics

Comparative Map Data

Gbp4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	231,304,910 - 231,318,883 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	231,305,244 - 231,318,879 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	239,078,909 - 239,092,524 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	236,973,203 - 236,986,820 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	231,836,590 - 231,850,207 (+)	NCBI	Rnor_WKY
Rnor_6.0	2	248,249,232 - 248,263,104 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	248,249,468 - 248,263,168 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	266,777,820 - 266,791,543 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	240,495,963 - 240,509,393 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	240,453,144 - 240,495,609 (+)	NCBI
Celera	2	223,352,892 - 223,366,524 (+)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

GBP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	89,181,144 - 89,198,942 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	89,181,144 - 89,198,942 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	89,646,827 - 89,664,625 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	89,420,044 - 89,437,150 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	89,359,480 - 89,376,583	NCBI
Celera	1	87,892,646 - 87,910,446 (-)	NCBI		Celera
Cytogenetic Map	1	p22.2	NCBI
HuRef	1	87,764,057 - 87,781,858 (-)	NCBI		HuRef
CHM1_1	1	89,761,894 - 89,779,694 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	89,024,523 - 89,042,320 (-)	NCBI		T2T-CHM13v2.0

Gbp3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	142,265,781 - 142,278,974 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	142,265,787 - 142,278,970 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	142,560,016 - 142,573,213 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	142,560,026 - 142,573,209 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	142,223,016 - 142,236,176 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	142,497,531 - 142,510,595 (+)	NCBI		MGSCv36	mm8
Celera	3	148,982,608 - 148,995,787 (+)	NCBI		Celera
Cytogenetic Map	3	H1	NCBI

GBP7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	90,593,577 - 90,637,789 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	90,590,242 - 90,660,565 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	91,841,867 - 91,886,638 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

Variants

Variants in Gbp4
37 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	113
Count of miRNA genes:	90
Interacting mature miRNAs:	93
Transcripts:	ENSRNOT00000022648
Prediction methods:	Microtar, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	189599258	234599258	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189599258	234599258	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	199341726	234244620	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	211744537	249053267	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	211744537	249053267	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	211744537	249053267	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	211744537	249053267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	211744537	249053267	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	212828222	249053267	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	214226044	247136170	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	215377404	237938339	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	218414747	240841241	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
9587428	Epfw6	Epididymal fat weight QTL 6	7.47	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	2	223389739	249053267	Rat
7411555	Bw132	Body weight QTL 132		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	223389739	249053267	Rat
631563	Hcuc3	Hepatic copper content QTL 3	3.87		liver copper amount (VT:0003065)	liver copper weight to liver dry weight ratio (CMO:0001512)	2	229059610	249053267	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium					11							2
Low	3	16	51	36	8	36	7	8	19	21	29	9	7
Below cutoff		27	6	5		5	1	3	55	14	12		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001305261	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233424	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000022648 ⟹ ENSRNOP00000022648

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	231,305,244 - 231,318,879 (+)	Ensembl
Rnor_6.0 Ensembl	2	248,249,468 - 248,263,168 (+)	Ensembl

RefSeq Acc Id:

NM_001305261 ⟹ NP_001292190

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	231,305,244 - 231,318,879 (+)	NCBI
Rnor_6.0	2	248,249,470 - 248,263,104 (+)	NCBI
Celera	2	223,352,892 - 223,366,524 (+)	NCBI

Sequence:

