Kcnj12 (potassium inwardly-rectifying channel, subfamily J, member 12) - Rat Genome Database

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Gene: Kcnj12 (potassium inwardly-rectifying channel, subfamily J, member 12) Rattus norvegicus
Analyze
Symbol: Kcnj12
Name: potassium inwardly-rectifying channel, subfamily J, member 12
RGD ID: 621660
Description: Enables PDZ domain binding activity. Predicted to be involved in potassium ion import across plasma membrane; protein homotetramerization; and regulation of monoatomic ion transmembrane transport. Located in T-tubule; dendrite; and neuronal cell body. Orthologous to several human genes including KCNJ12 (potassium inwardly rectifying channel subfamily J member 12); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-sensitive inward rectifier potassium channel 12; inward rectifier K(+) channel Kir2.2; IRK-2; IRK2; Kir2.1; Kir2.2; MGC156606; potassium channel, inwardly rectifying subfamily J member 12; potassium channel, inwardly rectifying subfamily J, member 12; potassium voltage-gated channel subfamily J member 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,196,110 - 46,245,008 (+)NCBIGRCr8
mRatBN7.21045,696,621 - 45,745,528 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,696,849 - 45,745,492 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,398,782 - 50,445,413 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,889,171 - 49,935,802 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,392,752 - 45,439,368 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01047,282,208 - 47,343,501 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,281,786 - 47,341,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,055,301 - 47,116,715 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,169,007 - 47,215,218 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11047,182,206 - 47,228,820 (+)NCBI
Celera1044,949,489 - 44,995,656 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
Ampullosporin  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
clofibrate  (ISO)
dexamethasone  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
flavonoids  (EXP)
formaldehyde  (EXP)
fulvestrant  (ISO)
genistein  (EXP,ISO)
indometacin  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
maneb  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
Nutlin-3  (ISO)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenethyl isothiocyanate  (EXP)
phenylmercury acetate  (ISO)
potassium atom  (ISO)
propanal  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium azide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Kir2.6 regulates the surface expression of Kir2.x inward rectifier potassium channels. Dassau L, etal., J Biol Chem. 2011 Mar 18;286(11):9526-41. doi: 10.1074/jbc.M110.170597. Epub 2011 Jan 5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Molecular cloning, functional expression and localization of a novel inward rectifier potassium channel in the rat brain. Koyama H, etal., FEBS Lett 1994 Mar 21;341(2-3):303-7.
5. A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Leonoudakis D, etal., J Biol Chem 2004 Apr 30;279(18):19051-63. Epub 2004 Feb 11.
6. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
7. Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97. Leonoudakis D, etal., J Cell Sci. 2001 Mar;114(Pt 5):987-98.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function. Pruss H, etal., Brain Res Mol Brain Res. 2003 Feb 20;110(2):203-19.
11. Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brain. Pruss H, etal., Brain Res Mol Brain Res. 2005 Sep 13;139(1):63-79.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12034888   PMID:12477932   PMID:14629112   PMID:15284349   PMID:15827083   PMID:15833810   PMID:17670900   PMID:18026984   PMID:18063660   PMID:19122180   PMID:20921230   PMID:21874019  
PMID:23426663   PMID:26786162   PMID:26854211   PMID:28331977  


