Gene: Ltb4r (leukotriene B4 receptor) Rattus norvegicus
Analyze
Symbol:
Ltb4r
Name:
leukotriene B4 receptor
Description:
Exhibits leukotriene receptor activity. Involved in inflammatory response. Localizes to membrane raft. Used to study carotid artery disease. Orthologous to human LTB4R (leukotriene B4 receptor); PARTICIPATES IN G protein mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid; ammonium chloride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
BLT-1; BLT1; leukotriene B4 receptor 1; LTB4-R 1; LTB4-R1; Ltb4r1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
LTB4R (leukotriene B4 receptor) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Ltb4r1 (leukotriene B4 receptor 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ltb4r (leukotriene B4 receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
LTB4R (leukotriene B4 receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
LTB4R (leukotriene B4 receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ltb4r (leukotriene B4 receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
LTB4R (leukotriene B4 receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
LTB4R (leukotriene B4 receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Ltb4r (leukotriene B4 receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
LTB4R (leukotriene B4 receptor)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Mus musculus (house mouse):
Ltb4r1 (leukotriene B4 receptor 1)
Alliance
DIOPT (PANTHER|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Danio rerio (zebrafish):
ltb4r (leukotriene B4 receptor)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Danio rerio (zebrafish):
ltb4r2b (leukotriene B4 receptor 2b)
Alliance
DIOPT (PANTHER|OMA|OrthoFinder|OrthoInspector|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 15 34,449,299 - 34,453,352 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 15 34,452,116 - 34,453,171 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 15 38,337,878 - 38,341,864 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 15 33,928,726 - 33,929,781 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 15 33,944,425 - 33,945,481 (+) NCBI Celera 15 28,839,411 - 28,840,466 (+) NCBI Celera Cytogenetic Map 15 p13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - CTD
Anaphylaxis ISO RGD:1348020 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10934231 Chemical and Drug Induced Liver Injury ISO RGD:1550123 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28487374 Inflammation ISO RGD:1348020 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10934231 liver disease ISO RGD:1348020 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19784758 nephrosclerosis ISO RGD:1550123 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30818366
Gene-Chemical Interaction Annotations
1,2-dichloroethane increases expression ISO RGD:1550123 6480464 ethylene dichloride results in increased expression of LTB4R1 mRNA CTD PMID:28189721 , PMID:28960355 1,2-dimethylhydrazine multiple interactions EXP 6480464 [APC protein affects the susceptibility to 1, 2-Dimethylhydrazine] which results in decreased expression of LTB4R mRNA CTD PMID:27840820 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1348020 6480464 [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LTB4R mRNA CTD PMID:14761676 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1550123 6480464 Tetrachlorodibenzodioxin results in increased expression of LTB4R1 mRNA CTD PMID:28487374 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1550123 6480464 LTB4R1 mRNA promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA], LTB4R1 mRNA promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA] CTD PMID:28487374 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1550123 6480464 Tetrachlorodibenzodioxin results in decreased expression of LTB4R1 mRNA CTD PMID:24680724 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine affects response to substance ISO RGD:1550123 6480464 LTB4R1 protein affects the susceptibility to Platelet Activating Factor CTD PMID:10934231 3,3',5-triiodo-L-thyronine multiple interactions ISO RGD:1348020 6480464 [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LTB4R mRNA CTD PMID:14761676 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid multiple interactions EXP 6480464 MK-886 binds to and results in decreased activity of LTB4R protein, MK-886 inhibits the reaction [LTB4R protein results in increased susceptibility to Formaldehyde] CTD PMID:19835937 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases expression ISO RGD:1348020 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of LTB4R mRNA CTD PMID:19038236 5-azacytidine decreases expression ISO RGD:1348020 6480464 Azacitidine results in decreased expression of LTB4R mRNA CTD PMID:20823114 all-trans-retinoic acid increases expression ISO RGD:1348020 6480464 Tretinoin results in increased expression of LTB4R mRNA CTD PMID:17218384 all-trans-retinoic acid affects expression ISO RGD:1348020 6480464 Tretinoin affects the expression of LTB4R mRNA CTD PMID:15498508 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of LTB4R mRNA CTD PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of LTB4R mRNA CTD PMID:30779732 arachidonic acid affects response to substance ISO RGD:1550123 6480464 LTB4R1 protein affects the susceptibility