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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Cocaine-Related Disorders | | ISO | RGD:1348855 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:15091342 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Cocaine-Related Disorders | | ISO | RGD:1348855 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:15091342 | |
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# | Reference Title | Reference Citation |
1. | The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins. | An N, etal., J Biol Chem. 2008 Sep 5;283(36):24718-28. Epub 2008 Jun 19. |
2. | Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis. | Blumer JB, etal., J Biol Chem 2002 May 3;277(18):15897-903. |
3. | Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha. | Blumer JB, etal., J Biol Chem 2003 Jun 27;278(26):23217-20. Epub 2003 Apr 28. |
4. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
5. | Receptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation. | Ghosh M, etal., J Biol Chem 2003 Sep 12;278(37):34747-50. Epub 2003 Jul 24. |
6. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
7. | Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3. | Peterson YK, etal., J Biol Chem 2000 Oct 27;275(43):33193-6. |
8. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
9. | Receptor-independent activators of heterotrimeric G-protein signaling pathways. | Takesono A, etal., J Biol Chem 1999 Nov 19;274(47):33202-5. |
PMID:8889548 | PMID:11024022 | PMID:11042168 | PMID:11121039 | PMID:11278352 | PMID:12477932 | PMID:12642577 | PMID:12834360 | PMID:14530282 | PMID:14726514 | PMID:15091342 | PMID:15489334 |
PMID:15937104 | PMID:16009138 | PMID:16154268 | PMID:16458856 | PMID:18541531 | PMID:18719114 | PMID:20065032 | PMID:20305814 | PMID:21343176 | PMID:22074847 | PMID:23404409 | PMID:23504261 |
Gpsm1 (Rattus norvegicus - Norway rat) |
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GPSM1 (Homo sapiens - human) |
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Gpsm1 (Mus musculus - house mouse) |
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Gpsm1 (Chinchilla lanigera - long-tailed chinchilla) |
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GPSM1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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GPSM1 (Canis lupus familiaris - dog) |
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Gpsm1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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GPSM1 (Sus scrofa - pig) |
No map positions available. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GPSM1 (Chlorocebus sabaeus - green monkey) |
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Gpsm1 (Heterocephalus glaber - naked mole-rat) |
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Variants in Gpsm1
71 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
RH130608 |
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RH140521 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 43 | 13 | 6 | 3 | 6 | 74 | 21 | 39 | 9 | ||||
Low | 3 | 44 | 35 | 16 | 35 | 8 | 11 | 14 | 2 | 2 | 8 | ||
Below cutoff |
RefSeq Transcripts | NM_001145469 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_144745 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006233670 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008761620 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017591462 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017591463 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039104257 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039104258 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC129824 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AF107723 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AY136742 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC086535 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC105302 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BF408282 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CB615566 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CB743977 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH474001 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JACYVU010000115 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000067840 ⟹ ENSRNOP00000062075 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000084567 ⟹ ENSRNOP00000070079 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000097564 ⟹ ENSRNOP00000079739 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000102548 ⟹ ENSRNOP00000089684 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000111577 ⟹ ENSRNOP00000094743 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000118478 ⟹ ENSRNOP00000084484 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001145469 ⟹ NP_001138941 | ||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | NM_144745 ⟹ NP_653346 | ||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006233670 ⟹ XP_006233732 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_008761620 ⟹ XP_008759842 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017591463 ⟹ XP_017446952 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039104257 ⟹ XP_038960185 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_039104258 ⟹ XP_038960186 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_001138941 | (Get FASTA) | NCBI Sequence Viewer |
NP_653346 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006233732 | (Get FASTA) | NCBI Sequence Viewer | |
XP_008759842 | (Get FASTA) | NCBI Sequence Viewer | |
