Nr2f2 (nuclear receptor subfamily 2, group F, member 2) - Rat Genome Database

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Gene: Nr2f2 (nuclear receptor subfamily 2, group F, member 2) Rattus norvegicus
Analyze
Symbol: Nr2f2
Name: nuclear receptor subfamily 2, group F, member 2
RGD ID: 69305
Description: Enables sequence-specific DNA binding activity. Involved in positive regulation of systemic arterial blood pressure; regulation of DNA-templated transcription; and response to estradiol. Predicted to be located in cytosol and nucleoplasm. Used to study hypertension. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apolipoprotein A-I regulatory protein 1; apolipoprotein AI regulatory protein 1; ARP-1; COUP transcription factor 2; COUP transcription factor II; COUP-TF II; COUP-TF2; COUPb; nuclear receptor subfamily 2 group F member 2; ovalbumin upstream promoter beta nuclear receptor; Tfcoup2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nr2f2em1Mcwi  
Genetic Models: SS-Nr2f2em1Mcwi
Candidate Gene For: Bp313
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81133,419,161 - 133,434,290 (-)NCBIGRCr8
mRatBN7.21124,008,282 - 124,022,521 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,009,181 - 124,022,031 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1132,007,025 - 132,012,975 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01139,177,092 - 139,183,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,989,976 - 131,995,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,447,671 - 131,465,749 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,448,447 - 131,460,473 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01132,486,697 - 132,499,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41125,280,974 - 125,286,929 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11125,359,316 - 125,365,272 (-)NCBI
Celera1116,179,533 - 116,185,445 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Nr2f2Rathypertension  IMP 10401852 RGD 
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Original Reference(s)
Nr2f2Rat46, XY Disorders of Sex Development  ISONR2F2 (Homo sapiens)8554872ClinVar Annotator: match by term: 46 and XY disorder of sex developmentClinVar 
Nr2f2Rat46,XX sex reversal 5  ISONR2F2 (Homo sapiens)8554872ClinVar Annotator: match by term: 46 and xx sex reversal 5ClinVarPMID:25741868 more ...
Nr2f2RatCongenital Heart Defects, Multiple Types, 4  ISONR2F2 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital heart defects more ...ClinVarPMID:10215630 more ...
Nr2f2Ratgenetic disease  ISONR2F2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532 more ...
Nr2f2RatNeurodevelopmental Disorders  ISONR2F2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868 and PMID:28492532
Nr2f2RatSplenic Hypoplasia  ISONR2F2 (Homo sapiens)8554872ClinVar Annotator: match by term: AspleniaClinVarPMID:24702954 and PMID:25741868
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Nr2f2RatChemical and Drug Induced Liver Injury  ISONR2F2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25231249
Nr2f2RatDiaphragmatic Hernia  ISONR2F2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17436238
Nr2f2Ratendometriosis  ISONR2F2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22138541
Nr2f2RatFemale Infertility  ISONR2F2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17590085
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Original Reference(s)
Nr2f2Ratcongenital diaphragmatic hernia  ISSNr2f2 (Mus musculus)13592920OMIM:142340 more ...MouseDO 
Nr2f2Ratdilated cardiomyopathy  ISSNr2f2 (Mus musculus)13592920 MouseDO 
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Nr2f2Rat46,XX sex reversal 5  ISONR2F2 (Homo sapiens)7240710 OMIM 
Nr2f2RatCongenital Heart Defects, Multiple Types, 4  ISONR2F2 (Homo sapiens)7240710 OMIM 

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Nr2f2Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of NR2F2 mRNA]CTDPMID:31150632
Nr2f2Rat1,2-dimethylhydrazine multiple interactionsISONr2f2 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NR2F2 mRNACTDPMID:22206623
Nr2f2Rat1,2-dimethylhydrazine decreases expressionISONr2f2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of NR2F2 mRNACTDPMID:22206623
Nr2f2Rat1-fluoro-2,4-dinitrobenzene increases expressionISONR2F2 (Homo sapiens)6480464Dinitrofluorobenzene results in increased expression of NR2F2 mRNACTDPMID:23999411
Nr2f2Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of NR2F2 mRNACTDPMID:17109907 and PMID:17557909
Nr2f2Rat17beta-estradiol decreases expressionISONr2f2 (Mus musculus)6480464Estradiol results in decreased expression of NR2F2 mRNACTDPMID:25210133
Nr2f2Rat17beta-estradiol decreases expressionISONR2F2 (Homo sapiens)6480464Estradiol results in decreased expression of NR2F2 mRNACTDPMID:19167446
Nr2f2Rat17beta-estradiol multiple interactionsISONR2F2 (Homo sapiens)6480464EGF protein inhibits the reaction [Estradiol results in increased expression of NR2F2 mRNA]CTDPMID:24758408
Nr2f2Rat17beta-estradiol increases expressionISONR2F2 (Homo sapiens)6480464Estradiol results in increased expression of NR2F2 mRNACTDPMID:24758408
Nr2f2Rat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISONr2f2 (Mus musculus)6480464[Flame Retardants results in increased abundance of 2 more ...CTDPMID:38995820
Nr2f2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISONr2f2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of NR2F2 mRNACTDPMID:24058054
Nr2f2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISONr2f2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of NR2F2 mRNACTDPMID:21570461
Nr2f2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of NR2F2 mRNACTDPMID:22298810 and PMID:34747641
Nr2f2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of NR2F2 mRNACTDPMID:21215274 and PMID:33387578
Nr2f2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISONr2f2 (Mus musculus)6480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NR2F2 promoter]CTDPMID:19654925
Nr2f2Rat2-ethoxyethanol increases expressionEXP 64804642-ethoxyethanol results in increased expression of NR2F2 mRNACTDPMID:19643169
Nr2f2Rat2-methoxyethanol increases expressionEXP 6480464methyl cellosolve results in increased expression of NR2F2 mRNACTDPMID:19643169
Nr2f2Rat4,4'-sulfonyldiphenol increases expressionISONr2f2 (Mus musculus)6480464bisphenol S results in increased expression of NR2F2 mRNACTDPMID:39298647
Nr2f2Rat4-hydroxyphenyl retinamide increases expressionISONr2f2 (Mus musculus)6480464Fenretinide results in increased expression of NR2F2 mRNACTDPMID:28973697
Nr2f2Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of NR2F2 mRNACTDPMID:28959563

