Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | ISO | Higd1a (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of HIGD1A mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | ISO | Higd1a (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of HIGD1A mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | Higd1a (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of HIGD1A mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of HIGD1A mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of HIGD1A mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Higd1a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HIGD1A mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HIGD1A mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of HIGD1A mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HIGD1A mRNA | CTD | PMID:17942748 | 2,4-diaminotoluene | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | 2 and 4-diaminotoluene results in increased expression of HIGD1A mRNA | CTD | PMID:20713471 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of HIGD1A mRNA | CTD | PMID:21346803 | 2-hydroxypropanoic acid | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of HIGD1A mRNA | CTD | PMID:30851411 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:23196670 | 3,3',5-triiodo-L-thyronine | increases expression | EXP | | 6480464 | Triiodothyronine results in increased expression of HIGD1A mRNA | CTD | PMID:15953391 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of HIGD1A mRNA | CTD | PMID:19162173 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Higd1a (Mus musculus) | 6480464 | Fenretinide results in decreased expression of HIGD1A mRNA | CTD | PMID:28973697 | aflatoxin B1 | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of HIGD1A mRNA | CTD | PMID:22100608 | aflatoxin B1 | decreases methylation | ISO | HIGD1A (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of HIGD1A intron | CTD | PMID:30157460 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of HIGD1A mRNA | CTD | PMID:16483693 | Aroclor 1254 | decreases expression | ISO | Higd1a (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of HIGD1A mRNA | CTD | PMID:23650126 | arsane | affects methylation | ISO | HIGD1A (Homo sapiens) | 6480464 | Arsenic affects the methylation of HIGD1A gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | HIGD1A (Homo sapiens) | 6480464 | Arsenic affects the methylation of HIGD1A gene | CTD | PMID:25304211 | arsenous acid | increases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of HIGD1A mRNA | CTD | PMID:20458559 | benzo[a]pyrene | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of HIGD1A mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of HIGD1A mRNA | CTD | PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | HIGD1A (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of HIGD1A promoter | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | increases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of HIGD1A mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | ISO | Higd1a (Mus musculus) | 6480464 | bisphenol A results in decreased expression of HIGD1A mRNA | CTD | PMID:26063408 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of HIGD1A mRNA | CTD | PMID:32145629 | bisphenol A | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of HIGD1A mRNA | CTD | PMID:29275510 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of HIGD1A gene | CTD | PMID:28505145 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of HIGD1A mRNA | CTD | PMID:25181051 | butanal | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of HIGD1A mRNA | CTD | PMID:26079696 | caffeine | increases phosphorylation | ISO | HIGD1A (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of HIGD1A protein | CTD | PMID:35688186 | carbon nanotube | affects expression | ISO | Higd1a (Mus musculus) | 6480464 | Nanotubes and Carbon affects the expression of HIGD1A mRNA | CTD | PMID:25620056 | carbon nanotube | decreases expression | ISO | Higd1a (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of HIGD1A mRNA | CTD | PMID:25620056 | chloropicrin | increases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | chloropicrin results in increased expression of HIGD1A mRNA | CTD | PMID:26352163 | chlorpyrifos | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of HIGD1A mRNA | CTD | PMID:37019170 | clozapine | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | Clozapine results in increased expression of HIGD1A mRNA | CTD | PMID:14647396 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of HIGD1A mRNA | CTD | PMID:24386269 | cocaine | increases expression | EXP | | 6480464 | Cocaine results in increased expression of HIGD1A protein | CTD | PMID:25100957 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of HIGD1A mRNA | CTD | PMID:20187946 | copper atom | multiple interactions | ISO | HIGD1A (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of HIGD1A mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | HIGD1A (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of HIGD1A mRNA | CTD | PMID:20971185 | copper(II) sulfate | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of HIGD1A mRNA | CTD | PMID:19549813 | crocidolite asbestos | increases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in increased expression of HIGD1A mRNA | CTD | PMID:29523930 | cyclosporin A | decreases expression | ISO | Higd1a (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of HIGD1A mRNA | CTD | PMID:19770486 | cyclosporin A | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of HIGD1A mRNA | CTD | PMID:20106945 and PMID:25562108 | dexamethasone | increases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Dexamethasone results in increased expression of HIGD1A mRNA | CTD | PMID:25047013 | diarsenic trioxide | increases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of HIGD1A mRNA | CTD | PMID:20458559 | dicrotophos | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of HIGD1A mRNA | CTD | PMID:28302478 | dioxygen | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of HIGD1A mRNA | CTD | PMID:20880076 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of HIGD1A mRNA | CTD | PMID:21551480 | doxorubicin | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of HIGD1A mRNA | CTD | PMID:29803840 | epoxiconazole | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | epoxiconazole results in increased expression of HIGD1A mRNA | CTD | PMID:35436446 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of HIGD1A mRNA | CTD | PMID:24136188 | fluoranthene | multiple interactions | ISO | Higd1a (Mus musculus) | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in decreased expression of HIGD1A mRNA | CTD | PMID:28329830 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of HIGD1A mRNA | CTD | PMID:24136188 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of HIGD1A mRNA | CTD | PMID:33387578 | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of HIGD1A mRNA | CTD | PMID:24136188 | haloperidol | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | Haloperidol results in increased expression of HIGD1A mRNA | CTD | PMID:14647396 | ivermectin | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of HIGD1A protein | CTD | PMID:32959892 | methapyrilene | increases expression | EXP | | 6480464 | Methapyrilene results in increased expression of HIGD1A mRNA | CTD | PMID:30467583 | methotrexate | affects expression | ISO | Higd1a (Mus musculus) | 6480464 | Methotrexate affects the expression of HIGD1A mRNA | CTD | PMID:18502557 | methylmercury chloride | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of HIGD1A mRNA | CTD | PMID:28001369 | mifepristone | increases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Mifepristone results in increased expression of HIGD1A mRNA | CTD | PMID:17584828 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of HIGD1A mRNA | CTD | PMID:24136188 | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of HIGD1A mRNA | CTD | PMID:22110744 | nickel dichloride | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | nickel chloride results in increased expression of HIGD1A mRNA | CTD | PMID:12839937 | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of HIGD1A mRNA | CTD | PMID:24136188 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of HIGD1A mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | HIGD1A (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of HIGD1A mRNA | CTD | PMID:35430440 | paracetamol | affects expression | ISO | Higd1a (Mus musculus) | 6480464 | Acetaminophen affects the expression of HIGD1A mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of HIGD1A mRNA | CTD | PMID:33387578 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of HIGD1A mRNA | CTD | PMID:19162173 | phenylephrine | increases expression | EXP | | 6480464 | Phenylephrine results in increased expression of HIGD1A mRNA | CTD | PMID:18158353 | pirinixic acid | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | pirinixic acid results in increased expression of HIGD1A mRNA | CTD | PMID:17426115 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of HIGD1A mRNA | CTD | PMID:19162173 | pirinixic acid | multiple interactions | ISO | HIGD1A (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HIGD1A mRNA | CTD | PMID:19710929 | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of HIGD1A mRNA | CTD | PMID:19162173 | quercetin | affects expression | EXP | | 6480464 | Quercetin affects the expression of HIGD1A mRNA | CTD | PMID:18178720 | rac-lactic acid | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of HIGD1A mRNA | CTD | PMID:30851411 | resveratrol | multiple interactions | ISO | HIGD1A (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of HIGD1A mRNA | CTD | PMID:23557933 | rotenone | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | Rotenone results in increased expression of HIGD1A mRNA | CTD | PMID:32937126 | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of HIGD1A mRNA | CTD | PMID:19281266 | sulindac | increases expression | EXP | | 6480464 | Sulindac results in increased expression of HIGD1A mRNA | CTD | PMID:24136188 | tamoxifen | affects expression | ISO | Higd1a (Mus musculus) | 6480464 | Tamoxifen affects the expression of HIGD1A mRNA | CTD | PMID:17555576 | Tesaglitazar | increases expression | EXP | | 6480464 | tesaglitazar results in increased expression of HIGD1A mRNA | CTD | PMID:21515302 | tetrachloromethane | affects expression | ISO | Higd1a (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of HIGD1A mRNA | CTD | PMID:17484886 | tolcapone | decreases expression | EXP | | 6480464 | tolcapone results in decreased expression of HIGD1A mRNA | CTD | PMID:24136188 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of HIGD1A mRNA | CTD | PMID:25729387 | topotecan | increases expression | EXP | | 6480464 | Topotecan results in increased expression of HIGD1A mRNA | CTD | PMID:25729387 | triclosan | decreases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Triclosan results in decreased expression of HIGD1A mRNA | CTD | PMID:30510588 | triptonide | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | triptonide results in increased expression of HIGD1A mRNA | CTD | PMID:33045310 | tungsten | increases expression | ISO | Higd1a (Mus musculus) | 6480464 | Tungsten results in increased expression of HIGD1A mRNA | CTD | PMID:30912803 | valproic acid | decreases methylation | ISO | HIGD1A (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of HIGD1A gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Valproic Acid affects the expression of HIGD1A mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of HIGD1A mRNA | CTD | PMID:23179753 more ... | vorinostat | increases expression | ISO | HIGD1A (Homo sapiens) | 6480464 | vorinostat results in increased expression of HIGD1A mRNA | CTD | PMID:27188386 | |