Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of KCNG1 mRNA and [Progesterone co-treated with Estradiol] results in increased expression of KCNG1 mRNA | CTD | PMID:17404688 and PMID:20660070 | 17beta-estradiol | decreases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of KCNG1 protein | CTD | PMID:18191855 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KCNG1 mRNA | CTD | PMID:21802500 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KCNG1 mRNA | CTD | PMID:32109520 | 2-palmitoylglycerol | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of KCNG1 mRNA | CTD | PMID:37199045 | 3,4-methylenedioxymethamphetamine | affects expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine affects the expression of KCNG1 mRNA | CTD | PMID:30071829 | 4,4'-sulfonyldiphenol | decreases expression | ISO | Kcng1 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of KCNG1 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Kcng1 (Mus musculus) | 6480464 | bisphenol S affects the methylation of KCNG1 exon and bisphenol S affects the methylation of KCNG1 gene | CTD | PMID:31683443 and PMID:33297965 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of KCNG1 mRNA | CTD | PMID:24780913 | acrylamide | decreases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of KCNG1 mRNA | CTD | PMID:32763439 | aldehydo-D-glucose | multiple interactions | ISO | Kcng1 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of KCNG1 mRNA | CTD | PMID:37567420 | all-trans-retinoic acid | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of KCNG1 mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | decreases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of KCNG1 mRNA | CTD | PMID:23724009 | arsenous acid | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of KCNG1 mRNA | CTD | PMID:20458559 | benzo[a]pyrene | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of KCNG1 mRNA | CTD | PMID:21802500 | benzo[a]pyrene | affects methylation | ISO | KCNG1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KCNG1 3' UTR and Benzo(a)pyrene affects the methylation of KCNG1 intron | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | KCNG1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of KCNG1 5' UTR and Benzo(a)pyrene results in increased methylation of KCNG1 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | benzo[b]fluoranthene | increases expression | ISO | Kcng1 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of KCNG1 mRNA | CTD | PMID:26377693 | benzo[e]pyrene | increases methylation | ISO | KCNG1 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of KCNG1 intron | CTD | PMID:30157460 | bis(2-ethylhexyl) phthalate | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of KCNG1 mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of KCNG1 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of KCNG1 mRNA | CTD | PMID:34947998 | bisphenol A | decreases expression | ISO | Kcng1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of KCNG1 mRNA | CTD | PMID:30951980 | butanal | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of KCNG1 mRNA | CTD | PMID:26079696 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of KCNG1 promoter | CTD | PMID:22457795 | carbon nanotube | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Nanotubes and Carbon results in increased expression of KCNG1 mRNA | CTD | PMID:24389112 | carbon nanotube | increases expression | ISO | Kcng1 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of KCNG1 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to KCNG1 gene] | CTD | PMID:28238834 | choline | multiple interactions | ISO | Kcng1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNG1 gene | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of KCNG1 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of KCNG1 mRNA | CTD | PMID:27392435 | copper atom | multiple interactions | EXP | | 6480464 | [Copper co-treated with Dietary Sucrose] results in increased expression of KCNG1 mRNA | CTD | PMID:26033743 | copper atom | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in increased expression of KCNG1 mRNA | CTD | PMID:24690739 | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of KCNG1 mRNA | CTD | PMID:26033743 | copper(0) | multiple interactions | EXP | | 6480464 | [Copper co-treated with Dietary Sucrose] results in increased expression of KCNG1 mRNA | CTD | PMID:26033743 | copper(0) | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in increased expression of KCNG1 mRNA | CTD | PMID:24690739 | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of KCNG1 mRNA | CTD | PMID:26033743 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of KCNG1 mRNA | CTD | PMID:26577399 | D-glucose | multiple interactions | ISO | Kcng1 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of KCNG1 mRNA | CTD | PMID:37567420 | dexamethasone | decreases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Dexamethasone results in decreased expression of KCNG1 mRNA | CTD | PMID:25047013 | diarsenic trioxide | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of KCNG1 mRNA | CTD | PMID:20458559 | dimethylarsinic