show sequence

GGTTCCCTTTATCTCAATTTGTATGTGGGTGGCTGTTACTTTGACACTTCTAACAGTGGCTGCT
TCAAGGGAGCCTGGAGCAGTAGGAAGCTCAGTGAATGAACCAAGTTGGCTGAGGACTGTCAGGG
TTTTGGAGCCAGAGCGCCTGGGGAGCTGTGGTGTCTGAGTCTACCATGGAGGCACCCATTTGTC
TGGTGCAAAACTGGAAAGAGCAGCTGACAGTAAATCTGGAGGCCATAGGGATTCTTGAGCAGAT
AGCACAGCCTCTGGTGGTGGTGGCCATTGTTGGTTTATATCGGACAGGGAAGTCCTACCTCATG
AATCGCCTTGCAGGACGGAACCACGGCTTCTCCTTGGGCTCCACAGTGCAATCAGAGACCAAGG
GCATCTGGATGTGGTGTGTGCCCCATCCCACCAAGCCAACCCACACCCTGGTCCTTCTGGACAC
TGAGGGTCTTGGCGATGTAGAAAAGGGTGACCCTAAGAATGACTCATGGATCTTCGCCTTGGCC
GTGCTTCTGAGCAGCACCTTTGTCTACAACAGCATGAGCACCATCAACCACCAGGCCCTGGAGC
AGCTGCACTATGTGACTGAATTAACACAACTAATCCGAGCAAAATCAGACCCCAGGGAGGATAA
AGTGGAGGACTCTAGTGAGTTTGTAGGTTTCTTCCCAGACTTCATCTGGGCTGTTCGAGATTTT
GTTCTGGAGTTGAAGTTAGATGGTCGGCCCATCACAGAAGATGAGTACCTGGAGAATGCCCTGA
AGCTGATCCCAGAAAACAATCCCAAAGGCCAAAAGTCCAACATGACCAGAGAATGTATCAGATA
TTTTTTCCCGGTACGGAAGTGCTTTGTCTTTGATAGGCCCACAAACGACAAAAGTTTATTATTC
CAAATTGAAAACGTTCCAGAAAACCAACTAGAGTGGAATTTCCAAGTTGAATCAGAAAATTTCT
GTTCCTATATCTTTGCCAATGGCAAGACCAAGACGCTGAGAGGGGGAGTCATTGTCACAGGAAA
TCGGCTGGGGACTTTGGTGCAGACCTATGTGGATGCCATCAACAGTGGAACTGTGCCATGTTTG
GAGAACGCAGTGACGGCCCTGGCCCAACGTGAGAACTCTGCAGCTGTGCAGAAGGCAGCTGAGC
ACTACGCTGAGCAGATGGCCCAGAGACTAAGGCTCCCCACAGACACTCTCCAGGAGCTGCTGGA
GGTGCACTCAGCCTGTGAGAAGGAAGCCATTGCTGTCTTCATGGAGCACTCCTTCAAGGATGAT
GAACAGGAGTTTCAGAAGAGGCTGGTGGCCACCATAGAGAAATGGAAGGAAGAGTTCATGCTAC
GGAATGAAGCAGCATCCATCCGGCACTGCCAGGCTGAGCTGGAGAAGCTTTCAGAGTCCCTGAA
GGAAAGCATCTCATGTGGAGCTTTCTCTGTTCCGGGGGGGCACAGCCTCTACTTAGAAGCCAGG
AAGAAGGTTGAGCTGAGCTACGAGCAAGTGCCGAGGAAGGGAGTGAAGGCAAAAGAAGTCCTTA
AGAGTTTCCTACAGTCACAGGCTACTGTGGAGAACTCCATCCTGCAGTCAGACAAAGCTCTTAC
AGATGGAGAGAGGGCCGTAGCAGCTGAGCGGACCAAGAAGGAGGTGGCTGAGAAGGAAAGAGAG
CTGCTGAAACAGAGACAGAAGGAGCAAGAGCAAGTGATGGAGGCTCAGGAGAGAAGTTTCCAAG
AAAACATTGCTAAGCTTCAGGAGAAGATGGAGAGGGAAAGGGTGATGCTGCTCAGGGAGCAGGA
GAAGATGATGGAGCACAAGCTGAAGGTCCAAAAAGAACTGCTTGTTGAAGGATTCAGAAAGAAA
TCTGATATGTTAAAGAATGAAATAAGTCAACTGAGAGAAGAGATCGAAAGAACAAGAAAGAAAC
CCTCACTGTTTGCACACATCCTTGACACAGTTGGCAATGCATTCATTATGATTTTACCAGGAGC
TGGTAAAATATGTGGTGCGGGGATGAAAGTCCTTAGCTCACTTATGAAGTAGTCTGAAGAGTTT
CTGGGACGGAATATATAAAAACCAAGCTTCTATCATTTTGATACCAACTGTGTTTTTTAATACA
TGTGCTTTGGATTTTAAATACATGTGCTACTTTAGTAACTCATATTACAACGAAGTCAGAACTC
TCGTTAATAGCTAGATAATCAGATACAGCTTCATTGGAGTTGAGTTCTGTGTCCGTTCATTGCC
AGTTATATTCAAGGTTAAAGATACAAACCAATGAAGAATATAAGGATCATGCATACATAAATAC
CACCAAATTTCATTGCCACAATCTCTGTAATAAAGAGGGAAACCAGTCAGAATATAGTGAAATT
GTTAATAGAAAAGGTGTAAAATAAATCAAACAGAAATATGGCCACATGGAGACACATTGGCAAT
TGTATCCCAGTCTTACAGGACAGATAATTTGTTACAAAGATCTCTTGTAAAAACTGACAAGTGG
GTTTTCATAGGACCGGAAGTATGAGAAAAATGATTGATAATAAAAGCAGTGCATATTAAATTTA

