Ilk (integrin-linked kinase) - Rat Genome Database

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Gene: Ilk (integrin-linked kinase) Rattus norvegicus
Symbol: Ilk
Name: integrin-linked kinase
RGD ID: 620063
Description: Enables SH3 domain binding activity; integrin binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell differentiation; and positive regulation of intracellular signal transduction. Located in several cellular components, including costamere; dendritic shaft; and focal adhesion. Part of protein-containing complex. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ILK (integrin linked kinase); PARTICIPATES IN integrin mediated signaling pathway; altered integrin mediated signaling pathway; pancreatic cancer pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
Previously known as: 59 kDa serine/threonine-protein kinase; beta-integrin-linked kinase; ILK-1; ILK-2; integrin linked kinase; integrin-linked protein kinase; p59ILK
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81169,500,716 - 169,506,972 (+)NCBIGRCr8
mRatBN7.21160,088,839 - 160,095,140 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1160,088,897 - 160,095,140 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1168,111,452 - 168,117,707 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01175,297,450 - 175,303,706 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,199,208 - 168,205,462 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,578,941 - 170,585,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,578,889 - 170,585,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,584,793 - 177,591,044 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,481,299 - 163,487,550 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,576,775 - 163,583,027 (+)NCBI
Celera1158,020,986 - 158,027,237 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-nitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
azoxystrobin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethyl trans-caffeate  (ISO)
flavonoids  (EXP)
FR900359  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
linsidomine  (EXP)
Mizoribine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
notoginsenoside R1  (EXP)
ouabain  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
Propiverine  (EXP)
pyrimidifen  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
triptonide  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in ureteric bud morphogenesis  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cell population proliferation  (ISO)
cell projection organization  (IEA,ISO)
cell-matrix adhesion  (IBA)
establishment or maintenance of epithelial cell apical/basal polarity  (IEA,ISO)
fibroblast migration  (IEA,ISO)
integrin-mediated signaling pathway  (IBA,IEA,IMP,ISO)
myelin assembly  (IMP)
myelination in peripheral nervous system  (IEA,ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of neural precursor cell proliferation  (IEA,ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of protein kinase activity  (IMP)
negative regulation of smooth muscle cell migration  (IMP)
negative regulation of smooth muscle cell proliferation  (IMP)
nerve development  (IEA,ISO)
neural precursor cell proliferation  (IEA,ISO)
neuron projection morphogenesis  (IMP)
outflow tract morphogenesis  (IEA,ISO)
peptidyl-serine phosphorylation  (IMP)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
platelet aggregation  (ISO)
positive regulation of axon extension  (IMP)
positive regulation of axonogenesis  (IMP)
positive regulation of BMP signaling pathway  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IEA,IMP,ISO)
positive regulation of cell-matrix adhesion  (IMP)
positive regulation of cellular senescence  (IMP)
positive regulation of dendrite morphogenesis  (IMP)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of MAP kinase activity  (IMP)
positive regulation of MAPK cascade  (IMP)
positive regulation of myoblast differentiation  (IMP)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
positive regulation of phosphorylation  (ISO)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of signal transduction  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (IEA,ISO)
protein phosphorylation  (IDA)
regulation of actin cytoskeleton organization  (IMP)
regulation of cell growth  (IMP)
Schwann cell development  (ISO)
substrate adhesion-dependent cell spreading  (IBA,IEA,IMP,ISO)
supramolecular fiber organization  (IMP)
tumor necrosis factor-mediated signaling pathway  (IEA,ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid. Ahmed N, etal., J Pathol. 2003 Oct;201(2):229-37.
2. Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy. Chen H, etal., Lab Invest. 2005 Nov;85(11):1342-56.
3. Adeno-associated virus-mediated ILK gene silencing in the rat NAc core. Chen Q, etal., J Neurosci Methods. 2008 Aug 30;173(2):208-14. Epub 2008 Jun 17.
4. Integrin-linked kinase induces both senescence-associated alterations and extracellular fibronectin assembly in aging cardiac fibroblasts. Chen X, etal., J Gerontol A Biol Sci Med Sci. 2006 Dec;61(12):1232-45.
5. Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination. Chun SJ, etal., J Cell Biol. 2003 Oct 27;163(2):397-408.
6. Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase. Deng JT, etal., Biochem J 2002 Oct 15;367(Pt 2):517-24.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Integrin-linked kinase expression increases with prostate tumor grade. Graff JR, etal., Clin Cancer Res. 2001 Jul;7(7):1987-91.
10. Role of the integrin-linked kinase (ILK) in determining neuronal polarity. Guo W, etal., Dev Biol. 2007 Jun 15;306(2):457-68. Epub 2007 Mar 20.
11. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Hannigan GE, etal., Nature. 1996 Jan 4;379(6560):91-6. doi: 10.1038/379091a0.
12. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
13. Integrin-linked kinase in the vascular smooth muscle cell response to injury. Ho B, etal., Am J Pathol. 2008 Jul;173(1):278-88. Epub 2008 Jun 5.
14. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
15. TGF-beta1 regulates the PINCH-1-integrin-linked kinase-alpha-parvin complex in glomerular cells. Jung KY, etal., J Am Soc Nephrol. 2007 Jan;18(1):66-73. Epub 2006 Dec 13.
16. TGF-beta1-induced PINCH-1-ILK-alpha-parvin complex formation regulates mesangial cell proliferation and hypertrophy. Kim SM, etal., Exp Mol Med. 2007 Aug 31;39(4):514-23.
17. Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex. Kim YB, etal., J Biol Chem. 2008 Apr 11;283(15):10089-96. Epub 2008 Feb 5.
18. ILK, PINCH and parvin: the tIPP of integrin signalling. Legate KR, etal., Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Integrin-linked kinase is a positive mediator of L6 myoblast differentiation. Miller MG, etal., Biochem Biophys Res Commun. 2003 Oct 24;310(3):796-803.
21. Role of integrin-linked kinase in nerve growth factor-stimulated neurite outgrowth. Mills J, etal., J Neurosci. 2003 Mar 1;23(5):1638-48.
22. Rat seminiferous epithelium contains a unique junction (Ectoplasmic specialization) with signaling properties both of cell/cell and cell/matrix junctions. Mulholland DJ, etal., Biol Reprod. 2001 Jan;64(1):396-407.
23. An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth. Naska S, etal., J Neurosci. 2006 Dec 20;26(51):13344-56.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. Nikolopoulos SN and Turner CE, J Biol Chem 2001 Jun 29;276(26):23499-505.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. [Expression of integrin-linked kinase in prostate cancer and its significance] Qi XP, etal., Zhonghua Nan Ke Xue. 2005 Jan;11(1):34-7.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. White DE, etal., Oncogene. 2001 Oct 25;20(48):7064-72.
33. Involvement of integrin-linked kinase in carbon tetrachloride-induced hepatic fibrosis in rats. Zhang Y, etal., Hepatology. 2006 Sep;44(3):612-22.
Additional References at PubMed
PMID:9366252   PMID:10637513   PMID:10871859   PMID:12432066   PMID:12670870   PMID:12835312   PMID:15489334   PMID:15528771   PMID:15565145   PMID:15831470   PMID:16201970   PMID:16679308  
PMID:16728409   PMID:16962068   PMID:17021600   PMID:17194454   PMID:18037995   PMID:18080083   PMID:18325335   PMID:18702665   PMID:19118217   PMID:19215949   PMID:19349584   PMID:19489098  
PMID:19629758   PMID:19946888   PMID:20018240   PMID:20347724   PMID:20675382   PMID:21084641   PMID:21343177   PMID:21350838   PMID:21423176   PMID:21928230   PMID:21949693   PMID:22064318  
PMID:23382103   PMID:23658024   PMID:24131868   PMID:24490163   PMID:24719101   PMID:24906011   PMID:25098415   PMID:25931508   PMID:26305322   PMID:26311435   PMID:26467393   PMID:26514267  
PMID:26520903   PMID:27111285   PMID:30657569   PMID:31255599   PMID:34012255  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81169,500,716 - 169,506,972 (+)NCBIGRCr8
mRatBN7.21160,088,839 - 160,095,140 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1160,088,897 - 160,095,140 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1168,111,452 - 168,117,707 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01175,297,450 - 175,303,706 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,199,208 - 168,205,462 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,578,941 - 170,585,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,578,889 - 170,585,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,584,793 - 177,591,044 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,481,299 - 163,487,550 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,576,775 - 163,583,027 (+)NCBI
Celera1158,020,986 - 158,027,237 (+)NCBICelera
Cytogenetic Map1q32NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38116,603,774 - 6,610,870 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,603,708 - 6,610,874 (+)EnsemblGRCh38hg38GRCh38
GRCh37116,625,004 - 6,632,101 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,581,540 - 6,588,677 (+)NCBINCBI36Build 36hg18NCBI36
Build 34116,581,587 - 6,588,673NCBI
Celera116,744,031 - 6,751,167 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef116,283,875 - 6,291,037 (+)NCBIHuRef
CHM1_1116,623,840 - 6,631,006 (+)NCBICHM1_1
T2T-CHM13v2.0116,662,246 - 6,669,338 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397105,385,797 - 105,392,132 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7105,385,799 - 105,392,132 (+)EnsemblGRCm39 Ensembl
GRCm387105,736,590 - 105,742,925 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7105,736,592 - 105,742,925 (+)EnsemblGRCm38mm10GRCm38
MGSCv377112,885,104 - 112,891,439 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367105,610,569 - 105,616,743 (+)NCBIMGSCv36mm8
