Ptprk (protein tyrosine phosphatase, receptor type, K) - Rat Genome Database
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Gene: Ptprk (protein tyrosine phosphatase, receptor type, K) Rattus norvegicus
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Symbol: Ptprk
Name: protein tyrosine phosphatase, receptor type, K
RGD ID: 619706
Description: Predicted to have several functions, including beta-catenin binding activity; gamma-catenin binding activity; and protein tyrosine phosphatase activity. Involved in T cell differentiation; cell adhesion; and neuron projection development. Predicted to localize to several cellular components, including leading edge membrane; neuronal cell body; and photoreceptor outer segment. Orthologous to human PTPRK (protein tyrosine phosphatase receptor type K); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: protein tyrosine phosphatase, receptor type, K, extracellular region; receptor-like protein tyrosine phosphatase kappa extracellular region (RPTPK); receptor-type tyrosine-protein phosphatase kappa; Rptpk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   WKAH.LEC-Ptprkthid/Tj  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2116,738,896 - 17,236,687 (-)NCBI
Rnor_6.0 Ensembl117,446,417 - 18,058,055 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0117,445,052 - 18,058,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0119,260,651 - 19,574,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0118,602,550 - 18,714,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4117,328,563 - 17,752,200 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1117,332,345 - 17,752,187 (-)NCBI
Celera115,151,226 - 15,646,653 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
GW 7647  (EXP,ISO)
L-methionine  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
mifepristone  (ISO)
nickel dichloride  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
parathion  (ISO)
pentanal  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sunitinib  (ISO)
Tanshinone I  (ISO)
taurine  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
topotecan  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8474452   PMID:8663237   PMID:15899872   PMID:16263724   PMID:16849327   PMID:17909891   PMID:18276111   PMID:18308476   PMID:20203423  


Genomics

Comparative Map Data
Ptprk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2116,738,896 - 17,236,687 (-)NCBI
Rnor_6.0 Ensembl117,446,417 - 18,058,055 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0117,445,052 - 18,058,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0119,260,651 - 19,574,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0118,602,550 - 18,714,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4117,328,563 - 17,752,200 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1117,332,345 - 17,752,187 (-)NCBI
Celera115,151,226 - 15,646,653 (-)NCBICelera
Cytogenetic Map1p12NCBI
PTPRK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6127,968,785 - 128,520,616 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl6127,968,779 - 128,520,674 (-)EnsemblGRCh38hg38GRCh38
GRCh386127,968,785 - 128,520,603 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376128,289,930 - 128,841,744 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366128,331,625 - 128,883,416 (-)NCBINCBI36hg18NCBI36
Build 346128,331,624 - 128,883,416NCBI
Celera6129,032,183 - 129,588,206 (-)NCBI
Cytogenetic Map6q22.33NCBI
HuRef6125,866,873 - 126,423,070 (-)NCBIHuRef
CHM1_16128,554,184 - 129,106,253 (-)NCBICHM1_1
Ptprk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391027,950,406 - 28,473,393 (+)NCBIGRCm39mm39
GRCm39 Ensembl1027,950,816 - 28,473,393 (+)Ensembl
GRCm381028,074,820 - 28,597,397 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1028,074,820 - 28,597,397 (+)EnsemblGRCm38mm10GRCm38
MGSCv371027,794,626 - 28,317,203 (+)NCBIGRCm37mm9NCBIm37
MGSCv361027,764,236 - 28,285,656 (+)NCBImm8
Celera1028,989,399 - 29,512,323 (+)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1015.06NCBI
Ptprk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554368,975,554 - 9,380,971 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554368,975,742 - 9,371,608 (-)NCBIChiLan1.0ChiLan1.0
PTPRK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16129,864,573 - 130,421,909 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6129,864,573 - 130,421,644 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06125,753,656 - 126,312,124 (-)NCBIMhudiblu_PPA_v0panPan3
PTPRK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl166,597,563 - 67,124,540 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1166,596,659 - 67,022,631 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ptprk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366391,279,795 - 1,683,944 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl134,693,367 - 35,258,701 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1134,693,363 - 35,258,699 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2138,212,995 - 38,839,894 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRK
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11345,062,273 - 45,619,939 (+)NCBI
ChlSab1.1 Ensembl1345,062,342 - 45,619,929 (+)Ensembl
Ptprk
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247532,357,800 - 2,878,176 (-)NCBI

Position Markers
RH144364  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0117,500,945 - 17,501,151NCBIRnor6.0
Rnor_5.0118,656,084 - 18,656,290UniSTSRnor5.0
Celera115,205,463 - 15,205,669UniSTS
RH 3.4 Map1167.0UniSTS
Cytogenetic Map1p12UniSTS
AU028812  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0117,975,973 - 17,976,071NCBIRnor6.0
Rnor_5.0119,495,320 - 19,495,418UniSTSRnor5.0
RGSC_v3.4117,681,690 - 17,681,788UniSTSRGSC3.4
Celera115,576,743 - 15,576,833UniSTS
Cytogenetic Map1p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124368159Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128468970Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1134993530Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1134993530Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)1134993530Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1164407321Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)125439343579402Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)125439343579402Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)125439343579402Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)125439386904217Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1186804543724576Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1457869349578693Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1565577285706974Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11131448975844121Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11131448983657083Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11131448983657083Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11131448983657083Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11131448983657083Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11131465834993348Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11249343957493439Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11362925158629251Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)11603307820130904Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11614314349547474Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11614314349547474Rat


Related Rat Strains
The following Strains have been annotated to Ptprk

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:47
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000020988
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 49 39 4 39 1 1 74 35 37 11 1
Low 8 2 15 2 7 10 4 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020988   ⟹   ENSRNOP00000020988
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl117,446,417 - 18,058,055 (-)Ensembl
RefSeq Acc Id: NM_001029902   ⟹   NP_001025073
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2116,738,896 - 17,236,687 (-)NCBI
Rnor_6.0117,446,417 - 18,058,055 (-)NCBI
Rnor_5.0118,602,550 - 18,714,238 (-)NCBI
Rnor_5.0119,260,651 - 19,574,958 (-)NCBI
RGSC_v3.4117,328,563 - 17,752,200 (-)RGD
Celera115,151,226 - 15,646,653 (-)RGD
Sequence:
RefSeq Acc Id: XM_008758616   ⟹   XP_008756838
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,252 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758618   ⟹   XP_008756840
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,252 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589314   ⟹   XP_017444803
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,254 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589315   ⟹   XP_017444804
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,254 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589316   ⟹   XP_017444805
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,254 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589317   ⟹   XP_017444806
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,253 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589318   ⟹   XP_017444807
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,253 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589319   ⟹   XP_017444808
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,253 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589320   ⟹   XP_017444809
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,253 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589321   ⟹   XP_017444810
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,253 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589322   ⟹   XP_017444811
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,252 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589323   ⟹   XP_017444812
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,252 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589325   ⟹   XP_017444814
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,252 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589326   ⟹   XP_017444815
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,472,692 - 18,058,266 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589327   ⟹   XP_017444816
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,472,692 - 18,058,265 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589328   ⟹   XP_017444817
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,253 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589329   ⟹   XP_017444818
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0117,445,052 - 18,058,253 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001025073   ⟸   NM_001029902
- Peptide Label: precursor
- UniProtKB: A5I9F0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008756838   ⟸   XM_008758616
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_008756840   ⟸   XM_008758618
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_017444804   ⟸   XM_017589315
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017444805   ⟸   XM_017589316
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017444803   ⟸   XM_017589314
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017444817   ⟸   XM_017589328
- Peptide Label: isoform X16
- Sequence:
RefSeq Acc Id: XP_017444808   ⟸   XM_017589319
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017444810   ⟸   XM_017589321
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_017444818   ⟸   XM_017589329
- Peptide Label: isoform X17
- Sequence:
RefSeq Acc Id: XP_017444807   ⟸   XM_017589318
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017444809   ⟸   XM_017589320
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017444806   ⟸   XM_017589317
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017444814   ⟸   XM_017589325
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_017444812   ⟸   XM_017589323
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_017444811   ⟸   XM_017589322
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_017444815   ⟸   XM_017589326
- Peptide Label: isoform X14
- Sequence:
RefSeq Acc Id: XP_017444816   ⟸   XM_017589327
- Peptide Label: isoform X15
- Sequence:
RefSeq Acc Id: ENSRNOP00000020988   ⟸   ENSRNOT00000020988
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619706 AgrOrtholog
Ensembl Genes ENSRNOG00000047605 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020988 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020988 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro ConA-like_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  MAM_dom UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPRJ_TM UniProtKB/TrEMBL
  Tyr/Dual-sp_Pase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_rcpt/non-rcpt UniProtKB/TrEMBL
KEGG Report rno:360302 UniProtKB/TrEMBL
NCBI Gene 360302 ENTREZGENE
Pfam fn3 UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  PTP_tm UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PhenoGen Ptprk PhenoGen
PRINTS MAMDOMAIN UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  MAM_1 UniProtKB/TrEMBL
  MAM_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  FN_III-like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A5HV09_RAT UniProtKB/TrEMBL
  A5HV10_RAT UniProtKB/TrEMBL
  A5I9F0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LPL4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Ptprk  protein tyrosine phosphatase, receptor type, K  Ptprk  protein tyrosine phosphatase, receptor type, K, extracellular region  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ptprk  protein tyrosine phosphatase, receptor type, K, extracellular region  Rptpk  receptor-like protein tyrosine phosphatase kappa extracellular region (RPTPK)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Rptpk  receptor-like protein tyrosine phosphatase kappa extracellular region (RPTPK)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains extracellular domain can support homophilic adhesion 634006