ethanolamines - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	ethanolamines	go back to main search page
Accession:	CHEBI:23981	browse the term
Synonyms:	related_synonym:	ethanolamine

show annotations for term's descendants Sort by:
Rat (819) Mouse (826) Human (824) Chinchilla (0) Bonobo (0) Dog (3) Squirrel (0) Pig (3) Green Monkey (0) Naked Mole-rat (0) All
Genes (819)

(-)-ephedrine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein A1

multiple interactions

[Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein A2

multiple interactions

[Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein

NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355

G

apolipoprotein B

multiple interactions

[Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein C1

multiple interactions

[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein

NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375

G

apolipoprotein C2

multiple interactions

[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein

NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476

G

apolipoprotein C3

multiple interactions

[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein

NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583

G

caspase 3

multiple interactions

[Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

complement factor D

multiple interactions

[Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD mRNA]; [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD protein]

NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Ephedrine results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

H2A.X variant histone

multiple interactions

[Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

(R)-octopamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 1

multiple interactions

Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein]

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

multiple interactions

Octopamine inhibits the reaction [Norepinephrine binds to ADRB2 protein]

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

adrenoceptor beta 3

increases activity
multiple interactions

Octopamine results in increased activity of ADRB3 protein
Octopamine inhibits the reaction [Norepinephrine binds to ADRB3 protein]

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

solute carrier family 6 member 2

multiple interactions

Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]

NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357

G

solute carrier family 6 member 3

multiple interactions

indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 6 member 4

multiple interactions

Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

G

trace-amine-associated receptor 1

multiple interactions
increases activity

[Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]

PMID:17234900 PMID:19725810

NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084

9-[2-(phosphonomethoxy)ethyl]guanine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 6

multiple interactions
increases response to substance

9-((2-phosphonylmethoxy)ethyl)guanine analog inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine]; Quercetin inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog]
SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine; SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

acebutolol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 1

multiple interactions
increases activity

[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; CGP 20712A inhibits the reaction [[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP]; CGP 20712A inhibits the reaction [Acebutolol results in increased activity of ADRB1 protein]

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

multiple interactions

[Acebutolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Acebutolol results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

mitogen activated protein kinase 1

multiple interactions

[Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

renin

decreases activity

Acebutolol results in decreased activity of REN protein

PMID:6110712 PMID:6118215

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

acetophenazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

acetophenazine binds to and results in decreased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

albuterol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases expression
multiple interactions

Albuterol results in increased expression of ABCB11 mRNA
Carvedilol inhibits the reaction [Albuterol results in increased expression of ABCB11 mRNA]

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

adrenoceptor beta 1

multiple interactions

Albuterol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Albuterol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

PMID:8096834 PMID:14730417

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

decreases response to substance
increases activity
multiple interactions
increases phosphorylation
decreases expression

ADRB2 gene polymorphism results in decreased susceptibility to Albuterol
Albuterol results in increased activity of ADRB2 protein
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in decreased abundance of Potassium; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Albuterol binds to and results in increased activity of ADRB2 protein; Albuterol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Albuterol results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]
Albuterol results in increased phosphorylation of ADRB2 protein
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Hydroxyindoleacetic Acid; Albuterol binds to and results in increased activity of ADRB2 protein
Albuterol results in decreased expression of ADRB2 protein

PMID:2463453 PMID:8102213 PMID:8937731 PMID:10516654 PMID:10952688 More...

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

adrenoceptor beta 3

multiple interactions

[Albuterol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Albuterol binds to and results in increased activity of ADRB3 protein; Albuterol inhibits the reaction [cyanopindolol binds to ADRB3 protein]

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

BCL2 associated X, apoptosis regulator

increases expression

Albuterol results in increased expression of BAX

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Albuterol results in decreased expression of BCL2

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

catalase

multiple interactions

CAT protein inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 3

multiple interactions

Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

multiple interactions

[Beclomethasone co-treated with Albuterol] results in decreased secretion of CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

CD44 molecule

multiple interactions

Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cyclin dependent kinase 2

increases expression

Albuterol results in increased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

increases expression

Albuterol results in increased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

creatine kinase, M-type

increases secretion

Albuterol results in increased secretion of CKM protein

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

colony stimulating factor 2

multiple interactions

[Beclomethasone co-treated with Albuterol] results in decreased secretion of CSF2 protein

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression

Albuterol results in increased expression of CYP17A1

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

[Cyproterone co-treated with Albuterol] results in decreased expression of CYP19A1

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

fibroblast growth factor 2

multiple interactions

[Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Albuterol promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein]

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibronectin 1

multiple interactions

[Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

glucose-6-phosphate dehydrogenase

increases activity

Albuterol results in increased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

insulin-like growth factor 1

affects expression

Albuterol affects the expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 10

decreases expression

Albuterol results in decreased expression of IL10 mRNA

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

decreases expression

Albuterol results in decreased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
decreases expression

Albuterol promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
Albuterol results in decreased expression of IL1B mRNA

PMID:11112151 PMID:32816093

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

increases expression

Albuterol results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 4

multiple interactions

Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions

1-Methyl-3-isobutylxanthine promotes the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]; Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]; ICI 118551 inhibits the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

increases expression
multiple interactions

Albuterol results in increased expression of IL6 protein
Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
[Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Dexamethasone co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Theophylline co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Albuterol promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Albuterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

PMID:18362475 PMID:20388727 PMID:20519841

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 2

increases expression

Albuterol results in increased expression of INS; Albuterol results in increased expression of INS protein

PMID:8098220 PMID:9088585

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

low density lipoprotein receptor

affects response to substance

LDLR gene SNP affects the susceptibility to Albuterol

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

mitogen activated protein kinase 1

multiple interactions

[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein
Albuterol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK1 protein]

PMID:16980553 PMID:20519841

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein
Albuterol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:16980553 PMID:20519841

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

myeloperoxidase

multiple interactions

[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol; Ascorbic Acid inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; CAT protein inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Sodium Azide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Sodium Cyanide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mechanistic target of rapamycin kinase

increases expression

Albuterol results in increased expression of MTOR mRNA

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

NFKB inhibitor alpha

increases expression

Albuterol results in increased expression of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

[Beclomethasone co-treated with Albuterol] affects the localization of NR3C1 protein

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

phosphodiesterase 4A

multiple interactions

[Albuterol co-treated with Rolipram] results in increased expression of PDE4A mRNA

NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961

G

phosphodiesterase 4B

multiple interactions

[Albuterol co-treated with Rolipram] results in increased expression of PDE4B mRNA

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

phosphotyrosine interaction domain containing 1

increases expression

Albuterol results in increased expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

phosphoinositide-3-kinase regulatory subunit 1

affects expression

Albuterol affects the expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

paraoxonase 1

decreases activity

Albuterol results in decreased activity of PON1 protein

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

PPARG coactivator 1 alpha

increases expression

Albuterol results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein kinase AMP-activated catalytic subunit alpha 2

increases expression

Albuterol results in increased expression of PRKAA2 mRNA

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

platelet-activating factor receptor

increases expression

Albuterol results in increased expression of PTAFR protein

NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

Albuterol promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
Albuterol results in decreased expression of PTGS2 mRNA

PMID:11112151 PMID:32816093

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RB transcriptional corepressor 1

decreases expression
multiple interactions
increases expression

Albuterol results in decreased expression of RB1 protein
ICI 118551 inhibits the reaction [Albuterol results in decreased expression of RB1 protein]
Albuterol results in increased expression of RB1 protein

PMID:16446544 PMID:18362475

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

renin

increases expression

Albuterol results in increased expression of REN protein

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

solute carrier family 10 member 1

multiple interactions
increases expression

[Carvedilol co-treated with Albuterol] results in decreased expression of SLC10A1 protein; Carvedilol inhibits the reaction [Albuterol results in increased expression of SLC10A1 mRNA]; Carvedilol inhibits the reaction [Albuterol results in increased expression of SLC10A1 protein]
Albuterol results in increased expression of SLC10A1 mRNA; Albuterol results in increased expression of SLC10A1 protein

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

secretory leukocyte peptidase inhibitor

decreases expression

Albuterol results in decreased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

Thy-1 cell surface antigen

multiple interactions

Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]

NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659

G

tumor necrosis factor

decreases secretion
multiple interactions

Albuterol results in decreased secretion of TNF protein
[Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; [Dexamethasone co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Albuterol promotes the reaction [Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]

PMID:8937731 PMID:10229875 PMID:20388727 PMID:20519841

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression

Albuterol results in increased expression of TP53

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

uncoupling protein 1

increases expression

Albuterol results in increased expression of UCP1 protein

NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852

G

uncoupling protein 3

multiple interactions

[Albuterol co-treated with acipimox] results in decreased expression of UCP3 mRNA

NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762

anandamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases export

ABCB1 protein results in increased export of anandamide

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily G member 2

multiple interactions
decreases expression

8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [anandamide results in decreased expression of ABCG2 mRNA]; anandamide affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of ABCG2 mRNA]; anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]; Colforsin inhibits the reaction [anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]]; iodopravadoline inhibits the reaction [anandamide results in decreased expression of ABCG2 mRNA]
anandamide results in decreased expression of ABCG2 mRNA; anandamide results in decreased expression of ABCG2 protein

PMID:30610963 PMID:34756920

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

acyl-CoA oxidase 1

multiple interactions

anandamide affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of ACOX1 mRNA]

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

1-acylglycerol-3-phosphate O-acyltransferase 2

multiple interactions

anandamide affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of AGPAT2 mRNA]

NCBI chr 3:9,416,837...9,428,567
Ensembl chr 3:9,416,843...9,428,371

G

amyloid beta precursor protein

decreases response to substance
decreases metabolic processing
decreases abundance

anandamide results in decreased susceptibility to APP protein
APP protein results in decreased metabolism of anandamide
APP protein results in decreased abundance of anandamide

PMID:22233683 PMID:26976670

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

arrestin, beta 2

multiple interactions

anandamide promotes the reaction [CNR1 protein affects the localization of ARRB2 protein]

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

bradykinin receptor B1

multiple interactions
decreases activity

AM 251 inhibits the reaction [anandamide results in decreased activity of BDKRB1 protein]

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

caspase 3

increases cleavage
multiple interactions

anandamide results in increased cleavage of CASP3 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [anandamide results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

CD36 molecule

increases expression

anandamide results in increased expression of CD36 mRNA; anandamide results in increased expression of CD36 protein

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

glycoprotein hormones, alpha polypeptide

decreases expression

anandamide results in decreased expression of CGA mRNA

NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191

G

cannabinoid receptor 1

affects activity
increases response to substance
decreases expression
affects binding
increases activity
multiple interactions

anandamide affects the activity of CNR1 protein
CNR1 protein results in increased susceptibility to anandamide
anandamide results in decreased expression of CNR1 protein
anandamide binds to CNR1 protein
anandamide results in increased activity of CNR1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased activity of CNR1]; anandamide promotes the reaction [CNR1 protein affects the localization of ARRB2 protein]; CNR1 affects the reaction [TRPV1 affects the susceptibility to anandamide]; Pertussis Toxin inhibits the reaction [anandamide results in increased activity of CNR1]; Rimonabant inhibits the reaction [anandamide results in increased activity of CNR1]
[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; [CNR1 protein affects the susceptibility to Chlorpyrifos] which affects the hydrolysis of anandamide; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; SR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]

PMID:10871313 PMID:11408034 PMID:11891798 PMID:12657697 PMID:14504685 More...

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

cannabinoid receptor 2

affects activity
affects binding
multiple interactions

anandamide affects the activity of CNR2 protein
anandamide binds to CNR2 protein
anandamide binds to and results in increased activity of CNR2 protein; CNR2 affects the reaction [TRPV1 affects the susceptibility to anandamide]

PMID:10617657 PMID:10688601 PMID:15453094 PMID:19147270 PMID:30102254

NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548

G

cAMP responsive element binding protein 1

multiple interactions
decreases phosphorylation

anandamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]; Colforsin inhibits the reaction [anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]]
anandamide results in decreased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

corticotropin releasing hormone

decreases abundance

CRH protein results in decreased abundance of anandamide

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cytochrome P450, family 2, subfamily j, polypeptide 4

multiple interactions
increases metabolic processing

cannabichromene inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]; Cannabidiol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]; cannabigerol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]; Cannabinol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]; delta-8-tetrahydrocannabinol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]; Dronabinol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

anandamide results in increased expression of DDIT3 mRNA; anandamide results in increased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [anandamide results in increased expression of DDIT3 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [anandamide results in increased expression of DDIT3 protein]

PMID:21949157 PMID:26513129 PMID:29441458

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation
multiple interactions

anandamide results in increased phosphorylation of EIF2S1 protein
4-phenylbutyric acid inhibits the reaction [anandamide results in increased phosphorylation of EIF2S1 protein]

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

endogenous retrovirus group FRD member 1, envelope

decreases expression

anandamide results in decreased expression of ERVFRD-1 mRNA

NCBI chr12:22,151,211...22,158,264
Ensembl chr12:22,151,211...22,158,264

G

coagulation factor III, tissue factor

multiple interactions
increases expression

anandamide promotes the reaction [IL1B protein results in increased expression of F3 protein]
anandamide results in increased expression of F3 protein

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid amide hydrolase

increases degradation
increases response to substance
decreases metabolic processing
multiple interactions
affects expression

FAAH results in increased degradation of anandamide
FAAH gene mutant form results in increased susceptibility to anandamide
FAAH gene mutant form results in decreased metabolism of anandamide
FAAH protein results in increased degradation of anandamide
[Chlorpyrifos results in decreased activity of FAAH protein] which results in increased abundance of anandamide; [cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester results in decreased activity of FAAH protein] which results in increased abundance of anandamide; [Lipopolysaccharides results in decreased expression of FAAH protein] which results in increased abundance of anandamide; FAAH protein results in increased metabolism of and results in decreased activity of anandamide; Nitroglycerin promotes the reaction [FAAH protein results in increased degradation of anandamide]; Silybin inhibits the reaction [FAAH protein results in increased metabolism of and results in decreased activity of anandamide]
anandamide affects the expression of FAAH protein
[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester results in decreased activity of FAAH protein] which results in decreased metabolism of anandamide; [nimesulide results in decreased expression of PTGS2] promotes the reaction [FAAH affects the metabolism of anandamide]; [PF 3845 results in decreased activity of FAAH protein] which results in decreased metabolism of anandamide; Rimonabant inhibits the reaction [FAAH gene mutant form results in increased susceptibility to anandamide]

PMID:11556820 PMID:16131814 PMID:16886060 PMID:19515121 PMID:20702753 More...

NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677

G

fatty acid binding protein 1

multiple interactions
affects abundance
affects binding

11-hydroxy-delta(9)-tetrahydrocannabinol inhibits the reaction [anandamide analog binds to FABP1 protein]; Dronabinol inhibits the reaction [anandamide analog binds to FABP1 protein]
FABP1 protein affects the abundance of anandamide
FABP1 protein affects the reaction [Dronabinol results in increased abundance of anandamide]; FABP1 protein affects the reaction [glyceryl 2-arachidonate results in increased abundance of anandamide]

PMID:29414765 PMID:30232874

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

anandamide inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; capsazepine inhibits the reaction [anandamide results in increased expression of FOS protein]; resiniferatoxin inhibits the reaction [anandamide results in increased expression of FOS protein]
anandamide results in increased expression of FOS; anandamide results in increased expression of FOS protein

PMID:9748483 PMID:15601931 PMID:19515121

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

interferon gamma

multiple interactions

anandamide affects the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of TNF]; anandamide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of IL1B]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

increases expression

anandamide results in increased expression of IGF1 protein

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 12B

multiple interactions

[OMDM-1 cpd co-treated with anandamide] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]; anandamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 1 beta

multiple interactions

anandamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]
anandamide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of IL1B]; anandamide promotes the reaction [IL1B protein results in increased expression of F3 protein]

PMID:12813001 PMID:15748152 PMID:27556861 PMID:30611738

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

leptin

decreases abundance
multiple interactions
decreases activity
decreases transport

LEP protein results in decreased abundance of anandamide
Dietary Fats inhibits the reaction [LEP protein results in decreased abundance of anandamide]
LEP protein results in decreased activity of anandamide
LEP protein results in decreased transport of anandamide

PMID:16154199 PMID:29967158

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

mitogen activated protein kinase kinase 1

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein; U 0126 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein]

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein; U 0126 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein]

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
anandamide results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; Hydrogen Peroxide promotes the reaction [anandamide results in increased phosphorylation of MAPK1 protein]; JTE 907 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Pertussis Toxin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; Rimonabant inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]

PMID:12657697 PMID:19477951 PMID:21179406

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
anandamide results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; Hydrogen Peroxide promotes the reaction [anandamide results in increased phosphorylation of MAPK3 protein]; JTE 907 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Pertussis Toxin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; rimonabant inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:12657697 PMID:19477951 PMID:21179406

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 1

increases expression

anandamide results in increased expression of MMP1 mRNA

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 3

increases expression

anandamide results in increased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

multiple interactions
increases expression

N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [anandamide results in increased expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

nitric oxide synthase 2

multiple interactions

anandamide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; anandamide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:11891798 PMID:15748152

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

poly (ADP-ribose) polymerase 1

increases cleavage

anandamide results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

peroxisome proliferator activated receptor alpha

multiple interactions

anandamide binds to and results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression
increases metabolic processing

[nimesulide results in decreased expression of PTGS2] which results in increased activity of anandamide
anandamide results in increased expression of PTGS2 mRNA; anandamide results in increased expression of PTGS2 protein
PTGS2 results in increased metabolism of anandamide
[nimesulide results in decreased expression of PTGS2] promotes the reaction [FAAH affects the metabolism of anandamide]

PMID:16330497 PMID:17245358 PMID:20702753

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

selectin P

multiple interactions
increases expression

anandamide inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased expression of SELP protein]
anandamide results in increased expression of SELP protein

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

TIMP metallopeptidase inhibitor 1

increases expression
multiple interactions

anandamide results in increased expression of TIMP1 mRNA
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [anandamide results in increased expression of TIMP1 mRNA]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions
increases abundance

anandamide inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]
anandamide inhibits the reaction [[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein]
TNF protein results in increased abundance of anandamide
anandamide affects the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of TNF]

PMID:12509806 PMID:12813001 PMID:20626112 PMID:30611738

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions
increases response to substance
increases activity
affects response to substance
affects binding

3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [anandamide promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]; anandamide binds to and results in increased activity of TRPV1 protein; capsazepine inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; CNR1 affects the reaction [TRPV1 affects the susceptibility to anandamide]; CNR2 affects the reaction [TRPV1 affects the susceptibility to anandamide]; Egtazic Acid inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; methyl arachidonylfluorophosphonate promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; N-(2-methyl-3-hydroxyphenyl)-5,8,11,14-eicosatetraenamide inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; Nitroprusside promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; Phenylmethylsulfonyl Fluoride promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; rimonabant inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]
TRPV1 protein results in increased susceptibility to anandamide
anandamide results in increased activity of TRPV1 protein
3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [anandamide promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]; anandamide binds to and results in increased activity of TRPV1 protein; bisindolylmaleimide inhibits the reaction [anandamide results in increased activity of TRPV1 protein]; Eicosapentaenoic Acid inhibits the reaction [anandamide results in increased activity of TRPV1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [anandamide results in increased activity of TRPV1 protein]
anandamide binds to TRPV1 protein

PMID:11140687 PMID:11278420 PMID:14504685 PMID:15453094 PMID:15601931 More...

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

vascular endothelial growth factor A

multiple interactions

anandamide results in decreased expression of and results in decreased secretion of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

atenolol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

Atenolol inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atenolol results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

adrenoceptor alpha 2A

affects response to substance

ADRA2A gene SNP affects the susceptibility to Atenolol

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

adrenoceptor beta 1

decreases activity
multiple interactions
affects binding
affects response to substance
decreases expression

Atenolol results in decreased activity of ADRB1 protein
Atenolol binds to and results in decreased activity of ADRB1 protein; Atenolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
Atenolol binds to ADRB1 protein
[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine; [Atenolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; Atenolol binds to and results in decreased activity of ADRB1 protein; Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]; Atenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]
ADRB1 protein polymorphism affects the susceptibility to Atenolol
Atenolol results in decreased expression of ADRB1 mRNA

PMID:1389726 PMID:2462161 PMID:2897299 PMID:8102213 PMID:8386603 More...

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

increases expression
affects binding
multiple interactions

Atenolol results in increased expression of ADRB2 protein
Atenolol binds to ADRB2 protein
Atenolol binds to and results in decreased activity of ADRB2 protein; Atenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
[Atenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Atenolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Atenolol binds to and results in decreased activity of ADRB2 protein; Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]

PMID:2462161 PMID:6093157 PMID:9593075 PMID:11425575 PMID:11483288 More...

