Gene: Npr1 (natriuretic peptide receptor 1) Rattus norvegicus
Symbol: Npr1
Name: natriuretic peptide receptor 1
Description: ENCODES a protein that exhibits GTP binding; guanylate cyclase activity; natriuretic peptide receptor activity; INVOLVED IN cell surface receptor signaling pathway; cGMP biosynthetic process; dopamine metabolic process; PARTICIPATES IN atrial natriuretic peptide signaling pathway; brain natriuretic peptide signaling pathway; purine metabolic pathway; ASSOCIATED WITH increased systemic arterial blood pressure; increased systemic arterial diastolic blood pressure; ASSOCIATED WITH Hypertension; Hypertrophy, Left Ventricular; Aortic Rupture (ortholog); FOUND IN plasma membrane; receptor complex (ortholog); INTERACTS WITH 2,6-dinitrotoluene; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,3',4,4',5-pentachlorobiphenyl
Type: protein-coding
Also known as: ANP-A; ANPR-A; Anpra; atrial natriuretic peptide A-type receptor; atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor A; atrial natriuretic peptide receptor type A; GC-A; Gca; guanylate cyclase A; Natriuretic peptide receptor A/Guanylate cyclase A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); NPR-A; Npra
Homo sapiens (human) : NPR1 (natriuretic peptide receptor 1)  HGNC  AGR
Mus musculus (house mouse) : Npr1 (natriuretic peptide receptor 1)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Npr1 (natriuretic peptide receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NPR1 (natriuretic peptide receptor 1)
Canis lupus familiaris (dog) : NPR1 (natriuretic peptide receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npr1 (natriuretic peptide receptor 1)
more info ...
Is Marker For: Strains:   SS.MNS-(Mme-Gca)/Ayd  
QTLs:   Niddm8   Bp19   Cm67   Bp363   Kidm56   Bw176  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02189,840,403 - 189,857,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02209,271,276 - 209,287,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,724,916 - 182,740,242 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12182,675,021 - 182,690,348 (-)NCBI
Celera2169,869,831 - 169,885,101 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Npr1
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3195
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-11-14
Status: ACTIVE