XP_017446952 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038960185 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038960186 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAF08683 | (Get FASTA) | NCBI Sequence Viewer |
AAH86535 | (Get FASTA) | NCBI Sequence Viewer | |
AAN01268 | (Get FASTA) | NCBI Sequence Viewer | |
EDL93512 | (Get FASTA) | NCBI Sequence Viewer | |
EDL93513 | (Get FASTA) | NCBI Sequence Viewer | |
EDL93514 | (Get FASTA) | NCBI Sequence Viewer | |
EDL93515 | (Get FASTA) | NCBI Sequence Viewer | |
EDL93516 | (Get FASTA) | NCBI Sequence Viewer | |
EDL93517 | (Get FASTA) | NCBI Sequence Viewer | |
Q9R080 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_653346 ⟸ NM_144745 |
- Peptide Label: | isoform a |
- UniProtKB: | Q8K3E2 (UniProtKB/Swiss-Prot), Q9R080 (UniProtKB/Swiss-Prot), G3V9X2 (UniProtKB/TrEMBL), A6JTD0 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | NP_001138941 ⟸ NM_001145469 |
- Peptide Label: | isoform b |
- UniProtKB: | Q9R080 (UniProtKB/Swiss-Prot), A6JTD5 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006233732 ⟸ XM_006233670 |
- Peptide Label: | isoform X4 |
- UniProtKB: | A0A8I6AC91 (UniProtKB/TrEMBL), A6JTD2 (UniProtKB/TrEMBL), A6JTD4 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_008759842 ⟸ XM_008761620 |
- Peptide Label: | isoform X3 |
- UniProtKB: | Q9R080 (UniProtKB/Swiss-Prot), A0A8L2R2Q0 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_017446952 ⟸ XM_017591463 |
- Peptide Label: | isoform X2 |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000062075 ⟸ ENSRNOT00000067840 |
RefSeq Acc Id: | ENSRNOP00000070079 ⟸ ENSRNOT00000084567 |
RefSeq Acc Id: | XP_038960185 ⟸ XM_039104257 |
- Peptide Label: | isoform X1 |
- UniProtKB: | Q9R080 (UniProtKB/Swiss-Prot), Q8K3E2 (UniProtKB/Swiss-Prot) |
RefSeq Acc Id: | XP_038960186 ⟸ XM_039104258 |
- Peptide Label: | isoform X5 |
RefSeq Acc Id: | ENSRNOP00000079739 ⟸ ENSRNOT00000097564 |
RefSeq Acc Id: | ENSRNOP00000084484 ⟸ ENSRNOT00000118478 |
RefSeq Acc Id: | ENSRNOP00000089684 ⟸ ENSRNOT00000102548 |
RefSeq Acc Id: | ENSRNOP00000094743 ⟸ ENSRNOT00000111577 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q9R080-F1-model_v2 | AlphaFold | Q9R080 | 1-673 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:628682 | AgrOrtholog |
BioCyc Gene | G2FUF-50388 | BioCyc |
Ensembl Genes | ENSRNOG00000018666 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000062075 | ENTREZGENE |
ENSRNOP00000062075.1 | UniProtKB/TrEMBL | |
ENSRNOP00000070079.2 | UniProtKB/TrEMBL | |
ENSRNOP00000079739.1 | UniProtKB/TrEMBL | |
ENSRNOP00000084484.1 | UniProtKB/TrEMBL | |
ENSRNOP00000089684 | ENTREZGENE | |
ENSRNOP00000089684.1 | UniProtKB/TrEMBL | |
ENSRNOP00000094743.1 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000067840 | ENTREZGENE |
ENSRNOT00000067840.3 | UniProtKB/TrEMBL | |
ENSRNOT00000084567.2 | UniProtKB/TrEMBL | |
ENSRNOT00000097564.1 | UniProtKB/TrEMBL | |
ENSRNOT00000102548 | ENTREZGENE | |
ENSRNOT00000102548.1 | UniProtKB/TrEMBL | |
ENSRNOT00000111577.1 | UniProtKB/TrEMBL | |
ENSRNOT00000118478.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 1.25.40.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
InterPro | GoLoco_motif | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
TPR-like_helical_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TPR_repeat | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:246254 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
NCBI Gene | 246254 | ENTREZGENE |
PANTHER | G-PROTEIN-SIGNALING MODULATOR 1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
LD33695P | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | GoLoco | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
TPR_12 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TPR_7 | UniProtKB/TrEMBL | |
PhenoGen | Gpsm1 | PhenoGen |
PROSITE | GOLOCO | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
TPR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TPR_REGION | UniProtKB/Swiss-Prot | |
SMART | GoLoco | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
TPR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | SSF48452 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A0A8I5ZNN7_RAT | UniProtKB/TrEMBL |
A0A8I5ZZF6_RAT | UniProtKB/TrEMBL | |
A0A8I6AC91 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6AMW5_RAT | UniProtKB/TrEMBL | |
A0A8L2R2Q0 | ENTREZGENE, UniProtKB/TrEMBL | |
A6JTD0 | ENTREZGENE, UniProtKB/TrEMBL | |
A6JTD1_RAT | UniProtKB/TrEMBL | |
A6JTD2 | ENTREZGENE, UniProtKB/TrEMBL | |
A6JTD3_RAT | UniProtKB/TrEMBL | |
A6JTD4 | ENTREZGENE, UniProtKB/TrEMBL | |
A6JTD5 | ENTREZGENE, UniProtKB/TrEMBL | |
G3V9X2 | ENTREZGENE, UniProtKB/TrEMBL | |
GPSM1_RAT | UniProtKB/Swiss-Prot | |
Q8K3E2 | ENTREZGENE | |
Q9R080 | ENTREZGENE | |
UniProt Secondary | Q8K3E2 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2011-08-02 | Gpsm1 | G-protein signaling modulator 1 | Gpsm1 | G-protein signaling modulator 1 (AGS3-like, C. elegans) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-10-30 | Gpsm1 | G-protein signaling modulator 1 (AGS3-like, C. elegans) | Gpsm1 | G-protein signalling modulator 1 (AGS3-like, C. elegans) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2004-09-10 | Gpsm1 | G-protein signalling modulator 1 (AGS3-like, C. elegans) | Ags3 | activator of G-protein signaling 3 | Symbol and Name updated | 1299863 | APPROVED |
2003-02-27 | Ags3 | activator of G-protein signaling 3 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
Note Type | Note | Reference |
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gene_domains | contains four G-protein regulatory motifs that may bind G-protein alpha subunits | 631949 |
gene_physical_interaction | binds to Galpha and showed a preference for GalphaGDP versus GalphaGTPgammaS | 631950 |