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

adrenoceptor beta 3

multiple interactions

Atenolol inhibits the reaction [cyanopindolol binds to ADRB3 protein]

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

angiotensinogen

affects response to substance
decreases expression

AGT gene SNP affects the susceptibility to Atenolol
Atenolol results in decreased expression of AGT protein

PMID:14639093 PMID:14700505

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

amylase 2a3

multiple interactions

Atenolol inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Cisplatin results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Isoproterenol results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Lithium Chloride results in increased secretion of and results in increased activity of AMY1A protein]

NCBI chr 2:201,317,916...201,326,487
Ensembl chr 2:201,317,920...201,326,532

G

apolipoprotein A1

decreases expression

Atenolol results in decreased expression of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein A2

decreases expression

Atenolol results in decreased expression of APOA2 protein

NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355

G

apolipoprotein B

increases expression

Atenolol results in increased expression of APOB; Atenolol results in increased expression of APOB protein

PMID:1928808 PMID:2193493

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

activating transcription factor 1

multiple interactions

Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein]

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

G

beta-2 microglobulin

decreases expression

Atenolol results in decreased expression of B2M protein

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

bradykinin receptor B2

affects response to substance

BDKRB2 exon polymorphism affects the susceptibility to Atenolol

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

calcium voltage-gated channel subunit alpha1 C

increases response to substance

CACNA1C gene polymorphism results in increased susceptibility to Atenolol

NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648

G

caspase 3

multiple interactions

Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Atenolol promotes the reaction [Quercetin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]]; Atenolol promotes the reaction [Thyroxine results in decreased expression of CAT protein]; Quercetin promotes the reaction [Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]]

PMID:2575990 PMID:22391854

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin-dependent kinase 1

multiple interactions

Atenolol inhibits the reaction [Isoproterenol results in increased expression of CDK1 mRNA]

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cAMP responsive element binding protein 1

multiple interactions

Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

endothelin 1

affects response to substance

EDN1 gene polymorphism affects the susceptibility to Atenolol

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

epidermal growth factor receptor

multiple interactions

Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

Fas cell surface death receptor

multiple interactions

Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions

Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein]

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

FKBP prolyl isomerase 1B

multiple interactions

Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein]

NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653

G

FKBP prolyl isomerase 5

decreases expression

Atenolol results in decreased expression of FKBP5 mRNA

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

G

glucose-6-phosphate dehydrogenase

multiple interactions

Atenolol inhibits the reaction [Dopamine results in increased activity of G6PD protein]; Atenolol inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

gap junction protein, alpha 1

increases expression

Atenolol results in increased expression of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, alpha 4

increases expression

Atenolol results in increased expression of GJA4 protein

NCBI chr 5:139,633,324...139,635,857
Ensembl chr 5:139,633,287...139,635,925

G

G protein-coupled receptor kinase 2

decreases expression

Atenolol results in decreased expression of GRK2 mRNA; Atenolol results in decreased expression of GRK2 protein

NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582

G

insulin 2

multiple interactions

Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

potassium inwardly-rectifying channel, subfamily J, member 2

affects response to substance

KCNJ2 gene affects the susceptibility to Atenolol

NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445

G

potassium voltage-gated channel subfamily Q member 1

affects response to substance

KCNQ1 gene affects the susceptibility to Atenolol

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

G

lipase C, hepatic type

multiple interactions

LIPC gene SNP affects the susceptibility to and affects the metabolism of Atenolol

NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464

G

mitogen activated protein kinase 1

multiple interactions

[Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein]

PMID:16671086 PMID:17003101 PMID:17925438

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein]

PMID:16671086 PMID:17003101 PMID:17925438

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

nitric oxide synthase 2

multiple interactions

Atenolol inhibits the reaction [Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

natriuretic peptide A

decreases expression

Atenolol results in decreased expression of NPPA protein

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

multiple interactions
decreases expression
increases expression

[Atenolol co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA
Atenolol results in decreased expression of NPPB mRNA
Atenolol results in increased expression of NPPB protein

PMID:15969258 PMID:18192850

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

phospholipase A2 group IVC

multiple interactions

PLA2G4C gene SNP affects the susceptibility to and affects the metabolism of Atenolol

NCBI chr 1:74,237,714...74,275,757
Ensembl chr 1:74,236,211...74,274,656

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 5

multiple interactions

Atenolol inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein]

NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882

G

renin

multiple interactions
decreases expression
decreases activity

[aliskiren co-treated with Atenolol] results in decreased activity of REN protein; [Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein
Atenolol results in decreased expression of REN protein
Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]; Atenolol inhibits the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]
Atenolol results in decreased activity of REN protein

PMID:3142437 PMID:3333524 PMID:9300315 PMID:14639093 PMID:18957387

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

ryanodine receptor 2

increases activity
multiple interactions

Atenolol results in increased activity of RYR2 protein
Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein]

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

G

solute carrier family 19 member 1

decreases expression

Atenolol results in decreased expression of SLC19A1 mRNA

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

solute carrier family 22 member 1

multiple interactions

Atenolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 6 member 8

decreases expression

Atenolol results in decreased expression of SLC6A8 mRNA

NCBI chr X:151,384,675...151,393,979
Ensembl chr X:151,384,675...151,393,979

G

solute carrier organic anion transporter family, member 4C1

increases expression

Atenolol results in increased expression of SLCO4C1 mRNA

NCBI chr 9:97,177,497...97,229,161
Ensembl chr 9:97,178,861...97,229,715

G

small nucleolar RNA, H/ACA box 49

increases expression

Atenolol results in increased expression of SNORA49 mRNA

NCBI chr12:45,970,884...45,971,016
Ensembl chr12:45,970,884...45,971,016

G

small nuclear ribonucleoprotein polypeptide N

increases expression

Atenolol results in increased expression of SNRPN mRNA

NCBI chr 1:111,101,327...111,123,400
Ensembl chr 1:111,101,329...111,123,634

G

superoxide dismutase 1

multiple interactions

Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]
Atenolol promotes the reaction [Thyroxine results in decreased expression of SOD1 protein]

PMID:2575990 PMID:11163531

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]
Atenolol inhibits the reaction [Thyroxine results in increased expression of SOD2 protein]

PMID:2575990 PMID:11163531

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

transient receptor potential cation channel, subfamily A, member 1

decreases response to substance

TRPA1 gene mutant form results in decreased susceptibility to Atenolol

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

thioredoxin 1

increases expression

Atenolol results in increased expression of TXN mRNA

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

bambuterol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

bambuterol results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

adrenoceptor beta 2

increases activity

bambuterol results in increased activity of ADRB2 protein

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

butyrylcholinesterase

decreases activity

bambuterol results in decreased activity of BCHE protein

PMID:15652380 PMID:18582854 PMID:18977317

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

bitolterol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 2

multiple interactions
increases activity

ICI 118551 inhibits the reaction [bitolterol results in increased activity of ADRB2 protein]

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

clenbuterol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA dehydrogenase medium chain

increases expression

Clenbuterol results in increased expression of ACADM mRNA

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

adrenoceptor beta 2

multiple interactions
increases activity

[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose; ICI 118551 inhibits the reaction [[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose]
Clenbuterol results in increased activity of ADRB2 protein

PMID:16007677 PMID:18552870 PMID:34601065

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

adrenoceptor beta 3

multiple interactions

Clenbuterol binds to and results in increased activity of ADRB3 protein

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

AKT serine/threonine kinase 1

multiple interactions

Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

multiple interactions

Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein]

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

AKT serine/threonine kinase 3

multiple interactions

Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein]

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

estrogen related receptor, alpha

increases expression

Clenbuterol results in increased expression of ESRRA mRNA

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

glutamate decarboxylase 1

multiple interactions

Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]; Clenbuterol inhibits the reaction [Reserpine results in increased expression of GAD1 mRNA]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]]

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

interleukin 10

multiple interactions
affects expression

Clenbuterol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL10 protein]
Clenbuterol affects the expression of IL10 protein

PMID:15021963 PMID:15502056

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

increases expression

Clenbuterol results in increased expression of IL18 mRNA; Clenbuterol results in increased expression of IL18 protein

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions

Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

NFKB inhibitor alpha

multiple interactions

Clenbuterol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

ornithine decarboxylase 1

multiple interactions
increases stability
increases activity

Alprenolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Metoprolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Propranolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]
Clenbuterol results in increased stability of ODC1 protein

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

pyruvate dehydrogenase kinase 4

increases expression

Clenbuterol results in increased expression of PDK4 mRNA

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850

G

PPARG coactivator 1 alpha

increases expression
multiple interactions

Clenbuterol results in increased expression of PPARGC1A mRNA
Propranolol inhibits the reaction [Clenbuterol results in increased expression of PPARGC1A mRNA]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein kinase cAMP-activated catalytic subunit alpha

multiple interactions

Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Clenbuterol affects the reaction [Lipopolysaccharides affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

transcription factor A, mitochondrial

increases expression

Clenbuterol results in increased expression of TFAM mRNA

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

tumor necrosis factor

multiple interactions

Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:15021963 PMID:15710352

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

uncoupling protein 1

increases expression

Clenbuterol results in increased expression of UCP1 protein

NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852

clorprenaline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 2

increases activity

clorprenaline results in increased activity of ADRB2 protein

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

solute carrier family 22 member 2

multiple interactions

clorprenaline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

dicyclomine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

diethanolamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2-associated agonist of cell death

decreases expression

diethanolamine results in decreased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

decreases expression

diethanolamine results in decreased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

calbindin 1

increases expression

diethanolamine results in increased expression of CALB1 mRNA

NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431

G

caspase 3

decreases expression
increases activity

diethanolamine results in decreased expression of CASP3 mRNA
diethanolamine results in increased activity of CASP3 protein

PMID:16014740 PMID:18948303

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin D2

increases expression

diethanolamine results in increased expression of CCND2 mRNA

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin E1

increases expression

diethanolamine results in increased expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin-dependent kinase inhibitor 1A

decreases expression

diethanolamine results in decreased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

decreases expression

diethanolamine results in decreased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

E2F transcription factor 1

increases expression

diethanolamine results in increased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

interleukin 2

multiple interactions

[diethanolamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

diethanolamine results in increased expression of RRM2B mRNA

NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633

G

tumor protein p53

decreases expression

diethanolamine results in decreased expression of TRP53 mRNA
diethanolamine results in decreased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

Wnt family member 1

increases expression

diethanolamine results in increased expression of WNT1 mRNA

NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651

esmolol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

esmolol results in decreased activity of ABCB4 protein

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

bone morphogenetic protein 6

increases expression

esmolol results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

epiregulin

increases expression

esmolol results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

heme oxygenase 1

multiple interactions

esmolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 1 alpha

increases expression

esmolol results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

esmolol results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

increases expression

esmolol results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

esmolol results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

phosphotyrosine interaction domain containing 1

increases expression

esmolol results in increased expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

prostaglandin-endoperoxide synthase 2

increases expression

esmolol results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

renin

multiple interactions

esmolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

secretory leukocyte peptidase inhibitor

increases expression

esmolol results in increased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

TNF alpha induced protein 6

increases expression

esmolol results in increased expression of TNFAIP6 mRNA

NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649

etanidazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

affects response to substance

CAT protein affects the susceptibility to Etanidazole

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

ethambutol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 2

multiple interactions

[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of ABCC2 protein

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

angiotensin converting enzyme 2

increases expression

Ethambutol results in increased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acyl-CoA synthetase long-chain family member 4

multiple interactions

[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of ACSL4 protein

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

bone morphogenetic protein 6

decreases expression

Ethambutol results in decreased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

caspase 3

multiple interactions

[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of CASP3

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of CAT protein; [isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in decreased activity of CAT protein

PMID:34118364 PMID:36878459

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

affects expression

Ethambutol affects the expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

affects expression

Ethambutol affects the expression of CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cathepsin D

multiple interactions

Ethambutol results in increased expression of and affects the localization of CTSD protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Ethambutol results in increased expression of and affects the localization of CTSD protein]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

Ethambutol results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

Ethambutol results in decreased activity of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

Ethambutol results in decreased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity
increases expression
multiple interactions

Ethambutol results in decreased activity of CYP2E1 protein
Ethambutol results in increased expression of CYP2E1 mRNA
[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Ethambutol results in increased expression of and results in increased activity of CYP2E1 protein; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]

PMID:24910189 PMID:27334974 PMID:27919644

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of CYP7A1 protein
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

glutamic--pyruvic transaminase

multiple interactions

[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPT protein; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein]

PMID:35835356 PMID:36878459

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 4

multiple interactions

[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein]

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

granzyme B

increases secretion

Ethambutol results in increased secretion of GZMB protein

NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of HIF1A mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of HIF1A protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein]; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein]; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

interferon gamma

increases secretion

Ethambutol results in increased secretion of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

decreases expression

Ethambutol results in decreased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

increases secretion

Ethambutol results in increased secretion of IL13 protein

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 alpha

increases expression

Ethambutol results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

decreases expression

Ethambutol results in decreased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

decreases expression

Ethambutol results in decreased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

lysosomal-associated membrane protein 2

increases expression
multiple interactions

Ethambutol results in increased expression of LAMP2 protein
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Ethambutol results in increased expression of LAMP2 protein]

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

leptin

decreases expression

Ethambutol results in decreased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Ethambutol results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

myeloperoxidase

multiple interactions

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] promotes the reaction [[isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in increased activity of MPO protein]; [isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in increased activity of MPO protein

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of NR1H4

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

phosphotyrosine interaction domain containing 1

increases expression

Ethambutol results in increased expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

solute carrier family 10 member 1

multiple interactions

[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of SLC10A1

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 7 member 11

increases expression
multiple interactions

Ethambutol results in increased expression of SLC7A11 mRNA
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein]

PMID:32816093 PMID:36878459

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

secretory leukocyte peptidase inhibitor

increases expression

Ethambutol results in increased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

ethanolamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein B

multiple interactions

[3-deazaadenosine co-treated with Ethanolamine] results in decreased secretion of APOB protein alternative form; [Bezafibrate co-treated with Ethanolamine] results in decreased secretion of APOB protein alternative form; [Clofibric Acid co-treated with Ethanolamine] results in decreased secretion of APOB protein alternative form

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein E

multiple interactions

[3-deazaadenosine co-treated with Ethanolamine] results in decreased secretion of APOE protein; [Bezafibrate co-treated with Ethanolamine] results in decreased secretion of APOE protein; [Clofibric Acid co-treated with Ethanolamine] results in decreased secretion of APOE protein

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

epidermal growth factor

increases activity

Ethanolamine results in increased activity of EGF protein

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

fibroblast growth factor 1

increases activity

Ethanolamine results in increased activity of FGF1 protein

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

pancreatic lipase related protein 2

increases metabolic processing

PNLIPRP2 protein results in increased metabolism of Ethanolamine

NCBI chr 1:257,897,766...257,916,434
Ensembl chr 1:257,897,766...257,916,434

indinavir

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity
multiple interactions

Indinavir results in decreased activity of ABCB11 protein
Indinavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

PMID:20829430 PMID:23956101 PMID:24014644 PMID:28437613

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

acetylcholinesterase

multiple interactions

Indinavir inhibits the reaction [Celecoxib results in increased activity of ACHE protein]; Indinavir inhibits the reaction [Streptozocin results in increased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

adiponectin, C1Q and collagen domain containing

decreases expression
multiple interactions

Indinavir results in decreased expression of ADIPOQ protein
Indinavir results in decreased expression of ADIPOQ mRNA; Indinavir results in decreased expression of ADIPOQ protein
diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of ADIPOQ protein]; Indinavir inhibits the reaction [ADIPOQ protein modified form results in increased uptake of Deoxyglucose]

PMID:15865214 PMID:17668557 PMID:29991592

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

AE binding protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of AEBP1 mRNA

NCBI chr14:80,738,800...80,748,878
Ensembl chr14:80,738,892...80,748,877

G

arachidonate 5-lipoxygenase activating protein

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNA

NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986

G

alkaline phosphatase, biomineralization associated

multiple interactions

AGN 193109 inhibits the reaction [Indinavir promotes the reaction [Tretinoin results in increased expression of ALPL protein]]; Indinavir promotes the reaction [Tretinoin results in increased expression of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

apolipoprotein B

decreases secretion

Indinavir results in decreased secretion of APOB protein

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein C3

decreases secretion
decreases expression

Indinavir results in decreased secretion of APOC3 protein
Indinavir results in decreased expression of APOC3 mRNA

NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583

G

cAMP regulated phosphoprotein 21

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNA

NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297

G

acid sensing ion channel subunit 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ASIC2 mRNA

NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ATP2A2 mRNA

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

complement C1r

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C1R mRNA

NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484

G

complement C3a receptor 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C3AR1 mRNA

NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701

G

C-C motif chemokine ligand 2

increases expression
multiple interactions

Indinavir results in increased expression of CCL2 protein
diphenyleneiodonium inhibits the reaction [Indinavir results in increased expression of CCL2 protein]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

increases expression

Indinavir results in increased expression of CCL3 protein

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

CD36 molecule

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

cell death-inducing DFFA-like effector c

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CIDEC mRNA

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

G

chloride voltage-gated channel 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CLCN3 mRNA

NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119

G

C-reactive protein

decreases expression

Indinavir results in decreased expression of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

decorin

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

DNA-damage inducible transcript 3

increases expression

Indinavir results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dual specificity phosphatase 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DUSP3 mRNA

NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression

Indinavir results in increased expression of EIF2AK3 mRNA

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

ELOVL fatty acid elongase 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ELOVL3 mRNA

NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115

G

estrogen receptor 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ESR2 mRNA

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

ETS variant transcription factor 6

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ETV6 mRNA

NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992

G

fatty acid desaturase 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FADS2 mRNA

NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789

G

Fas apoptotic inhibitory molecule

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of FAIM mRNA

NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562

G

fatty acid synthase

increases expression
multiple interactions

Indinavir results in increased expression of FASN mRNA
[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

G0/G1switch 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucosidase, alpha; neutral C

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of GANC mRNA

NCBI chr 3:107,353,369...107,406,104
Ensembl chr 3:107,353,369...107,405,241

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of GUCY1B1 mRNA

NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916

G

hydroxyacyl-CoA dehydrogenase

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of HADH mRNA

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of HCN1 mRNA

NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774

G

histone cluster 1 H4 family member B

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of H4C9 mRNA

NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370

G

heat shock protein family A (Hsp70) member 5

increases expression

Indinavir results in increased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

IKAROS family zinc finger 4

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of IKZF4 mRNA

NCBI chr 7:1,063,283...1,102,940
Ensembl chr 7:1,056,890...1,084,341

G

interleukin 6

multiple interactions
increases expression

diphenyleneiodonium inhibits the reaction [Indinavir results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

kelch-like family member 28

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of KLHL28 mRNA

NCBI chr 6:82,987,360...83,018,971
Ensembl chr 6:82,990,945...83,016,164

G

laminin subunit gamma 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of LAMC2 mRNA

NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200

G

leptin

multiple interactions
decreases expression

diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein]
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA

PMID:16931933 PMID:17668557

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

lipoprotein lipase

decreases activity
multiple interactions
increases expression

Indinavir results in decreased activity of LPL protein
[Stavudine co-treated with Lamivudine co-treated with Indinavir] affects the expression of LPL mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LPL mRNA
Indinavir results in increased expression of LPL mRNA

PMID:11741158 PMID:11786383

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

malic enzyme 1

multiple interactions

[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

MGAT4 family, member C

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MGAT4C mRNA

NCBI chr 7:36,709,564...37,485,810
Ensembl chr 7:37,260,321...37,474,571

G

matrix metallopeptidase 2

multiple interactions

Indinavir inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; Indinavir inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]; Indinavir inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

Indinavir inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Indinavir inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Indinavir inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

melanocortin 2 receptor accessory protein

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of MRAP mRNA

NCBI chr11:29,991,974...30,003,024
Ensembl chr11:29,992,034...30,003,024

G

microsomal triglyceride transfer protein

decreases expression

Indinavir results in decreased expression of MTTP mRNA

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

myogenic differentiation 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MYOD1 mRNA

NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554

G

nucleosome assembly protein 1-like 5

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NAP1L5 mRNA

NCBI chr 4:88,022,670...88,024,988
Ensembl chr 4:88,022,569...88,024,654

G

nocturnin

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of NOCT mRNA

NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400

G

natriuretic peptide A

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NPPA mRNA

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

nuclear respiratory factor 1

increases expression

Indinavir results in increased expression of NRF1 mRNA

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

nucleoporin 210

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NUP210 mRNA

NCBI chr 4:123,511,558...123,609,874
Ensembl chr 4:123,511,559...123,609,874

G

ornithine decarboxylase antizyme 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of OAZ3 mRNA

NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399

G

prolyl 4-hydroxylase subunit beta

increases expression

Indinavir results in increased expression of P4HB mRNA

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

protocadherin related 15

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PCDH15 mRNA

NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNA

NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125

G

PHD finger protein 6

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PHF6 mRNA

NCBI chr X:132,656,658...132,699,720
Ensembl chr X:132,656,672...132,699,127

G

p53-induced death domain protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIDD1 mRNA

NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699

G

piwi-like RNA-mediated gene silencing 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIWIL2 mRNA

NCBI chr15:45,431,402...45,498,034
Ensembl chr15:45,431,703...45,497,702

G

porcupine O-acyltransferase

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PPN mRNA

NCBI chr X:14,285,864...14,298,481
Ensembl chr X:14,285,871...14,298,481

G

POU class 5 homeobox 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of POU5F1 mRNA