Genomics

Comparative Map Data
Kcnj12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,196,110 - 46,245,008 (+)NCBIGRCr8
mRatBN7.21045,696,621 - 45,745,528 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,696,849 - 45,745,492 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,398,782 - 50,445,413 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,889,171 - 49,935,802 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,392,752 - 45,439,368 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01047,282,208 - 47,343,501 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,281,786 - 47,341,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,055,301 - 47,116,715 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,169,007 - 47,215,218 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11047,182,206 - 47,228,820 (+)NCBI
Celera1044,949,489 - 44,995,656 (+)NCBICelera
Cytogenetic Map10q22NCBI
KCNJ12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381721,376,357 - 21,419,870 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1721,376,357 - 21,419,870 (+)EnsemblGRCh38hg38GRCh38
GRCh371721,279,669 - 21,323,182 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361721,220,292 - 21,263,772 (+)NCBINCBI36Build 36hg18NCBI36
Build 341721,259,201 - 21,260,985NCBI
Celera1721,271,752 - 21,272,289 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1720,481,596 - 20,525,235 (+)NCBIHuRef
CHM1_11721,289,329 - 21,332,814 (+)NCBICHM1_1
T2T-CHM13v2.01721,325,282 - 21,368,794 (+)NCBIT2T-CHM13v2.0
Kcnj12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,912,970 - 60,964,095 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,913,390 - 60,961,957 (+)EnsemblGRCm39 Ensembl
GRCm381161,022,564 - 61,073,269 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,022,564 - 61,071,131 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,879,306 - 60,884,633 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,881,999 - 60,887,324 (+)NCBIMGSCv36mm8
Celera1165,306,038 - 65,311,351 (+)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.96NCBI
Kcnj12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555771,348,350 - 1,359,300 (+)NCBIChiLan1.0ChiLan1.0
KCNJ12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21949,967,813 - 50,011,313 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11754,836,539 - 54,880,048 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01730,190,240 - 30,233,740 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KCNJ12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1542,819,412 - 42,860,916 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl542,850,372 - 42,860,899 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha542,987,898 - 42,998,425 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0542,927,297 - 42,967,865 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl542,957,319 - 42,967,865 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1542,924,011 - 42,934,540 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0542,871,014 - 42,881,560 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0543,063,962 - 43,074,489 (+)NCBIUU_Cfam_GSD_1.0
Kcnj12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560262,563,301 - 62,600,937 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936741266,311 - 303,947 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,506,577 - 61,507,870 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,424,459 - 61,511,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNJ12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11619,489,982 - 19,533,316 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660591,221,509 - 1,264,620 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248495,092,750 - 5,132,246 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnj12
213 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:59
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000057953
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
BI282301  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,743,226 - 45,743,391 (+)MAPPERmRatBN7.2
Rnor_6.01047,341,200 - 47,341,364NCBIRnor6.0
Rnor_5.01047,114,409 - 47,114,573UniSTSRnor5.0
RGSC_v3.41047,215,005 - 47,215,169UniSTSRGSC3.4
Celera1044,995,443 - 44,995,607UniSTS
RH 3.4 Map10529.78UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 74 73 42 25 42 6 201 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000057953   ⟹   ENSRNOP00000054762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1045,696,849 - 45,745,492 (+)Ensembl
Rnor_6.0 Ensembl1047,282,208 - 47,341,411 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089123   ⟹   ENSRNOP00000070521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1045,739,838 - 45,745,492 (+)Ensembl
Rnor_6.0 Ensembl1047,281,786 - 47,341,392 (+)Ensembl
RefSeq Acc Id: NM_053981   ⟹   NP_446433
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,196,110 - 46,242,920 (+)NCBI
mRatBN7.21045,696,621 - 45,743,440 (+)NCBI
Rnor_6.01047,282,208 - 47,341,413 (+)NCBI
Rnor_5.01047,055,301 - 47,116,715 (+)NCBI
RGSC_v3.41047,169,007 - 47,215,218 (+)RGD
Celera1044,949,489 - 44,995,656 (+)RGD
Sequence:
RefSeq Acc Id: XM_017596964   ⟹   XP_017452453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,237,773 - 46,245,008 (+)NCBI
mRatBN7.21045,738,329 - 45,745,528 (+)NCBI
Rnor_6.01047,316,648 - 47,343,501 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085061   ⟹   XP_038940989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,237,061 - 46,245,008 (+)NCBI
mRatBN7.21045,738,221 - 45,745,528 (+)NCBI
RefSeq Acc Id: NP_446433   ⟸   NM_053981
- UniProtKB: P52188 (UniProtKB/Swiss-Prot),   Q6U7S0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452453   ⟸   XM_017596964
- Peptide Label: isoform X1
- UniProtKB: P52188 (UniProtKB/Swiss-Prot),   A6HF69 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054762   ⟸   ENSRNOT00000057953
Ensembl Acc Id: ENSRNOP00000070521   ⟸   ENSRNOT00000089123
RefSeq Acc Id: XP_038940989   ⟸   XM_039085061
- Peptide Label: isoform X2
- UniProtKB: P52188 (UniProtKB/Swiss-Prot),   Q6U7S0 (UniProtKB/TrEMBL)
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying Kir N-   Potassium channel inwardly rectifying transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52188-F1-model_v2 AlphaFold P52188 1-427 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697257
Promoter ID:EPDNEW_R7782
Type:single initiation site
Name:Kcnj12_1
Description:potassium voltage-gated channel subfamily J member 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01047,282,199 - 47,282,259EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621660 AgrOrtholog
BioCyc Gene G2FUF-24829 BioCyc
Ensembl Genes ENSRNOG00000002303 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057953.3 UniProtKB/TrEMBL
  ENSRNOT00000089123.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1400 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8364361 IMAGE-MGC_LOAD
InterPro Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir2.2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kir_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117052 UniProtKB/TrEMBL
MGC_CLONE MGC:156606 IMAGE-MGC_LOAD
NCBI Gene 117052 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11767:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnj12 PhenoGen
PRINTS KIR22CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002303 RatGTEx
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HF69 ENTREZGENE, UniProtKB/TrEMBL
  KCJ12_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6U7S0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-19 Kcnj12  potassium inwardly-rectifying channel, subfamily J, member 12  Kcnj12  potassium voltage-gated channel subfamily J member 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Kcnj12  potassium voltage-gated channel subfamily J member 12  Kcnj12  potassium channel, inwardly rectifying subfamily J, member 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnj12  potassium channel, inwardly rectifying subfamily J, member 12  Kcnj12  potassium inwardly-rectifying channel, subfamily J, member 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcnj12  potassium inwardly-rectifying channel, subfamily J, member 12      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kcnj12  potassium inwardly-rectifying channel, subfamily J, member 12      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology shows 70%, 40% and 45% identity to mouse Irk1, rat Romk1 and rat Girk1 729027