hide sequence

RefSeq Acc Id:

XM_006233424 ⟹ XP_006233486

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	231,304,910 - 231,318,883 (+)	NCBI
Rnor_6.0	2	248,249,232 - 248,263,104 (+)	NCBI
Rnor_5.0	2	266,777,820 - 266,791,543 (+)	NCBI

Sequence:

show sequence

AGACTTGTATGCCAAGTGTGGTTCTGTTTTCTCTGTTTTTAATATCAGTGATGGAACACGCTCT
GGAAAAGAAAACACTCTCAAACTGCGAAATGTGGCAGGGTGATAACTTCAAAAGTCCAGATGAA
TCTTGGAAATTCCTCCTGCTCAACTCAGCTCAGCTGACATCACAAACTCAGTTATTTTGTTCGA
GCCCTCAGTGACTGAGTCATCTGGCAAGAAGCAGGGTTTCGATTTCGGTTCCCTTTATCTCAAT
TTGTATGTGGGTGGCTGTTACTTTGACACTTCTAACAGTGGCTGCTTCAAGGGAGCCTGGAGCA
GTAGGAAGCTCAGTGAATGAACCAAGTTGGCTGAGGACTGTCAGGGTTTTGGAGCCAGAGCGCC
TGGGGAGCTGTGGTGTCTGAGTCTACCATGGAGGCACCCATTTGTCTGGTGCAAAACTGGAAAG
AGCAGCTGACAGTAAATCTGGAGGCCATAGGGATTCTTGAGCAGATAGCACAGCCTCTGGTGGT
GGTGGCCATTGTTGGTTTATATCGGACAGGGAAGTCCTACCTCATGAATCGCCTTGCAGGACGG
AACCACGGCTTCTCCTTGGGCTCCACAGTGCAATCAGAGACCAAGGGCATCTGGATGTGGTGTG
TGCCCCATCCCACCAAGCCAACCCACACCCTGGTCCTTCTGGACACTGAGGGTCTTGGCGATGT
AGAAAAGGGTGACCCTAAGAATGACTCATGGATCTTCGCCTTGGCCGTGCTTCTGAGCAGCACC
TTTGTCTACAACAGCATGAGCACCATCAACCACCAGGCCCTGGAGCAGCTGCACTATGTGACTG
AATTAACACAACTAATCCGAGCAAAATCAGACCCCAGGGAGGATAAAGTGGAGGACTCTAGTGA
GTTTGTAGGTTTCTTCCCAGACTTCATCTGGGCTGTTCGAGATTTTGTTCTGGAGTTGAAGTTA
GATGGTCGGCCCATCACAGAAGATGAGTACCTGGAGAATGCCCTGAAGCTGATCCCAGAAAACA
ATCCCAAAGGCCAAAAGTCCAACATGACCAGAGAATGTATCAGATATTTTTTCCCGGTACGGAA
GTGCTTTGTCTTTGATAGGCCCACAAACGACAAAAGTTTATTATTCCAAATTGAAAACGTTCCA
GAAAACCAACTAGAGTGGAATTTCCAAGTTGAATCAGAAAATTTCTGTTCCTATATCTTTGCCA
ATGGGCTGGGGACTTTGGTGCAGACCTATGTGGATGCCATCAACAGTGGAACTGTGCCATGTTT
GGAGAACGCAGTGACGGCCCTGGCCCAACGTGAGAACTCTGCAGCTGTGCAGAAGGCAGCTGAG
CACTACGCTGAGCAGATGGCCCAGAGACTAAGGCTCCCCACAGACACTCTCCAGGAGCTGCTGG
