Mapk7 (mitogen-activated protein kinase 7) - Rat Genome Database

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Gene: Mapk7 (mitogen-activated protein kinase 7) Rattus norvegicus
Analyze
Symbol: Mapk7
Name: mitogen-activated protein kinase 7
RGD ID: 621505
Description: Enables ATP binding activity and MAP kinase activity. Involved in ERK5 cascade and negative regulation of smooth muscle cell apoptotic process. Predicted to be located in PML body and cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK7 (mitogen-activated protein kinase 7); PARTICIPATES IN Erk5 MAPK signaling pathway; altered Erk5 MAPK signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; Alisol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: big MAP kinase 1; BMK-1; Bmk1; BMK1 kinase; ERK-5; Erk5; extracellular signal-regulated kinase 5; LOC100912585; MAP kinase 7; MAPK 7; mitogen-activated protein kinase 7-like; Prkm7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,669,721 - 46,675,768 (-)NCBIGRCr8
mRatBN7.21046,170,264 - 46,176,262 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,170,167 - 46,176,267 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,873,542 - 50,878,848 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01050,364,065 - 50,369,371 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,867,492 - 45,872,798 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01047,768,592 - 47,775,130 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,766,680 - 47,775,055 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1049,002,126 - 49,009,156 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,541,086 - 47,547,066 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,649,203 - 47,654,316 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11047,662,825 - 47,664,689 (-)NCBI
Celera1045,422,029 - 45,427,142 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Alisol A  (EXP)
Alisol B  (EXP)
Alisol C 23-acetate  (EXP)
ammonium chloride  (EXP)
aprepitant  (EXP)
arecoline  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
capsaicin  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucitol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
doxorubicin  (EXP,ISO)
hesperidin  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ketamine  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-phosphocreatine  (EXP)
okadaic acid  (ISO)
ouabain  (ISO)
palytoxin  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
pterostilbene  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
trans-piceid  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)
PML body  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. Abe J, etal., J Biol Chem. 1996 Jul 12;271(28):16586-90.
2. Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. Erazo T, etal., Mol Cell Biol. 2013 Apr;33(8):1671-86. doi: 10.1128/MCB.01246-12. Epub 2013 Feb 19.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. Guo YS, etal., J Biol Chem 2002 Dec 13;277(50):48755-63.
5. Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer. McCracken SR, etal., Oncogene. 2008 May 8;27(21):2978-88. Epub 2007 Dec 10.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. Raviv Z, etal., J Cell Sci. 2004 Apr 1;117(Pt 9):1773-84. Epub 2004 Mar 16.
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults. Suzaki Y, etal., J Biol Chem. 2002 Mar 15;277(11):9614-21. Epub 2002 Jan 8.
12. The ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats. Wang RM, etal., Brain Res. 2009 Feb 19;1255:32-41. doi: 10.1016/j.brainres.2008.12.011. Epub 2008 Dec 11.
13. Regulation of cellular functions by the ERK5 signalling pathway. Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6.
14. Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor. Woo CH, etal., FASEB J. 2010 Dec;24(12):4917-28. doi: 10.1096/fj.10-162636. Epub 2010 Aug 19.
15. Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1. Yang CC, etal., Nucleic Acids Res 1998 Oct 15;26(20):4771-7.