to Arachidonic Acid CTD PMID:10934231 benzo[a]pyrene decreases expression ISO RGD:1550123 6480464 Benzo(a)pyrene results in decreased expression of LTB4R1 mRNA CTD PMID:22228805 bis(2-chloroethyl) sulfide increases expression ISO RGD:1550123 6480464 Mustard Gas results in increased expression of LTB4R1 mRNA CTD PMID:15674844 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of LTB4R mRNA CTD PMID:25181051 buta-1,3-diene decreases expression ISO RGD:1550123 6480464 1, 3-butadiene results in decreased expression of LTB4R1 mRNA CTD PMID:29038090 calciol decreases expression ISO RGD:1550123 6480464 Cholecalciferol results in decreased expression of LTB4R1 mRNA CTD PMID:16508948 calcitriol decreases expression ISO RGD:1348020 6480464 Calcitriol results in decreased expression of LTB4R mRNA CTD PMID:26485663 carbon nanotube increases expression ISO RGD:1550123 6480464 Nanotubes, Carbon analog results in increased expression of LTB4R1 mRNA, Nanotubes, Carbon results in increased expression of LTB4R1 mRNA CTD PMID:25554681 , PMID:25620056 chromium(6+) affects expression ISO RGD:1550123 6480464 chromium hexavalent ion affects the expression of LTB4R1 mRNA CTD PMID:28472532 cisplatin increases expression ISO RGD:1550123 6480464 Cisplatin results in increased expression of LTB4R1 mRNA CTD PMID:25270620 clopidogrel multiple interactions ISO RGD:1550123 6480464 clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of LTB4R1 mRNA] CTD PMID:19172522 copper atom multiple interactions ISO RGD:1348020 6480464 [Disulfiram binds to Copper] which results in increased expression of LTB4R mRNA CTD PMID:24690739 copper(0) multiple interactions ISO RGD:1348020 6480464 [Disulfiram binds to Copper] which results in increased expression of LTB4R mRNA CTD PMID:24690739 dextran sulfate multiple interactions ISO RGD:1550123 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of LTB4R1 mRNA CTD PMID:29950665 dibenz[a,h]anthracene increases expression ISO RGD:1550123 6480464 1 more ... CTD PMID:26377693 dichloroacetic acid decreases expression ISO RGD:1550123 6480464 Dichloroacetic Acid results in decreased expression of LTB4R1 mRNA CTD PMID:28962523 dioxygen multiple interactions ISO RGD:1550123 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of LTB4R1 mRNA CTD PMID:30529165 disulfiram multiple interactions ISO RGD:1348020 6480464 [Disulfiram binds to Copper] which results in increased expression of LTB4R mRNA CTD PMID:24690739 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of LTB4R mRNA CTD PMID:18035473 formaldehyde multiple interactions EXP 6480464 MK-886 inhibits the reaction [LTB4R protein results in increased susceptibility to Formaldehyde] CTD PMID:19835937 formaldehyde increases expression ISO RGD:1348020 6480464 Formaldehyde results in increased expression of LTB4R mRNA CTD PMID:23649840 formaldehyde increases response to substance EXP 6480464 LTB4R protein results in increased susceptibility to Formaldehyde CTD PMID:19835937 furan increases expression ISO RGD:1550123 6480464 furan results in increased expression of LTB4R1 mRNA CTD PMID:24183702 hydroxyurea increases expression ISO RGD:1550123 6480464 Hydroxyurea results in increased expression of LTB4R1 mRNA CTD PMID:27208086 leukotriene B4 multiple interactions ISO RGD:1550123 6480464 [SC 41930 binds to and results in decreased activity of LTB4R protein] which results in decreased abundance of Leukotriene B4, Leukotriene B4 binds to and affects the activity of LTB4R1 protein CTD PMID:10934232 , PMID:8014878 leukotriene B4 multiple interactions ISO RGD:1348020 6480464 Leukotriene B4 binds to and results in increased activity of LTB4R protein more ... CTD PMID:7473568 leukotriene B4 affects response to substance ISO RGD:1550123 6480464 LTB4R1 protein affects the susceptibility to Leukotriene B4 CTD PMID:10934232 leukotriene B4 affects binding ISO RGD:1348020 6480464 Leukotriene B4 analog binds to LTB4R1 protein CTD PMID:11006272 lipopolysaccharide multiple interactions ISO RGD:1550123 6480464 clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of LTB4R1 mRNA] CTD PMID:19172522 methotrexate decreases expression ISO RGD:1348020 6480464 Methotrexate results in decreased expression of LTB4R mRNA CTD PMID:24449571 Methylazoxymethanol acetate increases expression EXP 6480464 Methylazoxymethanol Acetate results in increased expression of LTB4R mRNA CTD PMID:28349193 nickel atom increases expression ISO RGD:1348020 6480464 Nickel results in increased expression of LTB4R mRNA CTD PMID:25583101 nitrobenzenes decreases expression EXP 6480464 Nitrobenzenes analog results in decreased expression of LTB4R mRNA CTD PMID:19784758 ozone decreases expression ISO RGD:1550123 6480464 Ozone results in decreased expression of LTB4R1 mRNA CTD PMID:29471542 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of LTB4R mRNA CTD PMID:19784758 paracetamol decreases expression ISO RGD:1348020 6480464 Acetaminophen results in decreased expression of LTB4R mRNA CTD PMID:26690555 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of LTB4R mRNA CTD PMID:19784758 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of LTB4R mRNA CTD PMID:19784758 pirinixic acid increases expression ISO RGD:1550123 6480464 pirinixic acid results in increased expression of LTB4R1 mRNA CTD PMID:20059764 pirinixic acid decreases expression ISO RGD:1550123 6480464 pirinixic acid