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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-diethylaminoethanol
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Accession:CHEBI:52153 term browser browse the term
Definition:A member of the class of ethanolamines that is aminoethanol in which the hydrogens of the amino group are replaced by ethyl groups.
Synonyms:exact_synonym: 2-(diethylamino)ethanol
 related_synonym: DEAE;   Diethyl(2-hydroxyethyl)amine;   Diethylaminoethanol;   Formula=C6H15NO;   InChI=1S/C6H15NO/c1-3-7(4-2)5-6-8/h8H,3-6H2,1-2H3;   InChIKey=BFSVOASYOCHEOV-UHFFFAOYSA-N;   N,N-Diethyl-2-aminoethanol;   N,N-Diethylethanolamine;   N,N-diethyl-N-(beta-hydroxyethyl)amine;   SMILES=CCN(CC)CCO;   beta-(diethylamino)ethyl alcohol;   beta-hydroxytriethylamine;   diethylethanolamine;   diethylmonoethanolamine
 xref: Beilstein:741863;   CAS:100-37-8;   HMDB:HMDB0033971;   PMID:22325017;   Reaxys:741863;   Wikipedia:2-Diethylaminoethanol


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dicyclomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
oxybuprocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO benoxinate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO benoxinate results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO benoxinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
procaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of AKT1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]
CTD PMID:32061592 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Procaine results in increased expression of ALPL mRNA CTD PMID:22083529 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Calca calcitonin-related polypeptide alpha increases secretion ISO Procaine results in increased secretion of CALCA protein CTD PMID:18172555 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of CASP12 protein] CTD PMID:20079824 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Cdh5 cadherin 5 decreases expression
multiple interactions
ISO Procaine results in decreased expression of CDH5 protein
HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]
CTD PMID:32061592 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Procaine CTD PMID:9300133 PMID:15475733 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Procaine results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
affects binding
ISO [HRH1 protein binds to Procaine] which results in increased import of Calcium; HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]; HRH1 protein affects the reaction [Procaine results in increased transport of fluorescein isothiocyanate bovine serum albumin] CTD PMID:32061592 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of ITPR1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]
CTD PMID:32061592 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of MAPK1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]
CTD PMID:32061592 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of MAPK3 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]
CTD PMID:32061592 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Procaine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of PLCG1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]
CTD PMID:32061592 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity EXP Procaine results in increased activity of TRPV1 protein CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        refrigerant 17691
          ammonia 17278
            organic amino compound 17278
              tertiary amino compound 8677
                2-diethylaminoethanol 16
                  chloroprocaine + 0
                  dicyclomine + 1
                  oxybuprocaine + 3
                  procaine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        amino alcohol 1035
                                          ethanolamines 800
                                            ethanolamine 77
                                              2-diethylaminoethanol 16
                                                chloroprocaine + 0
                                                dicyclomine + 1
                                                oxybuprocaine + 3
                                                procaine 14
paths to the root