acid | multiple interactions | ISO | Kcng1 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of KCNG1 mRNA | CTD | PMID:34876320 | diquat | decreases expression | ISO | Kcng1 (Mus musculus) | 6480464 | Diquat results in decreased expression of KCNG1 mRNA | CTD | PMID:36851058 | disulfiram | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in increased expression of KCNG1 mRNA | CTD | PMID:24690739 | dorsomorphin | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of KCNG1 mRNA | CTD | PMID:31078653 | ethanol | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Ethanol results in increased expression of KCNG1 mRNA | CTD | PMID:31059573 | ethanol | affects splicing | ISO | Kcng1 (Mus musculus) | 6480464 | Ethanol affects the splicing of KCNG1 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | Kcng1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNG1 gene | CTD | PMID:20938992 | formaldehyde | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of KCNG1 mRNA | CTD | PMID:27664576 | fructose | multiple interactions | ISO | Kcng1 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of KCNG1 mRNA | CTD | PMID:37567420 | glucose | multiple interactions | ISO | Kcng1 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of KCNG1 mRNA | CTD | PMID:37567420 | ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of KCNG1 mRNA | CTD | PMID:20080153 | L-methionine | multiple interactions | ISO | Kcng1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNG1 gene | CTD | PMID:20938992 | lamivudine | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [Zidovudine co-treated with Lamivudine] results in increased expression of KCNG1 mRNA | CTD | PMID:15784690 | manganese(II) chloride | increases expression | EXP | | 6480464 | manganese chloride results in increased expression of KCNG1 mRNA | CTD | PMID:28801915 | methapyrilene | increases methylation | ISO | KCNG1 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of KCNG1 intron | CTD | PMID:30157460 | methylarsonic acid | multiple interactions | ISO | Kcng1 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of KCNG1 mRNA | CTD | PMID:34876320 | methylmercury chloride | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of KCNG1 mRNA | CTD | PMID:28001369 | Muraglitazar | decreases expression | EXP | | 6480464 | muraglitazar results in decreased expression of KCNG1 mRNA | CTD | PMID:21515302 | nickel sulfate | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of KCNG1 mRNA | CTD | PMID:22714537 | panobinostat | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | panobinostat results in increased expression of KCNG1 mRNA | CTD | PMID:26272509 | panobinostat | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNG1 mRNA | CTD | PMID:27188386 | pentanal | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | pentanal results in increased expression of KCNG1 mRNA | CTD | PMID:26079696 | progesterone | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of KCNG1 mRNA and [Progesterone co-treated with Estradiol] results in increased expression of KCNG1 mRNA | CTD | PMID:17404688 and PMID:20660070 | progesterone | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Progesterone results in increased expression of KCNG1 mRNA | CTD | PMID:17404688 and PMID:21795739 | SB 431542 | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of KCNG1 mRNA | CTD | PMID:23806026 | sodium arsenate | multiple interactions | ISO | Kcng1 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of KCNG1 mRNA | CTD | PMID:34876320 | sodium arsenite | decreases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of KCNG1 mRNA | CTD | PMID:34032870 | sodium arsenite | multiple interactions | ISO | Kcng1 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of KCNG1 mRNA | CTD | PMID:34876320 | sunitinib | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of KCNG1 mRNA | CTD | PMID:31533062 | trichostatin A | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of KCNG1 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNG1 mRNA | CTD | PMID:27188386 | triptonide | increases expression | ISO | Kcng1 (Mus musculus) | 6480464 | triptonide results in increased expression of KCNG1 mRNA | CTD | PMID:33045310 | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of KCNG1 mRNA | CTD | PMID:21515302 | valproic acid | increases methylation | ISO | KCNG1 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of KCNG1 gene | CTD | PMID:29154799 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of KCNG1 mRNA | CTD | PMID:29427782 | valproic acid | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNG1 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of KCNG1 mRNA | CTD | PMID:23179753 more ... | valproic acid | affects expression | ISO | KCNG1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of KCNG1 mRNA | CTD | PMID:25979313 | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of KCNG1 promoter | CTD | PMID:20927350 | zidovudine | multiple interactions | ISO | KCNG1 (Homo sapiens) | 6480464 | [Zidovudine co-treated with Lamivudine] results in increased expression of KCNG1 mRNA | CTD | PMID:15784690 | |