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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-diethylaminoethanol
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Accession:CHEBI:52153 term browser browse the term
Definition:A member of the class of ethanolamines that is aminoethanol in which the hydrogens of the amino group are replaced by ethyl groups.
Synonyms:exact_synonym: 2-(diethylamino)ethanol
 related_synonym: DEAE;   Diethyl(2-hydroxyethyl)amine;   Diethylaminoethanol;   Formula=C6H15NO;   InChI=1S/C6H15NO/c1-3-7(4-2)5-6-8/h8H,3-6H2,1-2H3;   InChIKey=BFSVOASYOCHEOV-UHFFFAOYSA-N;   N,N-Diethyl-2-aminoethanol;   N,N-Diethylethanolamine;   N,N-diethyl-N-(beta-hydroxyethyl)amine;   SMILES=CCN(CC)CCO;   beta-(diethylamino)ethyl alcohol;   beta-hydroxytriethylamine;   diethylethanolamine;   diethylmonoethanolamine
 xref: Beilstein:741863;   CAS:100-37-8;   HMDB:HMDB0033971;   PMID:22325017;   Reaxys:741863;   Wikipedia:2-Diethylaminoethanol



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dicyclomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
oxybuprocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO benoxinate results in increased expression of AIFM1 protein CTD PMID:27590991 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO benoxinate results in increased expression of BAX protein CTD PMID:27590991 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO benoxinate results in decreased expression of BCL2L1 protein CTD PMID:27590991 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp2 caspase 2 increases activity ISO benoxinate results in increased activity of CASP2 protein CTD PMID:27590991 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 increases activity ISO benoxinate results in increased activity of CASP3 protein CTD PMID:27590991 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity ISO benoxinate results in increased activity of CASP9 protein CTD PMID:27590991 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO benoxinate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO benoxinate results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO benoxinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
procaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of AKT1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]
CTD PMID:32061592 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Procaine results in increased expression of ALPL mRNA CTD PMID:22083529 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Calca calcitonin-related polypeptide alpha increases secretion ISO Procaine results in increased secretion of CALCA protein CTD PMID:18172555 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Capn1 calpain 1 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN1 protein] CTD PMID:26998625 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Capn2 calpain 2 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN2 protein] CTD PMID:26998625 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP12 protein]; Procaine inhibits the reaction [Paraoxon results in increased expression of CASP12 protein] CTD PMID:20079824 PMID:26998625 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP3 protein] CTD PMID:26998625 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdh5 cadherin 5 decreases expression
multiple interactions
ISO Procaine results in decreased expression of CDH5 protein
HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]
CTD PMID:32061592 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Procaine CTD PMID:9300133 PMID:15475733 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Procaine results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
affects binding
ISO [HRH1 protein binds to Procaine] which results in increased import of Calcium; HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]; HRH1 protein affects the reaction [Procaine results in increased transport of fluorescein isothiocyanate bovine serum albumin] CTD PMID:32061592 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [Procaine co-treated with Paraoxon] results in increased expression of HSPA5 protein CTD PMID:26998625 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of ITPR1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]
CTD PMID:32061592 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of MAPK1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]
CTD PMID:32061592 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of MAPK3 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]
CTD PMID:32061592 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Procaine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of PLCG1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]
CTD PMID:32061592 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity EXP Procaine results in increased activity of TRPV1 protein CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        NMR chemical shift reference compound 17992
          ammonia 17848
            organic amino compound 17848
              tertiary amino compound 10141
                2-diethylaminoethanol 25
                  chloroprocaine + 0
                  dicyclomine + 1
                  oxybuprocaine + 9
                  procaine 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    main group molecular entity 19866
                      s-block molecular entity 19698
                        hydrogen molecular entity 19684
                          hydrides 19159
                            inorganic hydride 18151
                              pnictogen hydride 18140
                                nitrogen hydride 18046
                                  azane 17849
                                    ammonia 17848
                                      organic amino compound 17848
                                        amino alcohol 1071
                                          ethanolamines 821
                                            ethanolamine 89
                                              2-diethylaminoethanol 25
                                                chloroprocaine + 0
                                                dicyclomine + 1
                                                oxybuprocaine + 9
                                                procaine 18
paths to the root