CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 2-diethylaminoethanol
Accession: CHEBI:52153
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Definition: A member of the class of ethanolamines that is aminoethanol in which the hydrogens of the amino group are replaced by ethyl groups.
Synonyms: exact_synonym: 2-(diethylamino)ethanol
related_synonym: DEAE; Diethyl(2-hydroxyethyl)amine; Diethylaminoethanol; Formula=C6H15NO; InChI=1S/C6H15NO/c1-3-7(4-2)5-6-8/h8H,3-6H2,1-2H3; InChIKey=BFSVOASYOCHEOV-UHFFFAOYSA-N; N,N-Diethyl-2-aminoethanol; N,N-Diethylethanolamine; N,N-diethyl-N-(beta-hydroxyethyl)amine; SMILES=CCN(CC)CCO; beta-(diethylamino)ethyl alcohol; beta-hydroxytriethylamine; diethylethanolamine; diethylmonoethanolamine
xref: Beilstein:741863; CAS:100-37-8; HMDB:HMDB0033971; PMID:22325017; Reaxys:741863; Wikipedia:2-Diethylaminoethanol
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Aifm1
apoptosis inducing factor, mitochondria associated 1
increases expression
ISO
benoxinate results in increased expression of AIFM1 protein
CTD
PMID:27590991
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
benoxinate results in increased expression of BAX protein
CTD
PMID:27590991
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
benoxinate results in decreased expression of BCL2L1 protein
CTD
PMID:27590991
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Casp2
caspase 2
increases activity
ISO
benoxinate results in increased activity of CASP2 protein
CTD
PMID:27590991
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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Casp3
caspase 3
increases activity
ISO
benoxinate results in increased activity of CASP3 protein
CTD
PMID:27590991
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases activity
ISO
benoxinate results in increased activity of CASP9 protein
CTD
PMID:27590991
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
benoxinate results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
benoxinate results in increased activity of NR1I2 protein
CTD
PMID:25455453
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
benoxinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Akt1
AKT serine/threonine kinase 1
increases phosphorylation multiple interactions
ISO
Procaine results in increased phosphorylation of AKT1 protein HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]
CTD
PMID:32061592
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alpl
alkaline phosphatase, biomineralization associated
increases expression
ISO
Procaine results in increased expression of ALPL mRNA
CTD
PMID:22083529
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Calca
calcitonin-related polypeptide alpha
increases secretion
ISO
Procaine results in increased secretion of CALCA protein
CTD
PMID:18172555
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Capn1
calpain 1
multiple interactions
ISO
Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN1 protein]
CTD
PMID:26998625
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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Capn2
calpain 2
multiple interactions
ISO
Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN2 protein]
CTD
PMID:26998625
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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Casp12
caspase 12
multiple interactions
ISO
Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP12 protein]; Procaine inhibits the reaction [Paraoxon results in increased expression of CASP12 protein]
CTD
PMID:20079824 PMID:26998625
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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Casp3
caspase 3
multiple interactions
ISO
Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP3 protein]
CTD
PMID:26998625
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cdh5
cadherin 5
decreases expression multiple interactions
ISO
Procaine results in decreased expression of CDH5 protein HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]
CTD
PMID:32061592
NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
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Ces2h
carboxylesterase 2H
increases hydrolysis
ISO
CES2 protein results in increased hydrolysis of Procaine
CTD
PMID:9300133 PMID:15475733
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Esr1
estrogen receptor 1
increases expression
ISO
Procaine results in increased expression of ESR1 mRNA
CTD
PMID:22083529
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Hrh1
histamine receptor H 1
multiple interactions affects binding
ISO
[HRH1 protein binds to Procaine] which results in increased import of Calcium; HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]; HRH1 protein affects the reaction [Procaine results in increased transport of fluorescein isothiocyanate bovine serum albumin]
CTD
PMID:32061592
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
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Hspa5
heat shock protein family A (Hsp70) member 5
multiple interactions
ISO
[Procaine co-treated with Paraoxon] results in increased expression of HSPA5 protein
CTD
PMID:26998625
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
increases phosphorylation multiple interactions
ISO
Procaine results in increased phosphorylation of ITPR1 protein HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]
CTD
PMID:32061592
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation multiple interactions
ISO
Procaine results in increased phosphorylation of MAPK1 protein HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]
CTD
PMID:32061592
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation multiple interactions
ISO
Procaine results in increased phosphorylation of MAPK3 protein HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]
CTD
PMID:32061592
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
Procaine results in increased activity of NR1I2 protein
CTD
PMID:25455453
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Plcg1
phospholipase C, gamma 1
increases phosphorylation multiple interactions
ISO
Procaine results in increased phosphorylation of PLCG1 protein HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]
CTD
PMID:32061592
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
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Trpv1
transient receptor potential cation channel, subfamily V, member 1
increases activity
EXP
Procaine results in increased activity of TRPV1 protein
CTD
PMID:18172555
NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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