Advanced Search (OLGA)

Gene: Apba1 (amyloid beta precursor protein binding family A member 1) Rattus norvegicus

Analyze

Symbol:

Apba1

Name:

amyloid beta precursor protein binding family A member 1

RGD ID:

620844

Description:

Enables several functions, including PDZ domain binding activity; amyloid-beta binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in chemical synaptic transmission and presynaptic modulation of chemical synaptic transmission. Predicted to act upstream of or within several processes, including carboxylic acid transport; in utero embryonic development; and locomotory behavior. Located in dendritic spine. Part of protein-containing complex. Orthologous to human APBA1 (amyloid beta precursor protein binding family A member 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

adapter protein X11alpha; amyloid beta (A4) precursor protein-binding family A APBA1: amyloid beta (A4) precursor protein-binding family A member 1 (X11); amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11); amyloid beta (A4) precursor protein-binding, family A, member 1; amyloid beta A4 precursor protein-binding family A member 1; amyloid-beta A4 precursor protein-binding family A member 1; mint-1; Mint1; neuron-specific X11 protein; neuronal Munc18-1-interacting protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	230,790,297 - 230,995,986 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	230,790,297 - 230,995,986 (+)	Ensembl				GRCr8
mRatBN7.2	1	221,363,769 - 221,569,496 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	221,363,778 - 221,566,553 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	229,804,697 - 230,010,786 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	236,734,753 - 236,940,843 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	229,552,787 - 229,758,875 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	241,594,565 - 241,796,512 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	241,594,565 - 241,796,513 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	248,875,910 - 249,079,588 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	227,106,828 - 227,309,416 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	218,575,430 - 218,778,639 (+)	NCBI		Celera
RGSC_v3.1	1	227,270,850 - 227,473,431 (+)	NCBI
Cytogenetic Map	1	q51	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-palmitoylglycerol (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

D-glucose (ISO)

diallyl trisulfide (ISO)

dichromium trioxide (ISO)

endosulfan (EXP)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

FR900359 (ISO)

gentamycin (EXP)

glucose (ISO)

lead diacetate (ISO)

lead(0) (ISO)

linsidomine (EXP)

methapyrilene (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (EXP)

resveratrol (ISO)

scopolamine (EXP)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chemical synaptic transmission (IBA,IEA,ISO)

establishment of localization in cell (IEA,ISO)

gamma-aminobutyric acid secretion (IEA,ISO)

glutamate secretion (IEA,ISO)

in utero embryonic development (IEA,ISO)

intracellular protein transport (IEA,ISO)

locomotory behavior (IEA,ISO)

multicellular organism growth (IEA,ISO)

presynaptic modulation of chemical synaptic transmission (IEA,ISO)

protein transport (IEA)

regulation of gene expression (IEA,ISO)

synaptic vesicle exocytosis (IEA,TAS)

Cellular Component

cytoplasm (IBA,IEA)

cytosol (TAS)

dendritic spine (IBA,IDA)

glutamatergic synapse (IEA,ISO)

Golgi apparatus (IEA,ISO)

membrane (IEA,ISO)

nucleus (IEA)

perinuclear region of cytoplasm (IEA)

plasma membrane (IBA)

presynapse (IEA)

presynaptic active zone membrane (IEA,ISO)

protein-containing complex (IDA)

Schaffer collateral - CA1 synapse (IEA,ISO)

Molecular Function

amyloid-beta binding (IBA,IPI)

PDZ domain binding (IPI)

phosphatidylinositol-4,5-bisphosphate binding (IDA)

protein binding (IPI,ISO)

protein kinase binding (IPI)

