Ywhab (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta) - Rat Genome Database

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Gene: Ywhab (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta) Rattus norvegicus
Analyze
Symbol: Ywhab
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
RGD ID: 61998
Description: Predicted to enable several functions, including histone deacetylase binding activity; identical protein binding activity; and phosphoserine residue binding activity. Involved in negative regulation of DNA-templated transcription. Part of transcription repressor complex. Used to study visual epilepsy. Biomarker of brain ischemia. Orthologous to human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 14-3-3 protein beta-subtype; 14-3-3 protein beta/alpha; 14-3-3proteinbeta-subtype; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; 3-monooxygenase/tryptophan5monooxygenaseactivationproteinbetapolypeptide; KCIP-1; prepronerve growth factor RNH-1; protein kinase C inhibitor protein 1; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Eau4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,078,904 - 173,101,508 (+)NCBIGRCr8
mRatBN7.23152,659,663 - 152,682,105 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,659,651 - 152,682,105 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,467,118 - 156,489,555 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03164,966,056 - 164,988,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,710,239 - 162,732,648 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,391,108 - 160,399,931 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,391,106 - 160,399,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,577,934 - 166,586,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,926,025 - 154,948,297 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13154,832,060 - 154,854,385 (+)NCBI
Celera3151,308,216 - 151,330,624 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
finasteride  (EXP)
flucloxacillin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
ketanserin  (ISO)
lead(0)  (ISO)
melatonin  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
ochratoxin A  (EXP)
paracetamol  (ISO)
PCB138  (EXP)
phencyclidine  (ISO)
phenethyl isothiocyanate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
saxitoxin  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. Aoki H, etal., J Virol. 2000 Feb;74(4):1736-41.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. CaM kinase IIdeltaC phosphorylation of 14-3-3beta in vascular smooth muscle cells: activation of class II HDAC repression. Ellis JJ, etal., Mol Cell Biochem 2003 Jan;242(1-2):153-61.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. 14-3-3 beta in the healthy and diseased male reproductive system. Graf M, etal., Hum Reprod. 2011 Jan;26(1):59-66. doi: 10.1093/humrep/deq319. Epub 2010 Nov 26.
7. A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis. Komiya Y, etal., J Biol Chem. 2008 Jul 4;283(27):18753-64. Epub 2008 May 5.
8. AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane. Koumanov F, etal., J Biol Chem. 2011 May 13;286(19):16574-82. doi: 10.1074/jbc.M111.226092. Epub 2011 Mar 17.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals. O'Kelly I, etal., Cell. 2002 Nov 15;111(4):577-88.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
16. Interaction of 14-3-3 with Bid during seizure-induced neuronal death. Shinoda S, etal., J Neurochem. 2003 Jul;86(2):460-9.
17. Novel surrogate markers for acute brain damage: cerebrospinal fluid levels corrrelate with severity of ischemic neurodegeneration in the rat. Siman R, etal., J Cereb Blood Flow Metab. 2005 Nov;25(11):1433-44.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation. Takai R, etal., J Biochem (Tokyo) 1995 Nov;118(5):1045-53.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Implication of Akt-dependent Prp19 alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation. Urano-Tashiro Y, etal., J Neurosci Res. 2010 Oct;88(13):2787-97. doi: 10.1002/jnr.22455.
22. Molecular cloning of rat cDNAs for beta and gamma subtypes of 14-3-3 protein and developmental changes in expression of their mRNAs in the nervous system. Watanabe M, etal., Brain Res Mol Brain Res 1993 Jan;17(1-2):135-46.
23. Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain. Watanabe M, etal., Brain Res Mol Brain Res 1994 Aug;25(1-2):113-21.
