Symbol:
Ercc6l
Name:
ERCC excision repair 6 like, spindle assembly checkpoint helicase
Description:
Predicted to have DNA translocase activity. Orthologous to human ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type:
protein-coding
RefSeq Status:
INFERRED
Also known as:
DNA excision repair protein ERCC-6-like; excision repair cross-complementation group 6-like; excision repair cross-complementing rodent repair deficiency complementation group 6 - like; excision repair cross-complementing rodent repair deficiency complementation group 6-like; LOC317252; RGD1565734; similar to SNF2/RAD54 family protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Ercc6l (excision repair cross-complementing rodent repair deficiency complementation group 6 like) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ercc6l (ERCC excision repair 6 like, spindle assembly checkpoint helicase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ercc6l (ERCC excision repair 6 like, spindle assembly checkpoint helicase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
RAD54L (RAD54 like) HGNC
Panther
Homo sapiens (human):
ERCC6 (ERCC excision repair 6, chromatin remodeling factor) HGNC
Panther
Homo sapiens (human):
RAD54B (RAD54 homolog B) HGNC
Panther
Homo sapiens (human):
ERCC6L2 (ERCC excision repair 6 like 2) HGNC
Panther
Alliance orthologs 3
Mus musculus (house mouse):
Ercc6l (excision repair cross-complementing rodent repair deficiency complementation group 6 like)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
ercc6l (excision repair cross-complementation group 6-like)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
F53H4.6
Alliance
DIOPT (Ensembl Compara, OrthoFinder)
Caenorhabditis elegans (roundworm):
csb-1
Alliance
DIOPT (Ensembl Compara, OrthoFinder)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 72,018,373 - 72,034,140 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 72,018,373 - 72,034,099 (-) Ensembl Rnor_5.0 X 72,862,788 - 72,878,439 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 90,195,080 - 90,212,006 (-) NCBI RGSC3.4 rn4 RGSC3.4 Celera X 67,599,264 - 67,615,061 (-) NCBI Celera Cytogenetic Map X q22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1-chloro-2,4-dinitrobenzene increases expression ISO RGD:1558137 6480464 Dinitrochlorobenzene results in increased expression of ERCC6L mRNA CTD PMID:18242016 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of ERCC6L mRNA CTD PMID:30723492 17beta-estradiol increases expression ISO RGD:1606557 6480464 Estradiol results in increased expression of ERCC6L mRNA CTD PMID:19167446 , PMID:20106945 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1558137 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:1558137 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1606557 6480464 Tetrachlorodibenzodioxin results in decreased expression of ERCC6L mRNA CTD PMID:21802500 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ERCC6L mRNA CTD PMID:22298810 3-methylcholanthrene increases expression ISO RGD:1558137 6480464 Methylcholanthrene results in increased expression of ERCC6L mRNA CTD PMID:20713471 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:1558137 6480464 Oxazolone results in increased expression of ERCC6L mRNA CTD PMID:18242016 4-hydroxynon-2-enal decreases expression ISO RGD:1558137 6480464 4-hydroxy-2-nonenal results in decreased expression of ERCC6L mRNA CTD PMID:19191707 aflatoxin B1 affects expression ISO RGD:1606557 6480464 Aflatoxin B1 affects the expression of ERCC6L protein CTD PMID:20106945 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of ERCC6L mRNA CTD PMID:23630614 aflatoxin B1 increases expression ISO RGD:1606557 6480464 Aflatoxin B1 results in increased expression of ERCC6L mRNA CTD PMID:22100608 aflatoxin B1 decreases expression ISO RGD:1558137 6480464 Aflatoxin B1 results in decreased expression of ERCC6L mRNA CTD PMID:19770486 atrazine decreases expression ISO RGD:1606557 6480464 Atrazine results in decreased expression of ERCC6L mRNA CTD PMID:22378314 benzo[a]pyrene decreases expression ISO RGD:1606557 6480464 Benzo(a)pyrene results in decreased expression of ERCC6L mRNA CTD PMID:21802500 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1606557 6480464 7 more ... CTD PMID:20382639 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ERCC6L mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1606557 6480464 bisphenol A results in decreased expression of ERCC6L mRNA CTD PMID:29275510 calcitriol multiple interactions ISO RGD:1606557 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of ERCC6L mRNA CTD PMID:21592394 calcitriol decreases expression ISO RGD:1606557 6480464 Calcitriol results in decreased expression of ERCC6L mRNA CTD PMID:21592394 carbamazepine affects expression ISO RGD:1606557 6480464 Carbamazepine affects the expression of ERCC6L mRNA CTD PMID:25979313 carbon nanotube increases expression ISO RGD:1558137 6480464 Nanotubes, Carbon analog results in increased expression of ERCC6L mRNA, Nanotubes, Carbon results in increased expression of ERCC6L mRNA CTD PMID:25554681 choline multiple interactions ISO RGD:1558137 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ERCC6L mRNA CTD PMID:20938992 chromium(6+) affects expression ISO RGD:1558137 6480464 chromium hexavalent ion affects the expression of ERCC6L mRNA CTD PMID:28472532 copper(II) sulfate decreases expression ISO RGD:1606557 6480464 Copper Sulfate results in decreased expression of ERCC6L mRNA CTD PMID:19549813 coumestrol increases expression ISO RGD:1606557 6480464 Coumestrol results in increased expression of ERCC6L mRNA CTD PMID:19167446 coumestrol multiple interactions ISO RGD:1606557 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 cyclosporin A