AGGTGCACTCAGCCTGTGAGAAGGAAGCCATTGCTGTCTTCATGGAGCACTCCTTCAAGGATGA
TGAACAGGAGTTTCAGAAGAGGCTGGTGGCCACCATAGAGAAATGGAAGGAAGAGTTCATGCTA
CGGAATGAAGCAGCATCCATCCGGCACTGCCAGGCTGAGCTGGAGAAGCTTTCAGAGTCCCTGA
AGGAAAGCATCTCATGTGGAGCTTTCTCTGTTCCGGGGGGGCACAGCCTCTACTTAGAAGCCAG
GAAGAAGGTTGAGCTGAGCTACGAGCAAGTGCCGAGGAAGGGAGTGAAGGCAAAAGAAGTCCTT
AAGAGTTTCCTACAGTCACAGGCTACTGTGGAGAACTCCATCCTGCAGTCAGACAAAGCTCTTA
CAGATGGAGAGAGGGCCGTAGCAGCTGAGCGGACCAAGAAGGAGGTGGCTGAGAAGGAAAGAGA
GCTGCTGAAACAGAGACAGAAGGAGCAAGAGCAAGTGATGGAGGCTCAGGAGAGAAGTTTCCAA
GAAAACATTGCTAAGCTTCAGGAGAAGATGGAGAGGGAAAGGGTGATGCTGCTCAGGGAGCAGG
AGAAGATGATGGAGCACAAGCTGAAGGTCCAAAAAGAACTGCTTGTTGAAGGATTCAGAAAGAA
ATCTGATATGTTAAAGAATGAAATAAGTCAACTGAGAGAAGAGATCGAAAGAACAAGAAAGAAA
CCCTCACTGTTTGCACACATCCTTGACACAGTTGGCAATGCATTCATTATGATTTTACCAGGAG
CTGGTAAAATATGTGGTGCGGGGATGAAAGTCCTTAGCTCACTTATGAAGTAGTCTGAAGAGTT
TCTGGGACGGAATATATAAAAACCAAGCTTCTATCATTTTGATACCAACTGTGTTTTTTAATAC
ATGTGCTTTGGATTTTAAATACATGTGCTACTTTAGTAACTCATATTACAACGAAGTCAGAACT
CTCGTTAATAGCTAGATAATCAGATACAGCTTCATTGGAGTTGAGTTCTGTGTCCGTTCATTGC
CAGTTATATTCAAGGTTAAAGATACAAACCAATGAAGAATATAAGGATCATGCATACATAAATA
CCACCAAATTTCATTGCCACAATCTCTGTAATAAAGAGGGAAACCAGTCAGAATATAGTGAAAT
TGTTAATAGAAAAGGTGTAAAATAAATCAAACAGAAATATGGCCACATGGAGACACATTGGCAA
TTGTATCCCAGTCTTACAGGACAGATAATTTGTTACAAAGATCTCTTGTAAAAACTGACAAGTG
GGTTTTCATAGGACCGGAAGTATGAGAAAAATGATTGATAATAAAAGCAGTGCATATTAAATTT
A

hide sequence

Protein Sequences


Protein RefSeqs	NP_001292190	(Get FASTA)	NCBI Sequence Viewer
	XP_006233486	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL82351	(Get FASTA)	NCBI Sequence Viewer
	EDL82352	(Get FASTA)	NCBI Sequence Viewer
	EDL82353	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_006233486 ⟸ XM_006233424

- Peptide Label:

isoform X1

- Sequence:

