Apba1 (amyloid beta precursor protein binding family A member 1) - Rat Genome Database

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Gene: Apba1 (amyloid beta precursor protein binding family A member 1) Rattus norvegicus
Analyze
Symbol: Apba1
Name: amyloid beta precursor protein binding family A member 1
RGD ID: 620844
Description: Enables several functions, including PDZ domain binding activity; amyloid-beta binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in chemical synaptic transmission and presynaptic modulation of chemical synaptic transmission. Predicted to act upstream of or within several processes, including carboxylic acid transport; in utero embryonic development; and locomotory behavior. Located in dendritic spine. Part of protein-containing complex. Orthologous to human APBA1 (amyloid beta precursor protein binding family A member 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adapter protein X11alpha; amyloid beta (A4) precursor protein-binding family A APBA1: amyloid beta (A4) precursor protein-binding family A member 1 (X11); amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11); amyloid beta (A4) precursor protein-binding, family A, member 1; amyloid beta A4 precursor protein-binding family A member 1; amyloid-beta A4 precursor protein-binding family A member 1; mint-1; Mint1; neuron-specific X11 protein; neuronal Munc18-1-interacting protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81230,790,297 - 230,995,986 (+)NCBIGRCr8
mRatBN7.21221,363,769 - 221,569,496 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,363,778 - 221,566,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1229,804,697 - 230,010,786 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,734,753 - 236,940,843 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01229,552,787 - 229,758,875 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,594,565 - 241,796,512 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,594,565 - 241,796,513 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01248,875,910 - 249,079,588 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,106,828 - 227,309,416 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11227,270,850 - 227,473,431 (+)NCBI
Celera1218,575,430 - 218,778,639 (+)NCBICelera
Cytogenetic Map1q51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms. Biederer T, etal., J Neurosci 2002 Sep 1;22(17):7340-51.
2. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Butz S, etal., Cell 1998 Sep 18;94(6):773-82.
3. Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion. Deak F, etal., EMBO J. 2006 Jun 21;25(12):2856-66. Epub 2006 Jun 8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. CASK associates with glutamate receptor interacting protein and signaling molecules. Hong CJ and Hsueh YP, Biochem Biophys Res Commun. 2006 Dec 22;351(3):771-6. Epub 2006 Oct 30.
7. Scaffold protein X11alpha interacts with kalirin-7 in dendrites and recruits it to Golgi outposts. Jones KA, etal., J Biol Chem. 2014 Dec 19;289(51):35517-29. doi: 10.1074/jbc.M114.587709. Epub 2014 Nov 5.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Leonoudakis D, etal., J Biol Chem 2004 Apr 30;279(18):19051-63. Epub 2004 Feb 11.
10. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
11. The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Liu W, etal., Cell. 2011 Jun 24;145(7):1088-101. doi: 10.1016/j.cell.2011.05.015.
12. Association of neuronal calcium channels with modular adaptor proteins. Maximov A, etal., J Biol Chem. 1999 Aug 27;274(35):24453-6.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. Okamoto M and Sudhof TC, J Biol Chem 1997 Dec 12;272(50):31459-64.
16. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Setou M, etal., Science. 2000 Jun 9;288(5472):1796-802.
20. Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. Ushkaryov YA, etal., Science 1992 Jul 3;257(5066):50-6.
