Eef2k (eukaryotic elongation factor-2 kinase) - Rat Genome Database

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Gene: Eef2k (eukaryotic elongation factor-2 kinase) Rattus norvegicus
Analyze
Symbol: Eef2k
Name: eukaryotic elongation factor-2 kinase
RGD ID: 2538
Description: Enables elongation factor-2 kinase activity. Involved in several processes, including cellular response to anoxia; cellular response to brain-derived neurotrophic factor stimulus; and positive regulation of cellular component organization. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; eEF-2 kinase; eEF-2K; elongation factor 2 kinase; eukaroytic elongation factor 2 kinase; Eukaryotic elongation factor 2 kinase; SMEF2K
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81184,824,420 - 184,888,048 (+)NCBIGRCr8
GRCr8 Ensembl1184,824,420 - 184,888,048 (+)EnsemblGRCr8 Ensembl
mRatBN7.21175,393,119 - 175,456,756 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1175,393,154 - 175,455,164 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1183,753,768 - 183,794,993 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01190,939,743 - 190,980,965 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,625,310 - 183,666,539 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01190,780,211 - 190,839,926 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1190,780,236 - 190,842,324 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01197,704,669 - 197,766,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,712,404 - 179,754,345 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1173,143,531 - 173,184,040 (+)NCBICelera
RGSC_v3.11179,832,738 - 179,895,924 (+)NCBI
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
azoxystrobin  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
bisphenol AF  (ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
diazinon  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
glucose  (ISO)
glycine betaine  (EXP)
hydroquinone  (ISO)
iron atom  (EXP)
iron dichloride  (ISO)
iron(0)  (EXP)
ketamine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP,ISO)
phenethyl isothiocyanate  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
triadimefon  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Prolactin regulation of the calmodulin-dependent protein kinase III elongation factor-2 system in the rat corpus luteum. Albarracin CT, etal., J Biol Chem. 1994 Mar 11;269(10):7772-6.
2. Localization of translational components at the ultramicroscopic level at postsynaptic sites of the rat brain. Asaki C, etal., Brain Res. 2003 May 16;972(1-2):168-76.
3. Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus. Davidkova G and Carroll RC, J Neurosci. 2007 Nov 28;27(48):13273-8.
4. Regulation of protein-synthesis elongation-factor-2 kinase by cAMP in adipocytes. Diggle TA, etal., Biochem J. 1998 Dec 15;336 ( Pt 3):525-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Gastric Adenocarcinoma Predictive Long Intergenic Non-Coding RNA Promotes Tumor Occurrence and Progression in Non-Small Cell Lung Cancer via Regulation of the miR-661/eEF2K Signaling Pathway. Gu H, etal., Cell Physiol Biochem. 2018;51(5):2136-2147. doi: 10.1159/000495831. Epub 2018 Dec 6.
8. Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Horman S, etal., Curr Biol. 2002 Aug 20;12(16):1419-23.
9. Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2. Horman S, etal., J Biol Chem. 2003 Oct 24;278(43):41970-6. Epub 2003 Aug 14.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain. Li X, etal., FEBS J. 2005 Aug;272(16):4211-20.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Cloning and expression of cDNA encoding protein synthesis elongation factor-2 kinase. Redpath NT, etal., J Biol Chem 1996 Jul 19;271(29):17547-54.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions. Rose AJ, etal., J Physiol. 2009 Apr 1;587(Pt 7):1547-63. doi: 10.1113/jphysiol.2008.167528. Epub 2009 Feb 2.
18. Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. Ryazanov AG, etal., Proc Natl Acad Sci U S A 1997 May 13;94(10):4884-9.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neurons. Takei N, etal., J Biol Chem. 2009 Sep 25;284(39):26340-8. doi: 10.1074/jbc.M109.023010. Epub 2009 Jul 22.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Terai K, etal., Mol Cell Biol. 2005 Nov;25(21):9554-75.
23. Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis. Verpelli C, etal., J Neurosci. 2010 Apr 28;30(17):5830-42. doi: 10.1523/JNEUROSCI.0119-10.2010.