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator-activated receptor gamma

decreases expression

Indinavir results in decreased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PR/SET domain 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNA

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

receptor accessory protein 6

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of REEP6 mRNA

NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597

G

ring finger protein 151

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of RNF151 mRNA

NCBI chr10:13,742,682...13,747,192
Ensembl chr10:13,742,682...13,745,000

G

RPA interacting protein

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of RPAIN mRNA

NCBI chr10:55,692,410...55,699,910
Ensembl chr10:55,692,417...55,699,933

G

S100 calcium binding protein A8

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

solute carrier family 25 member 19

multiple interactions

SLC25A19 protein affects the susceptibility to [Stavudine co-treated with Lamivudine co-treated with Indinavir]; SLC25A19 protein affects the susceptibility to [Zidovudine co-treated with Lamivudine co-treated with Indinavir]

NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447

G

solute carrier family 2 member 4

multiple interactions

[Indinavir results in decreased activity of SLC2A4 protein] inhibits the reaction [resveratrol results in increased uptake of Deoxyglucose]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

serine peptidase inhibitor, Kazal type 5

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of SPINK5 mRNA

NCBI chr18:36,264,452...36,333,143
Ensembl chr18:36,264,452...36,332,185

G

transcription factor AP-2 alpha

decreases expression

Indinavir results in decreased expression of TFAP2A mRNA

NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507

G

TIMP metallopeptidase inhibitor 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

tumor necrosis factor

multiple interactions

Indinavir inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tripartite motif-containing 42

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TRIM42 mRNA

NCBI chr 8:97,902,349...97,923,268
Ensembl chr 8:97,902,353...97,923,268

G

uncoupling protein 1

decreases expression

Indinavir results in decreased expression of UCP1 mRNA

NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852

G

Wnt family member 10A

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of WNT10A mRNA

NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400

lysophosphatidylethanolamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

baculoviral IAP repeat-containing 3

multiple interactions

lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of BIRC3 protein]

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

caspase 3

multiple interactions

lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]
lysophosphatidylethanolamine analog inhibits the reaction [Glycochenodeoxycholic Acid results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

CASP8 and FADD-like apoptosis regulator

multiple interactions
increases expression

lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of CFLAR mRNA]
lysophosphatidylethanolamine analog results in increased expression of CFLAR protein
Glycochenodeoxycholic Acid promotes the reaction [lysophosphatidylethanolamine analog results in increased expression of CFLAR protein]; lysophosphatidylethanolamine analog promotes the reaction [Glycochenodeoxycholic Acid results in increased expression of CFLAR protein]
lysophosphatidylethanolamine analog results in increased expression of CFLAR mRNA; lysophosphatidylethanolamine analog results in increased expression of CFLAR protein

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

glycogen synthase kinase 3 beta

multiple interactions

[lysophosphatidylethanolamine analog co-treated with cobaltous chloride] results in increased phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
increases expression

lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of and results in increased degradation of MCL1 protein]
lysophosphatidylethanolamine analog results in increased expression of MCL1 protein
lysophosphatidylethanolamine analog inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of and results in increased degradation of MCL1 protein]

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

nuclear receptor subfamily 5, group A, member 2

multiple interactions

[NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of lysophosphatidylethanolamine; [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of lysophosphatidylethanolamine analog

NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326

G

poly (ADP-ribose) polymerase 1

multiple interactions

lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in increased activity of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

tumor protein p53

multiple interactions

[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of lysophosphatidylethanolamine

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

metaproterenol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 2

decreases expression
increases activity
affects expression
increases phosphorylation
multiple interactions

Metaproterenol results in decreased expression of ADRB2 protein
Metaproterenol results in increased activity of ADRB2 protein
Metaproterenol affects the expression of ADRB2 mRNA
Metaproterenol results in increased phosphorylation of ADRB2 protein
[Metaproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; Metaproterenol binds to and results in increased activity of ADRB2 protein

PMID:16980553 PMID:24705868 PMID:34601065

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

BCL2 associated X, apoptosis regulator

increases expression

Metaproterenol results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

branched chain amino acid transaminase 1

increases expression

Metaproterenol results in increased expression of BCAT1 mRNA

NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597

G

BCL2, apoptosis regulator

decreases expression

Metaproterenol results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2 interacting protein 1

increases expression

Metaproterenol results in increased expression of BNIP1 protein

NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157

G

clusterin

increases expression

Metaproterenol results in increased expression of CLU protein

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

fatty acid binding protein 3

increases expression

Metaproterenol results in increased expression of FABP3 protein

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

four and a half LIM domains 1

increases expression

Metaproterenol results in increased expression of FHL1 mRNA

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

G

interleukin 1 alpha

decreases expression

Metaproterenol results in decreased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

decreases expression

Metaproterenol results in decreased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

LIM and cysteine-rich domains 1

increases expression

Metaproterenol results in increased expression of LMCD1 mRNA

NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046

G

phosphotyrosine interaction domain containing 1

increases expression

Metaproterenol results in increased expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

prostaglandin-endoperoxide synthase 2

decreases expression

Metaproterenol results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

Rho family GTPase 1

increases expression

Metaproterenol results in increased expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

serpin family E member 1

increases expression

Metaproterenol results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

secretory leukocyte peptidase inhibitor

increases expression

Metaproterenol results in increased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

secreted phosphoprotein 1

increases expression

Metaproterenol results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

transforming growth factor, beta 2

increases expression

Metaproterenol results in increased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

TIMP metallopeptidase inhibitor 1

increases expression

Metaproterenol results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

troponin I3, cardiac type

increases expression

Metaproterenol results in increased expression of TNNI3 protein

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

G

troponin T2, cardiac type

increases expression

Metaproterenol results in increased expression of TNNT2 protein

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

mirabegron

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

multiple interactions

mirabegron inhibits the reaction [Acetic Acid results in decreased secretion of ADIPOQ protein]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

AKT serine/threonine kinase 1

multiple interactions

mirabegron inhibits the reaction [Acetic Acid results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

caspase 3

multiple interactions

mirabegron inhibits the reaction [Acetic Acid results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

mirabegron inhibits the reaction [Acetic Acid results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

glutathione S-transferase mu 1

multiple interactions

mirabegron inhibits the reaction [Acetic Acid results in decreased expression of GSTM1 protein]

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

myeloperoxidase

multiple interactions

mirabegron inhibits the reaction [Acetic Acid results in increased expression of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

mirabegron inhibits the reaction [Acetic Acid results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

toll-like receptor 4

multiple interactions

mirabegron inhibits the reaction [Acetic Acid results in increased expression of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

N,N-dimethylethanolamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

Deanol inhibits the reaction [Metribolone results in increased activity of AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

N-methylethanolamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

histamine receptor H3

multiple interactions

N-methylaminoethanol binds to and results in decreased activity of HRH3 protein

NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642

octopamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 1

multiple interactions

Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein]

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

multiple interactions

Octopamine inhibits the reaction [Norepinephrine binds to ADRB2 protein]

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

adrenoceptor beta 3

increases activity
multiple interactions

Octopamine results in increased activity of ADRB3 protein
Octopamine inhibits the reaction [Norepinephrine binds to ADRB3 protein]

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

solute carrier family 6 member 2

multiple interactions

Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]

NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357

G

solute carrier family 6 member 3

multiple interactions

indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 6 member 4

multiple interactions

Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

G

trace-amine-associated receptor 1

multiple interactions
increases activity

[Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]

PMID:17234900 PMID:19725810

NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084

oleoyl ethanolamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases export

ABCB1 protein results in increased export of N-oleoylethanolamine

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

peroxisome proliferator activated receptor alpha

increases response to substance
multiple interactions

PPARA results in increased susceptibility to N-oleoylethanolamine
N-oleoylethanolamine binds to and results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

prostaglandin-endoperoxide synthase 2

decreases expression

N-oleoylethanolamine results in decreased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

olomoucine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin-dependent kinase 1

multiple interactions

olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; olomoucine inhibits the reaction [TP53 results in decreased phosphorylation of CDK1 protein]

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

decreases activity
multiple interactions

olomoucine results in decreased activity of CDK2 protein
olomoucine inhibits the reaction [CDK2 protein results in increased phosphorylation of TPI1 protein]

PMID:12387751 PMID:15026556 PMID:20149834

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

RB transcriptional corepressor 1

increases expression

olomoucine results in increased expression of RB1 mRNA; olomoucine results in increased expression of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

Sp1 transcription factor

increases expression

olomoucine results in increased expression of SP1 mRNA; olomoucine results in increased expression of SP1 protein

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

tumor protein p53

multiple interactions

olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; olomoucine inhibits the reaction [TP53 results in decreased phosphorylation of CDK1 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

triosephosphate isomerase 1

multiple interactions

olomoucine inhibits the reaction [CDK2 protein results in increased phosphorylation of TPI1 protein]

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

oxybuprocaine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor, mitochondria associated 1

increases expression

benoxinate results in increased expression of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

BCL2 associated X, apoptosis regulator

increases expression

benoxinate results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl2-like 1

decreases expression

benoxinate results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

caspase 2

increases activity

benoxinate results in increased activity of CASP2 protein

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

increases activity

benoxinate results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

benoxinate results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

potassium voltage-gated channel subfamily H member 2

decreases activity

benoxinate results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

nuclear receptor subfamily 1, group I, member 2

increases activity

benoxinate results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

solute carrier family 22 member 2

multiple interactions

benoxinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

palmitoyl ethanolamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases export

ABCB1 protein results in increased export of palmidrol

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

apolipoprotein B

affects folding

palmidrol affects the folding of APOB protein

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

aquaporin 3 (Gill blood group)

multiple interactions

[palmidrol co-treated with TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA]

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

G

aquaporin 4

affects expression

palmidrol affects the expression of AQP4 mRNA

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

claudin 3

multiple interactions
decreases expression

[TNF protein co-treated with IFNG protein co-treated with palmidrol] results in decreased expression of CLDN3 mRNA
palmidrol results in decreased expression of CLDN3 mRNA

NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001

G

claudin 5

decreases expression

palmidrol results in decreased expression of CLDN5 mRNA

NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992

G

cannabinoid receptor 1

multiple interactions

[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to palmidrol analog

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

cannabinoid receptor 2

affects binding
multiple interactions

palmidrol binds to CNR2 protein
[SR 144528 binds to and results in decreased activity of CNR2 protein] which results in decreased susceptibility to palmidrol analog

PMID:10617657 PMID:10688601 PMID:17558434

NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548

G

glutathione S-transferase alpha 1

multiple interactions

palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of GSTA1 protein]

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

interferon gamma

multiple interactions

[palmidrol co-treated with TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA; [TNF protein co-treated with IFNG protein co-treated with palmidrol] results in decreased expression of CLDN3 mRNA; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of TRPV1 mRNA]; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

multiple interactions

[hempseed oil co-treated with palmidrol] results in decreased expression of IL10 mRNA

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 6

multiple interactions

[hempseed oil co-treated with palmidrol] results in decreased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

lipocalin 2

multiple interactions

palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of LCN2 protein]

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

peroxisome proliferator activated receptor alpha

multiple interactions
affects localization

[MK-886 binds to and results in decreased activity of PPARA protein] which results in decreased susceptibility to palmidrol analog; [palmidrol co-treated with glyceryl 2-arachidonate] affects the localization of PPARA protein; [palmidrol co-treated with glyceryl 2-arachidonate] affects the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of PPARA protein]
palmidrol affects the localization of PPARA protein

PMID:17558434 PMID:31787870

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

tumor necrosis factor

multiple interactions

[palmidrol co-treated with TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA; [TNF protein co-treated with IFNG protein co-treated with palmidrol] results in decreased expression of CLDN3 mRNA; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of TRPV1 mRNA]; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of TRPV1 mRNA]

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

penbutolol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

Penbutolol results in decreased activity of ABCB4 protein

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

bone morphogenetic protein 6

increases expression

Penbutolol results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

epiregulin

increases expression

Penbutolol results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

interleukin 1 alpha

increases expression

Penbutolol results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

Penbutolol results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

increases expression

Penbutolol results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Penbutolol results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

phosphotyrosine interaction domain containing 1

increases expression

Penbutolol results in increased expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

prostaglandin-endoperoxide synthase 2

increases expression

Penbutolol results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

solute carrier family 7 member 11

increases expression

Penbutolol results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

secretory leukocyte peptidase inhibitor

increases expression

Penbutolol results in increased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

perphenazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carboxylesterase 1D

multiple interactions

Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Perphenazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

follicle stimulating hormone subunit beta

decreases expression

Perphenazine results in decreased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

Perphenazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Perphenazine results in decreased activity of KCNH2 protein

PMID:21158687 PMID:28551711

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

luteinizing hormone subunit beta

decreases expression

Perphenazine results in decreased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

prolactin

increases expression

Perphenazine results in increased expression of PRL protein

PMID:6770916 PMID:7262630 PMID:17335319

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

solute carrier family 22 member 2

multiple interactions

Perphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

troponin I3, cardiac type

increases expression

Perphenazine results in increased expression of TNNI3 protein

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

phenylephrine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 9

decreases expression

Phenylephrine results in decreased expression of ABCC9 mRNA

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

G

abhydrolase domain containing 2, acylglycerol lipase

increases expression

Phenylephrine results in increased expression of ABHD2 mRNA

NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions
increases phosphorylation
affects response to substance

ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]
Phenylephrine results in increased phosphorylation of ABL1 protein
ABL1 protein affects the susceptibility to Phenylephrine

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

ankyrin repeat and BTB domain containing 3

decreases expression

Phenylephrine results in decreased expression of ABTB3 mRNA

NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834

G

acyl-CoA dehydrogenase medium chain

multiple interactions
decreases expression

AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of ACADM mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of ACADM mRNA]

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acetyl-CoA acetyltransferase 2

increases expression

Phenylephrine results in increased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

angiotensin I converting enzyme

affects response to substance

ACE protein affects the susceptibility to Phenylephrine

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acyl-CoA thioesterase 2

increases expression

Phenylephrine results in increased expression of ACOT2 mRNA

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

actin, alpha 1, skeletal muscle

multiple interactions
increases expression

[Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]

PMID:10642269 PMID:10710348 PMID:11230109 PMID:11499749 PMID:11513749 More...

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin alpha 2, smooth muscle

multiple interactions
increases expression

MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA]

PMID:16556869 PMID:18158353

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin related protein 3

increases expression

Phenylephrine results in increased expression of ACTR3 mRNA

NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124

G

ADAM metallopeptidase domain 17

multiple interactions

ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]

NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639

G

adenylate cyclase 5

increases response to substance

ADCY5 protein results in increased susceptibility to Phenylephrine

NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974

G

alcohol dehydrogenase, iron containing, 1

decreases expression

Phenylephrine results in decreased expression of ADHFE1 mRNA

NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517

G

adrenomedullin

multiple interactions
decreases response to substance
decreases expression
decreases secretion
increases expression

[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
ADM protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in decreased expression of ADM mRNA
Phenylephrine results in decreased secretion of ADM protein
Phenylephrine results in increased expression of ADM mRNA; Phenylephrine results in increased expression of ADM protein

PMID:11470465 PMID:15370692 PMID:17250927

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adenosine A1 receptor

multiple interactions
increases expression

1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]
Phenylephrine results in increased expression of ADORA1 mRNA; Phenylephrine results in increased expression of ADORA1 protein

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2a receptor

multiple interactions
increases expression

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]
Phenylephrine results in increased expression of ADORA2A mRNA; Phenylephrine results in increased expression of ADORA2A protein

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adenosine A3 receptor

multiple interactions
increases expression

2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
Phenylephrine results in increased expression of ADORA3 mRNA; Phenylephrine results in increased expression of ADORA3 protein

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

ADP-ribosylhydrolase like 1

increases expression

Phenylephrine results in increased expression of ADPRHL1 mRNA

NCBI chr16:76,283,186...76,315,075
Ensembl chr16:76,283,103...76,354,440

G

adrenoceptor alpha 1A

multiple interactions
increases activity
affects activity
increases response to substance
affects binding
affects response to substance

5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]; [KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the abundance of Phosphatidylinositol 4,5-Diphosphate; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Phenylephrine binds to and results in increased activity of ADRA1A protein; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]; Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Ro 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]
8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; [Phenylephrine affects the activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased transport of Glucose; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; GR 127935 promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Granisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Phenylephrine binds to and results in increased activity of ADRA1A protein
ADRA1A protein results in increased susceptibility to Phenylephrine
Phenylephrine binds to ADRA1A protein
ADRA1A protein affects the susceptibility to Phenylephrine

PMID:8183249 PMID:11709419 PMID:12935885 PMID:15306222 PMID:15365637 More...

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

adrenoceptor alpha 1B

affects response to substance
increases response to substance
multiple interactions
decreases expression
increases activity

ADRA1B protein affects the susceptibility to Phenylephrine
ADRA1B protein results in increased susceptibility to Phenylephrine
[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein; [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein
4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; chlorethylclonidine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; Estradiol promotes the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]
Phenylephrine results in decreased expression of ADRA1B mRNA; Phenylephrine results in decreased expression of ADRA1B protein
Phenylephrine results in increased activity of ADRA1B protein
[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]

PMID:10801782 PMID:11499749 PMID:11693201 PMID:15306222 PMID:16498073 More...

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

G

adrenoceptor alpha 1D

affects response to substance
increases activity
affects binding
multiple interactions
increases response to substance

ADRA1D protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased activity of ADRA1D protein
Phenylephrine binds to ADRA1D protein
[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]
BMY 7378 inhibits the reaction [ADRA1D protein results in increased susceptibility to Phenylephrine]; Phenylephrine binds to and results in increased activity of ADRA1D protein
ADRA1D affects the susceptibility to Phenylephrine

PMID:8183249 PMID:11901185 PMID:15306222 PMID:15493479 PMID:16371063 More...

NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354

G

adrenoceptor alpha 2A

multiple interactions

Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]; Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]]

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

adrenoceptor alpha 2B

affects response to substance
multiple interactions

ADRA2B protein affects the susceptibility to Phenylephrine
ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]

NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355

G

adrenoceptor beta 2

multiple interactions

[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; CGP 20712A inhibits the reaction [[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

adrenoceptor beta 3

multiple interactions
increases response to substance

amibegron inhibits the reaction [ADRB3 protein results in increased susceptibility to Phenylephrine]

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

angiotensinogen

affects response to substance
increases response to substance
multiple interactions
increases expression

AGT protein affects the susceptibility to Phenylephrine
AGT protein modified form results in increased susceptibility to Phenylephrine
AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]; carvedilol inhibits the reaction [AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]]; carvedilol inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]; irbesartan inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
Phenylephrine results in increased expression of AGT mRNA; Phenylephrine results in increased expression of AGT protein
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]

PMID:2298476 PMID:7900855 PMID:16251426 PMID:16794485 PMID:27094369

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 2

multiple interactions
affects response to substance

[CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine
AGTR2 protein affects the susceptibility to Phenylephrine

PMID:11714657 PMID:19151255

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

apoptosis inducing factor, mitochondria associated 1

increases expression

Phenylephrine results in increased expression of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

adenylate kinase 4

increases expression

Phenylephrine results in increased expression of AK4 mRNA

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation
affects phosphorylation

Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
Phenylephrine affects the phosphorylation of AKT1 protein

PMID:10679475 PMID:18084315 PMID:28759639

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 18 family, member A1

increases expression

Phenylephrine results in increased expression of ALDH18A1 mRNA

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

angiopoietin 1

multiple interactions
increases expression

ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
Phenylephrine results in increased expression of ANGPT1 mRNA; Phenylephrine results in increased expression of ANGPT1 protein

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

angiopoietin-like 4

decreases expression

Phenylephrine results in decreased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

apolipoprotein E

affects response to substance

APOE protein affects the susceptibility to Phenylephrine

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

amphiregulin

increases expression

Phenylephrine results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

Rho guanine nucleotide exchange factor 12

decreases expression

Phenylephrine results in decreased expression of ARHGEF12 mRNA

NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:43,353,799...43,476,366

G

arrestin domain containing 3

decreases expression

Phenylephrine results in decreased expression of ARRDC3 mRNA

NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978

G

ankyrin repeat and SOCS box-containing 18

decreases expression

Phenylephrine results in decreased expression of ASB18 mRNA

NCBI chr 9:90,531,350...90,595,953
Ensembl chr 9:90,531,596...90,595,848

G

ankyrin repeat and SOCS box-containing 4

increases expression

Phenylephrine results in increased expression of ASB4 mRNA

NCBI chr 4:33,506,992...33,544,630
Ensembl chr 4:33,506,992...33,544,630

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Phenylephrine results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 5

increases expression

Phenylephrine results in increased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

Phenylephrine results in increased expression of ATP1B1 mRNA

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions
decreases expression
affects response to substance
increases expression
decreases activity

[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein
Phenylephrine results in decreased expression of ATP2A2 mRNA; Phenylephrine results in decreased expression of ATP2A2 protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of ATP2A2 protein]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in decreased expression of ATP2A2 protein] which results in decreased transport of Calcium; Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]
ATP2A2 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of ATP2A2 mRNA
Phenylephrine results in decreased activity of ATP2A2 protein

PMID:11499749 PMID:11577024 PMID:15795322 PMID:16236312 PMID:17287366 More...

