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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-diethylaminoethanol
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Accession:CHEBI:52153 term browser browse the term
Definition:A member of the class of ethanolamines that is aminoethanol in which the hydrogens of the amino group are replaced by ethyl groups.
Synonyms:exact_synonym: 2-(diethylamino)ethanol
 related_synonym: DEAE;   Diethyl(2-hydroxyethyl)amine;   Diethylaminoethanol;   Formula=C6H15NO;   InChI=1S/C6H15NO/c1-3-7(4-2)5-6-8/h8H,3-6H2,1-2H3;   InChIKey=BFSVOASYOCHEOV-UHFFFAOYSA-N;   N,N-Diethyl-2-aminoethanol;   N,N-Diethylethanolamine;   N,N-diethyl-N-(beta-hydroxyethyl)amine;   SMILES=CCN(CC)CCO;   beta-(diethylamino)ethyl alcohol;   beta-hydroxytriethylamine;   diethylethanolamine;   diethylmonoethanolamine
 xref: CAS:100-37-8;   HMDB:HMDB0033971;   PMID:22325017;   Reaxys:741863;   Wikipedia:2-Diethylaminoethanol


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chloroprocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO chloroprocaine results in increased expression of BAX protein
LINC00494 inhibits the reaction [chloroprocaine results in increased expression of BAX protein]		 CTD PMID:37650745 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO chloroprocaine results in decreased expression of CCND1 protein
LINC00494 inhibits the reaction [chloroprocaine results in decreased expression of CCND1 protein]		 CTD PMID:37650745 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Med19 mediator complex subunit 19 decreases expression
multiple interactions		 ISO chloroprocaine results in decreased expression of MED19 mRNA; chloroprocaine results in decreased expression of MED19 protein
LINC00494 inhibits the reaction [chloroprocaine results in decreased expression of MED19 mRNA]; LINC00494 inhibits the reaction [chloroprocaine results in decreased expression of MED19 protein]		 CTD PMID:37650745 NCBI chr 3:90,168,829...90,179,351
Ensembl chr 3:69,762,166...69,772,036 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions		 ISO chloroprocaine results in decreased expression of PCNA protein
LINC00494 inhibits the reaction [chloroprocaine results in decreased expression of PCNA protein]		 CTD PMID:37650745 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
dicyclomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
oxybuprocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO benoxinate results in increased expression of AIFM1 protein CTD PMID:27590991 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO benoxinate results in increased expression of BAX protein CTD PMID:27590991 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO benoxinate results in decreased expression of BCL2L1 protein CTD PMID:27590991 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Casp2 caspase 2 increases activity ISO benoxinate results in increased activity of CASP2 protein CTD PMID:27590991 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases activity ISO benoxinate results in increased activity of CASP3 protein CTD PMID:27590991 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO benoxinate results in increased activity of CASP9 protein CTD PMID:27590991 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO benoxinate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO benoxinate results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO benoxinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
procaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein] CTD PMID:32061592 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Procaine results in increased expression of ALPL mRNA CTD PMID:22083529 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases secretion ISO Procaine results in increased secretion of CALCA protein CTD PMID:18172555 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Capn1 calpain 1 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN1 protein] CTD PMID:26998625 NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capn2 calpain 2 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN2 protein] CTD PMID:26998625 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP12 protein]; Procaine inhibits the reaction [Paraoxon results in increased expression of CASP12 protein] CTD PMID:20079824 PMID:26998625 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP3 protein] CTD PMID:26998625 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdh5 cadherin 5 multiple interactions
decreases expression		 ISO HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein] CTD PMID:32061592 NCBI chr19:821,875...860,931
Ensembl chr19:815,411...854,368 		JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Procaine CTD PMID:9300133 PMID:15475733 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Procaine results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
affects binding		 ISO [HRH1 protein binds to Procaine] which results in increased import of Calcium; HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]; HRH1 protein affects the reaction [Procaine results in increased transport of fluorescein isothiocyanate bovine serum albumin] CTD PMID:32061592 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [Procaine co-treated with Paraoxon] results in increased expression of HSPA5 protein CTD PMID:26998625 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions
increases phosphorylation		 ISO HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein] CTD PMID:32061592 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Procaine results in increased phosphorylation of MAPK1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:32061592 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Procaine results in increased phosphorylation of MAPK3 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:32061592 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Procaine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Plcg1 phospholipase C, gamma 1 increases phosphorylation
multiple interactions		 ISO Procaine results in increased phosphorylation of PLCG1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]		 CTD PMID:32061592 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity EXP Procaine results in increased activity of TRPV1 protein CTD PMID:18172555 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      application 19720
        NMR chemical shift reference compound 18090
          ammonia 17888
            organic amino compound 17888
              tertiary amino compound 10171
                2-diethylaminoethanol 28
                  chloroprocaine + 4
                  dicyclomine + 1
                  oxybuprocaine + 9
                  procaine 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    main group molecular entity 19846
                      s-block molecular entity 19679
                        hydrogen molecular entity 19661
                          hydrides 19163
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18079
                                  azane 17889
                                    ammonia 17888
                                      organic amino compound 17888
                                        amino alcohol 1082
                                          ethanolamines 829
                                            ethanolamine 92
                                              2-diethylaminoethanol 28
                                                chloroprocaine + 4
                                                dicyclomine + 1
                                                oxybuprocaine + 9
                                                procaine 18
paths to the root