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Biological Process
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Nr2f2Ratanterior/posterior pattern specification acts_upstream_of_or_withinISONr2f2 (Mus musculus)1624291MGI:3579117 more ...RGDPMID:15829524
Nr2f2Ratanterior/posterior pattern specification acts_upstream_of_or_withinIEAUniProtKB:P43135 and ensembl:ENSMUSP000000327681600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratblood vessel morphogenesis acts_upstream_of_or_withinISONr2f2 (Mus musculus)1624291MGI:3579116 PMID:15875024RGDPMID:15875024
Nr2f2Ratblood vessel morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P43135 and ensembl:ENSMUSP000000327681600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratcell differentiation involved_inIBAFB:FBgn0003651 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nr2f2Ratfemale gonad development involved_inISSUniProtKB:P244681600115GO_REF:0000024UniProtGO_REF:0000024
Nr2f2Ratfemale gonad development involved_inIEAUniProtKB:P24468 and ensembl:ENSP000003777211600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratfemale gonad development involved_inISONR2F2 (Homo sapiens)1624291 PMID:29478779RGDPMID:29478779
Nr2f2Ratfertilization acts_upstream_of_or_withinISONr2f2 (Mus musculus)1624291MGI:2385933 more ...RGDPMID:17404209
Nr2f2Ratfertilization acts_upstream_of_or_withinIEAUniProtKB:P43135 and ensembl:ENSMUSP000000327681600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratforebrain development acts_upstream_of_or_withinIEAUniProtKB:P43135 and ensembl:ENSMUSP000000327681600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratforebrain development acts_upstream_of_or_withinISONr2f2 (Mus musculus)1624291 PMID:15548577RGDPMID:15548577
Nr2f2Ratin utero embryonic development acts_upstream_of_or_withinIEAUniProtKB:P43135 and ensembl:ENSMUSP000000327681600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratin utero embryonic development acts_upstream_of_or_withinISONr2f2 (Mus musculus)1624291MGI:2385933 more ...RGDPMID:17404209
Nr2f2Ratinterneuron migration acts_upstream_of_or_withinISONr2f2 (Mus musculus)1624291 PMID:15548577RGDPMID:15548577
Nr2f2Ratinterneuron migration acts_upstream_of_or_withinIEAUniProtKB:P43135 and ensembl:ENSMUSP000000327681600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratintracellular receptor signaling pathway involved_inIEAGO:00048791600115GO_REF:0000108GOCGO_REF:0000108
Nr2f2Ratlymph vessel development involved_inISONr2f2 (Mus musculus)1624291 PMID:19210544RGDPMID:19210544
Nr2f2Ratlymph vessel development involved_inIEAUniProtKB:P43135 and ensembl:ENSMUSP000000327681600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratlymphatic endothelial cell fate commitment involved_inISONR2F2 (Homo sapiens)1624291 PMID:18815287RGDPMID:18815287
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Cellular Component
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Nr2f2Ratcytosol located_inISONR2F2 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Nr2f2Ratcytosol located_inIEAUniProtKB:P24468 and ensembl:ENSP000003777211600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratcytosol located_inIEAUniProtKB:F1D8R0 and ensembl:ENSP000003777211600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratnucleoplasm located_inIEAUniProtKB:P24468 and ensembl:ENSP000003777211600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratnucleoplasm located_inISONR2F2 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Nr2f2Ratnucleoplasm located_inIEAUniProtKB:F1D8R0 and ensembl:ENSP000003777211600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratnucleus located_inISONr2f2 (Mus musculus)1624291 PMID:15548577 more ...RGDPMID:15548577 more ...
Nr2f2Ratnucleus located_inIEAUniProtKB:P43135 and ensembl:ENSMUSP000000327681600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratnucleus located_inIEAUniProtKB:P24468 and ensembl:ENSP000003777211600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Nr2f2Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Nr2f2Ratnucleus located_inISONR2F2 (Homo sapiens)1624291 PMID:19210544RGDPMID:19210544
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Molecular Function
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Nr2f2RatDNA binding enablesIEAUniProtKB:P43135 and ensembl:ENSMUSP000000327681600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Nr2f2RatDNA binding enablesISONr2f2 (Mus musculus)1624291 PMID:16912278RGDPMID:16912278
Nr2f2RatDNA-binding transcription factor activity enablesISONR2F2 (Homo sapiens)1624291 PMID:9343308RGDPMID:9343308
Nr2f2RatDNA-binding transcription factor activity enablesIEAUniProtKB:P24468 and ensembl:ENSP000003777211600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2RatDNA-binding transcription factor activity enablesIEAInterPro:IPR0016281600115GO_REF:0000002InterProGO_REF:0000002
Nr2f2RatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISONR2F2 (Homo sapiens)1624291 PMID:19210544RGDPMID:19210544
Nr2f2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Nr2f2Ratnuclear receptor activity enablesISSUniProtKB:P244681600115GO_REF:0000024UniProtGO_REF:0000024
Nr2f2Ratnuclear receptor activity enablesIEAUniProtKB:P24468 and ensembl:ENSP000003777211600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratnuclear receptor activity enablesIBAFB:FBgn0015239 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nr2f2Ratnuclear receptor activity enablesISONR2F2 (Homo sapiens)1624291 PMID:18798693RGDPMID:18798693
Nr2f2Ratprotein binding  IPIZfpm2 (Rattus norvegicus)10401852 RGD 
Nr2f2Ratprotein binding enablesISONR2F2 (Homo sapiens)1624291UniProtKB:P10588 more ...RGDPMID:18798693 more ...
Nr2f2Ratprotein homodimerization activity enablesISONR2F2 (Homo sapiens)1624291UniProtKB:P24468 and PMID:18798693RGDPMID:18798693
Nr2f2Ratprotein homodimerization activity enablesIEAUniProtKB:P24468 and ensembl:ENSP000003777211600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratretinoic acid binding enablesISSUniProtKB:P244681600115GO_REF:0000024UniProtGO_REF:0000024
Nr2f2Ratretinoic acid binding enablesIEAUniProtKB:P24468 and ensembl:ENSP000003777211600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2f2Ratretinoic acid binding enablesIBAPANTHER:PTN002786762 and UniProtKB:P244681600115GO_REF:0000033GO_CentralGO_REF:0000033
Nr2f2Ratretinoic acid binding enablesISONR2F2 (Homo sapiens)1624291 PMID:18798693RGDPMID:18798693
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Imported Annotations - PID (archival)