protein-containing complex binding (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms.	Biederer T, etal., J Neurosci 2002 Sep 1;22(17):7340-51.
2.	A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.	Butz S, etal., Cell 1998 Sep 18;94(6):773-82.
3.	Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion.	Deak F, etal., EMBO J. 2006 Jun 21;25(12):2856-66. Epub 2006 Jun 8.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	CASK associates with glutamate receptor interacting protein and signaling molecules.	Hong CJ and Hsueh YP, Biochem Biophys Res Commun. 2006 Dec 22;351(3):771-6. Epub 2006 Oct 30.
7.	Scaffold protein X11alpha interacts with kalirin-7 in dendrites and recruits it to Golgi outposts.	Jones KA, etal., J Biol Chem. 2014 Dec 19;289(51):35517-29. doi: 10.1074/jbc.M114.587709. Epub 2014 Nov 5.
8.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
9.	A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.	Leonoudakis D, etal., J Biol Chem 2004 Apr 30;279(18):19051-63. Epub 2004 Feb 11.
10.	Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.	Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
11.	The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye.	Liu W, etal., Cell. 2011 Jun 24;145(7):1088-101. doi: 10.1016/j.cell.2011.05.015.
12.	Association of neuronal calcium channels with modular adaptor proteins.	Maximov A, etal., J Biol Chem. 1999 Aug 27;274(35):24453-6.
13.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
14.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.	Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.	Okamoto M and Sudhof TC, J Biol Chem 1997 Dec 12;272(50):31459-64.
16.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
17.	GOA pipeline	RGD automated data pipeline
18.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
19.	Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.	Setou M, etal., Science. 2000 Jun 9;288(5472):1796-802.
20.	Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin.	Ushkaryov YA, etal., Science 1992 Jul 3;257(5066):50-6.

Additional References at PubMed

PMID:9822620	PMID:10971649	PMID:11036064	PMID:12547917	PMID:15240107	PMID:16849336	PMID:17167098	PMID:18007179	PMID:18054859	PMID:25931508	PMID:33159991

Genomics

Comparative Map Data

Apba1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	230,790,297 - 230,995,986 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	230,790,297 - 230,995,986 (+)	Ensembl				GRCr8
mRatBN7.2	1	221,363,769 - 221,569,496 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	221,363,778 - 221,566,553 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	229,804,697 - 230,010,786 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	236,734,753 - 236,940,843 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	229,552,787 - 229,758,875 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	241,594,565 - 241,796,512 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	241,594,565 - 241,796,513 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	248,875,910 - 249,079,588 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	227,106,828 - 227,309,416 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	218,575,430 - 218,778,639 (+)	NCBI		Celera
RGSC_v3.1	1	227,270,850 - 227,473,431 (+)	NCBI
Cytogenetic Map	1	q51	NCBI

APBA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	69,427,532 - 69,673,013 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	69,427,532 - 69,672,371 (-)	Ensembl			hg38	GRCh38
GRCh37	9	72,042,448 - 72,287,287 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	71,235,022 - 71,477,042 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	69,274,755 - 69,516,776	NCBI
Celera	9	42,632,969 - 42,877,657 (-)	NCBI		Celera
Cytogenetic Map	9	q21.12	NCBI
HuRef	9	41,881,637 - 42,126,250 (-)	NCBI		HuRef
CHM1_1	9	72,188,922 - 72,433,742 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	81,594,168 - 81,839,634 (-)	NCBI		T2T-CHM13v2.0

Apba1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	23,736,170 - 23,926,961 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	23,736,251 - 23,926,960 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	23,758,806 - 23,949,598 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	23,758,887 - 23,949,596 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	23,833,366 - 24,024,087 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	23,825,973 - 24,016,694 (+)	NCBI		MGSCv36	mm8
Celera	19	24,515,896 - 24,708,645 (+)	NCBI		Celera
Cytogenetic Map	19	B	NCBI
cM Map	19	18.45	NCBI

Apba1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955434	3,519,314 - 3,588,829 (+)	Ensembl
ChiLan1.0	NW_004955434	3,384,978 - 3,588,771 (+)	NCBI	ChiLan1.0	ChiLan1.0

APBA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	68,636,321 - 68,877,849 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	68,642,260 - 68,883,788 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	55,124,040 - 55,365,521 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	68,191,877 - 68,435,013 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	68,191,877 - 68,275,554 (-)	Ensembl			panPan2	panpan1.1

