Pole2 (DNA polymerase epsilon 2, accessory subunit) - Rat Genome Database

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Gene: Pole2 (DNA polymerase epsilon 2, accessory subunit) Rattus norvegicus
Analyze
Symbol: Pole2
Name: DNA polymerase epsilon 2, accessory subunit
RGD ID: 1311962
Description: Predicted to enable DNA binding activity. Predicted to be involved in DNA-templated DNA replication and error-prone translesion synthesis. Predicted to be located in nuclear body. Predicted to be part of epsilon DNA polymerase complex. Orthologous to human POLE2 (DNA polymerase epsilon 2, accessory subunit); PARTICIPATES IN nucleotide excision repair pathway; base excision repair pathway; DNA replication pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA polymerase epsilon subunit 2; LOC299112; polymerase (DNA directed), epsilon 2; polymerase (DNA directed), epsilon 2 (p59 subunit); polymerase (DNA directed), epsilon 2, accessory subunit; polymerase (DNA) epsilon 2, accessory subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2687,674,702 - 87,712,723 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl687,674,702 - 87,699,305 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx688,074,664 - 88,099,201 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0688,374,099 - 88,398,636 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0687,813,850 - 87,838,387 (-)NCBIRnor_WKY
Rnor_6.0691,494,348 - 91,532,355 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl691,494,393 - 91,518,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06100,953,300 - 100,977,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,155,518 - 91,180,121 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1691,158,976 - 91,183,577 (-)NCBI
Celera686,173,896 - 86,198,498 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-methylcholine  (ISO)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroethene  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
Enterolactone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycine betaine  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
irinotecan  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lucanthone  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. DNA polymerase epsilon - more than a polymerase. Pospiech H and Syvaoja JE, ScientificWorldJournal. 2003 Mar 24;3:87-104.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10801849   PMID:22465957  


Genomics

Comparative Map Data
Pole2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2687,674,702 - 87,712,723 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl687,674,702 - 87,699,305 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx688,074,664 - 88,099,201 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0688,374,099 - 88,398,636 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0687,813,850 - 87,838,387 (-)NCBIRnor_WKY
Rnor_6.0691,494,348 - 91,532,355 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl691,494,393 - 91,518,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06100,953,300 - 100,977,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,155,518 - 91,180,121 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1691,158,976 - 91,183,577 (-)NCBI
Celera686,173,896 - 86,198,498 (-)NCBICelera
Cytogenetic Map6q24NCBI
POLE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381449,643,555 - 49,688,214 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1449,643,555 - 49,688,422 (-)EnsemblGRCh38hg38GRCh38
GRCh371450,110,273 - 50,154,932 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,180,028 - 49,224,685 (-)NCBINCBI36Build 36hg18NCBI36
Build 341449,180,027 - 49,224,685NCBI
Celera1429,970,096 - 30,014,595 (-)NCBICelera
Cytogenetic Map14q21.3NCBI
HuRef1430,227,158 - 30,272,590 (-)NCBIHuRef
CHM1_11450,049,196 - 50,093,831 (-)NCBICHM1_1
T2T-CHM13v2.01443,841,772 - 43,886,260 (-)NCBIT2T-CHM13v2.0
Pole2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391269,248,547 - 69,274,979 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1269,248,547 - 69,274,969 (-)EnsemblGRCm39 Ensembl
GRCm381269,201,773 - 69,228,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,201,773 - 69,228,195 (-)EnsemblGRCm38mm10GRCm38
MGSCv371270,302,766 - 70,329,177 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361270,120,384 - 70,146,795 (-)NCBIMGSCv36mm8
Celera1270,293,615 - 70,320,108 (-)NCBICelera
Cytogenetic Map12C2NCBI
Pole2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,983,586 - 13,014,578 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540912,983,488 - 13,014,669 (+)NCBIChiLan1.0ChiLan1.0
POLE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11449,985,800 - 50,032,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01430,222,957 - 30,268,455 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11448,531,945 - 48,576,700 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1448,531,945 - 48,576,700 (-)Ensemblpanpan1.1panPan2
Pole2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864058,303,675 - 58,348,150 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936583341,456 - 386,395 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936583340,428 - 386,633 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1179,495,214 - 179,529,896 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11179,495,278 - 179,529,891 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21199,880,871 - 199,916,212 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POLE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12426,682,627 - 26,736,266 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2426,682,723 - 26,736,171 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605314,999,103 - 15,051,164 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pole2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473119,027,721 - 19,063,113 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473119,027,668 - 19,063,268 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pole2
189 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000005835
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat

Markers in Region
RH143484  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2687,676,924 - 87,677,060 (+)MAPPERmRatBN7.2
Rnor_6.0691,496,616 - 91,496,751NCBIRnor6.0
Rnor_5.06100,955,523 - 100,955,658UniSTSRnor5.0
RGSC_v3.4691,157,741 - 91,157,876UniSTSRGSC3.4
Celera686,176,119 - 86,176,254UniSTS
RH 3.4 Map6624.69UniSTS
Cytogenetic Map6q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 22 24 18 11 18 24 16 30
Low 2 16 26 16 8 16 4 4 50 19 11 11 4
Below cutoff 5 7 7 7 4 7 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001169108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide FQ231562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000005835   ⟹   ENSRNOP00000005835
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl687,674,702 - 87,699,305 (-)Ensembl
Rnor_6.0 Ensembl691,494,393 - 91,518,996 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104479   ⟹   ENSRNOP00000086117
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl687,675,513 - 87,699,305 (-)Ensembl
RefSeq Acc Id: NM_001169108   ⟹   NP_001162579
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2687,674,702 - 87,699,305 (-)NCBI
Rnor_6.0691,494,393 - 91,518,996 (-)NCBI
Rnor_5.06100,953,300 - 100,977,959 (-)NCBI
RGSC_v3.4691,155,518 - 91,180,121 (-)RGD
Celera686,173,896 - 86,198,498 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240154   ⟹   XP_006240216
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2687,674,702 - 87,699,308 (-)NCBI
Rnor_6.0691,494,348 - 91,519,658 (-)NCBI
Rnor_5.06100,953,300 - 100,977,959 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764698   ⟹   XP_008762920
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2687,674,702 - 87,712,723 (-)NCBI
Rnor_6.0691,494,393 - 91,532,355 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764701   ⟹   XP_008762923
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2687,674,702 - 87,712,719 (-)NCBI
Rnor_6.0691,494,393 - 91,532,355 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764702   ⟹   XP_008762924
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2687,674,702 - 87,712,723 (-)NCBI
Rnor_6.0691,494,393 - 91,529,923 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594087   ⟹   XP_017449576
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2687,674,702 - 87,712,719 (-)NCBI
Rnor_6.0691,494,393 - 91,532,355 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111982   ⟹   XP_038967910
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2687,674,702 - 87,699,308 (-)NCBI
RefSeq Acc Id: XM_039111983   ⟹   XP_038967911
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2687,674,702 - 87,712,723 (-)NCBI
RefSeq Acc Id: XM_039111985   ⟹   XP_038967913
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2687,674,702 - 87,712,723 (-)NCBI
RefSeq Acc Id: XM_039111986   ⟹   XP_038967914
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2687,674,702 - 87,712,723 (-)NCBI
RefSeq Acc Id: XM_039111987   ⟹   XP_038967915
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2687,674,702 - 87,712,723 (-)NCBI
RefSeq Acc Id: XM_039111988   ⟹   XP_038967916
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2687,674,702 - 87,712,723 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001162579   ⟸   NM_001169108
- UniProtKB: D4ABZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240216   ⟸   XM_006240154
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008762923   ⟸   XM_008764701
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008762920   ⟸   XM_008764698
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008762924   ⟸   XM_008764702
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017449576   ⟸   XM_017594087
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000005835   ⟸   ENSRNOT00000005835
RefSeq Acc Id: XP_038967913   ⟸   XM_039111985
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038967916   ⟸   XM_039111988
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038967911   ⟸   XM_039111983
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038967915   ⟸   XM_039111987
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038967914   ⟸   XM_039111986
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038967910   ⟸   XM_039111982
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000086117   ⟸   ENSRNOT00000104479
Protein Domains
DNA polymerase alpha/delta/epsilon subunit B   DNA polymerase epsilon subunit B N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ABZ5-F1-model_v2 AlphaFold D4ABZ5 1-527 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694633
Promoter ID:EPDNEW_R5157
Type:single initiation site
Name:Pole2_1
Description:DNA polymerase epsilon 2, accessory subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0691,518,980 - 91,519,040EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311962 AgrOrtholog
BioCyc Gene G2FUF-37255 BioCyc
Ensembl Genes ENSRNOG00000004242 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005835 ENTREZGENE
  ENSRNOP00000005835.5 UniProtKB/TrEMBL
  ENSRNOP00000086117.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005835 ENTREZGENE
  ENSRNOT00000005835.6 UniProtKB/TrEMBL
  ENSRNOT00000104479.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  3.60.21.60 UniProtKB/TrEMBL
InterPro DNA_pol_alpha/epsilon_bsu UniProtKB/TrEMBL
  DNA_pol_e_bsu_N UniProtKB/TrEMBL
  DNA_pol_epsilon_bsu UniProtKB/TrEMBL
KEGG Report rno:299112 UniProtKB/TrEMBL
NCBI Gene 299112 ENTREZGENE
PANTHER DNA POLYMERASE EPSILON SUBUNIT 2 UniProtKB/TrEMBL
  PTHR12708 UniProtKB/TrEMBL
Pfam DNA_pol_E_B UniProtKB/TrEMBL
  Dpoe2NT UniProtKB/TrEMBL
PhenoGen Pole2 PhenoGen
PIRSF DNA_pol_eps_2 UniProtKB/TrEMBL
UniProt A0A8I6A566_RAT UniProtKB/TrEMBL
  D4ABZ5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Pole2  DNA polymerase epsilon 2, accessory subunit  Pole2  polymerase (DNA) epsilon 2, accessory subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-09 Pole2  polymerase (DNA) epsilon 2, accessory subunit  Pole2  polymerase (DNA directed), epsilon 2, accessory subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Pole2  polymerase (DNA directed), epsilon 2, accessory subunit  Pole2  polymerase (DNA directed), epsilon 2 (p59 subunit)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pole2  polymerase (DNA directed), epsilon 2 (p59 subunit)   Pole2_predicted  polymerase (DNA directed), epsilon 2 (p59 subunit) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pole2_predicted  polymerase (DNA directed), epsilon 2 (p59 subunit) (predicted)      Symbol and Name status set to approved 70820 APPROVED