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Nr2f2Ratforkhead class A signaling pathway  ISONR2F2 (Homo sapiens)6484113 PIDPID:200226
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Nr2f2Ratdecreased urine protein level  IMP 10401852compared to SS/JrHsdMcwRGD 
Nr2f2Ratincreased heart ventricle muscle contractility  IMP 10401852compared to SS/JrHsdMcwRGD 

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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1. Kang S, etal., J Biol Chem 2003 Aug 15;278(33):30478-86. Epub 2003 May 30.
4. The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats. Katayama S, etal., Toxicol Appl Pharmacol. 2006 Dec 15;217(3):375-83. Epub 2006 Oct 6.
5. Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension. Kumarasamy S, etal., Nat Commun. 2015 Feb 17;6:6252. doi: 10.1038/ncomms7252.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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PMID:7823919   PMID:8910285   PMID:9343308   PMID:12972613   PMID:15546392   PMID:15548577   PMID:15572686   PMID:15829524   PMID:15875024   PMID:16251273   PMID:16721029   PMID:16912278  
PMID:17404209   PMID:18765640   PMID:18798693   PMID:18815287   PMID:19210544   PMID:19231526   PMID:19796622   PMID:20130170   PMID:21879463   PMID:23378030   PMID:24234421   PMID:24466353  
PMID:25372459   PMID:36648143  