APBA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	87,787,039 - 87,980,204 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	87,786,836 - 87,980,194 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	88,255,280 - 88,452,053 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	88,335,484 - 88,532,249 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	88,335,277 - 88,532,244 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	87,990,598 - 88,187,087 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	87,697,128 - 87,893,940 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	88,460,793 - 88,657,815 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Apba1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	135,402,119 - 135,473,424 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936503	5,699,558 - 5,771,030 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936503	5,699,580 - 5,770,920 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

APBA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	222,758,509 - 222,990,335 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	222,758,508 - 222,990,000 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	249,028,220 - 249,062,572 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

APBA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	80,506,807 - 80,733,095 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	80,506,776 - 80,577,500 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	68,922,453 - 69,148,957 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Apba1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	3,565,299 - 3,635,775 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624736	3,404,915 - 3,637,346 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Apba1
1495 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	100
Count of miRNA genes:	72
Interacting mature miRNAs:	89
Transcripts:	ENSRNOT00000020123
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8693637	Alc29	Alcohol consumption QTL 29	2.7	0.258	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	207987464	234238494	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	197814409	242814409	Rat
2302375	Bw83	Body weight QTL 83	4.87	0.0002	body mass (VT:0001259)	body weight (CMO:0000012)	1	197697768	242697768	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	201554356	246554356	Rat
5508828	Leukc3	Leukocyte quantity QTL 3			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	1	218108584	224054420	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
61455	Niddm7	Non-insulin dependent diabetes mellitus QTL 7	5.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	214537555	238757011	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	216255568	260522016	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	206081677	251081677	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	184550676	229550676	Rat
8693661	Alc34	Alcohol consumption QTL 34	2.2	0.611	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	207987464	228627600	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	201554356	246554356	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	201554356	246554356	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	221264111	259647894	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	213707201	252085212	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	201554356	246554356	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	197814409	242814409	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	193113876	238113876	Rat
734768	Niddm59	Non-insulin dependent diabetes mellitus QTL 59			body mass (VT:0001259)	body weight (CMO:0000012)	1	213843987	258843987	Rat
1358890	Bp259	Blood pressure QTL 259	3.06		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	210702053	260522016	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	218753816	256448513	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	196248093	241248093	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	197814409	242814409	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
1549910	Bw54	Body weight QTL 54		0.05	body mass (VT:0001259)	body weight (CMO:0000012)	1	214647894	259647894	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	214647894	259647894	Rat
1357399	Bw45	Body weight QTL 45	3.05		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	1	206329708	251329708	Rat
1357404	Bw42	Body weight QTL 42	4.49	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	206329708	251329708	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
10053715	Scort24	Serum corticosterone level QTL 24	2.13	0.0088	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	221414816	260522016	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	210702053	240947965	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	199368955	224569684	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	218753689	245907899	Rat
1331790	Bp201	Blood pressure QTL 201	3.127		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	198211513	225126682	Rat
10059587	Bw173	Body weight QTL 173	3.23	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	1	202069611	247069611	Rat
2292216	Bw80	Body weight QTL 80	3.23	0.0019	body mass (VT:0001259)	body weight (CMO:0000012)	1	213533809	243914901	Rat
61403	Niddm4	Non-insulin dependent diabetes mellitus QTL 4			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	206329708	222745518	Rat
1300168	Bp170	Blood pressure QTL 170	2.76		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	207702246	228581766	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	197697768	238755659	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	196248093	241248093	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	188377360	224054420	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
634340	Hcar5	Hepatocarcinoma resistance QTL 5	8		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	214537555	226660468	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	197670404	242670404	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	203995416	244113296	Rat
8693618	Alc25	Alcohol consumption QTL 25	3	0.28	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	207987464	228627600	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	192825253	243914732	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	216255568	260522016	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	201554356	246554356	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	218748008	257976495	Rat

Markers in Region

D1Got221

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	221,362,223 - 221,362,434 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	241,593,013 - 241,593,221	NCBI	Rnor6.0
Rnor_5.0	1	248,874,358 - 248,874,566	UniSTS	Rnor5.0
RGSC_v3.4	1	227,105,275 - 227,105,484	RGD	RGSC3.4
RGSC_v3.4	1	227,105,276 - 227,105,484	UniSTS	RGSC3.4
Celera	1	218,573,878 - 218,574,086	UniSTS
RGSC_v3.1	1	227,269,299 - 227,269,507	RGD
RH 3.4 Map	1	1615.7	RGD
RH 3.4 Map	1	1615.7	UniSTS
Cytogenetic Map	1	q51	UniSTS

BF393522

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	221,506,666 - 221,506,805 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	241,736,439 - 241,736,577	NCBI	Rnor6.0
Rnor_5.0	1	249,017,618 - 249,017,756	UniSTS	Rnor5.0
RGSC_v3.4	1	227,249,874 - 227,250,012	UniSTS	RGSC3.4
Celera	1	218,719,280 - 218,719,418	UniSTS
RH 3.4 Map	1	1617.72	UniSTS
Cytogenetic Map	1	q51	UniSTS

Mlf2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	221,563,065 - 221,563,671 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	241,793,026 - 241,793,631	NCBI	Rnor6.0
Rnor_5.0	1	249,073,158 - 249,073,763	UniSTS	Rnor5.0
RGSC_v3.4	1	227,305,930 - 227,306,535	UniSTS	RGSC3.4
Celera	1	218,775,149 - 218,775,754	UniSTS
Cytogenetic Map	1	q51	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	12	67	164	91	90	59	87	59	6	344	187	11	143	75	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092551	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF029105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000020123 ⟹ ENSRNOP00000020123

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	230,790,297 - 230,995,986 (+)	Ensembl
mRatBN7.2 Ensembl	1	221,363,778 - 221,566,553 (+)	Ensembl
Rnor_6.0 Ensembl	1	241,594,565 - 241,796,513 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094213 ⟹ ENSRNOP00000089303

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	230,790,297 - 230,995,986 (+)	Ensembl
mRatBN7.2 Ensembl	1	221,363,778 - 221,566,553 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105792 ⟹ ENSRNOP00000085566

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	221,522,896 - 221,566,553 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108892 ⟹ ENSRNOP00000105897

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	230,949,383 - 230,995,986 (+)	Ensembl

RefSeq Acc Id:

NM_031779 ⟹ NP_113967

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	230,790,297 - 230,995,986 (+)	NCBI
mRatBN7.2	1	221,363,781 - 221,569,496 (+)	NCBI
Rnor_6.0	1	241,594,565 - 241,796,512 (+)	NCBI
Rnor_5.0	1	248,875,910 - 249,079,588 (+)	NCBI
RGSC_v3.4	1	227,106,828 - 227,309,416 (+)	RGD
Celera	1	218,575,430 - 218,778,639 (+)	RGD

Sequence:

show sequence

GTCAGTCGCAGCCGCGCGGCCCTGGCGCGCGTCACGAGGGCGAGCGGGCGGCGAGCAGGGGGTG
GGGCCGCGGCCGGAGGGGCCCGAGCGGCTGCCGAGCAAAAGCCGGAGGAACGGGGCGCGGGCGG
CTGCGGTCCCGGTGGCGGCGGGGGAAGATGGTGGCGCTGGAGACGGGAGCAGCTGGAGAGCAGC
TTTATTCCCAGGCTTGGCACGGTCGCTGTCACTAGCGCCGCCTGCTCCCGCGGGCCCGCGACCC
AGCTGTCAGGCAAGGCCCCGTGAAGCCAAAATGAGCACACAGTGAGCCAGCGCAGCCTCTCGCC
AGCCATCCCCCGACGCCCACCATGAACCACTTGGAGGGCTCCGCGGAGGTGGAGGTGGCCGACG
AGGCGCCAGGAGGGGAGGTGAACGAGTCCGTGGAGGCCGACCTGGAGCACCCCGAGGTGGAGGA
AGAGCAGCAGCCGTCGCCCCCGCCGCCCGCAGGTCACGCACCCGAGGACCACCGCGCGCATCCG
GCGCCGCCGCCGCCGCCACCACCGCAGGAGGAGGAGGAGGAGCGCGGCGAGTGCCTGGCTCGCT
CGGCCAGCACCGAGAGCGGCTTCCACAACCACACGGACACCGCTGAGGGCGACGTGCTCGCCGC
GGCCCGAGACGGCTACGAGGCGGAGCGCGCGCAGGACGCCGACGATGAGAGCGCCTACGCCGTG
CAGTACCGGCCCGAGGCCGAGGAGTACACGGAGCAGGCGGAGGCCGAGCACGCCGAGGCGGCGC
AGCGGCGCGCGCTGCCCAACCACCTGCACTTCCACTCGCTGGAGCACGAGGAAGCCATGAACGC
CGCCTACTCGGGCTATGTCTACACGCACCGGCTCTTCCACCGCGCCGAGGACGAGCCCTACGCC
GAGCCCTACGCCGACTACGGCGGCCTCCAGGAGCACGTGTACGAGGAGATCGGGGACGCGCCTG
AGCTGGAGGCGCGCGACGGCCTGCGGCTCTATGAGCGGGAGCGCGACGAGGCGGCCGCCTACCG
CCAGGAGGCCCTAGGCGCGCGGCTGCACCACTACGACGAGCGCTCCGACGGCGAGTCCGACAGC
CCCGAGAAGGAGGCGGAGTTCGCGCCCTACCCGCGCATGGACAGTTATGAGCAGGAAGAGGACA
TCGACCAGATCGTGGCCGAGGTCAAGCAGAGCATGAGCTCGCAGAGCCTCGACAAGGCGGCCGA
AGACATGCCCGAGGCGGAGCAGGACCTGGAGCGCGCCCCGACCCCGGGAGGGGGACACCCCGAC
AGCCCTGGGCTGCCAGCACCTGCCGGGCAGCAGCAGCGAGTTGTGGGAACCCCGGGAGGCAGCG
AGGTTGGTCAGCGGTACAGCAAGGAAAAGAGGGATGCCATCTCGCTGGCCATCAAGGACATCAA
GGAGGCCATCGAAGAAGTGAAAACCAGGACCATCCGTTCGCCTTACACCCCCGACGAACCCAAA
GAGCCCATCTGGGTCATGCGCCAGGACATTAGCCCCACAAGGGACTGTGACGACCAGAGGCCCG
TGGACGGAGATTCTCCGTCTCCTGGCAGTTCCTCACCCCTGGGTGCTGAGTCATCAATCACACC
CCTTCATCCCGGTGACCCCACGGAAGCCTCCACTAATAAAGAGTCAAGAAAAAGCTTGGCTTCA
TTCCCAACCTACGTTGAAGTTCCTGGACCCTGCGACCCTGAAGACTTGATCGATGGAATTATTT
TTGCTGCCAATTACCTTGGTTCCACTCAGCTACTCTCAGACAAAACTCCCTCCAAAAACGTGCG
CATGATGCAGGCCCAGGAAGCAGTAAGCCGGATCAAGACGGCCCAGAAATTAGCCAAAAGCAGG