Celera7106,007,890 - 106,014,225 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map755.97NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541422,316,047 - 22,322,979 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541422,316,243 - 22,322,979 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v299,041,409 - 9,048,059 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1119,005,236 - 9,011,879 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0116,735,735 - 6,742,922 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,418,717 - 6,425,788 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,418,717 - 6,425,788 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12129,911,326 - 29,917,972 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2129,911,364 - 29,917,974 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2129,613,150 - 29,619,814 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02130,737,472 - 30,744,133 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2130,737,533 - 30,744,128 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12130,058,249 - 30,064,907 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02130,223,907 - 30,230,574 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02130,419,226 - 30,425,893 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494756,007,496 - 56,013,566 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936842661,996 - 667,993 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936842661,961 - 667,993 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl93,145,608 - 3,159,858 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.193,145,647 - 3,152,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.293,803,434 - 3,810,297 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1158,214,630 - 58,221,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl158,213,310 - 58,221,217 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038156,040,403 - 156,047,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248178,096,898 - 8,106,683 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248178,096,539 - 8,103,096 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ilk
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:42
Interacting mature miRNAs:47
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21160,093,405 - 160,095,075 (+)MAPPERmRatBN7.2
Rnor_6.01170,583,458 - 170,585,127NCBIRnor6.0
Rnor_5.01177,589,310 - 177,590,979UniSTSRnor5.0
RGSC_v3.41163,485,816 - 163,487,485UniSTSRGSC3.4
Celera1158,025,503 - 158,027,172UniSTS
Cytogenetic Map1q33UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000025906   ⟹   ENSRNOP00000025906
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1160,088,897 - 160,095,135 (+)Ensembl
Rnor_6.0 Ensembl1170,578,889 - 170,585,189 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100840   ⟹   ENSRNOP00000090879
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1160,091,430 - 160,095,140 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108565   ⟹   ENSRNOP00000090768
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1160,088,911 - 160,094,876 (+)Ensembl
RefSeq Acc Id: NM_133409   ⟹   NP_596900
Rat AssemblyChrPosition (strand)Source
GRCr81169,500,721 - 169,506,972 (+)NCBI
mRatBN7.21160,088,888 - 160,095,140 (+)NCBI
Rnor_6.01170,578,941 - 170,585,192 (+)NCBI
Rnor_5.01177,584,793 - 177,591,044 (+)NCBI
RGSC_v3.41163,481,299 - 163,487,550 (+)RGD
Celera1158,020,986 - 158,027,237 (+)RGD
RefSeq Acc Id: XM_039085303   ⟹   XP_038941231
Rat AssemblyChrPosition (strand)Source
GRCr81169,500,716 - 169,506,968 (+)NCBI
mRatBN7.21160,088,839 - 160,095,132 (+)NCBI
RefSeq Acc Id: NP_596900   ⟸   NM_133409
- UniProtKB: Q99J82 (UniProtKB/Swiss-Prot),   A6I7L9 (UniProtKB/TrEMBL),   A0A8I6AP40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025906   ⟸   ENSRNOT00000025906
RefSeq Acc Id: XP_038941231   ⟸   XM_039085303
- Peptide Label: isoform X1
- UniProtKB: Q99J82 (UniProtKB/Swiss-Prot),   A6I7L9 (UniProtKB/TrEMBL),   A0A8I6AP40 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090879   ⟸   ENSRNOT00000100840
RefSeq Acc Id: ENSRNOP00000090768   ⟸   ENSRNOT00000108565
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99J82-F1-model_v2 AlphaFold Q99J82 1-452 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690291
Promoter ID:EPDNEW_R816
Type:initiation region
Description:integrin-linked kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01170,578,932 - 170,578,992EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620063 AgrOrtholog
BioCyc Gene G2FUF-58009 BioCyc
Ensembl Genes ENSRNOG00000018993 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055024435 UniProtKB/Swiss-Prot
  ENSRNOG00060019426 UniProtKB/Swiss-Prot
  ENSRNOG00065032050 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025906.5 UniProtKB/Swiss-Prot
  ENSRNOT00000100840.1 UniProtKB/TrEMBL
  ENSRNOT00000108565.1 UniProtKB/TrEMBL
  ENSRNOT00055042011 UniProtKB/Swiss-Prot
  ENSRNOT00060033652 UniProtKB/Swiss-Prot
  ENSRNOT00065055222 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_ILK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170922 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PhenoGen Ilk PhenoGen
PIRSF Integrin-linked_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018993 RatGTEx
  ENSRNOG00055024435 RatGTEx
  ENSRNOG00060019426 RatGTEx
  ENSRNOG00065032050 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-02-09 Ilk  integrin-linked kinase  Ilk  integrin linked kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ilk  integrin linked kinase    integrin-linked kinase  Name updated 1299863 APPROVED
2002-08-07 Ilk  integrin-linked kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to focal adhesions with paxillin 633110
gene_function phosphorylates both CPI-17 (protein kinase C (PKC)-dependent phosphatase inhibitor of 17 kDa) and PHI-1 (phosphatase holoenzyme inhibitor-1) 633111
gene_physical_interaction interacts with Paxillin 633110