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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308386
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gdpd3
Name: glycerophosphodiester phosphodiesterase domain containing 3
Acc ID: CHEBI:63622
Term: sotalol
Definition: A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Chemical ID: MESH:D013015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gdpd3decreases expressionISOGDPD3 (Homo sapiens)6480464CTDSotalol results in decreased expression of GDPD3 mRNAPMID:17175557
Gdpd3increases expressionISOGDPD3 (Homo sapiens)6480464CTDSotalol results in increased expression of GDPD3 mRNAPMID:17175557
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