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

ATPase plasma membrane Ca2+ transporting 4

increases response to substance

ATP2B4 protein results in increased susceptibility to Phenylephrine

NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246

G

ATPase phospholipid transporting 9A (putative)

increases expression

Phenylephrine results in increased expression of ATP9A mRNA

NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818

G

ataxin 1

multiple interactions

Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to ATXN1 protein]]

NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360

G

activator of transcription and developmental regulator AUTS2

decreases expression

Phenylephrine results in decreased expression of AUTS2 mRNA

NCBI chr12:24,104,187...25,194,123
Ensembl chr12:24,104,192...25,194,416

G

arginine vasopressin

multiple interactions
increases secretion

Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of AVP protein]; bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dexamethasone inhibits the reaction [Phenylephrine results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]

PMID:2271928 PMID:11102496

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

arginine vasopressin-induced 1

increases expression

Phenylephrine results in increased expression of AVPI1 mRNA

NCBI chr 1:240,930,236...240,936,154
Ensembl chr 1:240,930,236...240,936,154

G

BCL2-associated agonist of cell death

increases expression

Phenylephrine results in increased expression of BAD protein

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BMP and activin membrane-bound inhibitor

increases expression

Phenylephrine results in increased expression of BAMBI mRNA

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

BCL2 associated X, apoptosis regulator

decreases expression
increases expression
multiple interactions

Phenylephrine results in decreased expression of BAX protein
Phenylephrine results in increased expression of BAX protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]

PMID:19910689 PMID:31605733

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCAR1 scaffold protein, Cas family member

multiple interactions
increases phosphorylation

ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

branched chain keto acid dehydrogenase E1 subunit alpha

decreases expression

Phenylephrine results in decreased expression of BCKDHA mRNA

NCBI chr 1:81,138,946...81,167,765
Ensembl chr 1:81,138,947...81,167,862

G

BCL2, apoptosis regulator

multiple interactions
decreases expression
increases expression

BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; Phenylephrine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]
Phenylephrine results in decreased expression of BCL2 protein
Phenylephrine results in increased expression of BCL2 mRNA; Phenylephrine results in increased expression of BCL2 protein

PMID:11042672 PMID:19910689 PMID:31605733 PMID:35979984

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

Phenylephrine inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 protein]
Phenylephrine results in decreased expression of BCL2L1 protein

PMID:11042672 PMID:31605733 PMID:35979984

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

3-hydroxybutyrate dehydrogenase 1

increases expression

Phenylephrine results in increased expression of BDH1 mRNA

NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671

G

3-hydroxybutyrate dehydrogenase 2

decreases expression

Phenylephrine results in decreased expression of BDH2 mRNA

NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072

G

bradykinin receptor B2

affects response to substance
increases expression

BDKRB2 affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of BDKRB2 mRNA

PMID:10614985 PMID:18158353

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

brain-derived neurotrophic factor

increases expression

Phenylephrine results in increased expression of BDNF mRNA

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

bone morphogenetic protein 2

increases expression

phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes

RGD

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 4

increases expression

phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes

RGD

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

bone morphogenetic protein 7

decreases expression
increases expression

Phenylephrine results in decreased expression of BMP7 mRNA
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes

CTD
RGD

PMID:18158353 PMID:26873969

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

BCL2 interacting protein 3 like

increases expression

Phenylephrine results in increased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

boule homolog, RNA binding protein

decreases expression

Phenylephrine results in decreased expression of BOLL mRNA

NCBI chr 9:56,734,890...56,859,917
Ensembl chr 9:56,733,584...56,859,916

G

bromodomain containing 4

multiple interactions
increases expression

Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]
Phenylephrine results in increased expression of BRD4 protein

NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539

G

BTG anti-proliferation factor 3

increases expression

Phenylephrine results in increased expression of BTG3 mRNA

NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170

G

calcineurin binding protein 1

multiple interactions

CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein]

PMID:10655507 PMID:17060317

NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357

G

calcium dependent secretion activator

decreases expression

Phenylephrine results in decreased expression of CADPS mRNA

NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779

G

calcitonin-related polypeptide alpha

affects response to substance

CALCA protein affects the susceptibility to Phenylephrine

PMID:11728430 PMID:18055875

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

calcitonin receptor like receptor

multiple interactions

[Phenylephrine co-treated with Isoproterenol] results in increased expression of CALCRL mRNA

NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910

G

calcium/calmodulin-dependent protein kinase II alpha

decreases expression

Phenylephrine results in decreased expression of CAMK2A mRNA

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

calcium/calmodulin-dependent protein kinase II delta

multiple interactions

CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein]

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

G

carbonic anhydrase 1

decreases activity

Phenylephrine results in decreased activity of CA1 protein

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

G

carbonic anhydrase 2

increases expression
decreases activity

Phenylephrine results in increased expression of CAR2 mRNA; Phenylephrine results in increased expression of CAR2 protein
Phenylephrine results in decreased activity of CA2 protein

PMID:17124262 PMID:28800181

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 4

increases expression

Phenylephrine results in increased expression of CA4 protein

NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501

G

caspase 2

affects activity

Phenylephrine affects the activity of CASP2 protein

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

multiple interactions
increases activity

Phenylephrine inhibits the reaction [Oxygen deficiency results in increased activity of CASP3 protein]
Phenylephrine results in increased activity of CASP3 protein

PMID:11042672 PMID:31605733

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

affects activity

Phenylephrine affects the activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

Phenylephrine results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

calcium-sensing receptor

multiple interactions

Phenylephrine inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]

NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811

G

catalase

multiple interactions
decreases expression

CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in decreased expression of CAT protein

PMID:16513848 PMID:18171680 PMID:20886221

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

multiple interactions

Sodium, Dietary affects the reaction [CAV1 protein results in increased susceptibility to Phenylephrine]

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

caveolin 3

multiple interactions
decreases response to substance
affects localization

CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CAV3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine affects the localization of CAV3 protein

PMID:12847114 PMID:19299911

NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]
Phenylephrine results in increased expression of CCL2 mRNA; Phenylephrine results in increased expression of CCL2 protein

PMID:15721863 PMID:15728586

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 27

increases expression

Phenylephrine results in increased expression of CCL27 mRNA

NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506

G

cellular communication network factor 1

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; calphostin C inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]
Phenylephrine results in increased expression of CCN1 mRNA; Phenylephrine results in increased expression of CCN1 protein

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cellular communication network factor 2

increases expression

Phenylephrine results in increased expression of CCN2 mRNA; Phenylephrine results in increased expression of CCN2 protein

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin D1

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND1 protein]

PMID:12163013 PMID:15603588

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

increases expression

Phenylephrine results in increased expression of CCND2 protein

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin D3

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND3 protein]

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin T1

multiple interactions

Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein]

NCBI chr 7:129,687,146...129,718,080
Ensembl chr 7:129,691,209...129,717,871

G

Cd200 molecule

decreases expression

Phenylephrine results in decreased expression of CD200 mRNA

NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648

G

cadherin 2

increases expression

Phenylephrine results in increased expression of CDH2 protein

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin dependent kinase 2

increases expression

Phenylephrine results in increased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

increases expression

Phenylephrine results in increased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

increases expression
increases stability

Phenylephrine results in increased expression of CDKN1A mRNA; Phenylephrine results in increased expression of CDKN1A protein
Phenylephrine results in increased stability of CDKN1A mRNA

PMID:10766810 PMID:15603588

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression

Phenylephrine results in increased expression of CDKN1B

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

CCAAT/enhancer binding protein alpha

decreases expression

Phenylephrine results in decreased expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CF transmembrane conductance regulator

multiple interactions

[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein; [Phenylephrine co-treated with 6-hydroxy-10-chlorobenzo(c)quinolizinium] results in increased activity of CFTR protein; Glyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

coiled-coil-helix-coiled-coil-helix domain containing 6

increases expression

Phenylephrine results in increased expression of CHCHD6 mRNA

NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216

G

chloride intracellular channel 2

decreases expression

Phenylephrine results in decreased expression of CLIC2 mRNA

NCBI chr20:149,337...164,375
Ensembl chr20:148,907...164,355

G

chloride intracellular channel 4

increases expression

Phenylephrine results in increased expression of CLIC4 mRNA

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

G

clusterin

increases expression

Phenylephrine results in increased expression of CLU mRNA; Phenylephrine results in increased expression of CLU protein

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

calponin 1

increases expression

Phenylephrine results in increased expression of CNN1 mRNA

NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098

G

collagen type XVIII alpha 1 chain

decreases expression

Phenylephrine results in decreased expression of COL18A1 mRNA

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

collectin sub-family member 12

decreases expression

Phenylephrine results in decreased expression of COLEC12 mRNA

NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618

G

corin, serine peptidase

increases expression

Phenylephrine results in increased expression of CORIN mRNA

NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503

G

cytochrome c oxidase copper chaperone COX11

decreases expression
multiple interactions

Phenylephrine results in decreased expression of COX11 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]

PMID:23818984 PMID:25107896

NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322

G

cytochrome c oxidase copper chaperone COX17

multiple interactions
decreases expression

Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]

PMID:23818984 PMID:25107896

NCBI chr11:62,400,733...62,406,507

G

cytochrome c oxidase subunit 4i1

decreases expression
multiple interactions

Phenylephrine results in decreased expression of COX4I1 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]

NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921

G

carnitine palmitoyltransferase 1B

multiple interactions
decreases expression
increases expression

4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B protein]
Phenylephrine results in decreased expression of CPT1B mRNA; Phenylephrine results in decreased expression of CPT1B protein
Phenylephrine results in increased expression of CPT1B mRNA

PMID:11879187 PMID:15721863 PMID:19699196

NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404

G

cAMP responsive element binding protein 1

multiple interactions

adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Propranolol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]

PMID:14741741 PMID:15522277

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

CREB binding protein

multiple interactions
increases response to substance

[Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of CREBBP protein; Phenylephrine results in increased phosphorylation of and results in increased activity of CREBBP protein
CREBBP protein results in increased susceptibility to Phenylephrine

PMID:11705990 PMID:12477714 PMID:15006641 PMID:15522277 PMID:19966502

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

cAMP responsive element modulator

increases expression

Phenylephrine results in increased expression of CREM mRNA

PMID:12791704 PMID:18158353

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

CRK proto-oncogene, adaptor protein

multiple interactions

ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]

NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406

G

casein kinase 2 alpha 1

decreases expression

Phenylephrine results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

chondroitin sulfate proteoglycan 4

increases expression

Phenylephrine results in increased expression of CSPG4 mRNA

NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010

G

cysteine and glycine-rich protein 2

increases expression

Phenylephrine results in increased expression of CSRP2 mRNA

NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745

G

cysteine and glycine rich protein 3

increases localization

Phenylephrine results in increased localization of CSRP3 protein

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

G

cystathionine gamma-lyase

increases activity

Phenylephrine results in increased activity of CTH protein

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

catenin beta 1

multiple interactions

Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin C

decreases expression

Phenylephrine results in decreased expression of CTSC mRNA

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

C-X-C motif chemokine ligand 1

decreases expression

Phenylephrine results in decreased expression of CXCL1 mRNA

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

decreases expression

Phenylephrine results in decreased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 11

decreases expression

Phenylephrine results in decreased expression of CXCL11 mRNA

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271

G

CXXC finger protein 4

decreases expression

Phenylephrine results in decreased expression of CXXC4 mRNA

NCBI chr 2:222,664,148...222,689,365
Ensembl chr 2:222,664,771...222,689,365

G

cytochrome P450, family 11, subfamily b, polypeptide 3

increases expression

Phenylephrine results in increased expression of CYP11B2 mRNA

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 26, subfamily b, polypeptide 1

increases expression

Phenylephrine results in increased expression of CYP26B1 mRNA

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions
increases response to substance
affects response to substance

20-hydroxy-5,8,11,14-eicosatetraenoic acid affects the reaction [CYP4A1 protein affects the susceptibility to Phenylephrine]; 20-hydroxy-5,8,11,14-eicosatetraenoic acid inhibits the reaction [DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]]; 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]; DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]

PMID:11124159 PMID:12388396

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 51

increases expression

Phenylephrine results in increased expression of CYP51 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

death associated protein kinase 1

decreases expression

Phenylephrine results in decreased expression of DAPK1 mRNA

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

diacylglycerol kinase epsilon

multiple interactions

DGKE protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein]

NCBI chr10:73,853,030...73,877,334
Ensembl chr10:73,855,583...73,877,100

G

diacylglycerol kinase zeta

multiple interactions

DGKZ protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:77,904,150...77,946,099

G

7-dehydrocholesterol reductase

increases expression

Phenylephrine results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

iodothyronine deiodinase 2

increases activity
increases expression

Phenylephrine results in increased activity of DIO2 protein
Phenylephrine results in increased expression of DIO2 mRNA

NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809

G

dynein, axonemal, heavy chain 12

decreases expression

Phenylephrine results in decreased expression of DNAH12 mRNA

NCBI chr16:1,936,354...2,092,663
Ensembl chr16:1,937,817...2,092,664

G

DnaJ heat shock protein family (Hsp40) member B5

increases expression

Phenylephrine results in increased expression of DNAJB5 mRNA

NCBI chr 5:57,176,840...57,186,067
Ensembl chr 5:57,176,845...57,185,490

G

dynamin 1-like

increases expression
multiple interactions

Phenylephrine results in increased expression of DNM1L protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

dermatopontin

decreases expression

Phenylephrine results in decreased expression of DPT mRNA

NCBI chr13:77,123,224...77,151,646
Ensembl chr13:77,123,115...77,151,639

G

dual specificity phosphatase 1

increases expression

Phenylephrine results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 6

multiple interactions

DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

E2F transcription factor 3

increases expression

Phenylephrine results in increased expression of E2F3 protein

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

E2F transcription factor 4

increases expression

Phenylephrine results in increased expression of E2F4 protein

NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806

G

E2F transcription factor 5

increases expression

Phenylephrine results in increased expression of E2F5 protein

NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990

G

endothelin converting enzyme 1

increases expression

Phenylephrine results in increased expression of ECE1 mRNA

NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371

G

extracellular matrix protein 1

increases expression

Phenylephrine results in increased expression of ECM1 mRNA

NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671

G

endothelial differentiation-related factor 1

multiple interactions
increases expression
affects response to substance

MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]
Phenylephrine results in increased expression of MBF1
MBF1 protein affects the susceptibility to Phenylephrine

NCBI chr 3:8,377,058...8,381,363
Ensembl chr 3:8,366,613...8,381,363

G

endothelin 1

multiple interactions
increases response to substance
increases expression

EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Polyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EDN1 mRNA; Phenylephrine results in increased expression of EDN1 protein

PMID:10788492 PMID:11739382 PMID:12724418 PMID:15007106 PMID:15220332 More...

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

multiple interactions

[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Phenylephrine; phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein]

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

endothelin receptor type B

increases expression

Phenylephrine results in increased expression of EDNRB protein

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

epidermal growth factor

multiple interactions

[EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions
increases phosphorylation

Atorvastatin inhibits the reaction [Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein]; Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein
Phenylephrine results in increased phosphorylation of EGFR protein
[EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]

PMID:14676212 PMID:16760267 PMID:18360054

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 3

increases expression

Phenylephrine results in increased expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

early growth response 1

multiple interactions
increases expression

EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]
Phenylephrine results in increased expression of EGR1; Phenylephrine results in increased expression of EGR1 mRNA
Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter]

PMID:7905536 PMID:10710348 PMID:10779383 PMID:15621046

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 4E

multiple interactions
increases phosphorylation

CGP 57380 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
increases phosphorylation

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]

PMID:12411397 PMID:12720544 PMID:12935885 PMID:15757502

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

ETS transcription factor ELK1

multiple interactions
increases phosphorylation
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]
Phenylephrine results in increased phosphorylation of ELK1 protein

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

ELOVL fatty acid elongase 5

increases expression

Phenylephrine results in increased expression of ELOVL5 mRNA

NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284

G

enolase 2

increases expression

Phenylephrine results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

enolase 3

increases expression

Phenylephrine results in increased expression of ENO3 mRNA

NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921

G

E1A binding protein p300

multiple interactions
increases expression
increases response to substance

EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EP300 mRNA; Phenylephrine results in increased expression of EP300 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA]; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; anacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of EP300 protein; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]
EP300 protein results in increased susceptibility to Phenylephrine

PMID:11705990 PMID:12477714 PMID:12724418 PMID:15006641 PMID:15220332 More...

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

endothelial PAS domain protein 1

decreases expression

Phenylephrine results in decreased expression of EPAS1 mRNA

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

erythrocyte membrane protein band 4.1 like 4B

increases expression

Phenylephrine results in increased expression of EPB41L4B mRNA

NCBI chr 5:71,691,706...71,852,583
Ensembl chr 5:71,694,331...71,851,990

G

Eph receptor A4

decreases expression

Phenylephrine results in decreased expression of EPHA4 mRNA

NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139

G

epoxide hydrolase 2

decreases expression

Phenylephrine results in decreased expression of EPHX2 mRNA

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

estrogen receptor 1

multiple interactions

ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Nitroprusside]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

EYA transcriptional coactivator and phosphatase 2

multiple interactions

EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]

NCBI chr 3:154,335,598...154,519,006
Ensembl chr 3:154,335,400...154,518,793

G

fatty acid binding protein 4

decreases expression

Phenylephrine results in decreased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid desaturase 3

increases expression

Phenylephrine results in increased expression of FADS3 mRNA

NCBI chr 1:206,685,667...206,702,538
Ensembl chr 1:206,685,894...206,704,769

G

family with sequence similarity 110, member B

decreases expression

Phenylephrine results in decreased expression of FAM110B mRNA

NCBI chr 5:18,789,362...18,929,647
Ensembl chr 5:18,789,389...18,929,828

G

fibrillin 1

multiple interactions

FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Epoprostenol metabolite]; FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Thromboxane A2 metabolite]; FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine]

NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889

G

ferredoxin 1

increases expression

Phenylephrine results in increased expression of FDX1 mRNA

NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414

G

fibroblast growth factor 12

increases expression

Phenylephrine results in increased expression of FGF12 mRNA

NCBI chr11:71,997,151...72,564,757
Ensembl chr11:71,997,099...72,562,607

G

fibroblast growth factor 18

increases expression

Phenylephrine results in increased expression of FGF18 mRNA

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818

G

fibroblast growth factor 2

multiple interactions

Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter]

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

four and a half LIM domains 1

increases expression

Phenylephrine results in increased expression of FHL1 mRNA

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

G

four and a half LIM domains 2

decreases response to substance

FHL2 gene mutant form results in decreased susceptibility to Phenylephrine

NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192

G

fission, mitochondrial 1

increases expression
multiple interactions

Phenylephrine results in increased expression of FIS1 protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]

NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377

G

Fms related receptor tyrosine kinase 1

multiple interactions
increases expression

FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of FLT1 protein

PMID:19542178 PMID:24903162

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

fibronectin 1

increases expression

Phenylephrine results in increased expression of FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
affects expression
affects response to substance
increases expression

[Phenylephrine co-treated with Isoproterenol] results in increased expression of FOS mRNA; U 0126 inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]
Phenylephrine affects the expression of FOS protein
FOS protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of FOS; Phenylephrine results in increased expression of FOS mRNA; Phenylephrine results in increased expression of FOS protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; [Phenylephrine co-treated with Adenosine Triphosphate] results in increased expression of FOS mRNA; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]; Troglitazone inhibits the reaction [Phenylephrine results in increased expression of FOS protein]

PMID:7844257 PMID:7900855 PMID:7905536 PMID:8750937 PMID:8809800 More...

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases activity
increases expression

Phenylephrine results in increased activity of FOSB protein
Phenylephrine results in increased expression of FOSB

PMID:7905536 PMID:15949472

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

forkhead box O1

multiple interactions

Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]; Phenylephrine results in increased expression of and results in decreased phosphorylation of and affects the localization of FOXO1 protein

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

follistatin like 3

affects expression

Phenylephrine affects the expression of FSTL3 mRNA

NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:9,923,576...9,939,639

G

FXYD domain-containing ion transport regulator 5

increases expression

Phenylephrine results in increased expression of FXYD5 mRNA

NCBI chr 1:86,267,937...86,277,329
Ensembl chr 1:86,267,406...86,277,519

G

polypeptide N-acetylgalactosaminyltransferase 13

decreases expression

Phenylephrine results in decreased expression of GALNT13 mRNA

NCBI chr 3:38,903,695...39,560,683
Ensembl chr 3:38,974,490...39,558,803

G

guanidinoacetate N-methyltransferase

decreases expression

Phenylephrine results in decreased expression of GAMT mRNA

NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778

G

GATA binding protein 4

multiple interactions
increases activity
increases expression
increases acetylation
affects response to substance

EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of GATA4 protein
Phenylephrine results in increased acetylation of GATA4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; MAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of GATA4 protein; Y 27632 inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]
GATA4 protein affects the susceptibility to Phenylephrine
[Phenylephrine co-treated with Isoproterenol] results in increased expression of GATA4 mRNA

PMID:10710348 PMID:10788492 PMID:11739382 PMID:12724418 PMID:15220332 More...