Additional References at PubMed
PMID:9822620   PMID:10971649   PMID:11036064   PMID:12547917   PMID:15240107   PMID:16849336   PMID:17167098   PMID:18007179   PMID:18054859   PMID:25931508   PMID:33159991  


Genomics

Comparative Map Data
Apba1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81230,790,297 - 230,995,986 (+)NCBIGRCr8
mRatBN7.21221,363,769 - 221,569,496 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,363,778 - 221,566,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1229,804,697 - 230,010,786 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,734,753 - 236,940,843 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01229,552,787 - 229,758,875 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,594,565 - 241,796,512 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,594,565 - 241,796,513 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01248,875,910 - 249,079,588 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,106,828 - 227,309,416 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11227,270,850 - 227,473,431 (+)NCBI
Celera1218,575,430 - 218,778,639 (+)NCBICelera
Cytogenetic Map1q51NCBI
APBA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38969,427,532 - 69,673,013 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl969,427,532 - 69,672,371 (-)EnsemblGRCh38hg38GRCh38
GRCh37972,042,448 - 72,287,287 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36971,235,022 - 71,477,042 (-)NCBINCBI36Build 36hg18NCBI36
Build 34969,274,755 - 69,516,776NCBI
Celera942,632,969 - 42,877,657 (-)NCBICelera
Cytogenetic Map9q21.12NCBI
HuRef941,881,637 - 42,126,250 (-)NCBIHuRef
CHM1_1972,188,922 - 72,433,742 (-)NCBICHM1_1
T2T-CHM13v2.0981,594,168 - 81,839,634 (-)NCBIT2T-CHM13v2.0
Apba1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391923,736,170 - 23,926,961 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1923,736,251 - 23,926,960 (+)EnsemblGRCm39 Ensembl
GRCm381923,758,806 - 23,949,598 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1923,758,887 - 23,949,596 (+)EnsemblGRCm38mm10GRCm38
MGSCv371923,833,366 - 24,024,087 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361923,825,973 - 24,016,694 (+)NCBIMGSCv36mm8
Celera1924,515,896 - 24,708,645 (+)NCBICelera
Cytogenetic Map19BNCBI
cM Map1918.45NCBI
Apba1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554343,519,314 - 3,588,829 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554343,384,978 - 3,588,771 (+)NCBIChiLan1.0ChiLan1.0
APBA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21168,636,321 - 68,877,849 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1968,642,260 - 68,883,788 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0955,124,040 - 55,365,521 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1968,191,877 - 68,435,013 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl968,191,877 - 68,275,554 (-)Ensemblpanpan1.1panPan2
APBA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1187,787,039 - 87,980,204 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl187,786,836 - 87,980,194 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha188,255,280 - 88,452,053 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0188,335,484 - 88,532,249 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl188,335,277 - 88,532,244 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1187,990,598 - 88,187,087 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0187,697,128 - 87,893,940 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0188,460,793 - 88,657,815 (+)NCBIUU_Cfam_GSD_1.0
Apba1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947135,402,119 - 135,473,424 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365035,699,558 - 5,771,030 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365035,699,580 - 5,770,920 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APBA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,758,509 - 222,990,335 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,758,508 - 222,990,000 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,028,220 - 249,062,572 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APBA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11280,506,807 - 80,733,095 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1280,506,776 - 80,577,500 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603868,922,453 - 69,148,957 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apba1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247363,565,299 - 3,635,775 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247363,404,915 - 3,637,346 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:72
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000020123
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
5508828Leukc3Leukocyte quantity QTL 3eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1227535119233480676Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1221820316234540296Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634340Hcar5Hepatocarcinoma resistance QTL 58liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1223964326236074012Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
D1Got221  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,362,223 - 221,362,434 (+)MAPPERmRatBN7.2