Additional References at PubMed
PMID:11139578   PMID:11296239   PMID:11381262   PMID:11544482   PMID:12042304   PMID:12221099   PMID:12826611   PMID:14515274   PMID:14675480   PMID:14769808   PMID:15623435   PMID:15631999  
PMID:15789369   PMID:16415348   PMID:16766652   PMID:17003042   PMID:17237256   PMID:17692050   PMID:17945186   PMID:18250560   PMID:18347059   PMID:18407464   PMID:18486117   PMID:18588859  
PMID:19365559   PMID:19519168   PMID:19581298   PMID:19846573   PMID:20052676   PMID:20075332   PMID:20551324   PMID:20628425   PMID:21597237   PMID:21672705   PMID:22267842   PMID:22293190  
PMID:22374674   PMID:22742729   PMID:22778217   PMID:22803331   PMID:22869143   PMID:23043106   PMID:23165802   PMID:23361876   PMID:23896225   PMID:24411019   PMID:24460840   PMID:24740537  
PMID:25666619   PMID:25689862   PMID:26606020   PMID:26739108   PMID:28887535   PMID:29996472   PMID:31413169   PMID:34902542  


Genomics

Comparative Map Data
Mapk7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,669,721 - 46,675,768 (-)NCBIGRCr8
mRatBN7.21046,170,264 - 46,176,262 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,170,167 - 46,176,267 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,873,542 - 50,878,848 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01050,364,065 - 50,369,371 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,867,492 - 45,872,798 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01047,768,592 - 47,775,130 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,766,680 - 47,775,055 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1049,002,126 - 49,009,156 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,541,086 - 47,547,066 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,649,203 - 47,654,316 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11047,662,825 - 47,664,689 (-)NCBI
Celera1045,422,029 - 45,427,142 (-)NCBICelera
Cytogenetic Map10q22NCBI
MAPK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381719,377,750 - 19,383,544 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1719,377,721 - 19,383,544 (+)EnsemblGRCh38hg38GRCh38
GRCh371719,281,063 - 19,286,857 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361719,221,659 - 19,227,445 (+)NCBINCBI36Build 36hg18NCBI36
Build 341719,222,399 - 19,227,445NCBI
Celera1716,693,845 - 16,699,668 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1718,660,602 - 18,666,426 (+)NCBIHuRef
CHM1_11719,289,782 - 19,295,605 (+)NCBICHM1_1
T2T-CHM13v2.01719,325,785 - 19,331,579 (+)NCBIT2T-CHM13v2.0
Mapk7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,379,638 - 61,385,101 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,379,638 - 61,385,232 (-)EnsemblGRCm39 Ensembl
GRCm381161,488,812 - 61,494,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,488,812 - 61,494,406 (-)EnsemblGRCm38mm10GRCm38
MGSCv371161,302,314 - 61,307,715 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361161,305,007 - 61,310,410 (-)NCBIMGSCv36mm8
MGSCv361161,918,787 - 61,924,191 (-)NCBIMGSCv36mm8
Cytogenetic Map11B2NCBI
cM Map1137.96NCBI
Mapk7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955467378,156 - 386,532 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955467381,801 - 387,078 (-)NCBIChiLan1.0ChiLan1.0
MAPK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21954,387,153 - 54,392,917 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11759,195,965 - 59,205,328 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01731,729,429 - 31,736,216 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11736,894,146 - 36,899,969 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1736,894,146 - 36,899,969 (-)Ensemblpanpan1.1panPan2
MAPK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1540,831,949 - 40,836,990 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl540,831,947 - 40,836,505 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha540,973,093 - 40,978,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0540,939,555 - 40,944,595 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl540,939,106 - 40,944,557 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1540,907,887 - 40,912,927 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0540,854,664 - 40,859,704 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,046,762 - 41,051,802 (-)NCBIUU_Cfam_GSD_1.0