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

G

growth differentiation factor 15

affects expression

Phenylephrine affects the expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

gamma-glutamyltransferase 1

multiple interactions

Phenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

gap junction protein, alpha 1

multiple interactions
increases expression
affects response to substance

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]
Phenylephrine results in increased expression of GJA1 mRNA; Phenylephrine results in increased expression of GJA1 protein
GJA1 protein affects the susceptibility to Phenylephrine

PMID:16352648 PMID:18445782 PMID:18593691

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, alpha 5

decreases expression

Phenylephrine results in decreased expression of GJA5 mRNA

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

G

galactosidase, alpha

affects response to substance

GLA protein affects the susceptibility to Phenylephrine

NCBI chr X:97,769,227...97,780,646
Ensembl chr X:97,768,996...97,780,664

G

glutaredoxin 3

affects response to substance
increases expression
multiple interactions

GLRX3 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of GLRX3 mRNA
GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]

NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010

G

glia maturation factor, gamma

increases expression

Phenylephrine results in increased expression of GMFG mRNA

NCBI chr 1:83,728,797...83,739,189
Ensembl chr 1:83,728,776...83,739,183

G

G protein subunit alpha q

multiple interactions

RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]

NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672

G

GNAS complex locus

affects response to substance

GNAS protein affects the susceptibility to Phenylephrine

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

gonadotropin releasing hormone 1

multiple interactions
increases secretion
decreases secretion

alfuzosin inhibits the reaction [Phenylephrine results in decreased secretion of GNRH1 protein]; alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of GNRH1 protein]; Testosterone affects the reaction [Phenylephrine affects the secretion of GNRH1 protein]

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

glycoprotein m6a

decreases expression

Phenylephrine results in decreased expression of GPM6A mRNA

NCBI chr16:36,641,282...36,973,377
Ensembl chr16:36,641,284...36,973,475

G

G protein-coupled receptor kinase 2

multiple interactions
increases expression

[Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein
Phenylephrine results in increased expression of GRK2 protein
GRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]

PMID:11499749 PMID:28759639

NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582

G

glycogen synthase kinase 3 beta

multiple interactions
increases phosphorylation

GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]

PMID:15795328 PMID:28759639

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione S-transferase kappa 1

decreases expression

Phenylephrine results in decreased expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase, mu 5

decreases expression

Phenylephrine results in decreased expression of GSTM3 mRNA

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

glycogen synthase 2

decreases activity

Phenylephrine results in decreased activity of GYS2 protein

NCBI chr 4:175,365,054...175,406,228
Ensembl chr 4:175,365,054...175,406,228

G

hepcidin antimicrobial peptide

decreases expression

Phenylephrine results in decreased expression of HAMP mRNA

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

heparin-binding EGF-like growth factor

increases expression

Phenylephrine results in increased expression of DTR mRNA

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

histone deacetylase 5

multiple interactions

[Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein

NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235

G

HDGF like 2

decreases expression

Phenylephrine results in decreased expression of HDGFL2 mRNA

NCBI chr 9:909,581...929,195
Ensembl chr 9:909,614...929,186

G

HECT and RLD domain containing E3 ubiquitin protein ligase 3

increases expression

Phenylephrine results in increased expression of HERC3 mRNA

NCBI chr 4:87,952,202...88,042,492
Ensembl chr 4:87,952,274...88,042,488

G

HEXIM P-TEFb complex subunit 1

multiple interactions

Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein]

NCBI chr10:88,062,808...88,064,920
Ensembl chr10:88,062,803...88,066,189

G

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions
decreases expression
decreases response to substance

HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
Phenylephrine results in decreased expression of HEY2 mRNA
HEY2 protein results in decreased susceptibility to Phenylephrine

PMID:16603706 PMID:20001863

NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218

G

HIG1 hypoxia inducible domain family, member 1A

increases expression

Phenylephrine results in increased expression of HIGD1A mRNA

NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

Phenylephrine results in increased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

homer scaffold protein 1

increases expression

Phenylephrine results in increased expression of HOMER1 mRNA alternative form

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

heat shock protein family B (small) member 3

increases expression

Phenylephrine results in increased expression of HSPB3 mRNA

NCBI chr 2:45,295,285...45,295,999
Ensembl chr 2:45,295,053...45,296,145

G

inhibitor of DNA binding 1

increases expression
increases expression

Phenylephrine results in increased expression of ID1 mRNA
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes

CTD
RGD

PMID:18158353 PMID:26873969

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 4

increases expression

Phenylephrine results in increased expression of ID4 mRNA

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

G

isopentenyl-diphosphate delta isomerase 1

increases expression

Phenylephrine results in increased expression of IDI1 mRNA

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

immediate early response 3

decreases response to substance
affects localization

IER3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine affects the localization of IER3 protein

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

insulin-like growth factor 1

affects response to substance

IGF1 protein affects the susceptibility to Phenylephrine

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 4

affects response to substance

IGFBP4 protein affects the susceptibility to Phenylephrine

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

insulin-like growth factor binding protein 5

decreases expression

Phenylephrine results in decreased expression of IGFBP5 mRNA

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

inhibitor of nuclear factor kappa B kinase subunit beta

increases activity
multiple interactions

Phenylephrine results in increased activity of IKBKB protein
IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 1 beta

multiple interactions
decreases response to substance
affects response to substance

Halothane affects the reaction [IL1B protein affects the susceptibility to Phenylephrine]
IL1B protein results in decreased susceptibility to Phenylephrine

PMID:11506125 PMID:13679239

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression
multiple interactions
decreases expression

Phenylephrine results in increased expression of IL6 mRNA
[resveratrol co-treated with Phenylephrine] results in increased expression of IL6 mRNA
Phenylephrine results in decreased expression of IL6 mRNA

PMID:11406463 PMID:12423672 PMID:22748497

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin-linked kinase

multiple interactions
affects localization

Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
Phenylephrine affects the localization of ILK protein
ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:16170337 PMID:18502941

NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140

G

inhibin subunit alpha

increases expression

Phenylephrine results in increased expression of INHA mRNA

NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248

G

interferon regulatory factor 7

decreases expression

Phenylephrine results in decreased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

ISG15 ubiquitin-like modifier

decreases expression

Phenylephrine results in decreased expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

integrin subunit alpha 9

increases expression

Phenylephrine results in increased expression of ITGA9 mRNA

NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754

G

integrin subunit beta 3 binding protein

increases expression

Phenylephrine results in increased expression of ITGB3BP mRNA

NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704

G

integrin subunit beta 8

increases expression

Phenylephrine results in increased expression of ITGB8 mRNA

NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476

G

inositol 1,4,5-trisphosphate receptor, type 2

increases activity
multiple interactions

Phenylephrine results in increased activity of ITPR2 protein
[Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA

NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases phosphorylation
increases expression
increases activity
affects response to substance

[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]
Phenylephrine results in increased phosphorylation of JUN protein
Phenylephrine results in increased expression of JUN; Phenylephrine results in increased expression of JUN mRNA; Phenylephrine results in increased expression of JUN protein
Phenylephrine results in increased activity of JUN protein
JUN protein affects the susceptibility to Phenylephrine
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased phosphorylation of JUN protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; pyrazolanthrone inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]

PMID:7905536 PMID:10710348 PMID:11799083 PMID:12169099 PMID:12574153 More...

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression
increases activity

Phenylephrine results in increased expression of JUNB
Phenylephrine results in increased activity of JUNB protein

PMID:7905536 PMID:15949472

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in decreased expression of JUND mRNA

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

potassium voltage-gated channel subfamily D member 2

multiple interactions
decreases expression
decreases response to substance

CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in decreased expression of KCND2 mRNA; Phenylephrine results in decreased expression of KCND2 protein
KCND2 protein results in decreased susceptibility to Phenylephrine

PMID:12403671 PMID:16385079 PMID:17060317

NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728

G

potassium voltage-gated channel subfamily D member 3

multiple interactions
decreases expression

[KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form]; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]
Phenylephrine results in decreased expression of KCND3 mRNA; Phenylephrine results in decreased expression of KCND3 protein

PMID:11249870 PMID:11709419 PMID:16385079 PMID:17060317

NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345

G

potassium voltage-gated channel subfamily H member 2

multiple interactions

Phenylephrine affects the reaction [KCNH2 protein results in increased transport of Potassium]

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium voltage-gated channel interacting protein 2

multiple interactions
decreases expression

MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]
Phenylephrine results in decreased expression of KCNIP2 mRNA; Phenylephrine results in decreased expression of KCNIP2 mRNA alternative form; Phenylephrine results in decreased expression of KCNIP2 protein

PMID:16385079 PMID:17060317 PMID:18158353

NCBI chr 1:244,641,147...244,664,939
Ensembl chr 1:244,641,150...244,664,874

G

KDEL endoplasmic reticulum protein retention receptor 3

increases expression

Phenylephrine results in increased expression of KDELR3 mRNA

NCBI chr 7:111,079,236...111,089,463
Ensembl chr 7:111,079,218...111,101,600

G

kinase insert domain receptor

decreases expression
multiple interactions
increases expression

Phenylephrine results in decreased expression of KDR mRNA
Copper inhibits the reaction [Phenylephrine results in increased expression of KDR protein]

PMID:18158353 PMID:24903162

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

kinesin family member 5B

decreases expression

Phenylephrine results in decreased expression of KIF5B mRNA

NCBI chr17:51,489,904...51,527,508
Ensembl chr17:51,489,944...51,527,508

G

KLF transcription factor 4

multiple interactions
decreases expression

Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]
Phenylephrine results in decreased expression of KLF4 mRNA; Phenylephrine results in decreased expression of KLF4 protein

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kelch-like family member 24

decreases expression

Phenylephrine results in decreased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

G

lysine methyltransferase 2E

decreases expression

Phenylephrine results in decreased expression of KMT2E mRNA

NCBI chr 4:11,658,218...11,727,373
Ensembl chr 4:11,658,979...11,727,373

G

laminin subunit gamma 1

increases expression

Phenylephrine results in increased expression of LAMC1 mRNA

NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492

G

laminin subunit gamma 2

increases expression

Phenylephrine results in increased expression of LAMC2 mRNA

NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200

G

low density lipoprotein receptor

increases expression

Phenylephrine results in increased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

galectin 3 binding protein

decreases expression

Phenylephrine results in decreased expression of LGALS3BP mRNA

NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256

G

LIM zinc finger domain containing 1

affects localization

Phenylephrine affects the localization of LIMS1 protein

NCBI chr20:26,309,833...26,418,511
Ensembl chr20:26,309,895...26,418,500

G

LIM and cysteine-rich domains 1

increases expression

Phenylephrine results in increased expression of LMCD1 mRNA

NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046

G

lipoprotein lipase

affects response to substance

LPL protein affects the susceptibility to Phenylephrine

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

leucine rich repeat containing 27

decreases expression

Phenylephrine results in decreased expression of LRRC27 mRNA

NCBI chr 1:194,004,967...194,035,087
Ensembl chr 1:194,005,182...194,035,084

G

LYL1, basic helix-loop-helix family member

increases expression

Phenylephrine results in increased expression of LYL1 mRNA

NCBI chr19:23,452,140...23,455,007
Ensembl chr19:23,452,140...23,455,007

G

MAF bZIP transcription factor K

increases expression

Phenylephrine results in increased expression of MAFK mRNA

NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048

G

mannosidase, alpha, class 1A, member 1

decreases expression

Phenylephrine results in decreased expression of MAN1A mRNA

NCBI chr20:33,202,509...33,385,747
Ensembl chr20:33,202,517...33,385,824

G

monoamine oxidase A

multiple interactions

[MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

monoamine oxidase B

multiple interactions

[MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

mitogen activated protein kinase kinase 1

multiple interactions

MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen-activated protein kinase kinase kinase 1

multiple interactions

MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions
increases activity

CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein]; KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein]

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

mitogen activated protein kinase kinase kinase 7

increases phosphorylation
multiple interactions

phenylephrin increases phosphorylation of Map3k7 protein in neonatal cardiomyocytes
Phenylephrine promotes the reaction [Map3k7 protein binds to Tab1 protein in neonatal cardiomyocytes]
Phenylephrine promotes the reaction [Map3k7 protein binds to Ripk2 protein]
Phenylephrine increases phosphorylation of Map3k7 protein in neonatal cardiomyocytes

RGD

PMID:32971071 PMID:35352799 PMID:34733837 PMID:35490166

RGD:155791643, RGD:155804287, RGD:155791674, RGD:155791668

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
increases expression
increases activity
affects phosphorylation

[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Phenylephrine results in increased expression of MAPK1 protein modified form
Phenylephrine results in increased activity of MAPK1 protein
Phenylephrine affects the phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 protein; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; BMY 7378 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; calphostin C inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Lovastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of MAPK1 protein; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Pertussis Toxin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]

PMID:10422649 PMID:10660688 PMID:10727428 PMID:10788492 PMID:10888249 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 10

multiple interactions

MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine]

NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201

G

mitogen activated protein kinase 14

increases phosphorylation

Phenylephrine results in increased phosphorylation of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation
increases expression
increases activity
affects phosphorylation

[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in increased expression of MAPK3 protein modified form
Phenylephrine results in increased activity of MAPK3 protein
Phenylephrine affects the phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 protein; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; BMY 7378 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; calphostin C inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of MAPK3 protein; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Pertussis Toxin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]

PMID:10422649 PMID:10660688 PMID:10727428 PMID:10788492 PMID:10888249 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 7

multiple interactions

Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein]

NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
Phenylephrine results in increased phosphorylation of MAPK8 protein

PMID:10727428 PMID:16385079 PMID:16517124 PMID:16809552

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 8 interacting protein 1

affects response to substance
multiple interactions

MAPK8IP1 protein affects the susceptibility to Phenylephrine
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation
affects response to substance

MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine]
Phenylephrine results in increased phosphorylation of MAPK9 protein

PMID:10727428 PMID:16949803

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MBL associated serine protease 1

decreases expression

Phenylephrine results in decreased expression of MASP1 mRNA

NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974

G

myocyte enhancer factor 2C

multiple interactions
increases expression
increases activity

Go 6976 inhibits the reaction [Phenylephrine results in increased activity of MEF2C protein]
Phenylephrine results in increased expression of MEF2C mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]; KN 62 inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]

PMID:10737771 PMID:19124542

NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880

G

microfibril associated protein 4

decreases expression

Phenylephrine results in decreased expression of MFAP4 mRNA

NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155

G

multifunctional ROCO family signaling regulator 1

decreases expression

Phenylephrine results in decreased expression of MFHAS1 mRNA

NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743

G

mitofusin 2

decreases expression
multiple interactions

Phenylephrine results in decreased expression of MFN2 mRNA; Phenylephrine results in decreased expression of MFN2 protein
CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]

PMID:17499311 PMID:20886221

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

monoglyceride lipase

decreases expression

Phenylephrine results in decreased expression of MGLL mRNA

NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179

G

microRNA 21

increases expression

Phenylephrine results in increased expression of MIR21 mRNA

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

mixed lineage kinase domain like pseudokinase

increases expression

Phenylephrine results in increased expression of MLKL protein

NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502

G

MLLT11, transcription factor 7 cofactor

increases expression

Phenylephrine results in increased expression of MLLT11 mRNA

NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199

G

matrix metallopeptidase 2

multiple interactions

MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]

PMID:16251426 PMID:16980344

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

increases expression

Phenylephrine results in increased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

Mov10 like RNA helicase 1

multiple interactions

MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

PMID:11854500 PMID:12754203

NCBI chr 7:120,070,171...120,135,406
Ensembl chr 7:120,070,135...120,134,765

G

methylsterol monooxygenase 1

increases expression

Phenylephrine results in increased expression of MSMO1 mRNA

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

G

moesin

increases expression

Phenylephrine results in increased expression of MSN mRNA

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

increases expression

Phenylephrine results in increased expression of MTHFD1L mRNA

NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905

G

mechanistic target of rapamycin kinase

multiple interactions

[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

musculoskeletal, embryonic nuclear protein 1

increases expression

Phenylephrine results in increased expression of MUSTN1 mRNA

NCBI chr16:6,072,908...6,075,161
Ensembl chr16:6,072,833...6,075,161

G

MYB proto-oncogene like 1

increases expression

Phenylephrine results in increased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

myosin binding protein C3

multiple interactions

MYBPC3 gene mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]
MYBPC3 mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]

NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405

G

myosin heavy chain 14

decreases expression

Phenylephrine results in decreased expression of MYH14 mRNA

NCBI chr 1:95,096,266...95,158,861
Ensembl chr 1:95,096,266...95,158,836

G

myosin heavy chain 6

multiple interactions
decreases expression

Prazosin inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]; THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]

PMID:11577024 PMID:15578571 PMID:15795322 PMID:17592507

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin heavy chain 7

multiple interactions
increases expression

CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]
Phenylephrine results in increased expression of MYH7 mRNA
Phenylephrine results in increased expression of MYH7 mRNA; Phenylephrine results in increased expression of MYH7 protein
anacardic acid inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; spiruchostatin A inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; THRB protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
[Phenylephrine co-treated with Isoproterenol] results in increased expression of MYH7 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]

PMID:10642269 PMID:10710348 PMID:11249870 PMID:11513749 PMID:11577024 More...

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

myosin, light chain 1

increases expression

Phenylephrine results in increased expression of MYL1 mRNA

NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261

G

myosin light chain 2

multiple interactions
increases phosphorylation
increases expression

ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]
Phenylephrine results in increased phosphorylation of MYL2 protein

PMID:11470465 PMID:11513749 PMID:14676212 PMID:15007106 PMID:18202317

NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983

G

myosin light chain 7

multiple interactions
increases phosphorylation

ML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]; wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]

NCBI chr14:80,780,684...80,783,259
Ensembl chr14:80,779,776...80,783,244

G

myosin light chain 9

increases phosphorylation

Phenylephrine results in increased phosphorylation of MYL9 protein

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

myosin light chain kinase 3

increases phosphorylation

Phenylephrine results in increased phosphorylation of MYLK3 protein

NCBI chr19:21,685,085...21,743,587
Ensembl chr19:21,691,929...21,742,954

G

myocardin

multiple interactions
increases expression

MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA]; MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]
Phenylephrine results in increased expression of MYOCD mRNA; Phenylephrine results in increased expression of MYOCD protein

PMID:14676212 PMID:16556869

NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627

G

myozenin 2

multiple interactions
decreases response to substance

MYOZ2 protein inhibits the reaction [Phenylephrine results in increased expression of RCAN1 protein]
MYOZ2 protein results in decreased susceptibility to Phenylephrine

NCBI chr 2:211,141,463...211,168,187
Ensembl chr 2:211,141,463...211,168,221

G

Ngfi-A binding protein 1

multiple interactions

[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB1 mRNA

NCBI chr 9:49,053,579...49,093,078
Ensembl chr 9:49,053,758...49,092,098

G

Ngfi-A binding protein 2

multiple interactions

[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA]

NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989

G

neurocalcin delta

increases expression

Phenylephrine results in increased expression of NCALD mRNA

NCBI chr 7:68,532,671...68,964,740
Ensembl chr 7:68,534,421...68,964,496

G

neutrophil cytosolic factor 1

increases phosphorylation
increases expression

Phenylephrine results in increased phosphorylation of NCF1 protein
Phenylephrine results in increased expression of NCF1 mRNA

PMID:14656924 PMID:15936005

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

nuclear factor of activated T-cells 1

multiple interactions
affects localization

Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]; Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein; sanggenone C inhibits the reaction [Phenylephrine affects the localization of NFATC1 protein]

PMID:12403671 PMID:19349967 PMID:28849031

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

nuclear factor of activated T-cells 3

increases localization
multiple interactions

Phenylephrine results in increased localization of NFATC3 protein
[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]

NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150

G

nuclear factor of activated T-cells 4

multiple interactions
increases localization
affects localization

Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]
Phenylephrine affects the localization of NFATC4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine affects the localization of NFATC4 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]

PMID:11044444 PMID:16055480

NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610

G

nuclear factor, interleukin 3 regulated

multiple interactions

U 0126 inhibits the reaction [Phenylephrine results in increased expression of NFIL3 mRNA]

NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858

G

NFKB inhibitor alpha

multiple interactions
increases degradation
decreases expression

4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in decreased expression of NFKBIA protein]; KN 93 inhibits the reaction [Phenylephrine results in increased degradation of NFKBIA protein]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:11381115 PMID:15629441 PMID:16421291

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nidogen 2

increases expression

Phenylephrine results in increased expression of NID2 mRNA

NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843

G

NK2 homeobox 5

multiple interactions

[Phenylephrine co-treated with Isoproterenol] results in increased expression of NKX2-5 mRNA

NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934

G

nodal growth differentiation factor

affects expression

Phenylephrine affects the expression of NODAL mRNA; Phenylephrine affects the expression of NODAL protein

NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837

G

nucleolar protein 3

decreases phosphorylation

Phenylephrine results in decreased phosphorylation of NOL3 protein

NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250

G

nitric oxide synthase 2

multiple interactions
increases activity
decreases response to substance
affects response to substance

NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Adenosine Diphosphate]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Calcimycin]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Nitroprusside]
Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 protein]
Phenylephrine results in increased activity of NOS2 protein
NOS2 protein results in decreased susceptibility to Phenylephrine
NOS2 protein affects the susceptibility to Phenylephrine

PMID:11498454 PMID:15753950 PMID:15902277

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

affects response to substance
decreases response to substance
multiple interactions
increases expression

NOS3 protein affects the susceptibility to Phenylephrine
NOS3 protein results in decreased susceptibility to Phenylephrine
NOS3 protein results in increased susceptibility to [Acetylcholine co-treated with Phenylephrine]
Phenylephrine results in increased expression of NOS3 mRNA; Phenylephrine results in increased expression of NOS3 protein

PMID:10954898 PMID:11504159 PMID:15381055 PMID:15753950 PMID:17403420

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

natriuretic peptide A

increases secretion
increases expression
multiple interactions
decreases response to substance

Phenylephrine results in increased secretion of NPPA protein
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes
Phenylephrine results in increased expression of NPPA mRNA; Phenylephrine results in increased expression of NPPA protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; (+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 8-(4-sulfophenyl)theophylline inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Oxygen deficiency] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Aldosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPA protein]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; chelerythrine promotes the reaction [2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Corticosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine affects the expression of NPPA protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Phenylephrine] results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPA protein]; IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; kenpaullone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; leptomycin B inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]; polydatin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; triflusal inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; U 0126 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; xestospongin C inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
NPPA protein results in decreased susceptibility to Phenylephrine
[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

CTD
RGD

PMID:2847676 PMID:8188982 PMID:10642269 PMID:10655507 PMID:10679475 More...