Additional References at PubMed
PMID:9560161   PMID:9679960   PMID:10407019   PMID:10409742   PMID:10869435   PMID:11984006   PMID:12446771   PMID:12618428   PMID:12650640   PMID:12963375   PMID:15489334   PMID:15543142  
PMID:15677482   PMID:17085597   PMID:17255105   PMID:18436566   PMID:18484353   PMID:18779656   PMID:19199708   PMID:19946888   PMID:20458337   PMID:20598904   PMID:21224381   PMID:21423176  
PMID:21618583   PMID:22846993   PMID:22871113   PMID:23622247   PMID:25468996   PMID:26438180   PMID:28684312   PMID:29749466  


Genomics

Comparative Map Data
Ywhab
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,078,904 - 173,101,508 (+)NCBIGRCr8
mRatBN7.23152,659,663 - 152,682,105 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,659,651 - 152,682,105 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,467,118 - 156,489,555 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03164,966,056 - 164,988,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,710,239 - 162,732,648 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,391,108 - 160,399,931 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,391,106 - 160,399,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,577,934 - 166,586,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,926,025 - 154,948,297 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13154,832,060 - 154,854,385 (+)NCBI
Celera3151,308,216 - 151,330,624 (+)NCBICelera
Cytogenetic Map3q42NCBI
YWHAB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382044,885,705 - 44,908,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2044,885,702 - 44,908,532 (+)EnsemblGRCh38hg38GRCh38
GRCh372043,514,346 - 43,537,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362042,947,758 - 42,970,575 (+)NCBINCBI36Build 36hg18NCBI36
Build 342042,947,757 - 42,970,574NCBI
Celera2040,222,982 - 40,245,799 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,256,131 - 40,279,005 (+)NCBIHuRef
CHM1_12043,417,179 - 43,440,099 (+)NCBICHM1_1
T2T-CHM13v2.02046,621,568 - 46,644,395 (+)NCBIT2T-CHM13v2.0
Ywhab
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,837,082 - 163,860,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2163,836,880 - 163,860,508 (+)EnsemblGRCm39 Ensembl
GRCm382163,995,197 - 164,018,588 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2163,994,960 - 164,018,588 (+)EnsemblGRCm38mm10GRCm38
MGSCv372163,820,933 - 163,844,323 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362163,686,638 - 163,710,028 (+)NCBIMGSCv36mm8
Celera2169,925,360 - 169,948,799 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.59NCBI
Ywhab
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,448,760 - 12,474,251 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544512,451,644 - 12,474,251 (-)NCBIChiLan1.0ChiLan1.0
YWHAB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,618,382 - 50,641,330 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,611,587 - 50,634,433 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,216,071 - 41,238,893 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,309,101 - 42,331,705 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,309,155 - 42,331,695 (+)Ensemblpanpan1.1panPan2
YWHAB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,304,808 - 32,325,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,304,812 - 32,323,938 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2431,950,457 - 31,971,435 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,016,092 - 33,036,942 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,016,085 - 33,059,979 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,277,256 - 32,298,231 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,392,197 - 32,412,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02432,933,875 - 32,954,868 (+)NCBIUU_Cfam_GSD_1.0
Ywhab
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,378,451 - 192,399,435 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,830,387 - 7,853,262 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,832,094 - 7,853,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YWHAB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,298,044 - 47,319,285 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,298,020 - 47,317,826 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,794,145 - 52,815,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YWHAB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,904,588 - 18,927,461 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,906,666 - 18,927,374 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605067,571,578 - 67,594,333 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ywhab
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,574,027 - 9,593,825 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247909,574,003 - 9,593,821 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ywhab
56 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:298
Count of miRNA genes:189
Interacting mature miRNAs:222
