Steep1 (STING1 ER exit protein 1) - Rat Genome Database

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Gene: Steep1 (STING1 ER exit protein 1) Rattus norvegicus
Analyze
Symbol: Steep1
Name: STING1 ER exit protein 1
RGD ID: 1564541
Description: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in endoplasmic reticulum membrane organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and protein exit from endoplasmic reticulum. Predicted to be located in several cellular components, including cell body; centrosome; and nucleoplasm. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 107. Orthologous to human STEEP1 (STING1 ER exit protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC313433; LOC313433; RGD1564541; similar to hypothetical protein FLJ22965; uncharacterized protein LOC313433; UPF0428 protein CXorf56 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X120,953,335 - 120,979,861 (-)NCBIGRCr8
mRatBN7.2X116,087,626 - 116,114,159 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,060,929 - 116,114,159 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX118,189,843 - 118,217,563 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X121,758,973 - 121,786,697 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,305,139 - 119,332,856 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,460,280 - 123,486,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,460,280 - 123,486,814 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X123,605,221 - 123,631,755 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,992,595 - 8,019,120 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX115,317,375 - 115,344,394 (-)NCBICelera
Cytogenetic MapXq34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell body  (IEA,ISO)
centrosome  (IEA,ISO)
cytoplasm  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO)
endoplasmic reticulum membrane  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:29374277  


Genomics

Comparative Map Data
Steep1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X120,953,335 - 120,979,861 (-)NCBIGRCr8
mRatBN7.2X116,087,626 - 116,114,159 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,060,929 - 116,114,159 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX118,189,843 - 118,217,563 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X121,758,973 - 121,786,697 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,305,139 - 119,332,856 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,460,280 - 123,486,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,460,280 - 123,486,814 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X123,605,221 - 123,631,755 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,992,595 - 8,019,120 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX115,317,375 - 115,344,394 (-)NCBICelera
Cytogenetic MapXq34NCBI
STEEP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X119,538,149 - 119,565,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX119,538,149 - 119,565,409 (-)EnsemblGRCh38hg38GRCh38
GRCh37X118,672,112 - 118,699,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X118,557,529 - 118,583,392 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX119,126,840 - 119,154,108 (-)NCBICelera
Cytogenetic MapXq24NCBI
HuRefX108,165,833 - 108,192,856 (-)NCBIHuRef
CHM1_1X118,583,359 - 118,610,624 (-)NCBICHM1_1
T2T-CHM13v2.0X117,915,908 - 117,943,135 (-)NCBIT2T-CHM13v2.0
Steep1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X36,087,388 - 36,127,956 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX36,087,390 - 36,137,764 (-)EnsemblGRCm39 Ensembl
GRCm38X36,827,161 - 36,864,303 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX36,823,737 - 36,874,111 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X34,388,538 - 34,404,241 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X33,255,180 - 33,305,588 (-)NCBIMGSCv36mm8
CeleraX23,572,190 - 23,587,885 (-)NCBICelera
Cytogenetic MapXA3.3NCBI
cM MapX21.23NCBI
Steep1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955534429,029 - 476,987 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955534429,207 - 443,810 (+)NCBIChiLan1.0ChiLan1.0
STEEP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X118,918,801 - 118,947,108 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X118,923,387 - 118,950,670 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X108,570,634 - 108,598,045 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X118,997,850 - 119,024,661 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX118,997,850 - 119,024,661 (-)Ensemblpanpan1.1panPan2
STEEP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X91,573,392 - 91,598,523 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX91,575,882 - 91,598,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX77,648,136 - 77,673,310 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X93,312,436 - 93,337,629 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX93,312,910 - 93,337,616 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X90,765,359 - 90,790,317 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X92,523,931 - 92,549,044 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X92,253,041 - 92,278,233 (-)NCBIUU_Cfam_GSD_1.0
Steep1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X90,612,443 - 90,636,476 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647910,351,059 - 10,404,657 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647910,351,016 - 10,373,416 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STEEP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX97,974,604 - 97,986,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X97,974,596 - 97,986,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X113,678,599 - 113,690,302 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STEEP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606532,291,932 - 32,316,567 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Steep1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248953,497,784 - 3,536,122 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248953,522,085 - 3,535,934 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Steep1
66 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:999
Count of miRNA genes:342
Interacting mature miRNAs:483
Transcripts:ENSRNOT00000016993
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X113805422126975220Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
RH130940  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X116,087,909 - 116,088,106 (+)MAPPERmRatBN7.2
Rnor_6.0X123,460,564 - 123,460,760NCBIRnor6.0
Rnor_5.0X123,605,505 - 123,605,701UniSTSRnor5.0
RGSC_v3.4X8,018,640 - 8,018,836UniSTSRGSC3.4
CeleraX115,317,659 - 115,317,855UniSTS
Cytogenetic MapXq12UniSTS
RH126553  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X120,954,035 - 120,954,283 (+)Marker Load Pipeline
mRatBN7.2X116,088,325 - 116,088,574 (+)MAPPERmRatBN7.2
Rnor_6.0X123,460,980 - 123,461,228NCBIRnor6.0
Rnor_5.0X123,605,921 - 123,606,169UniSTSRnor5.0
RGSC_v3.4X8,018,172 - 8,018,420UniSTSRGSC3.4
CeleraX115,318,075 - 115,318,323UniSTS
Cytogenetic MapXq12UniSTS
MARC_21759-21760:1023907404:5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X116,091,612 - 116,092,364 (+)MAPPERmRatBN7.2
Rnor_6.0X123,464,266 - 123,465,017NCBIRnor6.0
Rnor_5.0X123,609,207 - 123,609,958UniSTSRnor5.0
RGSC_v3.4X8,014,383 - 8,015,134UniSTSRGSC3.4
CeleraX115,321,361 - 115,322,112UniSTS
Cytogenetic MapXq12UniSTS
px-14c7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X116,106,432 - 116,106,569 (+)MAPPERmRatBN7.2
Rnor_6.0X123,479,092 - 123,479,228NCBIRnor6.0
Rnor_5.0X123,624,033 - 123,624,169UniSTSRnor5.0
RGSC_v3.4X8,000,181 - 8,000,317UniSTSRGSC3.4
CeleraX115,335,842 - 115,335,978UniSTS
Cytogenetic MapXq12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016993   ⟹   ENSRNOP00000016993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX116,087,626 - 116,114,159 (-)Ensembl
Rnor_6.0 EnsemblX123,460,280 - 123,486,814 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092415   ⟹   ENSRNOP00000075789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX123,472,761 - 123,474,154 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092455   ⟹   ENSRNOP00000075907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX116,060,929 - 116,101,527 (-)Ensembl
Rnor_6.0 EnsemblX123,462,333 - 123,474,288 (-)Ensembl
RefSeq Acc Id: NM_001107950   ⟹   NP_001101420
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X120,953,335 - 120,979,861 (-)NCBI
mRatBN7.2X116,087,626 - 116,114,159 (-)NCBI
Rnor_6.0X123,460,280 - 123,486,814 (-)NCBI
Rnor_5.0X123,605,221 - 123,631,755 (-)NCBI
RGSC_v3.4X7,992,595 - 8,019,120 (+)RGD
CeleraX115,317,375 - 115,344,394 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101420 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10824 (Get FASTA)   NCBI Sequence Viewer  
  EDM10825 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016993
  ENSRNOP00000016993.4
  ENSRNOP00000075907.2
RefSeq Acc Id: NP_001101420   ⟸   NM_001107950
- UniProtKB: D4A067 (UniProtKB/TrEMBL),   A6JMG3 (UniProtKB/TrEMBL),   A0A0U1RS26 (UniProtKB/TrEMBL),   A6JMG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075789   ⟸   ENSRNOT00000092415
Ensembl Acc Id: ENSRNOP00000075907   ⟸   ENSRNOT00000092455
Ensembl Acc Id: ENSRNOP00000016993   ⟸   ENSRNOT00000016993

