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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Spsb3 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Spsb3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SPSB3 mRNA | CTD | PMID:22206623 | Spsb3 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Spsb3 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of SPSB3 mRNA | CTD | PMID:17555576 | Spsb3 | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Spsb3 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of SPSB3 mRNA | CTD | PMID:17942748 | Spsb3 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Spsb3 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPSB3 mRNA | CTD | PMID:17942748 | Spsb3 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of SPSB3 mRNA | CTD | PMID:32145629 | Spsb3 | Rat | 17beta-estradiol | decreases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of SPSB3 mRNA | CTD | PMID:31614463 | Spsb3 | Rat | 17beta-estradiol | increases expression | ISO | Spsb3 (Mus musculus) | 6480464 | Estradiol results in increased expression of SPSB3 mRNA | CTD | PMID:39298647 | Spsb3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Spsb3 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPSB3 mRNA | CTD | PMID:17942748 | Spsb3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Spsb3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SPSB3 mRNA | CTD | PMID:21570461 | Spsb3 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of SPSB3 mRNA | CTD | PMID:21346803 | Spsb3 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of SPSB3 mRNA | CTD | PMID:21346803 | Spsb3 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Spsb3 (Mus musculus) | 6480464 | bisphenol S results in increased expression of SPSB3 mRNA | CTD | PMID:39298647 | Spsb3 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Spsb3 (Mus musculus) | 6480464 | bisphenol S affects the methylation of SPSB3 gene | CTD | PMID:31683443 | Spsb3 | Rat | acrolein | multiple interactions | ISO | SPSB3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SPSB3 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SPSB3 mRNA | CTD | PMID:32699268 | Spsb3 | Rat | alpha-pinene | multiple interactions | ISO | SPSB3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SPSB3 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SPSB3 mRNA | CTD | PMID:32699268 | Spsb3 | Rat | aristolochic acid A | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of SPSB3 mRNA | CTD | PMID:33212167 | Spsb3 | Rat | arsane | affects methylation | ISO | SPSB3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of SPSB3 gene | CTD | PMID:25304211 | Spsb3 | Rat | arsenic atom | affects methylation | ISO | SPSB3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of SPSB3 gene | CTD | PMID:25304211 | Spsb3 | Rat | beta-lapachone | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of SPSB3 mRNA | CTD | PMID:38218311 | Spsb3 | Rat | bis(2-ethylhexyl) phthalate | increases methylation | ISO | Spsb3 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased methylation of SPSB3 gene | CTD | PMID:34319233 | Spsb3 | Rat | bisphenol A | decreases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SPSB3 mRNA | CTD | PMID:19371625 | Spsb3 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SPSB3 mRNA | CTD | PMID:32145629 | Spsb3 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of SPSB3 gene | CTD | PMID:28505145 | Spsb3 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SPSB3 mRNA | CTD | PMID:25181051 more ... | Spsb3 | Rat | bisphenol A | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of SPSB3 mRNA | CTD | PMID:25047013 | Spsb3 | Rat | bortezomib | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Bortezomib results in increased expression of SPSB3 mRNA | CTD | PMID:20977926 | Spsb3 | Rat | cisplatin | multiple interactions | ISO | SPSB3 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of SPSB3 mRNA | CTD | PMID:27392435 | Spsb3 | Rat | cobalt dichloride | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of SPSB3 mRNA | CTD | PMID:19376846 | Spsb3 | Rat | diuron | decreases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Diuron results in decreased expression of SPSB3 mRNA | CTD | PMID:35967413 | Spsb3 | Rat | elemental selenium | multiple interactions | ISO | SPSB3 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of SPSB3 mRNA | CTD | PMID:19244175 | Spsb3 | Rat | elemental selenium | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Selenium results in increased expression of SPSB3 mRNA | CTD | PMID:19244175 | Spsb3 | Rat | ethyl methanesulfonate | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of SPSB3 mRNA | CTD | PMID:23649840 | Spsb3 | Rat | folic acid | decreases expression | ISO | Spsb3 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of SPSB3 mRNA | CTD | PMID:25629700 | Spsb3 | Rat | formaldehyde | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of SPSB3 mRNA | CTD | PMID:23649840 | Spsb3 | Rat | genistein | decreases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Genistein results in decreased expression of SPSB3 mRNA | CTD | PMID:19371625 | Spsb3 | Rat | hydrogen peroxide | affects expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of SPSB3 mRNA | CTD | PMID:20044591 | Spsb3 | Rat | Licochalcone B | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | licochalcone B results in increased expression of SPSB3 mRNA | CTD | PMID:33647349 | Spsb3 | Rat | methyl methanesulfonate | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of SPSB3 mRNA | CTD | PMID:23649840 | Spsb3 | Rat | ozone | multiple interactions | ISO | SPSB3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SPSB3 mRNA more ... | CTD | PMID:32699268 | Spsb3 | Rat | paracetamol | affects expression | ISO | Spsb3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SPSB3 mRNA | CTD | PMID:17562736 | Spsb3 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SPSB3 mRNA | CTD | PMID:33387578 | Spsb3 | Rat | perfluorohexanesulfonic acid | decreases expression | ISO | Spsb3 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of SPSB3 mRNA | CTD | PMID:37995155 | Spsb3 | Rat | phenethyl isothiocyanate | increases expression | EXP | | 6480464 | phenethyl isothiocyanate results in increased expression of SPSB3 mRNA | CTD | PMID:17616710 | Spsb3 | Rat | resveratrol | decreases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | resveratrol results in decreased expression of SPSB3 mRNA | CTD | PMID:19371625 | Spsb3 | Rat | selenium atom | multiple interactions | ISO | SPSB3 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of SPSB3 mRNA | CTD | PMID:19244175 | Spsb3 | Rat | selenium atom | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Selenium results in increased expression of SPSB3 mRNA | CTD | PMID:19244175 | Spsb3 | Rat | silicon dioxide | decreases methylation | ISO | SPSB3 (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased methylation of SPSB3 gene | CTD | PMID:34973136 | Spsb3 | Rat | tamoxifen | affects expression | ISO | Spsb3 (Mus musculus) | 6480464 | Tamoxifen affects the expression of SPSB3 mRNA | CTD | PMID:17555576 | Spsb3 | Rat | temozolomide | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of SPSB3 mRNA | CTD | PMID:31758290 | Spsb3 | Rat | trichostatin A | affects expression | ISO | SPSB3 (Homo sapiens) | 6480464 | trichostatin A affects the expression of SPSB3 mRNA | CTD | PMID:28542535 | Spsb3 | Rat | triphenyl phosphate | affects expression | ISO | SPSB3 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SPSB3 mRNA | CTD | PMID:37042841 | Spsb3 | Rat | triptonide | increases expression | ISO | Spsb3 (Mus musculus) | 6480464 | triptonide results in increased expression of SPSB3 mRNA | CTD | PMID:33045310 | Spsb3 | Rat | tunicamycin | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of SPSB3 mRNA | CTD | PMID:22378314 and PMID:29453283 | Spsb3 | Rat | urethane | increases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Urethane results in increased expression of SPSB3 mRNA | CTD | PMID:28818685 | Spsb3 | Rat | valproic acid | increases methylation | ISO | SPSB3 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SPSB3 gene | CTD | PMID:29154799 | Spsb3 | Rat | valproic acid | affects expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SPSB3 mRNA | CTD | PMID:25979313 | Spsb3 | Rat | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of SPSB3 mRNA | CTD | PMID:23034163 | Spsb3 | Rat | vitamin E | multiple interactions | ISO | SPSB3 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of SPSB3 mRNA | CTD | PMID:19244175 | Spsb3 | Rat | zearalenone | decreases expression | ISO | SPSB3 (Homo sapiens) | 6480464 | Zearalenone results in decreased expression of SPSB3 mRNA | CTD | PMID:19371625 | |