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Gene: Eif4a3 (eukaryotic translation initiation factor 4A3) Rattus norvegicus
Symbol: Eif4a3
Name: eukaryotic translation initiation factor 4A3
RGD ID: 1591139
Description: Exhibits RNA stem-loop binding activity; ribonucleoprotein complex binding activity; and selenocysteine insertion sequence binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; cellular response to selenite ion; and negative regulation of selenocysteine incorporation. Localizes to several cellular components, including dendrite; neuronal cell body; and postsynaptic cytosol. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3); PARTICIPATES IN spliceosome pathway; mRNA decay pathway; RNA transport pathway; INTERACTS WITH 2,4-dibromophenyl 2,4,5-tribromophenyl ether; bisphenol A; disodium selenite.
Type: protein-coding
Also known as: ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD box protein 48; eIF-4A-III; eIF4A-III; eukaryotic initiation factor 4A-III; eukaryotic translation initiation factor 4A, isoform 3; LOC688288; similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 48
Homo sapiens (human) : EIF4A3 (eukaryotic translation initiation factor 4A3)  HGNC  Alliance
Mus musculus (house mouse) : Eif4a3 (eukaryotic translation initiation factor 4A3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eif4a3 (eukaryotic translation initiation factor 4A3)
Pan paniscus (bonobo/pygmy chimpanzee) : EIF4A3 (eukaryotic translation initiation factor 4A3)
Canis lupus familiaris (dog) : EIF4A3 (eukaryotic translation initiation factor 4A3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Eif4a3 (eukaryotic translation initiation factor 4A3)
Sus scrofa (pig) : EIF4A3 (eukaryotic translation initiation factor 4A3)
Chlorocebus sabaeus (African green monkey) : EIF4A3 (eukaryotic translation initiation factor 4A3)
Heterocephalus glaber (naked mole-rat) : Eif4a3 (eukaryotic translation initiation factor 4A3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.010108,415,201 - 108,425,195 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,415,202 - 108,425,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,027,035 - 108,037,029 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10103,096,825 - 103,106,820 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Eif4a3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1591139
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.