Myocd (myocardin) - Rat Genome Database

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Gene: Myocd (myocardin) Rattus norvegicus
Analyze
Symbol: Myocd
Name: myocardin
RGD ID: 631347
Description: Predicted to enable several functions, including R-SMAD binding activity; enzyme binding activity; and transcription coactivator activity. Involved in several processes, including cardiocyte differentiation; cellular response to hypoxia; and hepatic stellate cell activation. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in congenital megabladder. Orthologous to human MYOCD (myocardin); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Mycd; transcription factor myocardin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21049,833,219 - 49,928,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1049,836,641 - 49,927,627 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1054,505,304 - 54,596,319 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01053,995,291 - 54,086,296 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01049,509,995 - 49,600,991 (-)NCBIRnor_WKY
Rnor_6.01051,682,053 - 51,781,458 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1051,683,540 - 51,778,986 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01051,439,727 - 51,534,567 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41051,496,223 - 51,588,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11051,509,851 - 51,601,849 (-)NCBI
Celera1049,052,568 - 49,143,747 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle cell apoptotic process  (IEA,ISO)
cardiac muscle cell differentiation  (IBA,ISO)
cardiac muscle cell myoblast differentiation  (IEA,ISO)
cardiac vascular smooth muscle cell differentiation  (IDA)
cardiac ventricle development  (IEA,ISO)
cell growth involved in cardiac muscle cell development  (IMP)
cellular component maintenance  (IEA,ISO)
cellular response to growth factor stimulus  (IEP)
cellular response to hypoxia  (IEP)
digestive tract development  (IEA,ISO)
DNA-templated transcription  (ISO)
ductus arteriosus closure  (IEA,ISO)
heart development  (ISO)
hepatic stellate cell activation  (IMP)
lung alveolus development  (IEA,ISO)
muscle cell differentiation  (ISO)
negative regulation of amyloid-beta clearance  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of cell adhesion molecule production  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (IEA,ISO)
negative regulation of myotube differentiation  (IEA,ISO)
negative regulation of platelet-derived growth factor receptor-beta signaling pathway  (IEA,ISO)
negative regulation of skeletal muscle cell differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell migration  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
obsolete positive regulation of transcription from RNA polymerase II promoter involved in heart development  (ISO)
obsolete positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  (ISO)
positive regulation of cardiac muscle cell differentiation  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA binding  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of gene expression  (IEA,ISO)
positive regulation of miRNA maturation  (ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of smooth muscle cell differentiation  (IEA,ISO)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,ISO)
positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
regulation of cell growth by extracellular stimulus  (IEA,ISO)
regulation of histone acetylation  (IEA,ISO,ISS)
regulation of myoblast differentiation  (IEA,ISO)
regulation of phenotypic switching  (IEA,ISO)
regulation of smooth muscle cell differentiation  (IMP)
regulation of transcription by RNA polymerase II  (ISO)
response to hypoxia  (IEA,ISO)
smooth muscle cell differentiation  (IBA,IMP,ISO)
transcription by RNA polymerase II  (IEA,ISO)
urinary bladder development  (IEA,ISO)
uterus development  (IEA,ISO)
vascular associated smooth muscle cell differentiation  (IEA,ISO)
vasculogenesis  (IEA,ISO)
ventricular cardiac muscle cell differentiation  (IEA,ISO)

Cellular Component
chromatin  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells. Br√łnnum H, etal., Exp Cell Res. 2013 Feb 15;319(4):424-35. doi: 10.1016/j.yexcr.2012.12.019. Epub 2012 Dec 24.
2. Myocardin: a component of a molecular switch for smooth muscle differentiation. Chen J, etal., J Mol Cell Cardiol 2002 Oct;34(10):1345-56.
3. HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box. Doi H, etal., Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):2328-34. Epub 2005 Sep 8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Contribution of myocardin in the hypoxia-induced phenotypic switching of rat pulmonary arterial smooth muscle cells. Jie W, etal., Exp Mol Pathol. 2010 Dec;89(3):301-6. Epub 2010 Jul 14.
7. Enhancer of polycomb1 lessens neointima formation by potentiation of myocardin-induced smooth muscle differentiation. Joung H, etal., Atherosclerosis. 2012 May;222(1):84-91. doi: 10.1016/j.atherosclerosis.2012.02.015. Epub 2012 Feb 18.
8. Effects of flavonoids on MicroRNA 145 regulation through Klf4 and myocardin in neointimal formation in vitro and in vivo. Lin CM, etal., J Nutr Biochem. 2018 Feb;52:27-35. doi: 10.1016/j.jnutbio.2017.08.016. Epub 2017 Sep 14.
9. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. Liu ZP, etal., Dev Cell. 2005 Aug;9(2):261-70.
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Gene expression profiling and functional assays of activated hepatic stellate cells suggest that myocardin has a role in activation. Shimada H, etal., Liver Int. 2010 Jan;30(1):42-54. Epub 2009 Sep 28.
16. Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase. Tan WQ, etal., J Biol Chem. 2008 Oct 31;283(44):29730-9. Epub 2008 Sep 4.
17. Myocardin is a master regulator of smooth muscle gene expression. Wang Z, etal., Proc Natl Acad Sci U S A 2003 Jun 10;100(12):7129-34. Epub 2003 May 19.
Additional References at PubMed
PMID:11439182   PMID:12392987   PMID:12640126   PMID:12663482   PMID:12867591   PMID:14645532   PMID:14970199   PMID:15014501   PMID:15256479   PMID:15601857   PMID:15623517   PMID:15798203  
PMID:15907818   PMID:16224064   PMID:16818234   PMID:17030628   PMID:17215356   PMID:17940050   PMID:18188448   PMID:18296632   PMID:18451334   PMID:18511849   PMID:18945672   PMID:19098903  
PMID:19237536   PMID:19342595   PMID:19578358   PMID:19797053   PMID:19850880   PMID:20177053   PMID:20385216   PMID:20566642   PMID:20847050   PMID:21357509   PMID:21385583   PMID:22157009  
PMID:22362485   PMID:22411986   PMID:23283978   PMID:23526547   PMID:23825366   PMID:23855625   PMID:24068960   PMID:24252873   PMID:24344135   PMID:25157858   PMID:25485719   PMID:25614278  
PMID:26147104   PMID:26206583   PMID:27155398   PMID:27861881   PMID:27939576   PMID:28003268   PMID:29035375   PMID:29199045   PMID:29303357   PMID:31513549   PMID:31928221   PMID:34694145  


