Eae30 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Eae30 (Experimental allergic encephalomyelitis QTL 30) Rattus norvegicus

Symbol: Eae30
Name: Experimental allergic encephalomyelitis QTL 30
RGD ID: 2325726
Trait: nervous system integrity trait   (VT:0010566)    
Measurement Type: experimental autoimmune encephalomyelitis severity score   (CMO:0001419)    
LOD Score: Not Available
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81132,463,342 - 138,003,629RGD_MAPPER_PIPELINE
mRatBN7.21123,053,310 - 128,593,844RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01130,458,716 - 135,612,014RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01131,506,554 - 136,616,701RGDRnor5.0
RGSC_v3.41124,308,081 - 130,290,315RGDRGSC3.4
Cross Type: intercross
Strains Crossed: Kini:DA,PVG-G10 Kini:DA,PVG-G12 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Rgma is a candidate Gene for Eae30


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae30RatExperimental Autoimmune Encephalomyelitis  IDA 6892695 RGD 
Eae30Ratmultiple sclerosis  IAGP 6892695 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae30RatCNS inflammation  IDA 6892695 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae30Ratexperimental autoimmune encephalomyelitis severity score  IDA 6892695 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae30Ratmyelin oligodendrocyte glycoprotein  IDA 6892695 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae30Ratin vivo visual assessment  IDA 6892695 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae30RatKini:DA,PVG-G10  IEA 6892695 RGD 
Eae30RatKini:DA,PVG-G12  IEA 6892695 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae30Ratnervous system integrity trait  IDA 6892695 RGD 


#
Reference Title
Reference Citation
1. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Nohra R, etal., Genes Immun. 2010 Jan 14.
2. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Nohra R, etal., Genes Immun. 2010 Jun;11(4):279-93. Epub 2010 Jan 14.


1 to 20 of 34 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1332712Or5m12-ps1olfactory receptor family 5 subfamily M member 12, pseudogene 11123124617123125228Rat
40976304LOC120100448small nucleolar RNA SNORA171123620368123620504Rat
2323071Dcaf12-ps1DDB1 and CUL4 associated factor 12, pseudogene 11123731057123733750Rat
7683637LOC102553173uncharacterized LOC1025531731123943804123994246Rat
69305Nr2f2nuclear receptor subfamily 2, group F, member 21124008282124022521Rat
7661531LOC102553329uncharacterized LOC1025533291124017749124165290Rat
2322933Srsf7-ps1serine and arginine rich splicing factor 7, pseudogene 11124210206124239378Rat
11468718Rpl21-ps25ribosomal protein L21, pseudogene 251124344834124345343Rat
41237530LOC120100125U6 spliceosomal RNA1124419603124419709Rat
40953130LOC12009778560S ribosomal protein L27-like1124728576124728938Rat
41077517LOC120099851uncharacterized LOC1200998511124972989125042272Rat
1562967Mctp2multiple C2 and transmembrane domain containing 21125769932126002886Rat
7698364LOC102553828spermatogenesis-associated protein 13-like1126159731126164254Rat
41088730Trnaa-agc79transfer RNA alanine (anticodon AGC) 791126350554126350634Rat
9191646LOC103691162uncharacterized LOC1036911621126477043126482167Rat
1583787Mif-ps8macrophage migration inhibitory factor, pseudogene 81126777227126777631Rat
7634877LOC102554078uncharacterized LOC1025540781126851551126852404Rat
1311983Rgmarepulsive guidance molecule BMP co-receptor a1127128934127172918Rat
1310056Chd2chromodomain helicase DNA binding protein 21127188146127317041Rat
41219816LOC120099853uncharacterized LOC1200998531127336589127338218Rat

1 to 20 of 34 rows
1 to 20 of 80 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
33870D1Mit171891126242834126243023Ratregion
36007D1Rat361361127453884127454022Ratregion
37428D1Rat2002401125611501125611741Ratregion
37674D1Rat1791021125065093125065195Ratregion
36432D1Rat351451123479780123479925Ratregion
34777D1Rat371291127472095127472226Ratregion
35057D1Rat391351124668437124668572Ratregion
39316D1Rat2172291123053310123053539Ratregion
39492D1Rat3211491126571769126571918Ratregion
42486D1Rat4931001126920030126920130Ratregion
42487D1Rat4162331124501203124501436Ratregion
42488D1Rat3481311126458412126458554Ratregion
40764D1Rat2691901124977174124977364Ratregion
40922D1Rat2702421128593600128593844Ratregion
43279D1Got113881128354401128354489Ratregion
43280D1Got1081921126013438126013630Ratregion
43281D1Got1021531126780769126780924Ratregion
43284D1Got1012501124962840124963090Ratregion
43285D1Got1102591125245191125245450Ratregion
60784D1Wox291731123350408123350581Ratregion
1 to 20 of 80 rows

Flank 1: (D1Rat217)
Rat AssemblyChrPosition (strand)Source
GRCr81132,463,342 - 132,463,571 (+)Marker Load Pipeline
mRatBN7.21123,053,310 - 123,053,539 (+)MAPPER
Rnor_6.01130,458,716 - 130,458,942NCBI
Rnor_5.01131,506,554 - 131,506,780UniSTS
RGSC_v3.41124,308,081 - 124,308,308RGD
RGSC_v3.41124,308,082 - 124,308,308UniSTS
RGSC_v3.11124,386,424 - 124,386,651RGD
Celera1115,229,032 - 115,229,258UniSTS
FHH x ACI Map159.99RGD
FHH x ACI Map159.99UniSTS
Flank 2: (D1Rat270)
Rat AssemblyChrPosition (strand)Source
GRCr81138,003,387 - 138,003,629 (+)Marker Load Pipeline
mRatBN7.21128,593,600 - 128,593,844 (+)MAPPER
Rnor_6.01135,611,773 - 135,612,014NCBI
Rnor_5.01136,616,460 - 136,616,701UniSTS
RGSC_v3.41130,290,073 - 130,290,315RGD
RGSC_v3.41130,290,074 - 130,290,315UniSTS
RGSC_v3.11130,368,329 - 130,368,661RGD
Celera1120,707,723 - 120,707,964UniSTS
SHRSP x BN Map165.4299RGD
SHRSP x BN Map165.4299UniSTS


1 to 10 of 63 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat

1 to 10 of 63 rows


Note Type Note Reference
qtl_cross_type intercross  
qtl_general this region shows linkage to MOG-Eae, anti-MOG antibodies and levels of interleukin-6 2324646
qtl_general no linkage was seen in females to anti-MOG IgGs 2324646
qtl_general inducing agent: myelin oligodendrocyte glycoprotein aa1-125 2324646
qtl_general measurement method: after induction, animals were monitored and weighed daily beginning on day 7 p.i. until sacrificed 31-38 days, for changes in weight and for clinical signs of paresis/paralysis which were scored on a scale from 0-5; blood samples were taken and levels of MOG antibodies, IgG2b, IgG1 and total IgG determined by ELISA 2324646
qtl_map spans 6 Mb 2324646