Transcripts:ENSRNOT00000016981
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat

Markers in Region
RH140223  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23152,679,677 - 152,680,374 (+)MAPPERmRatBN7.2
Rnor_6.03160,397,507 - 160,398,203NCBIRnor6.0
Rnor_5.03166,584,377 - 166,585,073UniSTSRnor5.0
RGSC_v3.43154,946,030 - 154,946,726UniSTSRGSC3.4
Celera3151,328,197 - 151,328,893UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000016981   ⟹   ENSRNOP00000016981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3152,659,651 - 152,682,105 (+)Ensembl
Rnor_6.0 Ensembl3160,391,106 - 160,399,931 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118405   ⟹   ENSRNOP00000097549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3152,674,533 - 152,682,100 (+)Ensembl
RefSeq Acc Id: NM_019377   ⟹   NP_062250
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,079,071 - 173,101,508 (+)NCBI
mRatBN7.23152,659,663 - 152,682,105 (+)NCBI
Rnor_6.03160,391,108 - 160,399,931 (+)NCBI
Rnor_5.03166,577,934 - 166,586,801 (+)NCBI
RGSC_v3.43154,926,025 - 154,948,297 (+)RGD
Celera3151,308,216 - 151,330,624 (+)RGD
Sequence:
RefSeq Acc Id: XM_063284421   ⟹   XP_063140491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,078,904 - 173,101,508 (+)NCBI
RefSeq Acc Id: NP_062250   ⟸   NM_019377
- UniProtKB: P35213 (UniProtKB/Swiss-Prot),   A6JX54 (UniProtKB/TrEMBL),   A0A8I6GMK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016981   ⟸   ENSRNOT00000016981
RefSeq Acc Id: ENSRNOP00000097549   ⟸   ENSRNOT00000118405
RefSeq Acc Id: XP_063140491   ⟸   XM_063284421
- Peptide Label: isoform X1
Protein Domains
14-3-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35213-F1-model_v2 AlphaFold P35213 1-246 view protein structure
AF-Q9CQV8-F1-model_v2 AlphaFold Q9CQV8 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692644
Promoter ID:EPDNEW_R3167
Type:initiation region
Name:Ywhab_1
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationprotein, beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03160,391,078 - 160,391,138EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61998 AgrOrtholog
BioCyc Gene G2FUF-46886 BioCyc
Ensembl Genes ENSRNOG00000010945 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055004006 UniProtKB/Swiss-Prot
  ENSRNOG00060001133 UniProtKB/Swiss-Prot
  ENSRNOG00065025659 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016981 ENTREZGENE
  ENSRNOT00000016981.7 UniProtKB/Swiss-Prot
  ENSRNOT00000118405.1 UniProtKB/TrEMBL
  ENSRNOT00055006388 UniProtKB/Swiss-Prot
  ENSRNOT00060001581 UniProtKB/Swiss-Prot
  ENSRNOT00065044243 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.190.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100393 IMAGE-MGC_LOAD
InterPro 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56011 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91711 IMAGE-MGC_LOAD
NCBI Gene 56011 ENTREZGENE
PANTHER 14-3-3 PROTEIN BETA/ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18860 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ywhab PhenoGen
PIRSF 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS 1433ZETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 1433_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1433_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010945 RatGTEx
  ENSRNOG00055004006 RatGTEx
  ENSRNOG00060001133 RatGTEx
  ENSRNOG00065025659 RatGTEx
SMART 14_3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216826
UniProt 1433B_RAT UniProtKB/Swiss-Prot
  A0A8I6GMK2 ENTREZGENE, UniProtKB/TrEMBL
  A6JX53_RAT UniProtKB/TrEMBL
  A6JX54 ENTREZGENE, UniProtKB/TrEMBL
  A6JX55_RAT UniProtKB/TrEMBL
  P35213 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-11 Ywhab  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta  Ywhab  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ywhab  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide    tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide   Name updated 1299863 APPROVED
2002-06-10 Ywhab  tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide       Name updated 70584 APPROVED
2002-05-14 Ywhab  tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide      spelling corrected 68913 APPROVED
2002-01-14 Ywhab  tryosine 3-monooxgenase/tryptophan 5-momooxgenase activation protein, beta polypeptide      Correction to spelling of name 68926 APPROVED
2001-10-22 Ywhab  tryosine 3-monooxgenase/tryptophan 5-momoozgenase activation protein, gamma      Name updated 68913 WITHDRAWN
2001-10-22 Ywhab  tryosine 3-monooxgenase/tryptophan 5-momoozgenase activation protein, beta polypeptide      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED
2001-07-23 Ywhab  tryosine 3-monooxgenase/tryptophan 5-momoozgenase activation protein, gamma      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Ywhab  3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed throughout the brain and spinal chord by embryonic day 18 727985
gene_protein protein contains 245 aa residues 727985