Genomics

Comparative Map Data
Myocd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21049,833,219 - 49,928,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1049,836,641 - 49,927,627 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1054,505,304 - 54,596,319 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01053,995,291 - 54,086,296 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01049,509,995 - 49,600,991 (-)NCBIRnor_WKY
Rnor_6.01051,682,053 - 51,781,458 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1051,683,540 - 51,778,986 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01051,439,727 - 51,534,567 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41051,496,223 - 51,588,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11051,509,851 - 51,601,849 (-)NCBI
Celera1049,052,568 - 49,143,747 (-)NCBICelera
Cytogenetic Map10q24NCBI
MYOCD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381712,665,890 - 12,768,949 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1712,665,890 - 12,768,949 (+)EnsemblGRCh38hg38GRCh38
GRCh371712,569,207 - 12,672,266 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361712,510,231 - 12,607,686 (+)NCBINCBI36Build 36hg18NCBI36
Build 341712,510,230 - 12,607,686NCBI
Celera1712,594,549 - 12,695,987 (+)NCBICelera
Cytogenetic Map17p12NCBI
HuRef1712,464,600 - 12,566,080 (+)NCBIHuRef
CHM1_11712,577,982 - 12,679,406 (+)NCBICHM1_1
T2T-CHM13v2.01712,573,362 - 12,676,444 (+)NCBIT2T-CHM13v2.0
Myocd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,064,434 - 65,160,815 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,067,387 - 65,160,815 (-)EnsemblGRCm39 Ensembl
GRCm381165,173,608 - 65,269,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,176,561 - 65,269,989 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,990,063 - 65,083,491 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,992,756 - 65,086,175 (-)NCBIMGSCv36mm8
Celera1172,112,506 - 72,207,425 (-)NCBICelera
Cytogenetic Map11B3NCBI
Myocd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554674,656,380 - 4,743,110 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554674,653,065 - 4,743,438 (-)NCBIChiLan1.0ChiLan1.0
MYOCD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11743,578,967 - 43,681,659 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1743,584,259 - 43,681,659 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01738,880,120 - 38,983,246 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MYOCD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1536,674,476 - 36,774,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl536,674,300 - 36,769,327 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha536,774,863 - 36,918,323 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0536,738,753 - 36,883,183 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl536,782,154 - 36,879,172 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1536,711,643 - 36,856,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0536,659,301 - 36,802,936 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0536,843,479 - 36,993,391 (+)NCBIUU_Cfam_GSD_1.0
Myocd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560251,782,304 - 51,881,336 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365955,256,785 - 5,351,723 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365955,256,615 - 5,356,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOCD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1256,931,317 - 57,029,258 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11256,931,628 - 57,029,258 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21259,928,695 - 59,945,526 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYOCD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11611,923,464 - 12,100,897 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1612,000,197 - 12,095,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660599,137,934 - 9,239,568 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myocd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624877618,789 - 647,471 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myocd
434 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir145rno-miR-145-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)19542014

Predicted Target Of
Summary Value
Count of predictions:236
Count of miRNA genes:155
Interacting mature miRNAs:189
Transcripts:ENSRNOT00000057562
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat

