Ywhab (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta) - Rat Genome Database

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Gene: Ywhab (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta) Rattus norvegicus
Analyze
Symbol: Ywhab
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
RGD ID: 61998
Description: Exhibits protein C-terminus binding activity. Involved in negative regulation of transcription, DNA-templated. Localizes to cytoplasm; nucleus; and transcription repressor complex. Used to study visual epilepsy. Biomarker of brain ischemia. Orthologous to human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 14-3-3 protein beta-subtype; 14-3-3 protein beta/alpha; 14-3-3proteinbeta-subtype; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; 3-monooxygenase/tryptophan5monooxygenaseactivationproteinbetapolypeptide; KCIP-1; prepronerve growth factor RNH-1; protein kinase C inhibitor protein 1; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23152,659,663 - 152,682,105 (+)NCBI
Rnor_6.0 Ensembl3160,391,106 - 160,399,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03160,391,108 - 160,399,931 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03166,577,934 - 166,586,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,926,025 - 154,948,297 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13154,832,060 - 154,854,385 (+)NCBI
Celera3151,308,216 - 151,330,624 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bleomycin A2  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
ketanserin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
melatonin  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
ochratoxin A  (EXP)
paracetamol  (ISO)
PCB138  (EXP)
phencyclidine  (ISO)
phenethyl isothiocyanate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (EXP)

References

References - curated
1. Aoki H, etal., J Virol. 2000 Feb;74(4):1736-41.
2. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Ellis JJ, etal., Mol Cell Biochem 2003 Jan;242(1-2):153-61.
4. GOA data from the GO Consortium
5. Graf M, etal., Hum Reprod. 2011 Jan;26(1):59-66. doi: 10.1093/humrep/deq319. Epub 2010 Nov 26.
6. Komiya Y, etal., J Biol Chem. 2008 Jul 4;283(27):18753-64. Epub 2008 May 5.
7. Koumanov F, etal., J Biol Chem. 2011 May 13;286(19):16574-82. doi: 10.1074/jbc.M111.226092. Epub 2011 Mar 17.
8. MGD data from the GO Consortium
9. NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. O'Kelly I, etal., Cell. 2002 Nov 15;111(4):577-88.
11. Pipeline to import KEGG annotations from KEGG into RGD
12. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. RGD automated import pipeline for gene-chemical interactions
14. Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
15. Shinoda S, etal., J Neurochem. 2003 Jul;86(2):460-9.
16. Siman R, etal., J Cereb Blood Flow Metab. 2005 Nov;25(11):1433-44.
17. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Takai R, etal., J Biochem (Tokyo) 1995 Nov;118(5):1045-53.
19. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Urano-Tashiro Y, etal., J Neurosci Res. 2010 Oct;88(13):2787-97. doi: 10.1002/jnr.22455.
21. Watanabe M, etal., Brain Res Mol Brain Res 1993 Jan;17(1-2):135-46.
22. Watanabe M, etal., Brain Res Mol Brain Res 1994 Aug;25(1-2):113-21.
Additional References at PubMed
PMID:9560161   PMID:9679960   PMID:10407019   PMID:10409742   PMID:10869435   PMID:11984006   PMID:12446771   PMID:12618428   PMID:12650640   PMID:12963375   PMID:15489334   PMID:15543142  
PMID:15677482   PMID:17085597   PMID:17255105   PMID:18436566   PMID:18484353   PMID:18779656   PMID:19199708   PMID:19946888   PMID:20458337   PMID:20598904   PMID:21224381   PMID:21423176  
PMID:21618583   PMID:22846993   PMID:22871113   PMID:23622247   PMID:25468996   PMID:26438180   PMID:28684312   PMID:29749466  


Genomics

Candidate Gene Status
Ywhab is a candidate Gene for QTL Eau4
Comparative Map Data
Ywhab
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23152,659,663 - 152,682,105 (+)NCBI
Rnor_6.0 Ensembl3160,391,106 - 160,399,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03160,391,108 - 160,399,931 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03166,577,934 - 166,586,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,926,025 - 154,948,297 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13154,832,060 - 154,854,385 (+)NCBI
Celera3151,308,216 - 151,330,624 (+)NCBICelera
Cytogenetic Map3q42NCBI
YWHAB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2044,885,702 - 44,908,532 (+)EnsemblGRCh38hg38GRCh38
GRCh382044,885,705 - 44,908,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372043,514,346 - 43,537,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362042,947,758 - 42,970,575 (+)NCBINCBI36hg18NCBI36
Build 342042,947,757 - 42,970,574NCBI
Celera2040,222,982 - 40,245,799 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2040,256,131 - 40,279,005 (+)NCBIHuRef
CHM1_12043,417,179 - 43,440,099 (+)NCBICHM1_1
Ywhab
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,837,117 - 163,860,508 (+)NCBIGRCm39mm39
GRCm39 Ensembl2163,836,880 - 163,860,508 (+)Ensembl
GRCm382163,995,197 - 164,018,588 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2163,994,960 - 164,018,588 (+)EnsemblGRCm38mm10GRCm38
MGSCv372163,820,933 - 163,844,323 (+)NCBIGRCm37mm9NCBIm37
MGSCv362163,686,638 - 163,710,028 (+)NCBImm8
Celera2169,925,360 - 169,948,799 (+)NCBICelera
Cytogenetic Map2H3NCBI
Ywhab
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,448,760 - 12,474,251 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544512,451,644 - 12,474,251 (-)NCBIChiLan1.0ChiLan1.0
YWHAB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12042,309,101 - 42,331,705 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,309,155 - 42,331,695 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02041,216,071 - 41,238,893 (+)NCBIMhudiblu_PPA_v0panPan3
YWHAB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,304,808 - 32,325,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,304,812 - 32,323,938 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2431,950,457 - 31,971,435 (+)NCBI
ROS_Cfam_1.02433,016,092 - 33,036,942 (+)NCBI
UMICH_Zoey_3.12432,277,256 - 32,298,231 (+)NCBI
UNSW_CanFamBas_1.02432,392,197 - 32,412,966 (+)NCBI
UU_Cfam_GSD_1.02432,933,875 - 32,954,868 (+)NCBI
Ywhab
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,378,451 - 192,399,435 (-)NCBI
SpeTri2.0NW_0049365147,832,094 - 7,853,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YWHAB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,298,015 - 47,319,275 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,298,020 - 47,317,826 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,794,145 - 52,815,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YWHAB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,904,588 - 18,927,461 (-)NCBI
ChlSab1.1 Ensembl218,906,666 - 18,927,374 (-)Ensembl
Ywhab
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247909,574,003 - 9,593,821 (-)NCBI

