Man1b1 (mannosidase, alpha, class 1B, member 1) - Rat Genome Database

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Gene: Man1b1 (mannosidase, alpha, class 1B, member 1) Rattus norvegicus
Analyze
Symbol: Man1b1
Name: mannosidase, alpha, class 1B, member 1
RGD ID: 1563595
Description: Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing; mannose trimming involved in glycoprotein ERAD pathway; and trimming of terminal mannose on B branch. Predicted to be located in cytoplasmic vesicle and endoplasmic reticulum quality control compartment. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in Rafiq syndrome. Orthologous to human MAN1B1 (mannosidase alpha class 1B member 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; N-linked glycan biosynthetic pathway; INTERACTS WITH bisphenol A; C60 fullerene; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; LOC499751; mannosidase alpha class 1B member 1; RGD1563595; similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase); similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,143,877 - 8,165,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,143,381 - 8,165,006 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,248,895 - 11,270,140 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0319,835,125 - 19,856,370 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,024,968 - 18,046,213 (+)NCBIRnor_WKY
Rnor_6.032,547,259 - 2,569,051 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,547,986 - 2,569,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,528,747 - 2,550,463 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,493,476 - 3,514,884 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera32,970,480 - 2,991,187 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10521544   PMID:12090241   PMID:12477932   PMID:15294975   PMID:18003979   PMID:19946888   PMID:21062743   PMID:22160784   PMID:24769233  


Genomics

Comparative Map Data
Man1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,143,877 - 8,165,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,143,381 - 8,165,006 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,248,895 - 11,270,140 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0319,835,125 - 19,856,370 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,024,968 - 18,046,213 (+)NCBIRnor_WKY
Rnor_6.032,547,259 - 2,569,051 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,547,986 - 2,569,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,528,747 - 2,550,463 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,493,476 - 3,514,884 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera32,970,480 - 2,991,187 (+)NCBICelera
Cytogenetic Map3p13NCBI
MAN1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,086,985 - 137,109,183 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9137,086,857 - 137,109,189 (+)EnsemblGRCh38hg38GRCh38
GRCh379139,981,437 - 140,003,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,101,200 - 139,123,460 (+)NCBINCBI36Build 36hg18NCBI36
Build 349137,257,215 - 137,279,476NCBI
Celera9110,494,869 - 110,517,868 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,441,072 - 109,464,974 (+)NCBIHuRef
CHM1_19140,130,181 - 140,152,419 (+)NCBICHM1_1
T2T-CHM13v2.09149,322,873 - 149,347,137 (+)NCBIT2T-CHM13v2.0
Man1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,222,742 - 25,242,225 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,222,350 - 25,242,224 (+)EnsemblGRCm39 Ensembl
GRCm38225,332,730 - 25,352,213 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,332,338 - 25,352,212 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,188,263 - 25,207,733 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,154,765 - 25,174,221 (+)NCBIMGSCv36mm8
Celera225,060,285 - 25,079,751 (+)NCBICelera
Cytogenetic Map2A3NCBI
Man1b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,111,046 - 5,122,442 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,109,651 - 5,122,568 (-)NCBIChiLan1.0ChiLan1.0
MAN1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19137,117,150 - 137,139,066 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,118,361 - 137,139,066 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09108,148,020 - 108,168,931 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC480667
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,533,962 - 48,545,514 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,533,962 - 48,545,344 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,726,966 - 47,738,670 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,401,870 - 49,413,599 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1948,178,182 - 48,189,888 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,476,984 - 48,488,658 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,524,211 - 48,535,917 (+)NCBIUU_Cfam_GSD_1.0
Man1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,507,291 - 202,519,741 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669855,340 - 871,516 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936669855,349 - 867,763 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110258087
(Sus scrofa - pig)
No map positions available.
MAN1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,080,492 - 1,104,981 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,080,305 - 1,105,027 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,199,294 - 4,223,592 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Man1b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760813,045 - 825,153 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760813,657 - 826,020 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Man1b1
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:376
Count of miRNA genes:216
Interacting mature miRNAs:266
Transcripts:ENSRNOT00000016846
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat