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A067-F1-model_v2 AlphaFold D4A067 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701987
Promoter ID:EPDNEW_R12507
Type:multiple initiation site
Name:RGD1564541_1
Description:similar to hypothetical protein FLJ22965
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X123,474,135 - 123,474,195EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564541 AgrOrtholog
BioCyc Gene G2FUF-1304 BioCyc
Ensembl Genes ENSRNOG00000012564 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016993 ENTREZGENE
  ENSRNOT00000016993.6 UniProtKB/TrEMBL
  ENSRNOT00000092455.2 UniProtKB/TrEMBL
InterPro UPF0428 UniProtKB/TrEMBL
KEGG Report rno:313433 UniProtKB/TrEMBL
NCBI Gene 313433 ENTREZGENE
PANTHER PTHR46355 UniProtKB/TrEMBL
  STING ER EXIT PROTEIN UniProtKB/TrEMBL
PhenoGen Steep1 PhenoGen
RatGTEx ENSRNOG00000012564 RatGTEx
UniProt A0A0U1RS26 ENTREZGENE, UniProtKB/TrEMBL
  A6JMG2 ENTREZGENE, UniProtKB/TrEMBL
  A6JMG3 ENTREZGENE, UniProtKB/TrEMBL
  D4A067 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-10 Steep1  STING1 ER exit protein 1  RGD1564541  similar to hypothetical protein FLJ22965  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564541  similar to hypothetical protein FLJ22965   RGD1564541_predicted  similar to hypothetical protein FLJ22965 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564541_predicted  similar to hypothetical protein FLJ22965 (predicted)  LOC313433  similar to hypothetical protein FLJ22965  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC313433  similar to hypothetical protein FLJ22965      Symbol and Name status set to provisional 70820 PROVISIONAL