AAGAAGGCTCCTGAAGGCGAATCTCAGCCAATGACTGAGGTGGACCTCTTCATCTCCACCCAGA
GGATCAAAGTGTTGAATGCAGATACACAGGAGCCTATGATGGACCACCCTCTGAGGACCATTTC
CTACATCGCAGACATTGGGAACATCGTCGTGCTGATGGCCCGCAGGCGGATGCCCCGCTCCAAC
TCCCAGGAGAATGTGGAGGCCTCTCACCCATCCCAGGATGCAAAACGGCAGTACAAGATGATCT
GTCATGTCTTTGAGTCTGAGGACGCCCAGCTGATCGCACAGTCCATCGGGCAGGCCTTCAGCGT
TGCATACCAGGAGTTCCTCAGGGCCAACGGGATTAACCCAGAAGACCTGAGCCAGAAGGAGTAC
AGCGACCTGCTCAACACCCAGGACATGTACAACGATGACCTGATCCACTTCTCCAAGTCGGAAA
ACTGCAAAGATGTCTTCATAGAGAAGCAGAAAGGAGAAATCCTGGGAGTTGTGATTGTGGAGTC
TGGCTGGGGATCCATTCTGCCAACCGTGATCATTGCCAACATGATGCACGGAGGCCCCGCCGAG
AAGTCGGGGAAGCTGAACATCGGGGACCAGATCATGTCCATTAACGGCACCAGCCTGGTGGGCC
TGCCCCTGTCCACCTGCCAGAGCATCATTAAGGGCTTAAAGAACCAGTCCCGCGTGAAGCTGAA
CATCGTGAGGTGCCCCCCAGTGACCACAGTGCTAATTAGGAGGCCGGACCTTCGCTACCAGCTG
GGTTTCAGCGTGCAGAATGGAATTATCTGTAGCCTCATGAGAGGGGGAATAGCTGAGAGAGGAG
GTGTCCGCGTGGGACATCGGATCATTGAAATCAACGGCCAGAGTGTCGTAGCCACACCACACGA
GAAGATCGTCCACATACTCTCCAATGCTGTTGGGGAGATCCACATGAAGACAATGCCAGCAGCC
ATGTACAGACTGCTGACAGCCCAGGAGCAGCCCGTTTACATCTGAGCCGCACCTCCGCGGCGTG
GCAGCATGCATGGAGGACTCTCCTCACCGTGGTTGTGTTTCTTGTGCTGCATCTGTGTGTCCAC
TGAGACATTCCCCTCTCGCACCCAACGTTTGGTTTTACACAGGAAGAGAAGAATCGGCAAGGGC
CTCTTTGCTCTCTGTCTCTCTCCAGTTCGCTTTTTTATGTTCCATCCTTAACACCAGGGAAGTT
TGGTGTGTGCCCTCCTGAGGGTGGAGAGCAGCTAATATACCTAGGATCATGGTGGAGGCCTTTG
GGGGATCTTAAAGTGGTTGTTACTGCCCAAGGAGGCATCATCCCTCCCCAAGAGACACACACTT
CCCTGAAGGAGCTCTCAGAGGCAGCACAGGAGATGACTGAGCAGTGCCTAAAACTCACTTGCTG
ATCTCTCCGCCCTCCTCACCTCACTGATGGAAAGATGGTTGGTGACAGGTGACAGCACTGAATA
TCCTTAAAGCCCACATCTTTAAGGATGTTTGCTGCCTGCTGTGTAGTTGGAGCCCCGCACATTA
TTTCTGCCCAGAATTTCTGAGCCACTTTTAAATCCCTTCCCTAGTTTCTTTTAGTTGCAATGTG
TGTGCTAATTCAGGCCTAACTTCTGAGAAACAAGGACAAGGATGCTGTGACACCCACCTCAGAG
GTCCTGGCAAGTCACAGGGCCTCCAAGGTTCCCCAGGTTTCCAAGGTTACCAATTGGAGGATAA
CCACTGGCAGGTACTGTCCTAACGTACTTGCACAGGCGCTTATGTGTAACACACACACACACAC
ACACACACACACACACATGCCACCCACACACAA

