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Gene: Eif4a3 (eukaryotic translation initiation factor 4A3) Rattus norvegicus
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Symbol: Eif4a3
Name: eukaryotic translation initiation factor 4A3
RGD ID: 1591139
Description: Exhibits RNA stem-loop binding activity; ribonucleoprotein complex binding activity; and selenocysteine insertion sequence binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; cellular response to selenite ion; and negative regulation of selenocysteine incorporation. Localizes to several cellular components, including dendrite; neuronal cell body; and postsynaptic cytosol. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3); PARTICIPATES IN spliceosome pathway; mRNA decay pathway; RNA transport pathway; INTERACTS WITH 2,4-dibromophenyl 2,4,5-tribromophenyl ether; bisphenol A; disodium selenite.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD box protein 48; eIF-4A-III; eIF4A-III; eukaryotic initiation factor 4A-III; eukaryotic translation initiation factor 4A, isoform 3; LOC688288; similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 48
Orthologs:
Homo sapiens (human) : EIF4A3 (eukaryotic translation initiation factor 4A3)  HGNC  Alliance
Mus musculus (house mouse) : Eif4a3 (eukaryotic translation initiation factor 4A3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eif4a3 (eukaryotic translation initiation factor 4A3)
Pan paniscus (bonobo/pygmy chimpanzee) : EIF4A3 (eukaryotic translation initiation factor 4A3)
Canis lupus familiaris (dog) : EIF4A3 (eukaryotic translation initiation factor 4A3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Eif4a3 (eukaryotic translation initiation factor 4A3)
Sus scrofa (pig) : EIF4A3 (eukaryotic translation initiation factor 4A3)
Chlorocebus sabaeus (African green monkey) : EIF4A3 (eukaryotic translation initiation factor 4A3)
Heterocephalus glaber (naked mole-rat) : Eif4a3 (eukaryotic translation initiation factor 4A3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.010108,415,201 - 108,425,195 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,415,202 - 108,425,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,027,035 - 108,037,029 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10103,096,825 - 103,106,820 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Eif4a3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1591139
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.