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

multiple interactions
increases expression
increases secretion

ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes
Phenylephrine results in increased expression of NPPB mRNA; Phenylephrine results in increased expression of NPPB protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPB protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPB protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

CTD
RGD

PMID:10642269 PMID:11754973 PMID:11799083 PMID:11804996 PMID:11854500 More...

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

natriuretic peptide C

affects response to substance
multiple interactions

NPPC protein affects the susceptibility to Phenylephrine
SMR3B protein promotes the reaction [NPPC protein affects the susceptibility to Phenylephrine]

NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251

G

natriuretic peptide receptor 1

multiple interactions

[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]

NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505

G

neuropeptide Y

multiple interactions

[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]

PMID:10660688 PMID:11499749

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

neuropeptide Y receptor Y5

multiple interactions

NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]

NCBI chr16:23,055,427...23,063,384
Ensembl chr16:23,055,427...23,063,382

G

nuclear receptor subfamily 1, group I, member 2

affects response to substance

NR1I2 protein affects the susceptibility to Phenylephrine

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 3, group C, member 1

increases expression

Phenylephrine results in increased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions
increases expression

Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of NR3C2 protein; Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein]
Phenylephrine results in increased expression of NR3C2 mRNA

PMID:16533503 PMID:19966502

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

nuclear receptor subfamily 4, group A, member 3

increases expression

Phenylephrine results in increased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

neuronal regeneration related protein

decreases expression

Phenylephrine results in decreased expression of NREP mRNA

NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591

G

neuregulin 1

decreases expression

Phenylephrine results in decreased expression of NRG1 mRNA; Phenylephrine results in decreased expression of NRG1 protein

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

neurotensin

decreases response to substance

NTS protein results in decreased susceptibility to Phenylephrine

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

nucleoporin 62

multiple interactions
decreases expression

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]; leptomycin B inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]; trichostatin A inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]

NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174

G

osteoglycin

decreases expression

Phenylephrine results in decreased expression of OGN mRNA

NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739

G

oxytocin/neurophysin I prepropeptide

multiple interactions
increases secretion

Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]

PMID:11102496 PMID:15149956

NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490

G

purinergic receptor P2X 5

increases expression

Phenylephrine results in increased expression of P2RX5 mRNA

NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423

G

prolyl 4-hydroxylase subunit alpha 1

increases expression

Phenylephrine results in increased expression of P4HA1 mRNA

NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786

G

proton activated chloride channel 1

decreases expression

Phenylephrine results in decreased expression of PACC1 mRNA

NCBI chr13:102,904,668...102,929,770
Ensembl chr13:102,894,612...102,929,770

G

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

multiple interactions

Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to ATXN1 protein]]; Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to SOX2 protein]]; Phenylephrine inhibits the reaction [Iodine-131 results in decreased expression of PAFAH1B1 protein]

NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808

G

poly (ADP-ribose) polymerase 1

multiple interactions

Phenylephrine inhibits the reaction [Oxygen deficiency results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

parvin, alpha

affects localization

Phenylephrine affects the localization of PARVA protein

NCBI chr 1:166,547,142...166,704,958
Ensembl chr 1:166,547,132...166,704,950

G

proliferating cell nuclear antigen

increases expression
multiple interactions

Phenylephrine results in increased expression of PCNA protein
Phenylephrine promotes the reaction [Iodine-131 results in increased expression of PCNA protein]

PMID:15603588 PMID:32278511

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

Purkinje cell protein 4

decreases expression

Phenylephrine results in decreased expression of PCP4 mRNA

NCBI chr11:35,759,711...35,861,725
Ensembl chr11:35,800,713...35,861,725

G

proprotein convertase subtilisin/kexin type 6

increases expression

Phenylephrine results in increased expression of PCSK6 mRNA

NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:119,429,265...119,627,596

G

phosphodiesterase 1A

multiple interactions

PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein]

NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874

G

phosphodiesterase 4B

increases expression

Phenylephrine results in increased expression of PDE4B mRNA

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

phosphodiesterase 5A

multiple interactions

PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

G

pyruvate dehydrogenase kinase 2

decreases expression

Phenylephrine results in decreased expression of PDK2 mRNA

NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085

G

pyruvate dehydrogenase kinase 4

multiple interactions
decreases expression

4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]

PMID:15721863 PMID:15728586

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850

G

PDZ and LIM domain 3

increases expression

Phenylephrine results in increased expression of PDLIM3 mRNA

NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657

G

proliferation and apoptosis adaptor protein 15

increases expression

Phenylephrine results in increased expression of PEA15 mRNA

NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499

G

period circadian regulator 1

multiple interactions

U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER1 mRNA]

NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431

G

period circadian regulator 2

multiple interactions

U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER2 mRNA]

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459

G

peroxisomal biogenesis factor 11 alpha

decreases expression

Phenylephrine results in decreased expression of PEX11A mRNA

NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172

G

phosphofructokinase, liver type

increases expression

Phenylephrine results in increased expression of PFKL mRNA

NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315

G

phosphoglycerate dehydrogenase

increases expression

Phenylephrine results in increased expression of PHGDH mRNA

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

pleckstrin homology-like domain, family A, member 1

increases expression

Phenylephrine results in increased expression of PHLDA1 mRNA

NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861

G

polycystin 1, transient receptor potential channel interacting

affects response to substance

PKD1 protein affects the susceptibility to Phenylephrine

NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128

G

pyruvate kinase L/R

multiple interactions
decreases activity

Calcium inhibits the reaction [Phenylephrine results in decreased activity of PKLR protein]

NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870

G

plakophilin 4

decreases expression

Phenylephrine results in decreased expression of PKP4 mRNA

NCBI chr 3:43,632,364...43,835,834
Ensembl chr 3:43,631,880...43,835,474

G

phospholipase A2 group IIA

decreases expression

Phenylephrine results in decreased expression of PLA2G2A mRNA

NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014

G

phospholipase A2 group VI

affects response to substance

PLA2G6 protein affects the susceptibility to Phenylephrine

NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114

G

phospholipase A and acyltransferase 1

increases expression

Phenylephrine results in increased expression of PLAAT1 mRNA

NCBI chr11:71,517,492...71,537,142
Ensembl chr11:71,517,493...71,527,020

G

phospholipase C beta 1

increases expression

Phenylephrine results in increased expression of PLCB1 mRNA

NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869

G

phospholipase C beta 3

increases expression

Phenylephrine results in increased expression of PLCB3 mRNA

NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228

G

phospholipase C, delta 1

increases expression

Phenylephrine results in increased expression of PLCD1 mRNA

NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186

G

phospholipase C, gamma 1

increases expression

Phenylephrine results in increased expression of PLCG1 mRNA

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

proopiomelanocortin

multiple interactions
increases response to substance
increases secretion

Indomethacin inhibits the reaction [Phenylephrine results in increased secretion of POMC protein alternative form]
POMC protein results in increased susceptibility to Phenylephrine

PMID:2822310 PMID:3015460 PMID:10898105

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

peroxisome proliferator activated receptor alpha

multiple interactions
decreases expression

[pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA protein]
Phenylephrine results in decreased expression of PPARA mRNA; Phenylephrine results in decreased expression of PPARA protein

PMID:18701451 PMID:19699196

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

multiple interactions

[4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased activity of PPARD protein] which results in decreased susceptibility to Phenylephrine; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

PMID:15721863 PMID:18701451

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

protein phosphatase 1, regulatory subunit 12A

multiple interactions
increases phosphorylation

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]; polydatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]

PMID:24449418 PMID:25449040

NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425

G

protein phosphatase 1, regulatory (inhibitor) subunit 14A

multiple interactions
increases phosphorylation

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]

NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671

G

protein phosphatase 3 catalytic subunit beta

increases expression
increases activity
multiple interactions

Phenylephrine results in increased expression of PPP3CB mRNA
Phenylephrine results in increased expression of PPP3CB mRNA; Phenylephrine results in increased expression of PPP3CB protein
Phenylephrine results in increased activity of PPP3CB protein
CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]

PMID:10655507 PMID:16024800

NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981

G

protein kinase C, alpha

multiple interactions
increases expression
increases activity
increases localization

DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCA protein]
Phenylephrine results in increased expression of PRKCA protein modified form
GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of PRKCA protein modified form]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein
Phenylephrine results in increased activity of PRKCA protein

PMID:12435817 PMID:16809552 PMID:18487437 PMID:21565836

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, beta

multiple interactions
increases expression

Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]; RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein]

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, delta

increases expression
affects localization

Phenylephrine results in increased expression of PRKCD protein
Phenylephrine affects the localization of PRKCD protein

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

protein kinase C, epsilon

multiple interactions
increases expression
affects localization
increases localization

DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein]; Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCE protein]
Phenylephrine results in increased expression of PRKCE protein
Phenylephrine affects the localization of PRKCE protein
[chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrine; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein

PMID:12003851 PMID:12700091 PMID:12720544 PMID:16809552 PMID:18487437

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

protein kinase C, zeta

affects localization
increases phosphorylation
decreases activity
multiple interactions

Phenylephrine affects the localization of PRKCZ protein
Phenylephrine results in increased phosphorylation of PRKCZ protein
Phenylephrine results in decreased activity of PRKCZ protein
GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]

PMID:14736339 PMID:16809552 PMID:27094369

NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367

G

protein kinase D1

affects localization
increases phosphorylation
multiple interactions
increases activity

Phenylephrine affects the localization of PRKD1 protein
Phenylephrine increases phosphorylation of Prkd1 protein in neonatal ventricular myocytes
[Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein

CTD
RGD

PMID:19124542 PMID:16648482

NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042

G

protein kinase cGMP-dependent 1

multiple interactions
increases expression
increases activity
decreases activity

[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Copper] results in increased activity of PRKG1 protein; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]; PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein]; Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 mRNA]; Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 protein]; VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]; VIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of PRKG1 protein

PMID:11799084 PMID:16378109 PMID:19542178 PMID:19797176 PMID:26168186

NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080

G

protein C receptor

increases expression

Phenylephrine results in increased expression of PROCR mRNA

NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903

G

phosphoserine phosphatase

increases expression

Phenylephrine results in increased expression of PSPH mRNA

NCBI chr12:26,882,524...26,905,084
Ensembl chr12:26,883,133...26,905,074

G

prostaglandin I2 synthase

increases expression

Phenylephrine results in increased expression of PTGIS mRNA

NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451

G

prostaglandin-endoperoxide synthase 1

multiple interactions
affects response to substance

FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine]

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein]

PMID:17244722 PMID:18701451

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone-like hormone

increases expression
multiple interactions

Phenylephrine results in increased expression of PTHLH mRNA; Phenylephrine results in increased expression of PTHLH protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]

NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847

G

protein tyrosine phosphatase, receptor type, F

decreases expression

Phenylephrine results in decreased expression of PTPRF mRNA

NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023

G

protein tyrosine phosphatase, receptor type, K

decreases expression

Phenylephrine results in decreased expression of PTPRK mRNA

NCBI chr 1:16,738,896...17,236,687
Ensembl chr 1:16,850,576...17,103,605

G

PVR cell adhesion molecule

increases expression

Phenylephrine results in increased expression of PVR mRNA

NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715

G

PYD and CARD domain containing

decreases expression

Phenylephrine results in decreased expression of PYCARD mRNA

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

glycogen phosphorylase L

multiple interactions
increases expression

[Phenylephrine co-treated with Calcium] results in increased activity of PYGL protein; Glucose inhibits the reaction [[Phenylephrine co-treated with Calcium] results in increased activity of PYGL protein]
Phenylephrine results in increased expression of PYGL mRNA

PMID:747652 PMID:18158353

NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310

G

RAB3B, member RAS oncogene family

decreases expression

Phenylephrine results in decreased expression of RAB3B mRNA

NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401

G

Rac family small GTPase 1

increases activity

Phenylephrine results in increased activity of RAC1 protein

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions
increases phosphorylation

Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of RAF1 protein]

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

retinoic acid induced 14

increases expression

Phenylephrine results in increased expression of RAI14 mRNA

NCBI chr 2:59,546,284...59,682,687
Ensembl chr 2:59,546,284...59,681,971

G

receptor activity modifying protein 1

affects expression

Phenylephrine affects the expression of RAMP1 mRNA

NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151

G

receptor activity modifying protein 2

multiple interactions
increases expression
decreases expression

[Phenylephrine co-treated with Isoproterenol] results in increased expression of RAMP2 mRNA
Phenylephrine results in increased expression of RAMP2 mRNA
Phenylephrine results in decreased expression of RAMP2 mRNA

PMID:12899678 PMID:17250927

NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829

G

receptor activity modifying protein 3

increases expression

Phenylephrine results in increased expression of RAMP3 mRNA

NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902

G

RAN binding protein 1

multiple interactions

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]; leptomycin B inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]; Phenylephrine affects the localization of and affects the expression of RANBP1 protein; trichostatin A inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]

NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838

G

Rap guanine nucleotide exchange factor 4

increases expression

Phenylephrine results in increased expression of RAPGEF4 mRNA

NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316

G

receptor-associated protein of the synapse

decreases expression

Phenylephrine results in decreased expression of RAPSN mRNA

NCBI chr 3:77,015,073...77,024,378
Ensembl chr 3:76,983,471...77,024,373

G

RASD family, member 2

decreases expression

Phenylephrine results in decreased expression of RASD2 mRNA

NCBI chr19:13,594,291...13,605,016
Ensembl chr19:13,594,291...13,605,016

G

Ras association domain family member 1

decreases response to substance

RASSF1 protein results in decreased susceptibility to Phenylephrine

NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164

G

RB transcriptional corepressor 1

increases expression
affects phosphorylation

Phenylephrine results in increased expression of RB1 protein
Phenylephrine affects the phosphorylation of RB1 protein

PMID:15603588 PMID:18084315

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RANBP2-type and C3HC4-type zinc finger containing 1

multiple interactions
affects response to substance

Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]; Phenylephrine results in increased phosphorylation of and results in increased expression of RBCK1 protein; RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein]
RBCK1 protein affects the susceptibility to Phenylephrine

NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005

G

RNA binding fox-1 homolog 2

Phenylephrine increases expression of Rbfox2 mRNA and protein in vascular smooth muscle cells

RGD

NCBI chr 7:108,810,627...109,054,420
Ensembl chr 7:108,810,628...109,054,691

G

regulator of calcineurin 1

increases expression
multiple interactions

Phenylephrine results in increased expression of RCAN1 protein
Phenylephrine results in increased expression of RCAN1 mRNA
MYOZ2 protein inhibits the reaction [Phenylephrine results in increased expression of RCAN1 protein]

PMID:18025526 PMID:25358972

NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases activity
affects localization

[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]
Phenylephrine affects the localization of RELA protein

PMID:11381115 PMID:18701451

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

decreases activity
affects response to substance

Phenylephrine results in decreased activity of REN protein
REN1 protein affects the susceptibility to Phenylephrine

PMID:2847676 PMID:17679040

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

REV3 like, DNA directed polymerase zeta catalytic subunit

decreases expression

Phenylephrine results in decreased expression of REV3L mRNA

NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099

G

regulator of G-protein signaling 2

multiple interactions
increases expression
affects response to substance

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
RGS2 protein affects the susceptibility to Phenylephrine

PMID:15452191 PMID:16517124 PMID:17644703 PMID:18158353

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

regulator of G-protein signaling 3

multiple interactions

RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894

G

regulator of G-protein signaling 4

multiple interactions

RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068

G

ras homolog family member A

multiple interactions
increases activity

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]; monomethylarsonous acid promotes the reaction [Phenylephrine results in increased activity of RHOA protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]; polydatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]

PMID:10843871 PMID:15081308 PMID:21708234 PMID:24449418 PMID:25449040

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

receptor interacting serine/threonine kinase 1

increases expression

Phenylephrine results in increased expression of RIPK1 protein

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

receptor-interacting serine-threonine kinase 3

increases expression

Phenylephrine results in increased expression of RIPK3 protein

NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121

G

Rho family GTPase 1

increases expression

Phenylephrine results in increased expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

ring finger protein 39

increases expression

Phenylephrine results in increased expression of RNF39 mRNA

NCBI chr20:1,604,794...1,610,283
Ensembl chr20:1,604,794...1,610,283

G

Rho-associated coiled-coil containing protein kinase 2

increases expression

Phenylephrine results in increased expression of ROCK2 mRNA

NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031

G

ribosomal protein S6 kinase A5

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]

PMID:15522277 PMID:19002563

NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224

G

ribosomal protein S6 kinase B1

multiple interactions
increases phosphorylation

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; resveratrol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]

PMID:12411397 PMID:12720544 PMID:12935885 PMID:15757502 PMID:15795328 More...