show sequence

MEAPICLVQNWKEQLTVNLEAIGILEQIAQPLVVVAIVGLYRTGKSYLMNRLAGRNHGFSLGST
VQSETKGIWMWCVPHPTKPTHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSMSTI
NHQALEQLHYVTELTQLIRAKSDPREDKVEDSSEFVGFFPDFIWAVRDFVLELKLDGRPITEDE
YLENALKLIPENNPKGQKSNMTRECIRYFFPVRKCFVFDRPTNDKSLLFQIENVPENQLEWNFQ
VESENFCSYIFANGLGTLVQTYVDAINSGTVPCLENAVTALAQRENSAAVQKAAEHYAEQMAQR
LRLPTDTLQELLEVHSACEKEAIAVFMEHSFKDDEQEFQKRLVATIEKWKEEFMLRNEAASIRH
CQAELEKLSESLKESISCGAFSVPGGHSLYLEARKKVELSYEQVPRKGVKAKEVLKSFLQSQAT
VENSILQSDKALTDGERAVAAERTKKEVAEKERELLKQRQKEQEQVMEAQERSFQENIAKLQEK
MERERVMLLREQEKMMEHKLKVQKELLVEGFRKKSDMLKNEISQLREEIERTRKKPSLFAHILD
TVGNAFIMILPGAGKICGAGMKVLSSLMK

hide sequence

RefSeq Acc Id:

NP_001292190 ⟸ NM_001305261

- UniProtKB:

D3ZQL3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEAPICLVQNWKEQLTVNLEAIGILEQIAQPLVVVAIVGLYRTGKSYLMNRLAGRNHGFSLGST
VQSETKGIWMWCVPHPTKPTHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSMSTI
NHQALEQLHYVTELTQLIRAKSDPREDKVEDSSEFVGFFPDFIWAVRDFVLELKLDGRPITEDE
YLENALKLIPENNPKGQKSNMTRECIRYFFPVRKCFVFDRPTNDKSLLFQIENVPENQLEWNFQ
VESENFCSYIFANGKTKTLRGGVIVTGNRLGTLVQTYVDAINSGTVPCLENAVTALAQRENSAA
VQKAAEHYAEQMAQRLRLPTDTLQELLEVHSACEKEAIAVFMEHSFKDDEQEFQKRLVATIEKW
KEEFMLRNEAASIRHCQAELEKLSESLKESISCGAFSVPGGHSLYLEARKKVELSYEQVPRKGV
KAKEVLKSFLQSQATVENSILQSDKALTDGERAVAAERTKKEVAEKERELLKQRQKEQEQVMEA
QERSFQENIAKLQEKMERERVMLLREQEKMMEHKLKVQKELLVEGFRKKSDMLKNEISQLREEI
ERTRKKPSLFAHILDTVGNAFIMILPGAGKICGAGMKVLSSLMK

hide sequence

RefSeq Acc Id:

ENSRNOP00000022648 ⟸ ENSRNOT00000022648

Protein Domains

GB1/RHD3-type G

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZQL3-F1-model_v2	AlphaFold	D3ZQL3	1-620	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310579	AgrOrtholog
BioCyc Gene	G2FUF-50997	BioCyc
Ensembl Genes	ENSRNOG00000028768	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000022648	ENTREZGENE
	ENSRNOP00000022648.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000022648	ENTREZGENE
	ENSRNOT00000022648.6	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
	Guanylate-binding protein, C-terminal domain	UniProtKB/TrEMBL
InterPro	G_GB1_RHD3_dom	UniProtKB/TrEMBL
	GBP_C	UniProtKB/TrEMBL
	Guanylate-bd_C	UniProtKB/TrEMBL
	Guanylate-bd_C_sf	UniProtKB/TrEMBL
	Guanylate-bd_N	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
KEGG Report	rno:310917	UniProtKB/TrEMBL
NCBI Gene	310917	ENTREZGENE
PANTHER	GUANYLATE BINDING PROTEIN	UniProtKB/TrEMBL
	GUANYLATE-BINDING PROTEIN 4	UniProtKB/TrEMBL
Pfam	GBP	UniProtKB/TrEMBL
	GBP_C	UniProtKB/TrEMBL
PhenoGen	Gbp4	PhenoGen
PROSITE	G_GB1_RHD3	UniProtKB/TrEMBL
Superfamily-SCOP	GBP	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	D3ZQL3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Gbp4	guanylate binding protein 4	LOC100911495	guanylate-binding protein 4-like	Data Merged	737654	PROVISIONAL
2012-07-05	LOC100911495	guanylate-binding protein 4-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-12	Gbp4	guanylate binding protein 4	Gbp4_predicted	guanylate nucleotide binding protein 4 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Gbp4_predicted	guanylate nucleotide binding protein 4 (predicted)	Gbp3_predicted	guanylate nucleotide binding protein 3 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Gbp3_predicted	guanylate nucleotide binding protein 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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