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Gene: Npr1 (natriuretic peptide receptor 1) Rattus norvegicus
Symbol: Npr1
Name: natriuretic peptide receptor 1
Description: Exhibits guanylate cyclase activity and protein kinase binding activity. Involved in several processes, including cGMP-mediated signaling; negative regulation of smooth muscle cell proliferation; and positive regulation of cGMP-mediated signaling. Localizes to plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1); PARTICIPATES IN atrial natriuretic peptide signaling pathway; brain natriuretic peptide signaling pathway; purine metabolic pathway; INTERACTS WITH 2,6-dinitrotoluene; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: ANP-A; ANPR-A; Anpra; atrial natriuretic peptide A-type receptor; atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor A; atrial natriuretic peptide receptor type A; GC-A; Gca; guanylate cyclase A; Natriuretic peptide receptor A/Guanylate cyclase A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); NPR-A; Npra
Homo sapiens (human) : NPR1 (natriuretic peptide receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Npr1 (natriuretic peptide receptor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npr1 (natriuretic peptide receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NPR1 (natriuretic peptide receptor 1)
Canis lupus familiaris (dog) : NPR1 (natriuretic peptide receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npr1 (natriuretic peptide receptor 1)
Sus scrofa (pig) : NPR1 (natriuretic peptide receptor 1)
Chlorocebus sabaeus (African green monkey) : NPR1 (natriuretic peptide receptor 1)
Heterocephalus glaber (naked mole-rat) : Npr1 (natriuretic peptide receptor 1)
more info ...
Is Marker For: Strains:   SS.MNS-(Mme-Gca)/Ayd  
QTLs:   Niddm8   Bp19   Cm67   Bp363   Am4   Kidm56   Bw176  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02189,840,403 - 189,857,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,840,403 - 189,856,090 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02209,271,276 - 209,287,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,724,916 - 182,740,242 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12182,675,021 - 182,690,348 (-)NCBI
Celera2169,869,831 - 169,885,101 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Npr1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3195
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.