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

ribosomal protein S6 kinase B2

multiple interactions

bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]

NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

decreases expression

Phenylephrine results in decreased expression of RRAD protein

NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417

G

RUNX1 partner transcriptional co-repressor 1

decreases expression

Phenylephrine results in decreased expression of RUNX1T1 mRNA

NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592

G

S100 calcium binding protein A6

multiple interactions

S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA]

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

S100 calcium binding protein B

increases expression
multiple interactions

Phenylephrine results in increased expression of S100B mRNA
S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

sterol-C5-desaturase

increases expression

Phenylephrine results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

stearoyl-Coenzyme A desaturase 2

increases expression

Phenylephrine results in increased expression of SCD2 mRNA

NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232

G

selenium binding protein 1

decreases expression

Phenylephrine results in decreased expression of SELENBP1 mRNA

NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594

G

semaphorin 6D

decreases expression

Phenylephrine results in decreased expression of SEMA6D mRNA

NCBI chr 3:111,883,415...111,941,100
Ensembl chr 3:111,883,872...111,941,094

G

septin 5

increases expression

Phenylephrine results in increased expression of SEPTIN5 mRNA

NCBI chr11:82,373,601...82,379,393
Ensembl chr11:82,369,754...82,379,393

G

serpin family E member 1

increases expression

Phenylephrine results in increased expression of SERPINE1 mRNA

PMID:15808835 PMID:15850565

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serum/glucocorticoid regulated kinase 1

increases phosphorylation
multiple interactions

Phenylephrine results in increased phosphorylation of SGK1 protein
Phenylephrine promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]

PMID:15795328 PMID:16533503

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

salt-inducible kinase 1

increases expression

Phenylephrine results in increased expression of SIK1 mRNA

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

sirtuin 6

multiple interactions

[SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine results in decreased expression of and results in decreased activity of SIRT6 protein; SIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914

G

solute carrier family 12 member 2

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine promotes the reaction [SLC12A2 protein results in increased uptake of Rubidium]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of SLC12A2 protein]; Phenylephrine promotes the reaction [SLC12A2 protein results in increased uptake of Rubidium]

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 16 member 10

decreases expression

Phenylephrine results in decreased expression of SLC16A10 mRNA

NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839

G

solute carrier family 16 member 3

increases expression

Phenylephrine results in increased expression of SLC16A3 mRNA

NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562

G

solute carrier family 16 member 7

decreases expression

Phenylephrine results in decreased expression of SLC16A7 mRNA

NCBI chr 7:61,043,667...61,211,547
Ensembl chr 7:61,051,167...61,154,994

G

solute carrier family 1 member 3

increases expression

Phenylephrine results in increased expression of SLC1A3 mRNA

NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605

G

solute carrier family 22 member 1

multiple interactions

[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 3

multiple interactions

[Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Phenylephrine

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 26 member 6

decreases activity
increases expression

Phenylephrine results in decreased activity of SLC26A6 protein
Phenylephrine results in increased expression of SLC26A6 protein

NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778

G

solute carrier family 29 member 1

increases expression

Phenylephrine results in increased expression of SLC29A1 mRNA

NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203

G

solute carrier family 2 member 1

increases expression

Phenylephrine results in increased expression of SLC2A1 mRNA

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 4 member 1 adaptor protein

decreases expression

Phenylephrine results in decreased expression of SLC4A1AP mRNA

NCBI chr 6:24,905,941...24,933,651
Ensembl chr 6:24,905,941...24,933,815

G

solute carrier family 4 member 3

increases activity

Phenylephrine results in increased activity of SLC4A3 protein

NCBI chr 9:77,036,243...77,053,940
Ensembl chr 9:77,037,016...77,049,105

G

solute carrier family 7 member 1

increases expression

Phenylephrine results in increased expression of SLC7A1 mRNA

NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849

G

solute carrier family 8 member A1

multiple interactions
increases expression
decreases expression

EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]
Phenylephrine results in increased expression of SLC8A1 mRNA
Phenylephrine results in decreased expression of SLC8A1 protein

PMID:11179087 PMID:15621046 PMID:19244478

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

G

solute carrier family 9 member A1

multiple interactions
increases expression
increases activity

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; 3-methylsulfonyl-4-piperidinobenzoyl guanidine inhibits the reaction [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in increased expression of SLC9A1 mRNA; Phenylephrine results in increased expression of SLC9A1 protein

PMID:15452191 PMID:16236312 PMID:16513848 PMID:16517124

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

G

SMAD family member 2

multiple interactions

Phenylephrine results in increased phosphorylation of and results in increased localization of and results in increased activity of SMAD2 protein

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SPARC related modular calcium binding 2

decreases expression

Phenylephrine results in decreased expression of SMOC2 mRNA

NCBI chr 1:55,262,472...55,391,804
Ensembl chr 1:55,262,530...55,391,693

G

submaxillary gland androgen regulated protein 3B

multiple interactions

SMR3B protein promotes the reaction [NPPC protein affects the susceptibility to Phenylephrine]

NCBI chr14:19,783,815...19,788,557
Ensembl chr14:19,783,816...19,788,492

G

sorbitol dehydrogenase

decreases expression

Phenylephrine results in decreased expression of SORD mRNA

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

SRY-box transcription factor 2

multiple interactions

Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to SOX2 protein]]

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

SRY-box transcription factor 6

decreases expression

Phenylephrine results in decreased expression of SOX6 mRNA

NCBI chr 1:169,723,306...170,334,846
Ensembl chr 1:169,729,194...170,277,386

G

Sp1 transcription factor

multiple interactions

[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

secreted phosphoprotein 1

increases expression

Phenylephrine results in increased expression of SPP1 protein

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sprouty RTK signaling antagonist 1

increases expression

Phenylephrine results in increased expression of SPRY1 mRNA

NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189

G

spectrin, alpha, erythrocytic 1

decreases expression

Phenylephrine results in decreased expression of SPTA1 mRNA

NCBI chr13:86,203,504...86,279,371
Ensembl chr13:86,203,504...86,279,371

G

squalene epoxidase

increases expression

Phenylephrine results in increased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

sequestosome 1

decreases expression

Phenylephrine results in decreased expression of SQSTM1 mRNA

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

increases expression

Phenylephrine results in increased expression of ST3GAL2 mRNA

NCBI chr19:38,888,851...38,939,874
Ensembl chr19:38,923,999...38,939,869

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

increases expression

Phenylephrine results in increased expression of ST3GAL4 mRNA

NCBI chr 8:33,415,666...33,465,319
Ensembl chr 8:33,415,671...33,524,389

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

increases expression

Phenylephrine results in increased expression of ST8SIA5 mRNA

NCBI chr18:70,736,395...70,802,537
Ensembl chr18:70,736,602...70,797,789

G

signal transducer and activator of transcription 1

decreases expression

Phenylephrine results in decreased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

affects localization
increases expression
multiple interactions

Phenylephrine affects the localization of STAT3 protein
Phenylephrine results in increased expression of STAT3
Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein; Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]; Verapamil inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]

PMID:19299911 PMID:27094369

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

stanniocalcin 1

affects expression

Phenylephrine affects the expression of STC1 mRNA

NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264

G

stathmin 1

decreases expression

Phenylephrine results in decreased expression of STMN1 mRNA

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

syntaxin 11

affects expression

Phenylephrine affects the expression of STX11 mRNA

NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164

G

tachykinin, precursor 1

multiple interactions
increases secretion
affects response to substance

alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of TAC1 protein]
TAC1 protein affects the susceptibility to Phenylephrine

PMID:11270094 PMID:17240043

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

tachykinin receptor 1

increases response to substance

TACR1 protein results in increased susceptibility to Phenylephrine

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

G

TATA-box binding protein associated factor 1

increases expression

Phenylephrine results in increased expression of TAF1 mRNA

NCBI chr X:66,640,915...66,716,543
Ensembl chr X:66,640,982...66,716,543

G

t-complex-associated testis expressed 1

decreases expression

Phenylephrine results in decreased expression of TCTE1 mRNA

NCBI chr 9:15,463,573...15,482,258
Ensembl chr 9:15,463,739...15,472,954

G

transcription factor Dp-1

increases expression

Phenylephrine results in increased expression of TFDP1 protein

NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817

G

transforming growth factor, beta 1

increases expression

Phenylephrine results in increased expression of TGFB1 mRNA
Phenylephrine results in increased expression of TGFB1 mRNA; Phenylephrine results in increased expression of TGFB1 protein

PMID:10406839 PMID:11821714 PMID:19443575

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor beta 1 induced transcript 1

increases expression
multiple interactions

Phenylephrine results in increased expression of TGFB1I1 protein
[Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 protein; [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 protein; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]

NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080

G

transforming growth factor, beta 2

increases expression

Phenylephrine results in increased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta 3

increases expression

Phenylephrine results in increased expression of TGFB3 mRNA

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

transforming growth factor, beta receptor 1

increases expression

Phenylephrine results in increased expression of TGFBR1 mRNA

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

transforming growth factor, beta receptor 2

increases expression

Phenylephrine results in increased expression of TGFBR2 mRNA

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

transglutaminase 2

multiple interactions
decreases activity
increases expression

ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; Ethanol inhibits the reaction [Phenylephrine results in decreased activity of TGM2 protein]
Phenylephrine results in increased expression of TGM2 mRNA

PMID:10801782 PMID:18158353

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

thyroid hormone receptor alpha

multiple interactions
increases expression

THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]
Phenylephrine results in increased expression of THRA protein

PMID:11577024 PMID:17389455

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

thyroid hormone receptor beta

decreases expression
increases expression
multiple interactions

Phenylephrine results in decreased expression of THRB mRNA; Phenylephrine results in decreased expression of THRB protein
Phenylephrine results in increased expression of THRB protein
THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; THRB protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB protein]

PMID:11577024 PMID:17389455

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

TIMP metallopeptidase inhibitor 1

multiple interactions
increases expression

BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]
Phenylephrine results in increased expression of TIMP1 mRNA; Phenylephrine results in increased expression of TIMP1 protein

PMID:18158353 PMID:19910689

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

transmembrane protein 140

decreases expression

Phenylephrine results in decreased expression of TMEM140 mRNA

NCBI chr 4:63,536,477...63,547,478
Ensembl chr 4:63,536,168...63,548,455

G

transmembrane protein 176B

decreases expression

Phenylephrine results in decreased expression of TMEM176B mRNA

NCBI chr 4:77,766,928...77,774,740
Ensembl chr 4:77,766,928...77,774,384

G

transmembrane protein 43

increases expression

Phenylephrine results in increased expression of TMEM43 mRNA

NCBI chr 4:123,977,680...123,992,823
Ensembl chr 4:123,977,625...123,992,825

G

thymosin beta 15B2

increases expression

Phenylephrine results in increased expression of TMSB15B2 mRNA

NCBI chr X:100,298,705...100,300,820
Ensembl chr X:100,298,514...100,300,886

G

tumor necrosis factor

decreases secretion
decreases response to substance
increases expression
multiple interactions

Phenylephrine results in decreased secretion of TNF protein
TNF protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in increased expression of TNF mRNA; Phenylephrine results in increased expression of TNF protein
Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]; Pilocarpine inhibits the reaction [Phenylephrine results in increased expression of TNF protein]

PMID:12423672 PMID:13679239 PMID:16020479 PMID:17872965 PMID:18701451

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

increases expression

Phenylephrine results in increased expression of TNFAIP3 protein

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF receptor superfamily member 12A

increases expression

Phenylephrine results in increased expression of TNFRSF12A mRNA

NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045

G

TNF superfamily member 11

increases expression
multiple interactions

Phenylephrine results in increased expression of TNFSF11 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

thymocyte selection-associated high mobility group box

decreases expression

Phenylephrine results in decreased expression of TOX mRNA

NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272

G

tropomyosin 2

increases expression

Phenylephrine results in increased expression of TPM2 mRNA

NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992

G

triadin

decreases expression

Phenylephrine results in decreased expression of TRDN mRNA

NCBI chr 1:23,955,651...24,410,494
Ensembl chr 1:23,955,651...24,410,595

G

tribbles pseudokinase 3

increases expression

Phenylephrine results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

tripartite motif-containing 2

decreases expression

Phenylephrine results in decreased expression of TRIM2 mRNA

NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927

G

tripartite motif-containing 25

decreases expression

Phenylephrine results in decreased expression of TRIM25 mRNA

NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257

G

tripartite motif-containing 34

decreases expression

Phenylephrine results in decreased expression of TRIM34 mRNA

NCBI chr 1:158,707,172...158,720,214
Ensembl chr 1:158,707,172...158,718,674

G

transient receptor potential cation channel, subfamily C, member 1

increases expression

Phenylephrine results in increased expression of TRPC1 protein

NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276

G

transient receptor potential cation channel, subfamily C, member 3

multiple interactions
increases expression

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium]; [Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium; TRPC3 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]
Phenylephrine results in increased expression of TRPC3 mRNA; Phenylephrine results in increased expression of TRPC3 protein

PMID:15672411 PMID:19244478

NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855

G

transient receptor potential cation channel, subfamily C, member 6

multiple interactions

TRPC6 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

G

transient receptor potential cation channel, subfamily M, member 8

multiple interactions

6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; capsazepine inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Phenanthrolines inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Phenylephrine binds to and results in increased activity of TRPM8 protein

NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with calcitonin gene-related peptide (8-37)]; TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with capsazepine]

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

TSC complex subunit 2

multiple interactions
increases phosphorylation

SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]

PMID:15757502 PMID:15795328

NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951

G

tubulin, beta 6 class V

increases expression

Phenylephrine results in increased expression of TUBB6 mRNA

NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418

G

thymidine phosphorylase

decreases expression
multiple interactions

Phenylephrine results in decreased expression of SCO2 protein
VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of SCO2 protein]

NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

tyrosinase

multiple interactions
increases activity

Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

ubinuclein 1

decreases expression

Phenylephrine results in decreased expression of UBN1 mRNA

NCBI chr10:10,496,576...10,532,010
Ensembl chr10:10,496,576...10,532,010

G

ubiquitin C-terminal hydrolase L1

increases expression

Phenylephrine results in increased expression of UCHL1 mRNA

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

G

urocortin

affects response to substance

UCN protein affects the susceptibility to Phenylephrine

NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950

G

vascular cell adhesion molecule 1

decreases expression

Phenylephrine results in decreased expression of VCAM1 mRNA

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

versican

increases expression

Phenylephrine results in increased expression of VCAN mRNA

NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637

G

vascular endothelial growth factor A

multiple interactions

VEGFA protein inhibits the reaction [Phenylephrine results in decreased abundance of Copper]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of SCO2 protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

increases expression
multiple interactions

Phenylephrine results in increased expression of VIM protein
VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]; VIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

vasoactive intestinal peptide

affects response to substance

VIP protein affects the susceptibility to Phenylephrine

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

G

WASP like actin nucleation promoting factor

multiple interactions

ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]

NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022

G

WAP four-disulfide core domain 1

increases expression

Phenylephrine results in increased expression of WFDC1 mRNA

NCBI chr19:47,720,191...47,739,121
Ensembl chr19:47,720,423...47,739,108

G

Wnt inhibitory factor 1

increases expression

Phenylephrine results in increased expression of WIF1 mRNA

NCBI chr 7:56,548,060...56,618,364
Ensembl chr 7:56,548,053...56,618,360

G

xenotropic and polytropic retrovirus receptor 1

increases expression

Phenylephrine results in increased expression of XPR1 mRNA

NCBI chr13:67,441,205...67,585,950
Ensembl chr13:67,446,380...67,585,946

G

zinc finger DHHC-type palmitoyltransferase 2

increases expression

Phenylephrine results in increased expression of ZDHHC2 mRNA

NCBI chr16:51,808,465...51,878,060
Ensembl chr16:51,808,468...51,878,060

G

zinc finger protein 46

decreases expression

Phenylephrine results in decreased expression of ZFP46 mRNA

NCBI chr 5:148,519,398...148,529,903
Ensembl chr 5:148,520,855...148,529,459

G

zinc finger protein 503

decreases expression

Phenylephrine results in decreased expression of ZFP503 mRNA

NCBI chr15:2,313,060...2,316,848
Ensembl chr15:2,313,060...2,316,848

G

zinc finger protein 866

decreases expression

Phenylephrine results in decreased expression of CXCL5 mRNA

NCBI chr16:19,653,966...19,675,968
Ensembl chr16:19,668,258...19,675,932

G

zinc finger protein, multitype 2

decreases response to substance
multiple interactions

ZFPM2 protein results in decreased susceptibility to Phenylephrine
ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 7:71,678,658...72,116,209
Ensembl chr 7:71,678,880...72,116,205

phosphatidylethanolamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

decreases abundance

AHR protein results in decreased abundance of phosphatidylethanolamine

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

phosphatidylethanolamine results in increased stability of and results in increased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

fibroblast growth factor 19

increases abundance

FGF19 protein results in increased abundance of phosphatidylethanolamine

NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

calpeptin inhibits the reaction [dehydroeburicoic acid promotes the reaction [MAP1LC3B protein binds to phosphatidylethanolamine]]; dehydroeburicoic acid promotes the reaction [MAP1LC3B protein binds to phosphatidylethanolamine]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

PPARG coactivator 1 beta

increases abundance

PPARGC1B results in increased abundance of phosphatidylethanolamine

NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194

G

phosphatase and tensin homolog

multiple interactions
affects binding

[TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to phosphatidylethanolamine]

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

thioredoxin 1

multiple interactions

[TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to phosphatidylethanolamine]

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

practolol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 2

multiple interactions

[Practolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

mitogen activated protein kinase 1

multiple interactions

[Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

renin

decreases activity

Practolol results in decreased activity of REN protein

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

procaine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

Procaine results in increased phosphorylation of AKT1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

alkaline phosphatase, biomineralization associated

increases expression

Procaine results in increased expression of ALPL mRNA

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

calcitonin-related polypeptide alpha

increases secretion

Procaine results in increased secretion of CALCA protein

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

calpain 1

multiple interactions

Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN1 protein]

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

calpain 2

multiple interactions

Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN2 protein]

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

caspase 12

multiple interactions

Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP12 protein]; Procaine inhibits the reaction [Paraoxon results in increased expression of CASP12 protein]

PMID:20079824 PMID:26998625

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions

Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cadherin 5

decreases expression
multiple interactions

Procaine results in decreased expression of CDH5 protein
HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]

NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368

G

carboxylesterase 2H

increases hydrolysis

CES2 protein results in increased hydrolysis of Procaine

PMID:9300133 PMID:15475733

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

estrogen receptor 1

increases expression

Procaine results in increased expression of ESR1 mRNA

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

histamine receptor H 1

multiple interactions
affects binding

[HRH1 protein binds to Procaine] which results in increased import of Calcium; HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]; HRH1 protein affects the reaction [Procaine results in increased transport of fluorescein isothiocyanate bovine serum albumin]

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

heat shock protein family A (Hsp70) member 5

multiple interactions

[Procaine co-treated with Paraoxon] results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

inositol 1,4,5-trisphosphate receptor, type 1

increases phosphorylation
multiple interactions

Procaine results in increased phosphorylation of ITPR1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]

NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Procaine results in increased phosphorylation of MAPK1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

Procaine results in increased phosphorylation of MAPK3 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

nuclear receptor subfamily 1, group I, member 2

increases activity

Procaine results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

phospholipase C, gamma 1

increases phosphorylation
multiple interactions

Procaine results in increased phosphorylation of PLCG1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

transient receptor potential cation channel, subfamily V, member 1

increases activity

Procaine results in increased activity of TRPV1 protein

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

rosuvastatin calcium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

decreases expression
multiple interactions

Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA]

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 11

multiple interactions

Rosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium

PMID:15901796 PMID:19853032

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 2

multiple interactions
increases expression
affects secretion

ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
Rosuvastatin Calcium results in increased expression of ABCC2 protein
[Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the secretion of Rosuvastatin Calcium

PMID:19853032 PMID:23562342 PMID:24909372

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression

Rosuvastatin Calcium results in increased expression of ABCC3 protein

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily G member 1

decreases expression

Rosuvastatin Calcium results in decreased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

ATP binding cassette subfamily G member 2

multiple interactions
increases activity

[Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
Rosuvastatin Calcium results in increased activity of ABCG2 protein

PMID:19853032 PMID:30083819

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

acetylcholinesterase

multiple interactions

[Piracetam co-treated with Rosuvastatin Calcium] inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]; Rosuvastatin Calcium inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

AKT serine/threonine kinase 1

affects phosphorylation

Rosuvastatin Calcium affects the phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

apolipoprotein A1

multiple interactions
increases expression

Niacin promotes the reaction [Rosuvastatin Calcium results in increased expression of APOA1 protein]

PMID:12767421 PMID:15539964

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein B

decreases expression

Rosuvastatin Calcium results in decreased expression of APOB protein

PMID:15539964 PMID:18702965

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

BCL2 associated X, apoptosis regulator

multiple interactions

Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Rosuvastatin Calcium results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

complement C3

decreases expression

Rosuvastatin Calcium results in decreased expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

caspase 3

increases activity
increases expression

Rosuvastatin Calcium results in increased activity of CASP3 protein
Rosuvastatin Calcium results in increased expression of CASP3 protein

PMID:21478229 PMID:32771489

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

increases activity
multiple interactions

Rosuvastatin Calcium results in increased activity of CAT protein
[Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]

PMID:20146376 PMID:32007421 PMID:35130744

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

decreases expression

Rosuvastatin Calcium results in decreased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cAMP responsive element binding protein 5

decreases expression

Rosuvastatin Calcium results in decreased expression of CREB5 mRNA

NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325

G

C-reactive protein

multiple interactions

Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

cytochrome b-245 alpha chain

multiple interactions
decreases expression

[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome b-245 beta chain

multiple interactions
decreases expression

Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species

PMID:16633368 PMID:21562509

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

estrogen receptor 1

decreases expression

Rosuvastatin Calcium results in decreased expression of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

Rosuvastatin Calcium results in increased expression of GCLC mRNA
[Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

G protein-coupled receptor 183

multiple interactions
increases expression

Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GPR183 mRNA]

NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559

G

granzyme K

multiple interactions
increases expression

Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GZMK mRNA]

NCBI chr 2:44,840,811...44,848,829
Ensembl chr 2:44,840,811...44,848,894

G

hepatocyte nuclear factor 4, alpha

increases secretion

HNF4A protein results in increased secretion of Rosuvastatin Calcium

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

interleukin 18 receptor accessory protein

decreases expression
multiple interactions

Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA]

NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959

G

interleukin 1 beta

decreases expression

Rosuvastatin Calcium results in decreased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Rosuvastatin Calcium results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium inwardly-rectifying channel, subfamily J, member 15

decreases expression

Rosuvastatin Calcium results in decreased expression of KCNJ15 mRNA

NCBI chr11:34,577,397...34,621,725
Ensembl chr11:34,577,363...34,621,952

G

kinase insert domain receptor

multiple interactions

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

myoglobin

affects expression

Rosuvastatin Calcium affects the expression of MB protein

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

myostatin

increases expression

Rosuvastatin Calcium results in increased expression of MSTN protein

NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933

G

NFE2 like bZIP transcription factor 2

multiple interactions

Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA]

PMID:32007421 PMID:35130744

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nitric oxide synthase 2

increases expression
multiple interactions

Rosuvastatin Calcium results in increased expression of NOS2 mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]

PMID:21443142 PMID:32007421 PMID:35130744

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions
increases expression
affects response to substance

Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]; Rosuvastatin Calcium results in increased phosphorylation of and results in increased activity of NOS3 protein
Rosuvastatin Calcium results in increased expression of NOS3 mRNA
NOS3 protein affects the susceptibility to Rosuvastatin Calcium

PMID:12354446 PMID:15681303 PMID:18162361 PMID:21562509

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

orosomucoid 1

multiple interactions
decreases expression

Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ORM1 mRNA]