hide sequence

RefSeq Acc Id:

XM_039092551 ⟹ XP_038948479

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	230,790,298 - 230,995,986 (+)	NCBI
mRatBN7.2	1	221,363,769 - 221,569,496 (+)	NCBI

RefSeq Acc Id:

XM_063275480 ⟹ XP_063131550

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	230,790,297 - 230,995,986 (+)	NCBI

RefSeq Acc Id:

XM_063275486 ⟹ XP_063131556

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	230,790,297 - 230,995,986 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_113967	(Get FASTA)	NCBI Sequence Viewer
	XP_038948479	(Get FASTA)	NCBI Sequence Viewer
	XP_063131550	(Get FASTA)	NCBI Sequence Viewer
	XP_063131556	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC05303	(Get FASTA)	NCBI Sequence Viewer
	EDM13024	(Get FASTA)	NCBI Sequence Viewer
	EDM13025	(Get FASTA)	NCBI Sequence Viewer
	EDM13026	(Get FASTA)	NCBI Sequence Viewer
	EDM13027	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020123
	ENSRNOP00000089303
GenBank Protein	O35430	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113967 ⟸ NM_031779

- UniProtKB:

O35430 (UniProtKB/Swiss-Prot), F1LR60 (UniProtKB/TrEMBL), A6I0P3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPP
PQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAE
EYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYG
GLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEF
APYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAP
AGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMR
QDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEV
PGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGE
SQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEA
SHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQ
DMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNI
GDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNG
IICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTA
QEQPVYI

hide sequence

Ensembl Acc Id:

ENSRNOP00000020123 ⟸ ENSRNOT00000020123

RefSeq Acc Id:	XP_038948479 ⟸ XM_039092551
- Peptide Label:	isoform X2
- UniProtKB:	O35430 (UniProtKB/Swiss-Prot), A0A8I6A9Y2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000085566 ⟸ ENSRNOT00000105792

Ensembl Acc Id:

ENSRNOP00000089303 ⟸ ENSRNOT00000094213

RefSeq Acc Id:	XP_063131556 ⟸ XM_063275486
- Peptide Label:	isoform X1
- UniProtKB:	O35430 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063131550 ⟸ XM_063275480
- Peptide Label:	isoform X1
- UniProtKB:	O35430 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000105897 ⟸ ENSRNOT00000108892

Protein Domains

PDZ PID

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35430-F1-model_v2	AlphaFold	O35430	1-839	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690823

Promoter ID:

EPDNEW_R1347

Type:

single initiation site

Name:

Apba1_1

Description:

amyloid beta precursor protein binding family A member 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	241,594,568 - 241,594,628	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620844	AgrOrtholog
BioCyc Gene	G2FUF-56102	BioCyc
Ensembl Genes	ENSRNOG00000014928	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000020123	ENTREZGENE
	ENSRNOT00000094213	ENTREZGENE
Gene3D-CATH	2.30.29.30	UniProtKB/Swiss-Prot
	2.30.42.10	UniProtKB/Swiss-Prot
InterPro	APP-Binding	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	PDZ_sf	UniProtKB/Swiss-Prot
	PH-like_dom_sf	UniProtKB/Swiss-Prot
	PTB/PI_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:83589	UniProtKB/Swiss-Prot
NCBI Gene	83589	ENTREZGENE
PANTHER	PTHR12345:SF14	UniProtKB/Swiss-Prot
	SYNTENIN RELATED	UniProtKB/Swiss-Prot
Pfam	PDZ	UniProtKB/Swiss-Prot
	PID	UniProtKB/Swiss-Prot
PhenoGen	Apba1	PhenoGen
PROSITE	PDZ	UniProtKB/Swiss-Prot
	PID	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000014928	RatGTEx
SMART	PDZ	UniProtKB/Swiss-Prot
	PTB	UniProtKB/Swiss-Prot
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot
	SSF50156	UniProtKB/Swiss-Prot
UniProt	A0A8I6A3M6_RAT	UniProtKB/TrEMBL
	A0A8I6A9Y2	ENTREZGENE, UniProtKB/TrEMBL
	A6I0P3	ENTREZGENE, UniProtKB/TrEMBL
	A6I0P4_RAT	UniProtKB/TrEMBL
	A6I0P5_RAT	UniProtKB/TrEMBL
	A6I0P6_RAT	UniProtKB/TrEMBL
	APBA1_RAT	UniProtKB/Swiss-Prot
	F1LR60	ENTREZGENE, UniProtKB/TrEMBL
	O35430	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-27	Apba1	amyloid beta precursor protein binding family A member 1	Apba1	amyloid beta (A4) precursor protein-binding, family A, member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Apba1	amyloid beta (A4) precursor protein-binding, family A, member 1		amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)	Name updated	1299863	APPROVED
2002-08-07	Apba1	amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains PTB and PDZ domains	727250
gene_expression	present only in brain	727250

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message