Eae30 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Eae30 (Experimental allergic encephalomyelitis QTL 30) Rattus norvegicus

Symbol: Eae30
Name: Experimental allergic encephalomyelitis QTL 30
RGD ID: 2325726
Trait: nervous system integrity trait   (VT:0010566)    
Measurement Type: experimental autoimmune encephalomyelitis severity score   (CMO:0001419)    
LOD Score: Not Available
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21123,053,310 - 128,593,844RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01130,458,716 - 135,612,014RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01131,506,554 - 136,616,701RGDRnor5.0
RGSC_v3.41124,308,081 - 130,290,315RGDRGSC3.4
Cross Type: intercross
Strains Crossed: Kini:DA,PVG-G10 Kini:DA,PVG-G12 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Rgma is a candidate Gene for Eae30

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Nohra R, etal., Genes Immun. 2010 Jan 14.
2. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Nohra R, etal., Genes Immun. 2010 Jun;11(4):279-93. Epub 2010 Jan 14.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1332712Or5m12-ps1olfactory receptor family 5 subfamily M member 12, pseudogene 11123124617123125228Rat
40976304LOC120100448small nucleolar RNA SNORA171123620368123620504Rat
2323071Dcaf12-ps1DDB1 and CUL4 associated factor 12, pseudogene 11123731057123733750Rat
7683637LOC102553173uncharacterized LOC1025531731123943804123994246Rat
69305Nr2f2nuclear receptor subfamily 2, group F, member 21124008282124022521Rat
7661531LOC102553329uncharacterized LOC1025533291124017749124165290Rat
2322933Srsf7-ps1serine and arginine rich splicing factor 7, pseudogene 11124210206124239378Rat
11468718Rpl21-ps25ribosomal protein L21, pseudogene 251124344834124345343Rat
41237530LOC120100125U6 spliceosomal RNA1124419603124419709Rat
40953130LOC12009778560S ribosomal protein L27-like1124728576124728938Rat
41077517LOC120099851uncharacterized LOC1200998511124972989125042272Rat
1562967Mctp2multiple C2 and transmembrane domain containing 21125769932126002886Rat
7698364LOC102553828spermatogenesis-associated protein 13-like1126159731126164254Rat
41088730Trnaa-agc79transfer RNA alanine (anticodon AGC) 791126350554126350634Rat
9191646LOC103691162uncharacterized LOC1036911621126477043126482167Rat
1583787Mif-ps8macrophage migration inhibitory factor, pseudogene 81126777227126777631Rat
7634877LOC102554078uncharacterized LOC1025540781126851551126852404Rat
1311983Rgmarepulsive guidance molecule BMP co-receptor a1127128934127172918Rat
1310056Chd2chromodomain helicase DNA binding protein 21127188146127317041Rat
41219816LOC120099853uncharacterized LOC1200998531127336589127338218Rat
40975001LOC120099854uncharacterized LOC1200998541127347845127351622Rat
41143699LOC120099855uncharacterized LOC1200998551127368228127374172Rat
41330022LOC120099856uncharacterized LOC1200998561127413163127418868Rat
1583735Top1-ps1DNA topoisomerase 1, pseudogene 11127423431127432141Rat
9249251LOC103691177histone H2A.Z pseudogene1127473174127484619Rat
1596692Fam174bfamily with sequence similarity 174, member B1127515393127618591Rat
41389607Ipmk-ps1inositol polyphosphate multikinase, pseudogene 11127578732127592426Rat
1583786Rpl26-ps7ribosomal protein L26, pseudogene 71127659594127660098Rat
621843St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 21127762573127838017Rat
41343720LOC120097791uncharacterized LOC1200977911127962107127984875Rat
41241885LOC120100156U1 spliceosomal RNA1128006617128006780Rat
2322257Rps27-ps9ribosomal protein S27, pseudogene 91128028275128028907Rat
620227Slco3a1solute carrier organic anion transporter family, member 3a11128106232128388043Rat
41257043Actg1-ps11actin, gamma 1, pseudogene 111128530958128550705Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33870D1Mit172131126242834126243023Ratregion
36007D1Rat361361127453884127454022Ratregion
37428D1Rat2002341125611501125611741Ratregion
37674D1Rat1791001125065093125065195Ratregion
36432D1Rat351651123479780123479925Ratregion
34777D1Rat371291127472095127472226Ratregion
35057D1Rat391351124668437124668572Ratregion
39316D1Rat2172271123053310123053539Ratregion
39492D1Rat3211491126571769126571918Ratregion
42486D1Rat4931001126920030126920130Ratregion
42487D1Rat4162331124501203124501436Ratregion
42488D1Rat3481311126458412126458554Ratregion
40764D1Rat2692061124977174124977364Ratregion
40922D1Rat2702361128593600128593844Ratregion
43279D1Got113881128354401128354489Ratregion
43280D1Got1081921126013438126013630Ratregion
43281D1Got1021531126780769126780924Ratregion
43284D1Got1012531124962840124963090Ratregion
43285D1Got1102591125245191125245450Ratregion
60784D1Wox291861123350408123350581Ratregion
1626906D1Mco602001124160661124160861Ratregion
1627093D1Mco502131124240462124240675Ratregion
1627150D1Mco591851124270036124270223Ratregion
1627162D1Mco491921124258528124258720Ratregion
1627193D1Mco552371126540680126540917Ratregion
1627204D1Mco532391128319846128320087Ratregion
1627486D1Mco541127592218127592440Ratregion
1638559D1Ulb11551123813887123814042Ratregion
1641710D1Got3181761128398080128398257Ratregion
5025990RH1304821881124007847124008035Ratregion
5031710AU0474072201123627949123628309Ratregion
5029157RH1437311641127316426127316590Ratregion
5034820AI0118882321124056116124057694Ratregion
5029555AA819234931127172765127172858Ratregion
5032543STS-L295562321127766718127766950Ratregion
5034928AI2358352151124066334124066549Ratregion
5034942AI2294921911123934893123935283Ratregion
5025610RH1289841941127382536127382730Ratregion
5030729BF404388901127608198127608288Ratregion
5030735BE1078031641126851622126851786Ratregion
5055043RH1435731461127301816127301962Ratregion
5057153D1Bda262621127766672127766934Ratregion
5057151D1Bda252091124010253124010462Ratregion
5056169RH1442232471127578492127578739Ratregion
5056611RH1444781911127627118127627309Ratregion
5059264BF3879012131128116921128117134Ratregion
5054155RH1430621741124047625124047799Ratregion
5041214RH1287282171127302778127302995Ratregion
5046054RH1315311821128106375128106557Ratregion
5046392RH1317262201127317552127317772Ratregion
5049038RH1332501871124014364124014551Ratregion
5039346RH1276532011127188314127188515Ratregion
5041230RH1287371511127351362127351513Ratregion
5072706RH1370061701124897988124898158Ratregion
5077380RH1397231851124797141124797326Ratregion
5077874RH1400101931123963270123963463Ratregion
5080478RH1416021911127298650127298841Ratregion
5078846RH1405862201125769961125770181Ratregion
5074126RH1378372501128395640128395890Ratregion
5068246AU0472611421127835974127836118Ratregion
5068248AU0472602791127835940127836217Ratregion
5063824AW5353851941127205413127205607Ratregion
5062128BE1062391671123980059123980226Ratregion
5065474BE1156171681127423790127423946Ratregion
5064234BE1208201511123868267123868418Ratregion
5066464AU0483412311123876736123877184Ratregion
5066464AU0483412311123876951123877184Ratregion
5089723AU0493251751128045090128045265Ratregion
5083982AI2317201461124006324124006470Ratregion
5081523BE1171681601124005702124005862Ratregion
5084550AI1782482091125771316125771525Ratregion
5080716RH1417402151124010196124010411Ratregion
5083409BF3910751541123943878123944032Ratregion
5503750ST10BE4802811124270774124271055Ratregion
5504624PMC316637P14661124013509124013975Ratregion
5506608NR2F2_20748521124009003124009855Ratregion
5499645MARC_6238-6239:992007182:34721124344833124345305Ratregion
5501930MARC_17499-17500:1016469992:15901127242417127243007Ratregion
5502911Nr2f29131124009237124010150Ratregion
152025209rs10500138901123556856123556856Ratregion
Position Markers