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

platelet and endothelial cell adhesion molecule 1

multiple interactions

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein]

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

selectin P

decreases expression

Rosuvastatin Calcium results in decreased expression of SELP mRNA

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

serpin family E member 2

multiple interactions

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]

NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826

G

solute carrier organic anion transporter family, member 1a4

multiple interactions
increases uptake
decreases expression
affects transport

Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium]
diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]
Rosuvastatin Calcium results in decreased expression of SLCO1A4 protein
SLCO1A4 protein affects the transport of Rosuvastatin Calcium

PMID:19833843 PMID:24909372 PMID:26888941 PMID:28867436

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

solute carrier organic anion transporter family member 1B2

multiple interactions
increases uptake

Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]

PMID:26888941 PMID:31299240

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

solute carrier organic anion transporter family, member 2b1

increases uptake
multiple interactions

SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium
Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

superoxide dismutase 1

multiple interactions
increases expression

[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

trefoil factor 1

decreases expression

Rosuvastatin Calcium results in decreased expression of TFF1 mRNA

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

transforming growth factor, beta 1

multiple interactions
decreases expression

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
Rosuvastatin Calcium results in decreased expression of TGFB1 mRNA

PMID:15681303 PMID:27097221

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

decreases expression
multiple interactions

Rosuvastatin Calcium results in decreased expression of TNF mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein]

PMID:15681303 PMID:32007421 PMID:35130744

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

troponin I3, cardiac type

multiple interactions

Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]

PMID:32007421 PMID:35130744

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

G

vanin 3

decreases expression

Rosuvastatin Calcium results in decreased expression of VNN3P mRNA

NCBI chr 1:21,571,364...21,583,626
Ensembl chr 1:21,571,364...21,583,626

G

WT1 transcription factor

increases expression

Rosuvastatin Calcium results in increased expression of WT1 mRNA

NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643

sotalol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases transport

valspodar inhibits the reaction [ABCB1 protein results in increased transport of Sotalol]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

adrenoceptor beta 1

multiple interactions

Sotalol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

affects binding
multiple interactions

Sotalol binds to ADRB2 protein
[Sotalol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP

PMID:2169833 PMID:17925438

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

N-acylsphingosine amidohydrolase 1

increases expression

Sotalol results in increased expression of ASAH1 mRNA

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression
increases expression

Sotalol results in decreased expression of ASNS mRNA
Sotalol results in increased expression of ASNS mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

DEPP autophagy regulator 1

increases expression

Sotalol results in increased expression of DEPP1 mRNA

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

fibronectin type III domain containing 4

increases expression

Sotalol results in increased expression of FNDC4 mRNA

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression
decreases expression

Sotalol results in increased expression of GDPD3 mRNA
Sotalol results in decreased expression of GDPD3 mRNA

NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063

G

inhibin subunit beta E

decreases expression
increases expression

Sotalol results in decreased expression of INHBE mRNA
Sotalol results in increased expression of INHBE mRNA

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

potassium voltage-gated channel subfamily H member 2

decreases response to substance
decreases activity
multiple interactions
affects binding

KCNH2 gene mutant form results in decreased susceptibility to Sotalol
Sotalol results in decreased activity of KCNH2 protein
Potassium inhibits the reaction [Sotalol results in decreased activity of KCNH2 protein]
Sotalol analog binds to KCNH2 protein

PMID:15673388 PMID:16757186 PMID:16960444 PMID:18701618 PMID:24052561 More...

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

lanosterol synthase

decreases expression

Sotalol results in decreased expression of LSS mRNA

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

nuclear receptor subfamily 0, group B, member 2

decreases expression
increases expression

Sotalol results in decreased expression of NR0B2 mRNA
Sotalol results in increased expression of NR0B2 mRNA

PMID:15342952 PMID:17175557

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear protein 1, transcriptional regulator

increases expression

Sotalol results in increased expression of NUPR1 mRNA

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

phytanoyl-CoA 2-hydroxylase

increases expression

Sotalol results in increased expression of PHYH mRNA

NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409

G

plasminogen activator, tissue type

increases expression

Sotalol results in increased expression of PLAT protein

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

serine (or cysteine) peptidase inhibitor, clade A, member 3N

increases expression

Sotalol results in increased expression of SERPINA3 mRNA

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

solute carrier family 2 member 3

increases expression

Sotalol results in increased expression of SLC2A3 mRNA

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

WD repeat domain, phosphoinositide interacting 1

increases expression

Sotalol results in increased expression of WIPI1 mRNA

NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846

synephrine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

multiple interactions

Synephrine binds to and results in increased activity of ADRA1A protein

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

adrenoceptor alpha 2A

affects binding

Synephrine binds to ADRA2A protein

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

adrenoceptor alpha 2C

affects binding

Synephrine binds to ADRA2C protein

NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846

G

adrenoceptor beta 2

increases activity

Synephrine results in increased activity of ADRB2 protein

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

carbonic anhydrase 1

decreases activity

Synephrine results in decreased activity of CA1 protein

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

G

carbonic anhydrase 2

decreases activity

Synephrine results in decreased activity of CA2 protein

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

C-C motif chemokine ligand 11

multiple interactions

Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]
Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]; Synephrine inhibits the reaction [IL4 protein results in increased expression of CCL11 mRNA]

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

interleukin 10

multiple interactions

Synephrine promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 4

multiple interactions

Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]
Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]; Synephrine inhibits the reaction [IL4 protein results in increased expression of CCL11 mRNA]; Synephrine inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

myeloperoxidase

multiple interactions

Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NFKB inhibitor alpha

multiple interactions

Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

neuromedin U receptor 2

increases activity

Synephrine results in increased activity of NMUR2 protein

NCBI chr10:40,166,223...40,182,078
Ensembl chr10:40,166,226...40,182,078

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 22 member 1

multiple interactions

[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 3

multiple interactions

[Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Synephrine

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

signal transducer and activator of transcription 6

multiple interactions

Synephrine inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

tumor necrosis factor

multiple interactions

Synephrine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

terbutaline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1B

increases expression

Terbutaline results in increased expression of ADRA1B mRNA; Terbutaline results in increased expression of ADRA1B protein

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

G

adrenoceptor alpha 1D

increases expression

Terbutaline results in increased expression of ADRA1D mRNA; Terbutaline results in increased expression of ADRA1D protein

NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354

G

adrenoceptor beta 1

multiple interactions

Terbutaline binds to and results in decreased activity of ADRB1 protein; Terbutaline binds to and results in increased activity of ADRB1 protein mutant form; Terbutaline inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Terbutaline inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

PMID:8096834 PMID:14730417 PMID:16648137

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

affects response to substance
multiple interactions
increases response to substance
decreases expression
increases phosphorylation
affects binding
increases activity

ADRB2 gene polymorphism affects the susceptibility to Terbutaline; ADRB2 protein affects the susceptibility to Terbutaline; ADRB2 protein polymorphism affects the susceptibility to Terbutaline
[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Potassium; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP3 protein]; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP7 protein]; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK1 protein]; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK3 protein]; ADRB2 gene polymorphism affects the reaction [Terbutaline results in increased metabolism of Lipids]; ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]; ADRB2 protein promotes the reaction [Terbutaline results in decreased activity of NFKB1 protein]; ADRB2 protein promotes the reaction [Terbutaline results in increased metabolism of Lipids]; ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of GAST protein]; Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Terbutaline results in increased activity of ADRB2 protein]; Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol]; Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]; Terbutaline binds to and results in increased activity of ADRB2 protein; Terbutaline inhibits the reaction [cyanopindolol binds to ADRB2 protein]
ADRB2 protein results in increased susceptibility to Terbutaline; ADRB2 protein SNP results in increased susceptibility to Terbutaline
Terbutaline results in decreased expression of ADRB2 protein
Terbutaline results in increased phosphorylation of ADRB2 protein
ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPB protein]; ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPC protein]; Terbutaline binds to and results in increased activity of ADRB2 protein
Terbutaline binds to ADRB2 protein
[Terbutaline binds to and results in increased activity of ADRB2 protein] which affects the abundance of Calcium; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased expression of TNF protein; [Terbutaline results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Terbutaline results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; [Terbutaline results in increased activity of ADRB2 protein] which results in increased transport of Chlorides; [Terbutaline results in increased activity of ADRB2 protein] which results in increased transport of Sodium; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine]; ICI 118551 inhibits the reaction [Terbutaline results in increased activity of ADRB2 protein]; Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Terbutaline binds to and results in increased activity of ADRB2 protein

PMID:1280742 PMID:9258252 PMID:9277405 PMID:10094932 PMID:10192281 More...

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

adrenoceptor beta 3

multiple interactions

[Terbutaline binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Terbutaline binds to and results in increased activity of ADRB3 protein; Terbutaline inhibits the reaction [cyanopindolol binds to ADRB3 protein]

PMID:7815362 PMID:14730417 PMID:16648137

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

alpha-2-HS-glycoprotein

affects response to substance
increases response to substance

AHSG protein affects the susceptibility to Terbutaline
AHSG gene polymorphism results in increased susceptibility to Terbutaline

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

amine oxidase, copper containing 1

multiple interactions
increases activity

Cycloheximide inhibits the reaction [Terbutaline results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Terbutaline results in increased activity of AOC1 protein]

NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840

G

aquaporin 4

increases expression

Terbutaline results in increased expression of AQP4 mRNA

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

aquaporin 5

affects expression

Terbutaline affects the expression of AQP5 protein

NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions
increases expression

[Terbutaline results in increased expression of ATP1A1 protein] which results in increased transport of Sodium; Propranolol inhibits the reaction [Terbutaline results in increased expression of ATP1A1 mRNA]
Terbutaline results in increased expression of ATP1A1 mRNA; Terbutaline results in increased expression of ATP1A1 protein

PMID:9700104 PMID:19880505

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

caspase 3

multiple interactions

[Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP3 protein]; Terbutaline inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

[Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP7 protein]; Terbutaline inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

choline O-acetyltransferase

decreases expression

Terbutaline results in decreased expression of CHAT protein

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

corticotropin releasing hormone

decreases expression

Terbutaline results in decreased expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

C-terminal Src kinase

multiple interactions

CSK protein promotes the reaction [Terbutaline results in increased abundance of Cyclic AMP]

NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Terbutaline results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glucose-6-phosphate dehydrogenase

increases activity

Terbutaline results in increased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

gastrin

multiple interactions
increases secretion

ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of GAST protein]; Calcium promotes the reaction [Terbutaline results in increased secretion of GAST protein]; Nitrendipine inhibits the reaction [Terbutaline results in increased secretion of GAST protein]

NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496

G

glucagon

increases secretion
multiple interactions

Terbutaline results in increased secretion of GCG protein
NPY protein inhibits the reaction [Terbutaline results in increased secretion of GCG protein]

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glial fibrillary acidic protein

increases expression

Terbutaline results in increased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

GNAS complex locus

increases localization
affects localization

Terbutaline results in increased localization of GNAS protein alternative form
Terbutaline affects the localization of GNAS protein

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

interferon gamma

multiple interactions

[IFNG protein co-treated with Lipopolysaccharides] inhibits the reaction [Terbutaline results in increased secretion of REN protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

multiple interactions
increases expression

Terbutaline promotes the reaction [IL1B protein results in increased expression of IL10 protein]; Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
Terbutaline results in increased expression of IL10 protein

PMID:9258252 PMID:10690878 PMID:12417450

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

Terbutaline promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Terbutaline promotes the reaction [IL1B protein results in increased expression of IL10 protein]
[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline]

PMID:9258252 PMID:20061444

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
affects expression
increases expression

ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ICI 118551 inhibits the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Terbutaline affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Terbutaline affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Terbutaline affects the expression of IL6 mRNA; Terbutaline affects the expression of IL6 protein
Terbutaline results in increased expression of IL6 mRNA

PMID:10469353 PMID:10525314 PMID:10857765 PMID:11096136

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 2

multiple interactions
increases expression

Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein]; Bisoprolol inhibits the reaction [Terbutaline results in increased expression of INS protein]; SST inhibits the reaction [Terbutaline results in increased expression of INS protein]

PMID:2563217 PMID:6373350 PMID:7042176 PMID:9186877 PMID:12795776

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

leptin

decreases expression

Terbutaline results in decreased expression of LEP mRNA; Terbutaline results in decreased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

mitogen activated protein kinase 1

multiple interactions

[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK1 protein]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]]; KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]]; Terbutaline inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK1 protein]; Terbutaline inhibits the reaction [Shiga Toxin results in increased activity of MAPK1 protein]
ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]

PMID:10469353 PMID:10857765 PMID:11675405 PMID:12608646 PMID:12826277 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK3 protein]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]]; KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]]; Terbutaline inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK3 protein]; Terbutaline inhibits the reaction [Shiga Toxin results in increased activity of MAPK3 protein]
ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]

PMID:10469353 PMID:10857765 PMID:11675405 PMID:12608646 PMID:12826277 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

myeloperoxidase

multiple interactions

[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Terbutaline

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

metallothionein 2A

multiple interactions

Terbutaline affects the reaction [Budesonide results in increased expression of MT2A mRNA]

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

neurofilament light chain

increases expression

Terbutaline results in increased expression of NEFL protein

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

nuclear factor kappa B subunit 1

multiple interactions
decreases activity

ADRB2 protein promotes the reaction [Terbutaline results in decreased activity of NFKB1 protein]; Terbutaline inhibits the reaction [Shiga Toxin results in increased activity of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nerve growth factor

decreases expression

Terbutaline results in decreased expression of NGF mRNA; Terbutaline results in decreased expression of NGF protein

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

neuropeptide Y

multiple interactions

NPY protein inhibits the reaction [Terbutaline results in increased secretion of GCG protein]

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

nuclear receptor subfamily 3, group C, member 1

increases expression
multiple interactions

Terbutaline results in increased expression of NR3C1 mRNA
Budesonide affects the reaction [Terbutaline results in increased expression of NR3C1 mRNA]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

ornithine decarboxylase 1

increases activity

Terbutaline results in increased activity of ODC1 protein

PMID:2472593 PMID:8421708

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

multiple interactions

PAFAH1B1 protein promotes the reaction [Terbutaline results in increased secretion of Phosphatidylcholines]

NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808

G

phosphoglycerate dehydrogenase

increases expression

Terbutaline results in increased expression of PHGDH mRNA

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

renin

multiple interactions
increases secretion
increases expression

4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone promotes the reaction [Terbutaline results in increased secretion of REN protein]; [IFNG protein co-treated with Lipopolysaccharides] inhibits the reaction [Terbutaline results in increased secretion of REN protein]; Cycloheximide inhibits the reaction [Terbutaline results in increased secretion of REN protein]; Dactinomycin inhibits the reaction [Terbutaline results in increased secretion of REN protein]; TNF protein inhibits the reaction [Terbutaline results in increased secretion of REN protein]
Terbutaline results in increased expression of REN mRNA

PMID:9203624 PMID:9256163

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

sodium channel epithelial 1 subunit alpha

multiple interactions
increases expression
increases response to substance

Propranolol inhibits the reaction [Terbutaline results in increased expression of SCNN1A mRNA]
SCNN1A protein results in increased susceptibility to Terbutaline

PMID:9700104 PMID:16258001

NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181

G

sodium channel epithelial 1 subunit beta

multiple interactions

Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]]; Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]

PMID:12372821 PMID:12608646

NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451

G

sodium channel epithelial 1 subunit gamma

multiple interactions

Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein]]; Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein]

PMID:12372821 PMID:12608646

NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816

G

surfactant protein B

increases expression
increases secretion
multiple interactions

Terbutaline results in increased expression of SFTPB mRNA
Terbutaline results in increased secretion of SFTPB protein
ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPB protein]

PMID:2539393 PMID:11704537 PMID:14565945

NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436

G

surfactant protein C

increases secretion
multiple interactions

Terbutaline results in increased secretion of SFTPC protein
ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPC protein]

PMID:11704537 PMID:14565945

NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777

G

surfactant protein D

multiple interactions

[Terbutaline co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SFTPD protein

NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927

G

solute carrier family 22 member 2

multiple interactions

Terbutaline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

somatostatin

multiple interactions

SST inhibits the reaction [Terbutaline results in increased expression of INS protein]

NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173

G

tumor necrosis factor

multiple interactions
decreases expression
affects expression
decreases secretion

ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF protein]]; KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF mRNA]]; KT 5720 inhibits the reaction [Terbutaline results in decreased expression of TNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline results in decreased expression of TNF mRNA]; Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF mRNA]; Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF protein]; TNF protein inhibits the reaction [Terbutaline results in increased secretion of REN protein]
Terbutaline results in decreased expression of TNF mRNA; Terbutaline results in decreased expression of TNF protein
[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline]
Terbutaline affects the expression of TNF mRNA; Terbutaline affects the expression of TNF protein
[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased expression of TNF protein; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Terbutaline results in decreased secretion of TNF protein

PMID:9256163 PMID:10094932 PMID:10469353 PMID:10525314 PMID:10690878 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

upstream transcription factor 1

multiple interactions

USF1 gene polymorphism promotes the reaction [Terbutaline results in increased metabolism of Lipids]; USF1 protein affects the reaction [Terbutaline results in increased metabolism of Lipids]

NCBI chr13:83,845,230...83,854,875
Ensembl chr13:83,822,035...83,854,885

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19808
role	19784
application	19627
NMR chemical shift reference compound	17938
ammonia	17797
organic amino compound	17797
amino alcohol	1069
ethanolamines	819
1-(2-chlorophenyl)-2-isopropylaminoethanol +	2
2-(piperidin-1-yl)ethanol +	0
2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)(methyl)amino]ethanol	0
2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]ethanol	0
2-\{[5,6-bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino\}ethanol	0
2-diethylaminoethanol +	25
3-(2-chlorobenzyl)-1-(2-\{[(1S)-2-hydroxy-1,2-dimethylpropyl]amino\}pyrimidin-4-yl)-1-(4-methoxyphenyl)urea	0
3-(2-chlorophenyl)-1-(2-\{[(1S)-2-hydroxy-1,2-dimethylpropyl]amino\}pyrimidin-4-yl)-1-(4-methoxyphenyl)urea	0
3-\{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl\}propanoic acid +	13
N,N-dimethylethanolamine +	1
N-(2-hydroxyethyl)piperazine +	87
N-acetylethanolamine	0
N-acylethanolamine +	52
N-methylethanolamine +	1
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid	0
[(2S,4S)-2-[(1R)-1-amino-2-hydroxyethyl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl]acetic acid	0
\{(2R)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-2-hydroxy-4,5-dioxoimidazolidin-1-yl\}acetic acid	0
acebutolol	6
atenolol +	51
atenolol-desisopropyl	0
bitolterol +	1
clenbuterol +	23
colterol	0
diethanolamine	13
dipivefrin	0
ethambutol +	35
ethanolamine +	89
garomefrine	0
methyl 3-\{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl\}propanoate +	13
mirabegron	8
olomoucine	6
penbutolol +	11
phenylethanolamines +	600
phosphoethanolamine +	64
practolol	4
sotalol	18
synephrine +	18
Path 2
Term	Annotations
CHEBI ontology	19808
subatomic particle	19806
composite particle	19806
hadron	19806
baryon	19806
nucleon	19806
atomic nucleus	19806
atom	19806
main group element atom	19756
main group molecular entity	19756
s-block molecular entity	19595
hydrogen molecular entity	19582
hydrides	19095
inorganic hydride	18093
pnictogen hydride	18082
nitrogen hydride	17989
azane	17798
ammonia	17797
organic amino compound	17797
amino alcohol	1069
ethanolamines	819
1-(2-chlorophenyl)-2-isopropylaminoethanol +	2
2-(piperidin-1-yl)ethanol +	0
2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)(methyl)amino]ethanol	0
2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]ethanol	0
2-\{[5,6-bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino\}ethanol	0
2-diethylaminoethanol +	25
3-(2-chlorobenzyl)-1-(2-\{[(1S)-2-hydroxy-1,2-dimethylpropyl]amino\}pyrimidin-4-yl)-1-(4-methoxyphenyl)urea	0
3-(2-chlorophenyl)-1-(2-\{[(1S)-2-hydroxy-1,2-dimethylpropyl]amino\}pyrimidin-4-yl)-1-(4-methoxyphenyl)urea	0
3-\{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl\}propanoic acid +	13
N,N-dimethylethanolamine +	1
N-(2-hydroxyethyl)piperazine +	87
N-acetylethanolamine	0
N-acylethanolamine +	52
N-methylethanolamine +	1
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid	0
[(2S,4S)-2-[(1R)-1-amino-2-hydroxyethyl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl]acetic acid	0
\{(2R)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-2-hydroxy-4,5-dioxoimidazolidin-1-yl\}acetic acid	0
acebutolol	6
atenolol +	51
atenolol-desisopropyl	0
bitolterol +	1
clenbuterol +	23
colterol	0
diethanolamine	13
dipivefrin	0
ethambutol +	35
ethanolamine +	89
garomefrine	0
methyl 3-\{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl\}propanoate +	13
mirabegron	8
olomoucine	6
penbutolol +	11
phenylethanolamines +	600
phosphoethanolamine +	64
practolol	4
sotalol	18
synephrine +	18

paths to the root