Markers in Region
RH130913  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,165,104 - 8,165,307 (+)MAPPERmRatBN7.2
Rnor_6.032,569,149 - 2,569,351NCBIRnor6.0
Rnor_5.032,550,562 - 2,550,764UniSTSRnor5.0
RGSC_v3.433,514,982 - 3,515,184UniSTSRGSC3.4
Celera32,991,286 - 2,991,488UniSTS
Cytogenetic Map3p13UniSTS
RH131536  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,164,634 - 8,164,825 (+)MAPPERmRatBN7.2
Rnor_6.032,568,679 - 2,568,869NCBIRnor6.0
Rnor_5.032,550,092 - 2,550,282UniSTSRnor5.0
RGSC_v3.433,514,512 - 3,514,702UniSTSRGSC3.4
Celera32,990,816 - 2,991,006UniSTS
Cytogenetic Map3p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 39 57 41 19 41 3 4 74 35 41 11 3
Low 4 5 7 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016846   ⟹   ENSRNOP00000016846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,143,897 - 8,165,006 (+)Ensembl
Rnor_6.0 Ensembl32,547,986 - 2,569,049 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102607   ⟹   ENSRNOP00000087091
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,143,904 - 8,165,000 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119867   ⟹   ENSRNOP00000085331
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,143,381 - 8,165,006 (+)Ensembl
RefSeq Acc Id: NM_001109196   ⟹   NP_001102666
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,143,942 - 8,165,006 (+)NCBI
Rnor_6.032,547,986 - 2,569,050 (+)NCBI
Rnor_5.032,528,747 - 2,550,463 (+)NCBI
Celera32,970,480 - 2,991,187 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105657   ⟹   XP_038961585
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,143,877 - 8,163,599 (+)NCBI
RefSeq Acc Id: XM_039105658   ⟹   XP_038961586
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,143,900 - 8,165,007 (+)NCBI
RefSeq Acc Id: XM_039105659   ⟹   XP_038961587
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,145,533 - 8,165,007 (+)NCBI
RefSeq Acc Id: XM_039105660   ⟹   XP_038961588
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,155,313 - 8,163,599 (+)NCBI
RefSeq Acc Id: XR_005501959
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,143,877 - 8,160,983 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001102666   ⟸   NM_001109196
- UniProtKB: B2GUY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016846   ⟸   ENSRNOT00000016846
RefSeq Acc Id: XP_038961585   ⟸   XM_039105657
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961586   ⟸   XM_039105658
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961587   ⟸   XM_039105659
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961588   ⟸   XM_039105660
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000087091   ⟸   ENSRNOT00000102607
RefSeq Acc Id: ENSRNOP00000085331   ⟸   ENSRNOT00000119867

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GUY0-F1-model_v2 AlphaFold B2GUY0 1-657 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691871
Promoter ID:EPDNEW_R2396
Type:multiple initiation site
Name:Man1b1_1
Description:mannosidase, alpha, class 1B, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,547,950 - 2,548,010EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563595 AgrOrtholog
BioCyc Gene G2FUF-50461 BioCyc
BioCyc Pathway PWY-7919 [protein N-glycosylation processing phase (plants and animals)] BioCyc
Ensembl Genes ENSRNOG00000012559 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016846 ENTREZGENE
  ENSRNOP00000016846.6 UniProtKB/TrEMBL
  ENSRNOP00000085331.1 UniProtKB/TrEMBL
  ENSRNOP00000087091.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016846 ENTREZGENE
  ENSRNOT00000016846.6 UniProtKB/TrEMBL
  ENSRNOT00000102607.1 UniProtKB/TrEMBL
  ENSRNOT00000119867.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8370469 IMAGE-MGC_LOAD
InterPro 6hp_glycosidase-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_47 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Seven-hairpin_glycosidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:499751 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187665 IMAGE-MGC_LOAD
NCBI Gene 499751 ENTREZGENE
Pfam Glyco_hydro_47 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Man1b1 PhenoGen
PRINTS GLYHDRLASE47 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A224_RAT UniProtKB/TrEMBL
  A0A8I6A2L3_RAT UniProtKB/TrEMBL
  A0A8L2Q8I6_RAT UniProtKB/TrEMBL
  B2GUY0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Man1b1  mannosidase, alpha, class 1B, member 1  RGD1563595_predicted  similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-10 RGD1563595_predicted  similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (predicted)    similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1563595_predicted  similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477) (predicted)  LOC499751  similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499751  similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477)      Symbol and Name status set to provisional 70820 PROVISIONAL