Flank 1: (D1Rat217)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21123,053,310 - 123,053,539 (+)MAPPER
Rnor_6.01130,458,716 - 130,458,942NCBI
Rnor_5.01131,506,554 - 131,506,780UniSTS
RGSC_v3.41124,308,081 - 124,308,308RGD
RGSC_v3.41124,308,082 - 124,308,308UniSTS
RGSC_v3.11124,386,424 - 124,386,651RGD
Celera1115,229,032 - 115,229,258UniSTS
FHH x ACI Map159.99RGD
FHH x ACI Map159.99UniSTS
Flank 2: (D1Rat270)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21128,593,600 - 128,593,844 (+)MAPPER
Rnor_6.01135,611,773 - 135,612,014NCBI
Rnor_5.01136,616,460 - 136,616,701UniSTS
RGSC_v3.41130,290,073 - 130,290,315RGD
RGSC_v3.41130,290,074 - 130,290,315UniSTS
RGSC_v3.11130,368,329 - 130,368,661RGD
Celera1120,707,723 - 120,707,964UniSTS
SHRSP x BN Map165.4299RGD
SHRSP x BN Map165.4299UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
2325726Eae30Experimental allergic encephalomyelitis QTL 30nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1123053310128593844Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_general this region shows linkage to MOG-Eae, anti-MOG antibodies and levels of interleukin-6 2324646
qtl_general no linkage was seen in females to anti-MOG IgGs 2324646
qtl_general inducing agent: myelin oligodendrocyte glycoprotein aa1-125 2324646
qtl_general measurement method: after induction, animals were monitored and weighed daily beginning on day 7 p.i. until sacrificed 31-38 days, for changes in weight and for clinical signs of paresis/paralysis which were scored on a scale from 0-5; blood samples were taken and levels of MOG antibodies, IgG2b, IgG1 and total IgG determined by ELISA 2324646
qtl_map spans 6 Mb 2324646