results in decreased expression of LTB4R1 mRNA CTD PMID:23811191 pirinixic acid multiple interactions ISO RGD:1550123 6480464 PPARA protein promotes the reaction [pirinixic acid results in increased expression of LTB4R1 mRNA] CTD PMID:20059764 potassium dichromate increases expression ISO RGD:1550123 6480464 Potassium Dichromate results in increased expression of LTB4R1 mRNA CTD PMID:23608068 quercetin increases expression ISO RGD:1348020 6480464 Quercetin results in increased expression of LTB4R mRNA CTD PMID:21632981 tamibarotene affects expression ISO RGD:1348020 6480464 tamibarotene affects the expression of LTB4R mRNA CTD PMID:15498508 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of LTB4R mRNA CTD PMID:19784758 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of LTB4R mRNA CTD PMID:19784758 titanium dioxide affects expression ISO RGD:1550123 6480464 titanium dioxide affects the expression of LTB4R1 mRNA CTD PMID:23557971 titanium dioxide multiple interactions ISO RGD:1550123 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of LTB4R1 mRNA CTD PMID:29950665 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of LTB4R mRNA CTD PMID:23869203 zinc dichloride decreases expression ISO RGD:1348020 6480464 zinc chloride results in decreased expression of LTB4R mRNA CTD PMID:19428942
Gene Ontology Annotations
Molecular Pathway Annotations
9589149 Insul29 Insulin level QTL 29 9.06 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 15 1 37708474 Rat 8552920 Pigfal8 Plasma insulin-like growth factor 1 level QTL 8 3 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 15 1 37708474 Rat 8694361 Abfw6 Abdominal fat weight QTL 6 10.2 0.001 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) 15 1 37708474 Rat 731170 Pur3 Proteinuria QTL 3 2.3 0.0005 urine protein amount (VT:0005160) urine protein excretion rate (CMO:0000759) 15 1 42844179 Rat 1641887 Alcrsp14 Alcohol response QTL 14 response to alcohol trait (VT:0010489) brain neurotensin receptor 1 density (CMO:0002068) 15 1 43521446 Rat 2298549 Neuinf12 Neuroinflammation QTL 12 3.5 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) 15 1 62301382 Rat 738017 Hcas7 Hepatocarcinoma susceptibility QTL 7 2.91 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464) 15 2327877 53535766 Rat 10401805 Kidm51 Kidney mass QTL 51 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 15 3881131 48881131 Rat 1582251 Gluco24 Glucose level QTL 24 3.2 0.0008 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 15 10719191 55719191 Rat 2317750 Glom26 Glomerulus QTL 26 4.3 urine protein amount (VT:0005160) urine protein level (CMO:0000591) 15 15492360 72568189 Rat 9590272 Scort14 Serum corticosterone level QTL 14 2.78 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 15 16980907 61980907 Rat 8694427 Bw163 Body weight QTL 163 4.82 0.001 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) 15 16980907 61980907 Rat 2300167 Bmd63 Bone mineral density QTL 63 5.9 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 15 17249641 62249641 Rat 2300173 Bmd62 Bone mineral density QTL 62 12.8 0.0001 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) 15 17249641 62249641 Rat 2293688 Bss29 Bone structure and strength QTL 29 5.31 0.0001 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) 15 17249641 62249641 Rat 1331729 Rf42 Renal function QTL 42 3.071 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) 15 18093208 81255430 Rat 61424 Scl1 Serum cholesterol level QTL 1 7.7 0.001 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 15 18513913 88036354 Rat 631550 Bw7 Body weight QTL 7 3.6 body mass (VT:0001259) body weight (CMO:0000012) 15 21021342 41082727 Rat 2324620 Coatc3 Coat color QTL 3 coat/hair pigmentation trait (VT:0010463) pigmented coat/hair area to total coat/hair area ratio (CMO:0001810) 15 21021342 52831189 Rat 10755503 Bp391 Blood pressure QTL 391 2.37 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 15 23778969 46825072 Rat 1578646 Bmd18 Bone mineral density QTL 18 5.2 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) 15 26381041 106550657 Rat 1578647 Bmd17 Bone mineral density QTL 17 4 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 15 26381041 106550657 Rat 1578660 Bss19 Bone structure and strength QTL 19 4.3 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) 15 26381041 106550657 Rat 10054130 Srcrt8 Stress Responsive Cort QTL 8 2.18 0.0085 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 15 28709741 73709741 Rat 1582214 Stl21 Serum triglyceride level QTL 21 3.1 0.022 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 15 33219101 89640841 Rat 1582227 Gluco30 Glucose level QTL 30 3.6 0.0003 blood glucose amount (VT:0000188) absolute change in blood glucose level area under curve (CMO:0002034) 15 33219101 89640841 Rat 1582228 Epfw3 Epididymal fat weight QTL 3 4.1 0.0002 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) 15 33219101 89640841 Rat 1582242 Gluco28 Glucose level QTL 28 3.3 0.0008 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 15 33219101 89640841 Rat 1582244 Bw79 Body weight QTL 79 4 0.0002 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) 15 33219101 89640841 Rat
Predicted Target Of
Count of predictions: 119 Count of miRNA genes: 101 Interacting mature miRNAs: 102 Transcripts: ENSRNOT00000027647 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