decreases expression ISO RGD:1606557 6480464 Cyclosporine results in decreased expression of ERCC6L mRNA CTD PMID:19159671 , PMID:25562108 diethyl maleate increases expression EXP 6480464 diethyl maleate results in increased expression of ERCC6L mRNA CTD PMID:21161181 dioxygen decreases expression ISO RGD:1606557 6480464 Oxygen deficiency results in decreased expression of ERCC6L mRNA CTD PMID:17175027 , PMID:26516004 Enterolactone multiple interactions ISO RGD:1606557 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ERCC6L mRNA CTD PMID:19167446 enzyme inhibitor multiple interactions ISO RGD:1606557 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ERCC6L protein CTD PMID:23301498 folic acid multiple interactions ISO RGD:1558137 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ERCC6L mRNA CTD PMID:20938992 folic acid multiple interactions ISO RGD:1606557 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of ERCC6L mRNA CTD PMID:24657277 L-methionine multiple interactions ISO RGD:1558137 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ERCC6L mRNA CTD PMID:20938992 leflunomide decreases expression ISO RGD:1606557 6480464 leflunomide results in decreased expression of ERCC6L mRNA CTD PMID:28988120 lucanthone decreases expression ISO RGD:1606557 6480464 Lucanthone results in decreased expression of ERCC6L mRNA CTD PMID:21148553 manganese atom decreases expression ISO RGD:1606557 6480464 Manganese results in decreased expression of ERCC6L mRNA CTD PMID:17175027 manganese(0) decreases expression ISO RGD:1606557 6480464 Manganese results in decreased expression of ERCC6L mRNA CTD PMID:17175027 manganese(II) chloride decreases expression ISO RGD:1606557 6480464 manganese chloride results in decreased expression of ERCC6L mRNA CTD PMID:17175027 MeIQx increases expression ISO RGD:1606557 6480464 2-amino-3 more ... CTD PMID:20816883 methotrexate multiple interactions ISO RGD:1606557 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of ERCC6L mRNA CTD PMID:24657277 methotrexate decreases expression ISO RGD:1606557 6480464 Methotrexate results in decreased expression of ERCC6L mRNA CTD PMID:24657277 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of ERCC6L mRNA CTD PMID:19041683 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of ERCC6L mRNA CTD PMID:25729387 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of ERCC6L mRNA CTD PMID:25729387 paracetamol increases expression ISO RGD:1606557 6480464 Acetaminophen results in increased expression of ERCC6L mRNA CTD PMID:22230336 phenethyl isothiocyanate decreases expression ISO RGD:1606557 6480464 phenethyl isothiocyanate results in decreased expression of ERCC6L mRNA CTD PMID:26678675 phenobarbital affects expression ISO RGD:1558137 6480464 Phenobarbital affects the expression of ERCC6L mRNA CTD PMID:23091169 pirinixic acid multiple interactions ISO RGD:1558137 6480464 [pirinixic acid co-treated with PPARA] results in increased expression of ERCC6L mRNA CTD PMID:20813756 pirinixic acid increases expression ISO RGD:1558137 6480464 pirinixic acid results in increased expression of ERCC6L mRNA CTD PMID:20813756 quercetin decreases expression ISO RGD:1606557 6480464 Quercetin results in decreased expression of ERCC6L mRNA CTD PMID:21632981 resveratrol multiple interactions ISO RGD:1606557 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of ERCC6L mRNA CTD PMID:19167446 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of ERCC6L mRNA CTD PMID:28374803 silicon dioxide increases expression ISO RGD:1606557 6480464 Silicon Dioxide analog results in increased expression of ERCC6L mRNA CTD PMID:25895662 silicon dioxide decreases expression ISO RGD:1606557 6480464 Silicon Dioxide analog results in decreased expression of ERCC6L mRNA CTD PMID:23806026 sodium arsenite decreases expression ISO RGD:1558137 6480464 sodium arsenite results in decreased expression of ERCC6L mRNA CTD PMID:17998272 sodium arsenite increases expression ISO RGD:1606557 6480464 sodium arsenite results in increased expression of ERCC6L mRNA CTD PMID:29301061 sodium arsenite affects methylation ISO RGD:1606557 6480464 sodium arsenite affects the methylation of ERCC6L gene CTD PMID:28589171 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of ERCC6L mRNA CTD PMID:22110744 sunitinib decreases expression ISO RGD:1606557 6480464 Sunitinib results in decreased expression of ERCC6L mRNA CTD PMID:31533062 testosterone multiple interactions ISO RGD:1606557 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of ERCC6L mRNA CTD PMID:21592394 testosterone decreases expression ISO RGD:1606557 6480464 Testosterone results in decreased expression of ERCC6L mRNA CTD PMID:21592394 tetrachloromethane increases expression ISO RGD:1558137 6480464 Carbon Tetrachloride results in increased expression of ERCC6L mRNA CTD PMID:17484886 thapsigargin decreases expression ISO RGD:1606557 6480464 Thapsigargin results in decreased expression of ERCC6L mRNA CTD PMID:22378314 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of ERCC6L mRNA CTD PMID:23411599 toluene 2,4-diisocyanate increases expression ISO RGD:1558137 6480464 Toluene 2, 4-Diisocyanate results in increased expression of ERCC6L mRNA CTD PMID:18242016 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of ERCC6L mRNA CTD PMID:25729387 triclosan decreases expression ISO RGD:1606557 6480464 Triclosan results in decreased expression of ERCC6L mRNA CTD PMID:30510588 trimellitic anhydride increases expression ISO RGD:1558137 6480464 trimellitic anhydride results in increased expression of ERCC6L mRNA CTD PMID:19042947 tunicamycin decreases expression ISO RGD:1606557 6480464 Tunicamycin results in decreased expression of ERCC6L mRNA CTD PMID:22378314 
Gene-Chemical Interaction Annotations
