Dkk3 (dickkopf WNT signaling pathway inhibitor 3) - Rat Genome Database

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Gene: Dkk3 (dickkopf WNT signaling pathway inhibitor 3) Rattus norvegicus
Analyze
Symbol: Dkk3
Name: dickkopf WNT signaling pathway inhibitor 3
RGD ID: 621846
Description: Predicted to enable co-receptor binding activity and receptor antagonist activity. Predicted to be involved in adrenal gland development; negative regulation of canonical Wnt signaling pathway; and negative regulation of cellular biosynthetic process. Predicted to be active in extracellular space. Orthologous to human DKK3 (dickkopf WNT signaling pathway inhibitor 3); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dickkopf 3 homolog; dickkopf 3 homolog (Xenopus laevis); dickkopf homolog 3; dickkopf homolog 3 (Xenopus laevis); dickkopf-related protein 3; p29; Reic
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21166,237,969 - 166,281,271 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1166,238,238 - 166,280,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1174,573,298 - 174,615,607 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01181,759,295 - 181,801,602 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01174,459,245 - 174,501,581 (-)NCBIRnor_WKY
Rnor_6.01176,940,424 - 176,983,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1176,940,693 - 176,983,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01183,919,812 - 183,962,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,924,617 - 169,964,692 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,043,564 - 170,084,626 (-)NCBI
Celera1164,115,480 - 164,157,817 (-)NCBICelera
Cytogenetic Map1q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dioxygen  (EXP)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalenes  (EXP)
nickel atom  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP)
pentanal  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sporidesmin A  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trametinib  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. Caricasole A, etal., J Biol Chem 2003 Sep 26;278(39):37024-31.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Cloning, expression, and functional characterization of the substrate binding subunit of rat type II iodothyronine 5'-deiodinase. Leonard DM, etal., J Biol Chem 2000 Aug 18;275(33):25194-201.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Divergent expression of type 2 deiodinase and the putative thyroxine-binding protein p29, in rat brain, suggests that they are functionally unrelated proteins. Montero-Pedrazuela A, etal., Endocrinology 2003 Mar;144(3):1045-52.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12844346   PMID:16981135   PMID:24006456   PMID:28259940   PMID:35658977  


Genomics

Comparative Map Data
Dkk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21166,237,969 - 166,281,271 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1166,238,238 - 166,280,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1174,573,298 - 174,615,607 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01181,759,295 - 181,801,602 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01174,459,245 - 174,501,581 (-)NCBIRnor_WKY
Rnor_6.01176,940,424 - 176,983,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1176,940,693 - 176,983,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01183,919,812 - 183,962,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,924,617 - 169,964,692 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,043,564 - 170,084,626 (-)NCBI
Celera1164,115,480 - 164,157,817 (-)NCBICelera
Cytogenetic Map1q33NCBI
DKK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,963,036 - 12,009,745 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1111,956,207 - 12,009,769 (-)EnsemblGRCh38hg38GRCh38
GRCh371111,984,583 - 12,030,883 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,941,119 - 11,987,493 (-)NCBINCBI36Build 36hg18NCBI36
Build 341111,941,228 - 11,987,205NCBI
Celera1112,109,802 - 12,156,171 (-)NCBICelera
Cytogenetic Map11p15.3NCBI
HuRef1111,660,573 - 11,706,919 (-)NCBIHuRef
CHM1_11111,983,471 - 12,029,827 (-)NCBICHM1_1
T2T-CHM13v2.01112,054,919 - 12,101,206 (-)NCBIT2T-CHM13v2.0
Dkk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397111,715,226 - 111,758,689 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7111,715,224 - 111,758,264 (-)EnsemblGRCm39 Ensembl
GRCm387112,116,019 - 112,159,482 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7112,116,017 - 112,159,057 (-)EnsemblGRCm38mm10GRCm38
MGSCv377119,259,533 - 119,302,571 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367111,907,200 - 111,950,238 (-)NCBIMGSCv36mm8
Celera7112,091,357 - 112,134,444 (-)NCBICelera
Cytogenetic Map7F1NCBI
Dkk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541427,456,770 - 27,508,109 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541427,466,636 - 27,507,186 (-)NCBIChiLan1.0ChiLan1.0
DKK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11111,824,955 - 11,871,139 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1111,824,955 - 11,871,139 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01112,131,306 - 12,177,906 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DKK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12135,032,501 - 35,074,664 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2135,033,552 - 35,074,664 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2134,597,515 - 34,637,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02135,909,311 - 35,949,713 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2135,899,250 - 35,950,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12135,170,822 - 35,211,124 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02135,348,672 - 35,389,042 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02135,635,088 - 35,675,523 (-)NCBIUU_Cfam_GSD_1.0
Dkk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494750,394,918 - 50,443,027 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365286,429,973 - 6,477,218 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365286,428,824 - 6,477,007 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl247,385,192 - 47,444,660 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1247,385,244 - 47,444,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2250,699,247 - 50,758,562 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DKK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1152,823,415 - 52,868,804 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl152,824,176 - 52,868,885 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038150,424,876 - 150,470,271 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dkk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247664,041,816 - 4,085,209 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247664,042,307 - 4,085,613 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dkk3
166 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:211
Count of miRNA genes:138
Interacting mature miRNAs:174
Transcripts:ENSRNOT00000022301
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383635Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat

Markers in Region
RH129863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21166,239,984 - 166,240,195 (+)MAPPERmRatBN7.2
Rnor_6.01176,942,440 - 176,942,650NCBIRnor6.0
Rnor_5.01183,921,833 - 183,922,043UniSTSRnor5.0
RGSC_v3.41169,924,730 - 169,924,940UniSTSRGSC3.4
Celera1164,117,227 - 164,117,437UniSTS
RH 3.4 Map11319.1UniSTS
Cytogenetic Map1q33UniSTS
RH137466  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21166,239,093 - 166,239,278 (+)MAPPERmRatBN7.2
Rnor_6.01176,941,549 - 176,941,733NCBIRnor6.0
Rnor_5.01183,920,942 - 183,921,126UniSTSRnor5.0
RGSC_v3.41169,923,839 - 169,924,023UniSTSRGSC3.4
Celera1164,116,336 - 164,116,520UniSTS
Cytogenetic Map1q33UniSTS
RH140377  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21166,241,102 - 166,241,298 (+)MAPPERmRatBN7.2
Rnor_6.01176,943,558 - 176,943,753NCBIRnor6.0
Rnor_5.01183,922,951 - 183,923,146UniSTSRnor5.0
RGSC_v3.41169,925,848 - 169,926,043UniSTSRGSC3.4
Celera1164,118,345 - 164,118,540UniSTS
RH 3.4 Map11319.1UniSTS
Cytogenetic Map1q33UniSTS
BF404521  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21166,281,059 - 166,281,271 (+)MAPPERmRatBN7.2
Rnor_6.01176,983,515 - 176,983,726NCBIRnor6.0
Rnor_5.01183,962,908 - 183,963,119UniSTSRnor5.0
RGSC_v3.41169,965,805 - 169,966,016UniSTSRGSC3.4
Celera1164,158,287 - 164,158,498UniSTS
RH 3.4 Map11324.3UniSTS
Cytogenetic Map1q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 2 66 22 29 11
Low 53 39 19 39 8 11 8 13 12 8
Below cutoff 2 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022301   ⟹   ENSRNOP00000022301
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1166,238,238 - 166,280,590 (-)Ensembl
Rnor_6.0 Ensembl1176,940,693 - 176,983,045 (-)Ensembl
RefSeq Acc Id: NM_138519   ⟹   NP_612528
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21166,238,238 - 166,280,590 (-)NCBI
Rnor_6.01176,940,693 - 176,983,045 (-)NCBI
Rnor_5.01183,919,812 - 183,962,473 (-)NCBI
RGSC_v3.41169,924,617 - 169,964,692 (-)RGD
Celera1164,115,480 - 164,157,817 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230009   ⟹   XP_006230071
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21166,237,969 - 166,281,271 (-)NCBI
Rnor_6.01176,940,424 - 176,983,076 (-)NCBI
Rnor_5.01183,919,812 - 183,962,473 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588739   ⟹   XP_017444228
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21166,237,969 - 166,281,271 (-)NCBI
Rnor_6.01176,940,424 - 176,983,076 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091150   ⟹   XP_038947078
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21166,237,969 - 166,281,271 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_612528   ⟸   NM_138519
- Peptide Label: precursor
- UniProtKB: B1H219 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230071   ⟸   XM_006230009
- Peptide Label: isoform X1
- UniProtKB: B1H219 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444228   ⟸   XM_017588739
- Peptide Label: isoform X1
- UniProtKB: B1H219 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022301   ⟸   ENSRNOT00000022301
RefSeq Acc Id: XP_038947078   ⟸   XM_039091150
- Peptide Label: isoform X2
Protein Domains
Dickkopf N-terminal cysteine-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1H219-F1-model_v2 AlphaFold B1H219 1-348 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621846 AgrOrtholog
BioCyc Gene G2FUF-57794 BioCyc
Ensembl Genes ENSRNOG00000016343 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022301 ENTREZGENE
  ENSRNOP00000022301.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022301 ENTREZGENE
  ENSRNOT00000022301.7 UniProtKB/TrEMBL
Gene3D-CATH Lipase, subunit A UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7189201 IMAGE-MGC_LOAD
  IMAGE:7321198 IMAGE-MGC_LOAD
InterPro Dickkopf_N UniProtKB/TrEMBL
  DKK-like UniProtKB/TrEMBL
KEGG Report rno:171548 UniProtKB/TrEMBL
MGC_CLONE MGC:187335 IMAGE-MGC_LOAD
  MGC:93187 IMAGE-MGC_LOAD
NCBI Gene 171548 ENTREZGENE
PANTHER DICKKOPF-RELATED PROTEIN 3 UniProtKB/TrEMBL
  PTHR12113 UniProtKB/TrEMBL
Pfam Dickkopf_N UniProtKB/TrEMBL
PhenoGen Dkk3 PhenoGen
UniProt B1H219 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-22 Dkk3  dickkopf WNT signaling pathway inhibitor 3  Dkk3  dickkopf 3 homolog (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-12-06 Dkk3  dickkopf 3 homolog (Xenopus laevis)  Dkk3  dickkopf homolog 3 (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Dkk3  dickkopf homolog 3 (Xenopus laevis)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dkk3  dickkopf homolog 3 (Xenopus laevis)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference