Enables ATP binding activity and MAP kinase activity. Involved in ERK5 cascade; negative regulation of smooth muscle cell apoptotic process; and protein autophosphorylation. Predicted to be located in PML body and cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK7 (mitogen-activated protein kinase 7); PARTICIPATES IN Erk5 MAPK signaling pathway; altered Erk5 MAPK signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; Alisol A.
[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of MAPK7 mRNA and Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK7 mRNA]
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAPK7 mRNA and Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to MAPK7 promoter]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MAPK7 mRNA
[alisol A co-treated with alisol A 24-acetate co-treated with alisol B co-treated with alisol B 23-acetate co-treated with alisol C 23-acetate co-treated with alisol F co-treated with alisol F 24-acetate] results in increased expression of MAPK7 mRNA
[alisol A co-treated with alisol A 24-acetate co-treated with alisol B co-treated with alisol B 23-acetate co-treated with alisol C 23-acetate co-treated with alisol F co-treated with alisol F 24-acetate] results in increased expression of MAPK7 mRNA
[alisol A co-treated with alisol A 24-acetate co-treated with alisol B co-treated with alisol B 23-acetate co-treated with alisol C 23-acetate co-treated with alisol F co-treated with alisol F 24-acetate] results in increased expression of MAPK7 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aprepitant inhibits the reaction [Rotenone results in decreased phosphorylation of MAPK7 protein]] and Aprepitant inhibits the reaction [Rotenone results in decreased phosphorylation of MAPK7 protein]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MAPK7 mRNA
[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of MAPK7 mRNA and Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK7 mRNA]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MAPK7 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MAPK7 mRNA
Okadaic Acid results in increased phosphorylation of and results in increased activity of MAPK7 protein and U 0126 inhibits the reaction [Okadaic Acid results in increased phosphorylation of and results in increased activity of MAPK7 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aprepitant inhibits the reaction [Rotenone results in decreased phosphorylation of MAPK7 protein]] and Aprepitant inhibits the reaction [Rotenone results in decreased phosphorylation of MAPK7 protein]
Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.
Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor.
MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.
Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults.
The ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats.
Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.