Mapk7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560260,209,586 - 60,214,727 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936881372,810 - 377,214 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936881372,713 - 377,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,144,136 - 60,158,739 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,144,138 - 60,148,743 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,962,827 - 17,969,027 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1617,964,408 - 17,968,714 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660592,882,238 - 2,888,383 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248495,656,515 - 5,664,721 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248495,655,631 - 5,661,779 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mapk7
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:292
Count of miRNA genes:92
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000003290, ENSRNOT00000057864, ENSRNOT00000072970, ENSRNOT00000073706
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat

Markers in Region
RH129756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,169,904 - 46,170,104 (+)MAPPERmRatBN7.2
Rnor_6.01049,003,684 - 49,003,883NCBIRnor6.0
Rnor_6.01047,768,233 - 47,768,432NCBIRnor6.0
Rnor_5.01048,788,343 - 48,788,542UniSTSRnor5.0
Rnor_5.01047,540,727 - 47,540,926UniSTSRnor5.0
RGSC_v3.41047,648,844 - 47,649,043UniSTSRGSC3.4
Celera1045,421,670 - 45,421,869UniSTS
RH 3.4 Map10529.92UniSTS
Cytogenetic Map10q23UniSTS
STS-U29725  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,170,430 - 46,170,681 (+)MAPPERmRatBN7.2
Rnor_6.01049,004,210 - 49,004,460NCBIRnor6.0
Rnor_6.01047,768,759 - 47,769,009NCBIRnor6.0
Rnor_5.01047,541,253 - 47,541,503UniSTSRnor5.0
Rnor_5.01048,788,869 - 48,789,119UniSTSRnor5.0
RGSC_v3.41047,649,370 - 47,649,620UniSTSRGSC3.4
Celera1045,422,196 - 45,422,446UniSTS
Cytogenetic Map10q23UniSTS
RH141658  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,170,359 - 46,170,574 (+)MAPPERmRatBN7.2
Rnor_6.01049,004,139 - 49,004,353NCBIRnor6.0
Rnor_6.01047,768,688 - 47,768,902NCBIRnor6.0
Rnor_5.01048,788,798 - 48,789,012UniSTSRnor5.0
Rnor_5.01047,541,182 - 47,541,396UniSTSRnor5.0
RGSC_v3.41047,649,299 - 47,649,513UniSTSRGSC3.4
Celera1045,422,125 - 45,422,339UniSTS
RH 3.4 Map10530.18UniSTS
Cytogenetic Map10q23UniSTS
G67083  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,174,461 - 46,175,014 (+)MAPPERmRatBN7.2
Rnor_6.01049,008,241 - 49,008,793NCBIRnor6.0
Rnor_6.01047,772,790 - 47,773,342NCBIRnor6.0
Rnor_5.01047,545,284 - 47,545,836UniSTSRnor5.0
Rnor_5.01048,792,900 - 48,793,452UniSTSRnor5.0
RGSC_v3.41047,653,401 - 47,653,953UniSTSRGSC3.4
Celera1045,426,227 - 45,426,779UniSTS
Cytogenetic Map10q23UniSTS
UniSTS:469818  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,170,282 - 46,170,553 (+)MAPPERmRatBN7.2
Rnor_6.01049,004,062 - 49,004,332NCBIRnor6.0
Rnor_6.01047,768,611 - 47,768,881NCBIRnor6.0
Rnor_5.01047,541,105 - 47,541,375UniSTSRnor5.0
Rnor_5.01048,788,721 - 48,788,991UniSTSRnor5.0
RGSC_v3.41047,649,222 - 47,649,492UniSTSRGSC3.4
Celera1045,422,048 - 45,422,318UniSTS
Cytogenetic Map10q23UniSTS
Mapk7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,174,537 - 46,175,220 (+)MAPPERmRatBN7.2
Rnor_6.01049,008,317 - 49,008,999NCBIRnor6.0
Rnor_6.01047,772,866 - 47,773,548NCBIRnor6.0
Rnor_5.01047,545,360 - 47,546,042UniSTSRnor5.0
Rnor_5.01048,792,976 - 48,793,658UniSTSRnor5.0
RGSC_v3.41047,653,477 - 47,654,159UniSTSRGSC3.4
Celera1045,426,303 - 45,426,985UniSTS
Cytogenetic Map10q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 2 1 2 45 10 27 2
Below cutoff 3 38 39 24 22 24 4 7 76 32 30 15 4

Sequence


RefSeq Acc Id: ENSRNOT00000057864   ⟹   ENSRNOP00000054673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1047,766,680 - 47,775,055 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000072970   ⟹   ENSRNOP00000064205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1046,170,167 - 46,175,714 (-)Ensembl
Rnor_6.0 Ensembl1049,004,342 - 49,009,156 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000073706   ⟹   ENSRNOP00000064398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1049,002,126 - 49,007,089 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111246   ⟹   ENSRNOP00000079913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1046,170,169 - 46,176,267 (-)Ensembl
RefSeq Acc Id: NM_001191547   ⟹   NP_001178476
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,669,721 - 46,674,834 (-)NCBI
mRatBN7.21046,170,264 - 46,175,377 (-)NCBI
Rnor_6.01047,768,592 - 47,773,705 (-)NCBI
Rnor_5.01047,541,086 - 47,547,066 (-)NCBI
Celera1045,422,029 - 45,427,142 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246417   ⟹   XP_006246479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,669,721 - 46,675,250 (-)NCBI
mRatBN7.21046,170,264 - 46,176,036 (-)NCBI
Rnor_6.01047,768,592 - 47,774,416 (-)NCBI
Rnor_5.01047,541,086 - 47,547,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246418   ⟹   XP_006246480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,669,721 - 46,675,768 (-)NCBI
mRatBN7.21046,170,264 - 46,176,262 (-)NCBI
Rnor_6.01047,768,592 - 47,775,130 (-)NCBI
Rnor_5.01047,541,086 - 47,547,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246420   ⟹   XP_006246482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,669,721 - 46,675,250 (-)NCBI
mRatBN7.21046,170,264 - 46,176,036 (-)NCBI
Rnor_6.01047,768,592 - 47,773,453 (-)NCBI
Rnor_5.01047,541,086 - 47,547,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767756   ⟹   XP_008765978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,669,721 - 46,675,250 (-)NCBI
mRatBN7.21046,170,264 - 46,176,036 (-)NCBI
Rnor_6.01047,768,592 - 47,773,453 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085036   ⟹   XP_038940964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,669,721 - 46,675,250 (-)NCBI
mRatBN7.21046,170,264 - 46,175,004 (-)NCBI
RefSeq Acc Id: XM_063268274   ⟹   XP_063124344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,669,721 - 46,675,502 (-)NCBI
RefSeq Acc Id: XM_063268275   ⟹   XP_063124345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,669,721 - 46,675,485 (-)NCBI
RefSeq Acc Id: XM_063268276   ⟹   XP_063124346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,669,721 - 46,675,667 (-)NCBI
RefSeq Acc Id: NP_001178476   ⟸   NM_001191547
- UniProtKB: P0C865 (UniProtKB/Swiss-Prot),   E9PTH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246480   ⟸   XM_006246418
- Peptide Label: isoform X1
- UniProtKB: P0C865 (UniProtKB/Swiss-Prot),   E9PTH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246479   ⟸   XM_006246417
- Peptide Label: isoform X1
- UniProtKB: P0C865 (UniProtKB/Swiss-Prot),   E9PTH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246482   ⟸   XM_006246420
- Peptide Label: isoform X2
- UniProtKB: P0C865 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008765978   ⟸   XM_008767756
- Peptide Label: isoform X2
- UniProtKB: P0C865 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_038940964   ⟸   XM_039085036
- Peptide Label: isoform X2
- UniProtKB: P0C865 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000064205   ⟸   ENSRNOT00000072970
RefSeq Acc Id: ENSRNOP00000054673   ⟸   ENSRNOT00000057864
RefSeq Acc Id: ENSRNOP00000064398   ⟸   ENSRNOT00000073706
RefSeq Acc Id: ENSRNOP00000079913   ⟸   ENSRNOT00000111246
RefSeq Acc Id: XP_063124346   ⟸   XM_063268276
- Peptide Label: isoform X2
- UniProtKB: P0C865 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063124344   ⟸   XM_063268274
- Peptide Label: isoform X1
- UniProtKB: P0C865 (UniProtKB/Swiss-Prot),   E9PTH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124345   ⟸   XM_063268275
- Peptide Label: isoform X2
- UniProtKB: P0C865 (UniProtKB/Swiss-Prot)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C865-F1-model_v2 AlphaFold P0C865 1-806 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621505 AgrOrtholog
BioCyc Gene G2FUF-24796 BioCyc
Ensembl Genes ENSRNOG00000002412 Ensembl
  ENSRNOG00000047907 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072970.3 UniProtKB/TrEMBL
  ENSRNOT00000111246.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114509 UniProtKB/TrEMBL
NCBI Gene 114509 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mapk7 PhenoGen
PROSITE MAPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002412 RatGTEx
  ENSRNOG00000047907 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PTH2 ENTREZGENE, UniProtKB/TrEMBL
  M0R4C3_RAT UniProtKB/TrEMBL
  MK07_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mapk7  mitogen-activated protein kinase 7  LOC100912585  mitogen-activated protein kinase 7-like  Data merged from RGD:6486357 737654 PROVISIONAL
2012-07-05 LOC100912585  mitogen-activated protein kinase 7-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Mapk7  mitogen-activated protein kinase 7      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mapk7  mitogen-activated protein kinase 7      Symbol and Name status set to provisional 70820 PROVISIONAL