RGD Reference Report - Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. - Rat Genome Database

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Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.

Authors: Okamoto, M  Sudhof, TC 
Citation: Okamoto M and Sudhof TC, J Biol Chem 1997 Dec 12;272(50):31459-64.
RGD ID: 727250
Pubmed: PMID:9395480   (View Abstract at PubMed)

Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. Mint proteins are detectable only in brain and are composed of an N-terminal sequence that binds Munc18-1, a middle phosphotyrosine-binding domain, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane. In brain, Mint proteins are part of a multimeric complex containing Munc18-1 and syntaxin that likely functions as an intermediate in synaptic vesicle docking/fusion. The phosphotyrosine-binding domain specifically binds to phosphatidylinositol phosphates known to be produced during vesicle exocytosis (Hay, J. C., Fisette, P. L., Jenkins, G. H., Fukami, K., Takonawa, T., Anderson, R. A., and Martin, T. F. J. (1995) Nature 374, 173-177). Our data suggest a model whereby local production of phosphatidylinositol phosphates may trigger the binding of vesicles to the active zone via the Mint.Munc18-1 complex in conjunction with syntaxin 1.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
synaptic vesicle exocytosis  TAS 727250; 727250 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein-containing complex  IDA 727250 RGD 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Apba1  (amyloid beta precursor protein binding family A member 1)
Apba2  (amyloid beta precursor protein binding family A member 2)
Stx1a  (syntaxin 1A)
Stxbp1  (syntaxin binding protein 1)


Additional Information