Additional References at PubMed
PMID:14709557   PMID:23184662   PMID:23640883   PMID:23812389   PMID:25943107   PMID:27005990   PMID:27317589   PMID:28205128   PMID:30737648   PMID:32569665   PMID:33191388   PMID:35598844  


Genomics

Comparative Map Data
Eef2k
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81184,824,420 - 184,888,048 (+)NCBIGRCr8
GRCr8 Ensembl1184,824,420 - 184,888,048 (+)EnsemblGRCr8 Ensembl
mRatBN7.21175,393,119 - 175,456,756 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1175,393,154 - 175,455,164 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1183,753,768 - 183,794,993 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01190,939,743 - 190,980,965 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,625,310 - 183,666,539 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01190,780,211 - 190,839,926 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1190,780,236 - 190,842,324 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01197,704,669 - 197,766,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,712,404 - 179,754,345 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1173,143,531 - 173,184,040 (+)NCBICelera
RGSC_v3.11179,832,738 - 179,895,924 (+)NCBI
Cytogenetic Map1q36NCBI
EEF2K
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381622,206,278 - 22,288,738 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1622,206,278 - 22,288,738 (+)EnsemblGRCh38hg38GRCh38
GRCh371622,217,599 - 22,300,059 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361622,125,093 - 22,207,567 (+)NCBINCBI36Build 36hg18NCBI36
Build 341622,125,256 - 22,205,452NCBI
Celera1620,997,480 - 21,079,953 (+)NCBICelera
Cytogenetic Map16p12.2NCBI
HuRef1620,462,336 - 20,544,660 (+)NCBIHuRef
CHM1_11622,091,272 - 22,173,735 (-)NCBICHM1_1
T2T-CHM13v2.01621,928,475 - 22,010,936 (-)NCBIT2T-CHM13v2.0
Eef2k
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397120,442,080 - 120,506,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7120,442,054 - 120,506,673 (+)EnsemblGRCm39 Ensembl
GRCm387120,842,642 - 120,907,219 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7120,842,831 - 120,907,450 (+)EnsemblGRCm38mm10GRCm38
MGSCv377127,986,397 - 128,047,515 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367120,634,032 - 120,695,150 (+)NCBIMGSCv36mm8
Celera7120,755,613 - 120,816,599 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map764.95NCBI
Eef2k
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955493865,830 - 922,765 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955493865,830 - 922,765 (+)NCBIChiLan1.0ChiLan1.0
EEF2K
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21823,051,125 - 23,133,784 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11627,571,678 - 27,654,230 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01616,443,579 - 16,526,061 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11622,518,150 - 22,598,735 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1622,537,518 - 22,596,091 (+)Ensemblpanpan1.1panPan2
EEF2K
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1623,368,296 - 23,433,853 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl623,371,546 - 23,433,929 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha624,863,141 - 24,928,560 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0623,506,671 - 23,572,566 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl623,506,218 - 23,572,676 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1623,308,900 - 23,374,695 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0623,218,207 - 23,280,831 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0623,600,299 - 23,665,719 (-)NCBIUU_Cfam_GSD_1.0
Eef2k
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344119,053,057 - 119,105,538 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365017,160,134 - 7,207,377 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365017,160,134 - 7,205,231 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EEF2K
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl323,887,125 - 23,956,373 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1323,887,120 - 23,980,231 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2324,287,297 - 24,412,626 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EEF2K
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1519,871,669 - 19,957,471 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl519,871,310 - 19,957,395 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660689,911,761 - 9,997,341 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eef2k
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247827,606,655 - 7,666,206 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247827,606,576 - 7,668,771 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eef2k
464 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:550
Count of miRNA genes:267
Interacting mature miRNAs:347
Transcripts:ENSRNOT00000022726
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat

Markers in Region
AI102667  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21175,432,817 - 175,432,969 (+)MAPPERmRatBN7.2
Rnor_6.01190,819,682 - 190,819,833NCBIRnor6.0