Position Markers
RH140223  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23152,679,677 - 152,680,374 (+)MAPPER
Rnor_6.03160,397,507 - 160,398,203NCBIRnor6.0
Rnor_5.03166,584,377 - 166,585,073UniSTSRnor5.0
RGSC_v3.43154,946,030 - 154,946,726UniSTSRGSC3.4
Celera3151,328,197 - 151,328,893UniSTS
Cytogenetic Map3q42UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3138374177177699992Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3148348517171467264Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3150368003177699992Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3136876155170935007Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3138374177177699992Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3153918022177699992Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3129787213177699992Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)3153412455170534769Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128986468173986468Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3146232777177699992Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3153381237174632112Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3125848628170848628Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3119471263164471263Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3156381661176418101Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3153412455165355668Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3126575595165355668Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3132875075176418101Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3148348739163640325Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3139578365177699992Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3153412455177699992Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3148034701177699992Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3153381237174632112Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3153381237174632112Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3130006659175006659Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3153381237174632112Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3153381237174632112Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3153381237174632112Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3153381237174632112Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:298
Count of miRNA genes:189
Interacting mature miRNAs:222
Transcripts:ENSRNOT00000016981
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016981   ⟹   ENSRNOP00000016981
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3160,391,106 - 160,399,931 (+)Ensembl
RefSeq Acc Id: NM_019377   ⟹   NP_062250
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23152,659,663 - 152,682,105 (+)NCBI
Rnor_6.03160,391,108 - 160,399,931 (+)NCBI
Rnor_5.03166,577,934 - 166,586,801 (+)NCBI
RGSC_v3.43154,926,025 - 154,948,297 (+)RGD
Celera3151,308,216 - 151,330,624 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062250   ⟸   NM_019377
- UniProtKB: P35213 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016981   ⟸   ENSRNOT00000016981

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692644
Promoter ID:EPDNEW_R3167
Type:initiation region
Name:Ywhab_1
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationprotein, beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03160,391,078 - 160,391,138EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61998 AgrOrtholog
Ensembl Genes ENSMUSG00000018326 UniProtKB/Swiss-Prot
  ENSRNOG00000010945 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000018470 UniProtKB/Swiss-Prot
  ENSRNOP00000016981 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000018470 UniProtKB/Swiss-Prot
  ENSRNOT00000016981 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.190.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100393 IMAGE-MGC_LOAD
InterPro 14-3-3 UniProtKB/Swiss-Prot
  14-3-3_CS UniProtKB/Swiss-Prot
  14-3-3_dom_sf UniProtKB/Swiss-Prot
  14-3-3_domain UniProtKB/Swiss-Prot
KEGG Report mmu:54401 UniProtKB/Swiss-Prot
  rno:56011 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91711 IMAGE-MGC_LOAD
NCBI Gene 56011 ENTREZGENE
PANTHER PTHR18860 UniProtKB/Swiss-Prot
Pfam 14-3-3 UniProtKB/Swiss-Prot
PhenoGen Ywhab PhenoGen
PIRSF 14-3-3 UniProtKB/Swiss-Prot
PRINTS 1433ZETA UniProtKB/Swiss-Prot
PROSITE 1433_1 UniProtKB/Swiss-Prot
  1433_2 UniProtKB/Swiss-Prot
SMART 14_3_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48445 UniProtKB/Swiss-Prot
TIGR TC216826
UniProt 1433B_MOUSE UniProtKB/Swiss-Prot
  1433B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O70455 UniProtKB/Swiss-Prot
  Q3TY33 UniProtKB/Swiss-Prot
  Q3UAN6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-11 Ywhab  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta  Ywhab  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ywhab  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide    tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide   Name updated 1299863 APPROVED
2002-06-10 Ywhab  tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide       Name updated 70584 APPROVED
2002-05-14 Ywhab  tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide      spelling corrected 68913 APPROVED
2002-01-14 Ywhab  tryosine 3-monooxgenase/tryptophan 5-momooxgenase activation protein, beta polypeptide      Correction to spelling of name 68926 APPROVED
2001-10-22 Ywhab  tryosine 3-monooxgenase/tryptophan 5-momoozgenase activation protein, beta polypeptide      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED
2001-10-22 Ywhab  tryosine 3-monooxgenase/tryptophan 5-momoozgenase activation protein, gamma      Name updated 68913 WITHDRAWN
2001-07-23 Ywhab  3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide      Name withdrawn 67952 WITHDRAWN
2001-07-23 Ywhab  tryosine 3-monooxgenase/tryptophan 5-momoozgenase activation protein, gamma      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed throughout the brain and spinal chord by embryonic day 18 727985
gene_protein protein contains 245 aa residues 727985