Nr2f2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81133,419,161 - 133,434,290 (-)NCBIGRCr8
mRatBN7.21124,008,282 - 124,022,521 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,009,181 - 124,022,031 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1132,007,025 - 132,012,975 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01139,177,092 - 139,183,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,989,976 - 131,995,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,447,671 - 131,465,749 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,448,447 - 131,460,473 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01132,486,697 - 132,499,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41125,280,974 - 125,286,929 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11125,359,316 - 125,365,272 (-)NCBI
Celera1116,179,533 - 116,185,445 (-)NCBICelera
Cytogenetic Map1q31NCBI
NR2F2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381596,326,046 - 96,340,263 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1596,325,938 - 96,340,263 (+)EnsemblGRCh38hg38GRCh38
GRCh371596,869,275 - 96,883,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361594,674,950 - 94,683,048 (+)NCBINCBI36Build 36hg18NCBI36
Build 341594,674,949 - 94,683,045NCBI
Celera1573,285,358 - 73,299,693 (+)NCBICelera
Cytogenetic Map15q26.2NCBI
HuRef1572,999,792 - 73,013,983 (+)NCBIHuRef
CHM1_11596,711,246 - 96,725,580 (+)NCBICHM1_1
T2T-CHM13v2.01594,090,629 - 94,104,848 (+)NCBIT2T-CHM13v2.0
Nr2f2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39770,001,694 - 70,016,494 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl770,001,692 - 70,016,483 (-)EnsemblGRCm39 Ensembl
GRCm38770,351,946 - 70,366,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl770,351,944 - 70,366,735 (-)EnsemblGRCm38mm10GRCm38
MGSCv37777,496,836 - 77,511,632 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36770,226,952 - 70,240,235 (-)NCBIMGSCv36mm8
Celera767,807,423 - 67,836,911 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map738.66NCBI
Nr2f2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541624,141,888 - 24,168,585 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541624,148,052 - 24,154,406 (+)NCBIChiLan1.0ChiLan1.0
NR2F2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21685,870,526 - 85,903,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11589,569,489 - 89,582,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01575,008,879 - 75,021,981 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11594,196,494 - 94,210,599 (+)NCBIpanpan1.1PanPan1.1panPan2
NR2F2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1344,135,143 - 44,148,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl344,136,463 - 44,148,524 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha346,838,728 - 46,852,294 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0344,548,234 - 44,561,807 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl344,475,116 - 44,561,446 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1344,070,866 - 44,084,429 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0344,300,713 - 44,314,268 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0344,625,819 - 44,639,411 (-)NCBIUU_Cfam_GSD_1.0
Nr2f2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640139,433,402 - 139,446,616 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364836,886,153 - 6,900,997 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364836,886,447 - 6,900,986 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR2F2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl783,076,124 - 83,090,535 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1783,076,119 - 83,090,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2788,960,806 - 88,972,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR2F2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12914,889,526 - 14,901,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2914,891,737 - 14,903,813 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605931,706,856 - 31,720,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr2f2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247687,701,674 - 7,728,408 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247687,713,771 - 7,728,102 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nr2f2
28 total Variants


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 125281249 125281250 C A snv FHL/EurMcwi (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:65
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000014152
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 54 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat

1 to 10 of 54 rows
RH133250  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,014,364 - 124,014,551 (+)MAPPERmRatBN7.2
Rnor_6.01131,452,853 - 131,453,039NCBIRnor6.0
Rnor_5.01132,491,879 - 132,492,065UniSTSRnor5.0
RGSC_v3.41125,285,093 - 125,285,279UniSTSRGSC3.4
Celera1116,183,609 - 116,183,795UniSTS
RH 3.4 Map11451.09UniSTS
Cytogenetic Map1q31UniSTS
D1Bda25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,010,253 - 124,010,462 (+)MAPPERmRatBN7.2
Rnor_6.01131,448,744 - 131,448,952NCBIRnor6.0
Rnor_5.01132,487,770 - 132,487,978UniSTSRnor5.0
RGSC_v3.41125,280,981 - 125,281,189UniSTSRGSC3.4
Celera1116,179,540 - 116,179,748UniSTS
Cytogenetic Map1q31UniSTS
RH141740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,010,196 - 124,010,411 (+)MAPPERmRatBN7.2
Rnor_6.01131,448,687 - 131,448,901NCBIRnor6.0
Rnor_5.01132,487,713 - 132,487,927UniSTSRnor5.0
RGSC_v3.41125,280,924 - 125,281,138UniSTSRGSC3.4
Celera1116,179,483 - 116,179,697UniSTS
RH 3.4 Map11451.2UniSTS
Cytogenetic Map1q31UniSTS
PMC316637P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,013,509 - 124,013,975 (+)MAPPERmRatBN7.2
Rnor_6.01131,451,998 - 131,452,463NCBIRnor6.0
Rnor_5.01132,491,024 - 132,491,489UniSTSRnor5.0
RGSC_v3.41125,284,238 - 125,284,703UniSTSRGSC3.4
Celera1116,182,754 - 116,183,219UniSTS
Cytogenetic Map1q31UniSTS