Rnor_5.01197,745,820 - 197,745,971UniSTSRnor5.0
RGSC_v3.41179,733,272 - 179,733,423UniSTSRGSC3.4
Celera1173,164,030 - 173,164,181UniSTS
Cytogenetic Map1q35UniSTS
RH133994  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21175,439,360 - 175,439,547 (+)MAPPERmRatBN7.2
Rnor_6.01190,826,223 - 190,826,409NCBIRnor6.0
Rnor_5.01197,752,355 - 197,752,541UniSTSRnor5.0
RGSC_v3.41179,740,875 - 179,741,061UniSTSRGSC3.4
Celera1173,170,564 - 173,170,750UniSTS
Cytogenetic Map1q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022726   ⟹   ENSRNOP00000022726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1184,824,420 - 184,888,048 (+)Ensembl
mRatBN7.2 Ensembl1175,393,154 - 175,455,164 (+)Ensembl
Rnor_6.0 Ensembl1190,780,236 - 190,842,324 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150775   ⟹   ENSRNOP00000107678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1184,824,420 - 184,888,048 (+)Ensembl
RefSeq Acc Id: NM_012947   ⟹   NP_037079
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81184,824,420 - 184,888,048 (+)NCBI
mRatBN7.21175,393,127 - 175,456,756 (+)NCBI
Rnor_6.01190,798,705 - 190,839,693 (+)NCBI
Rnor_5.01197,704,669 - 197,766,058 (+)NCBI
RGSC_v3.41179,712,404 - 179,754,345 (+)RGD
Celera1173,143,531 - 173,184,040 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230157   ⟹   XP_006230219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81184,825,090 - 184,885,743 (+)NCBI
mRatBN7.21175,393,824 - 175,454,452 (+)NCBI
Rnor_6.01190,780,465 - 190,839,926 (+)NCBI
Rnor_5.01197,704,669 - 197,766,058 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230158   ⟹   XP_006230220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81184,835,122 - 184,885,743 (+)NCBI
mRatBN7.21175,403,809 - 175,454,452 (+)NCBI
Rnor_6.01190,789,781 - 190,839,926 (+)NCBI
Rnor_5.01197,704,669 - 197,766,058 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101738   ⟹   XP_038957666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81184,824,497 - 184,885,743 (+)NCBI
mRatBN7.21175,393,119 - 175,454,446 (+)NCBI
RefSeq Acc Id: XM_063281805   ⟹   XP_063137875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81184,835,783 - 184,885,743 (+)NCBI
RefSeq Acc Id: NP_037079   ⟸   NM_012947
- UniProtKB: O09089 (UniProtKB/Swiss-Prot),   P70531 (UniProtKB/Swiss-Prot),   A6I8S8 (UniProtKB/TrEMBL),   Q6P757 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230219   ⟸   XM_006230157
- Peptide Label: isoform X1
- UniProtKB: O09089 (UniProtKB/Swiss-Prot),   P70531 (UniProtKB/Swiss-Prot),   A6I8S8 (UniProtKB/TrEMBL),   Q6P757 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230220   ⟸   XM_006230158
- Peptide Label: isoform X1
- UniProtKB: O09089 (UniProtKB/Swiss-Prot),   P70531 (UniProtKB/Swiss-Prot),   A6I8S8 (UniProtKB/TrEMBL),   Q6P757 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022726   ⟸   ENSRNOT00000022726
RefSeq Acc Id: XP_038957666   ⟸   XM_039101738
- Peptide Label: isoform X2
- UniProtKB: Q6P757 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137875   ⟸   XM_063281805
- Peptide Label: isoform X1
- UniProtKB: P70531 (UniProtKB/Swiss-Prot),   O09089 (UniProtKB/Swiss-Prot),   A6I8S8 (UniProtKB/TrEMBL),   Q6P757 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107678   ⟸   ENSRNOT00000150775
Protein Domains
Alpha-type protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70531-F1-model_v2 AlphaFold P70531 1-724 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690363
Promoter ID:EPDNEW_R888
Type:initiation region
Name:Eef2k_1
Description:eukaryotic elongation factor-2 kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01190,780,219 - 190,780,279EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2538 AgrOrtholog
BioCyc Gene G2FUF-57595 BioCyc
Ensembl Genes ENSRNOG00000016448 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022726 ENTREZGENE
  ENSRNOT00000022726.6 UniProtKB/Swiss-Prot
  ENSRNOT00000150775 ENTREZGENE
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
  MHCK/EF2 kinase UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599075 IMAGE-MGC_LOAD
InterPro Alpha-type_PK UniProtKB/Swiss-Prot
  eEF-2K UniProtKB/Swiss-Prot
  eEF2K_a_kinase_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MHCK_EF2_kinase UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25435 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72540 IMAGE-MGC_LOAD
NCBI Gene 25435 ENTREZGENE
PANTHER EUKARYOTIC ELONGATION FACTOR 2 KINASE UniProtKB/Swiss-Prot
  EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED UniProtKB/Swiss-Prot
Pfam Alpha_kinase UniProtKB/Swiss-Prot
PhenoGen Eef2k PhenoGen
PIRSF Elongation_factor_2_kinase UniProtKB/Swiss-Prot
PROSITE ALPHA_KINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016448 RatGTEx
SMART Alpha_kinase UniProtKB/Swiss-Prot
Superfamily-SCOP HCP-like UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC204086
UniProt A6I8S8 ENTREZGENE, UniProtKB/TrEMBL
  A6I8T0_RAT UniProtKB/TrEMBL
  EF2K_RAT UniProtKB/Swiss-Prot
  O09089 ENTREZGENE
  P70531 ENTREZGENE
  Q6P757 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O09089 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Eef2k  Eukaryotic elongation factor 2 kinase      Symbol and Name status set to approved 70586 APPROVED