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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diethanolamine
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Accession:CHEBI:28123 term browser browse the term
Definition:A member of the class of ethanolamines that is ethanolamine having a N-hydroxyethyl substituent.
Synonyms:related_synonym: 2,2'-Iminodiethanol;   Formula=C4H11NO2;   H2dea;   InChI=1S/C4H11NO2/c6-3-1-5-2-4-7/h5-7H,1-4H2;   InChIKey=ZBCBWPMODOFKDW-UHFFFAOYSA-N;   N,N-di(hydroxyethyl)amine;   SMILES=OCCNCCO;   bis-(2-hydroxy-ethyl)-amine;   diolamine
 alt_id: CHEBI:23706;   CHEBI:4519
 xref: CAS:111-42-2;   HMDB:HMDB0004437;   KEGG:C06772;   KEGG:D02337;   LINCS:LSM-26236
 xref_mesh: MESH:C020283
 xref: PMID:12571685;   PMID:15304302;   PMID:23567043;   PMID:24275050;   Reaxys:605315;   UM-BBD_compID:c0589;   Wikipedia:Diethanolamine


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diethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death decreases expression ISO
EXP
diethanolamine results in decreased expression of BAD mRNA CTD PMID:16014740 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP
ISO
diethanolamine results in decreased expression of BAX mRNA CTD PMID:16014740 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 decreases expression
increases activity
ISO
EXP
diethanolamine results in decreased expression of CASP3 mRNA
diethanolamine results in increased activity of CASP3 protein
CTD PMID:16014740, PMID:18948303 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd2 cyclin D2 increases expression ISO
EXP
diethanolamine results in increased expression of CCND2 mRNA CTD PMID:16014740 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccne1 cyclin E1 increases expression ISO
EXP
diethanolamine results in increased expression of CCNE1 mRNA CTD PMID:16014740 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO
EXP
diethanolamine results in decreased expression of CDKN1A mRNA CTD PMID:16014740 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO
EXP
diethanolamine results in decreased expression of CDKN1B mRNA CTD PMID:16014740 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO
EXP
diethanolamine results in increased expression of E2F1 mRNA CTD PMID:16014740 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [diethanolamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO diethanolamine results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO
EXP
diethanolamine results in decreased expression of TRP53 mRNA
diethanolamine results in decreased expression of TP53 mRNA
CTD PMID:16014740 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            xenobiotic metabolite 14043
              human xenobiotic metabolite 13294
                diethanolamine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        amino alcohol 882
                                          ethanolamines 769
                                            ethanolamine 61
                                              diethanolamine 11
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