Rnor_6.01241,593,013 - 241,593,221NCBIRnor6.0
Rnor_5.01248,874,358 - 248,874,566UniSTSRnor5.0
RGSC_v3.41227,105,275 - 227,105,484RGDRGSC3.4
RGSC_v3.41227,105,276 - 227,105,484UniSTSRGSC3.4
RGSC_v3.11227,269,299 - 227,269,507RGD
Celera1218,573,878 - 218,574,086UniSTS
RH 3.4 Map11615.7RGD
RH 3.4 Map11615.7UniSTS
Cytogenetic Map1q51UniSTS
BF393522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,506,666 - 221,506,805 (+)MAPPERmRatBN7.2
Rnor_6.01241,736,439 - 241,736,577NCBIRnor6.0
Rnor_5.01249,017,618 - 249,017,756UniSTSRnor5.0
RGSC_v3.41227,249,874 - 227,250,012UniSTSRGSC3.4
Celera1218,719,280 - 218,719,418UniSTS
RH 3.4 Map11617.72UniSTS
Cytogenetic Map1q51UniSTS
Mlf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,563,065 - 221,563,671 (+)MAPPERmRatBN7.2
Rnor_6.01241,793,026 - 241,793,631NCBIRnor6.0
Rnor_5.01249,073,158 - 249,073,763UniSTSRnor5.0
RGSC_v3.41227,305,930 - 227,306,535UniSTSRGSC3.4
Celera1218,775,149 - 218,775,754UniSTS
Cytogenetic Map1q51UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000020123   ⟹   ENSRNOP00000020123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,363,778 - 221,566,553 (+)Ensembl
Rnor_6.0 Ensembl1241,594,565 - 241,796,513 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094213   ⟹   ENSRNOP00000089303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,363,778 - 221,566,553 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105792   ⟹   ENSRNOP00000085566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,522,896 - 221,566,553 (+)Ensembl
RefSeq Acc Id: NM_031779   ⟹   NP_113967
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81230,790,297 - 230,995,986 (+)NCBI
mRatBN7.21221,363,781 - 221,569,496 (+)NCBI
Rnor_6.01241,594,565 - 241,796,512 (+)NCBI
Rnor_5.01248,875,910 - 249,079,588 (+)NCBI
RGSC_v3.41227,106,828 - 227,309,416 (+)RGD
Celera1218,575,430 - 218,778,639 (+)RGD
Sequence:
RefSeq Acc Id: XM_039092551   ⟹   XP_038948479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81230,790,298 - 230,995,986 (+)NCBI
mRatBN7.21221,363,769 - 221,569,496 (+)NCBI
RefSeq Acc Id: XM_063275480   ⟹   XP_063131550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81230,790,297 - 230,995,986 (+)NCBI
RefSeq Acc Id: XM_063275486   ⟹   XP_063131556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81230,790,297 - 230,995,986 (+)NCBI
RefSeq Acc Id: NP_113967   ⟸   NM_031779
- UniProtKB: O35430 (UniProtKB/Swiss-Prot),   F1LR60 (UniProtKB/TrEMBL),   A6I0P3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020123   ⟸   ENSRNOT00000020123
RefSeq Acc Id: XP_038948479   ⟸   XM_039092551
- Peptide Label: isoform X2
- UniProtKB: O35430 (UniProtKB/Swiss-Prot),   A0A8I6A9Y2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085566   ⟸   ENSRNOT00000105792
Ensembl Acc Id: ENSRNOP00000089303   ⟸   ENSRNOT00000094213
RefSeq Acc Id: XP_063131556   ⟸   XM_063275486
- Peptide Label: isoform X1
- UniProtKB: O35430 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131550   ⟸   XM_063275480
- Peptide Label: isoform X1
- UniProtKB: O35430 (UniProtKB/Swiss-Prot)
Protein Domains
PDZ   PID

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35430-F1-model_v2 AlphaFold O35430 1-839 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690823
Promoter ID:EPDNEW_R1347
Type:single initiation site
Name:Apba1_1
Description:amyloid beta precursor protein binding family A member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01241,594,568 - 241,594,628EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620844 AgrOrtholog
BioCyc Gene G2FUF-56102 BioCyc
Ensembl Genes ENSRNOG00000014928 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055031190 UniProtKB/Swiss-Prot
  ENSRNOG00060021137 UniProtKB/Swiss-Prot
  ENSRNOG00065024825 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020123.5 UniProtKB/TrEMBL
  ENSRNOT00000094213.1 UniProtKB/TrEMBL
  ENSRNOT00000105792.1 UniProtKB/TrEMBL
  ENSRNOT00055054130 UniProtKB/Swiss-Prot
  ENSRNOT00060036812 UniProtKB/Swiss-Prot
  ENSRNOT00065042702 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro APP-Binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83589 UniProtKB/Swiss-Prot
NCBI Gene 83589 ENTREZGENE
PANTHER PTHR12345:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNTENIN RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Apba1 PhenoGen
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014928 RatGTEx
  ENSRNOG00055031190 RatGTEx
  ENSRNOG00060021137 RatGTEx
  ENSRNOG00065024825 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A3M6_RAT UniProtKB/TrEMBL
  A0A8I6A9Y2 ENTREZGENE, UniProtKB/TrEMBL
  A6I0P3 ENTREZGENE, UniProtKB/TrEMBL
  A6I0P4_RAT UniProtKB/TrEMBL
  A6I0P5_RAT UniProtKB/TrEMBL
  A6I0P6_RAT UniProtKB/TrEMBL
  APBA1_RAT UniProtKB/Swiss-Prot
  F1LR60 ENTREZGENE, UniProtKB/TrEMBL
  O35430 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Apba1  amyloid beta precursor protein binding family A member 1  Apba1  amyloid beta (A4) precursor protein-binding, family A, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Apba1  amyloid beta (A4) precursor protein-binding, family A, member 1    amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)  Name updated 1299863 APPROVED
2002-08-07 Apba1  amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains PTB and PDZ domains 727250
gene_expression present only in brain 727250