Markers in Region
D10Rat62  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,900,287 - 49,900,435 (+)MAPPERmRatBN7.2
Rnor_6.01051,747,009 - 51,747,156NCBIRnor6.0
Rnor_5.01051,503,287 - 51,503,434UniSTSRnor5.0
RGSC_v3.41051,560,410 - 51,560,558RGDRGSC3.4
RGSC_v3.41051,560,411 - 51,560,558UniSTSRGSC3.4
RGSC_v3.11051,574,034 - 51,574,181RGD
Celera1049,116,392 - 49,116,539UniSTS
RH 3.4 Map10581.0UniSTS
RH 3.4 Map10581.0RGD
RH 2.0 Map10568.7RGD
FHH x ACI Map1040.36RGD
Cytogenetic Map10q24UniSTS
RH133589  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,907,920 - 49,908,113 (+)MAPPERmRatBN7.2
Rnor_6.01051,758,961 - 51,759,153NCBIRnor6.0
Rnor_5.01051,514,423 - 51,514,615UniSTSRnor5.0
RGSC_v3.41051,568,519 - 51,568,711UniSTSRGSC3.4
Celera1049,124,042 - 49,124,234UniSTS
RH 3.4 Map10580.3UniSTS
Cytogenetic Map10q24UniSTS
PMC150745P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,849,554 - 49,849,663 (+)MAPPERmRatBN7.2
Rnor_6.01051,696,454 - 51,696,562NCBIRnor6.0
Rnor_5.01051,452,647 - 51,452,755UniSTSRnor5.0
RGSC_v3.41051,509,143 - 51,509,251UniSTSRGSC3.4
Celera1049,065,353 - 49,065,461UniSTS
Cytogenetic Map10q24UniSTS
PMC309615P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,849,919 - 49,850,213 (+)MAPPERmRatBN7.2
Rnor_6.01051,696,819 - 51,697,112NCBIRnor6.0
Rnor_5.01051,453,012 - 51,453,305UniSTSRnor5.0
RGSC_v3.41051,509,508 - 51,509,801UniSTSRGSC3.4
Celera1049,065,718 - 49,066,011UniSTS
Cytogenetic Map10q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 36 6
Low 3 7 14 4 7 4 8 10 12 22 26 11 8
Below cutoff 27 21 12 21 1 62 13 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000057562   ⟹   ENSRNOP00000054372
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1049,836,641 - 49,927,627 (-)Ensembl
Rnor_6.0 Ensembl1051,683,540 - 51,778,986 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078675   ⟹   ENSRNOP00000072988
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1049,836,641 - 49,927,627 (-)Ensembl
Rnor_6.0 Ensembl1051,685,228 - 51,778,939 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109338   ⟹   ENSRNOP00000084177
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1049,836,641 - 49,892,157 (-)Ensembl
RefSeq Acc Id: NM_182667   ⟹   NP_872608
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21049,836,635 - 49,927,627 (-)NCBI
Rnor_6.01051,683,534 - 51,778,986 (-)NCBI
Rnor_5.01051,439,727 - 51,534,567 (-)NCBI
RGSC_v3.41051,496,223 - 51,588,226 (-)RGD
Celera1049,052,568 - 49,143,747 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246582   ⟹   XP_006246644
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21049,833,219 - 49,928,806 (-)NCBI
Rnor_6.01051,682,053 - 51,781,452 (-)NCBI
Rnor_5.01051,439,727 - 51,534,567 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246583   ⟹   XP_006246645
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21049,833,219 - 49,928,806 (-)NCBI
Rnor_6.01051,682,053 - 51,781,458 (-)NCBI
Rnor_5.01051,439,727 - 51,534,567 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_872608   ⟸   NM_182667
- UniProtKB: Q8R5I8 (UniProtKB/Swiss-Prot),   Q8R5I7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006246644   ⟸   XM_006246582
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246645   ⟸   XM_006246583
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000054372   ⟸   ENSRNOT00000057562
RefSeq Acc Id: ENSRNOP00000072988   ⟸   ENSRNOT00000078675
RefSeq Acc Id: ENSRNOP00000084177   ⟸   ENSRNOT00000109338
Protein Domains
SAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R5I7-F1-model_v2 AlphaFold Q8R5I7 1-938 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697286
Promoter ID:EPDNEW_R7811
Type:single initiation site
Name:Myocd_1
Description:myocardin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01051,779,041 - 51,779,101EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631347 AgrOrtholog
BioCyc Gene G2FUF-24715 BioCyc
Ensembl Genes ENSRNOG00000003669 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000054372 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072988 ENTREZGENE
  ENSRNOP00000072988.1 UniProtKB/TrEMBL
  ENSRNOP00000084177.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057562 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000078675 ENTREZGENE
  ENSRNOT00000078675.2 UniProtKB/TrEMBL
  ENSRNOT00000109338.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Myocardin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYOCD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RPEL_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246297 UniProtKB/Swiss-Prot
NCBI Gene 246297 ENTREZGENE
PANTHER PTHR22793 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22793:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RPEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myocd PhenoGen
PROSITE RPEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RPEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF68906 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K4C5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYX5_RAT UniProtKB/TrEMBL
  MYCD_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8R5I8 ENTREZGENE
UniProt Secondary Q7M6Y4 UniProtKB/Swiss-Prot
  Q8R5I8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Myocd  myocardin  Myocd  transcription factor myocardin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Myocd  transcription factor myocardin  Mycd    Symbol and Name updated 1299863 APPROVED