This gene Nr2f2 is modified in the following models/strains:
SS-Nr2f2em1Mcwi    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000014152   ⟹   ENSRNOP00000014152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,010,247 - 124,016,202 (-)Ensembl
Rnor_6.0 Ensembl1131,448,737 - 131,454,689 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084336   ⟹   ENSRNOP00000072005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,009,181 - 124,022,031 (-)Ensembl
Rnor_6.0 Ensembl1131,448,447 - 131,460,473 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100190   ⟹   ENSRNOP00000078685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,009,181 - 124,014,705 (-)Ensembl
RefSeq Acc Id: NM_080778   ⟹   NP_542956
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81133,420,227 - 133,426,179 (-)NCBI
mRatBN7.21124,010,247 - 124,016,202 (-)NCBI
Rnor_6.01131,448,737 - 131,454,689 (-)NCBI
Rnor_5.01132,486,697 - 132,499,845 (-)NCBI
RGSC_v3.41125,280,974 - 125,286,929 (-)RGD
Celera1116,179,533 - 116,185,445 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229366   ⟹   XP_006229428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81133,419,161 - 133,434,290 (-)NCBI
mRatBN7.21124,008,282 - 124,022,521 (-)NCBI
Rnor_6.01131,447,671 - 131,465,749 (-)NCBI
Rnor_5.01132,486,697 - 132,499,845 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588643   ⟹   XP_017444132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81133,419,161 - 133,425,607 (-)NCBI
mRatBN7.21124,008,282 - 124,015,639 (-)NCBI
Rnor_6.01131,447,671 - 131,454,067 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105995   ⟹   XP_038961923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81133,419,161 - 133,425,451 (-)NCBI
mRatBN7.21124,008,286 - 124,014,951 (-)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_542956 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229428 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444132 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961923 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB61297 (Get FASTA)   NCBI Sequence Viewer  
  EDM08487 (Get FASTA)   NCBI Sequence Viewer  
  EDM08488 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014152
  ENSRNOP00000014152.1
  ENSRNOP00000072005
GenBank Protein O09018 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_542956   ⟸   NM_080778
- UniProtKB: O09018 (UniProtKB/Swiss-Prot),   A6JBW1 (UniProtKB/TrEMBL),   A0A8I6A7N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229428   ⟸   XM_006229366
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1W0 (UniProtKB/TrEMBL),   A6JBW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444132   ⟸   XM_017588643
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000014152   ⟸   ENSRNOT00000014152
Ensembl Acc Id: ENSRNOP00000072005   ⟸   ENSRNOT00000084336
NR LBD   Nuclear receptor

Name Modeler Protein Id AA Range Protein Structure
AF-O09018-F1-model_v2 AlphaFold O09018 1-414 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690115
Promoter ID:EPDNEW_R637
Type:initiation region
Name:Nr2f2_1
Description:nuclear receptor subfamily 2, group F, member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01131,460,507 - 131,460,567EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58933 BioCyc
Ensembl Genes ENSRNOG00000010308 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014152 ENTREZGENE
  ENSRNOT00000014152.4 UniProtKB/Swiss-Prot
  ENSRNOT00000084336 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hormone_rcpt_NR2 UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:113984 UniProtKB/Swiss-Prot
NCBI Gene 113984 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PharmGKB NR2F2 RGD
PhenoGen Nr2f2 PhenoGen
PRINTS COUPTNFACTOR UniProtKB/Swiss-Prot
  STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010308 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
TIGR TC206011
UniProt A0A0G2K1W0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLR6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7N1 ENTREZGENE, UniProtKB/TrEMBL
  A6JBW0 ENTREZGENE, UniProtKB/TrEMBL
  A6JBW1 ENTREZGENE, UniProtKB/TrEMBL
  COT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr2f2  nuclear receptor subfamily 2, group F, member 2      Name updated 70584 APPROVED

Note Type Note Reference
gene_process a transcriptional repressor for the microsomal triglyceride transfer protein gene but a transcriptional activator for the CYP7A1 gene 737636