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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621405
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hey2
Name: hes-related family bHLH transcription factor with YRPW motif 2
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hey2decreases expressionISOHey2 (Mus musculus)6480464CTDPhenylephrine results in decreased expression of HEY2 mRNAPMID:16603706
Hey2decreases response to substanceISOHey2 (Mus musculus)6480464CTDHEY2 protein results in decreased susceptibility to PhenylephrinePMID:16603706 PMID:20001863
Hey2multiple interactionsISOHey2 (Mus musculus)6480464CTDHEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]PMID:16603706
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