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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sotalol
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Accession:CHEBI:63622 term browser browse the term
Definition:A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is sustituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Synonyms:exact_synonym: N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
 related_synonym: 4'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide;   Formula=C12H20N2O3S;   InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3;   InChIKey=ZBMZVLHSJCTVON-UHFFFAOYSA-N;   SMILES=CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1;   beta-cardone;   sotalolum
 alt_id: CHEBI:9206
 xref: CAS:3930-20-9;   DrugBank:DB00489;   Drug_Central:2464;   HMDB:HMDB0014632;   KEGG:C07309;   KEGG:D08525;   LINCS:LSM-1465
 xref_mesh: MESH:D013015
 xref: PMID:20562595;   PMID:21553267;   PMID:21854895;   Reaxys:2380820;   Wikipedia:Sotalol
 cyclic_relationship: is_conjugate_base_of CHEBI:63647

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sotalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport		 ISO valspodar inhibits the reaction [ABCB1 protein results in increased transport of Sotalol] CTD PMID:16671962 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Sotalol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:15060759 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985 		JBrowse link
G Adrb2 adrenoceptor beta 2 affects binding
multiple interactions		 ISO Sotalol binds to ADRB2 protein
[Sotalol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP		 CTD PMID:2169833, PMID:17925438 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Sotalol results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression
increases expression		 ISO Sotalol results in decreased expression of ASNS mRNA
Sotalol results in increased expression of ASNS mRNA		 CTD PMID:15342952, PMID:17175557 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Sotalol results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression
decreases expression		 ISO Sotalol results in increased expression of GDPD3 mRNA
Sotalol results in decreased expression of GDPD3 mRNA		 CTD PMID:17175557 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150 		JBrowse link
G Inhbe inhibin subunit beta E decreases expression
increases expression		 ISO Sotalol results in decreased expression of INHBE mRNA
Sotalol results in increased expression of INHBE mRNA		 CTD PMID:17175557 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases response to substance
decreases activity
affects binding
multiple interactions		 ISO KCNH2 gene mutant form results in decreased susceptibility to Sotalol
Sotalol results in decreased activity of KCNH2 protein
Sotalol analog binds to KCNH2 protein
Potassium inhibits the reaction [Sotalol results in decreased activity of KCNH2 protein]		 CTD PMID:15673388, PMID:16757186, PMID:16960444, PMID:18701618, PMID:24052561, PMID:30561737 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Lss lanosterol synthase decreases expression ISO Sotalol results in decreased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
increases expression		 ISO Sotalol results in decreased expression of NR0B2 mRNA
Sotalol results in increased expression of NR0B2 mRNA		 CTD PMID:15342952, PMID:17175557 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Sotalol results in increased expression of NUPR1 mRNA CTD PMID:17175557 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Sotalol results in increased expression of PHYH mRNA CTD PMID:17567588 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530 		JBrowse link
G Plat plasminogen activator, tissue type increases expression EXP Sotalol results in increased expression of PLAT protein CTD PMID:9594410 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889 		JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Sotalol results in increased expression of SERPINA3 mRNA CTD PMID:17175557 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO Sotalol results in increased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Sotalol results in increased expression of WIPI1 mRNA CTD PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        xenobiotic 18380
          sotalol 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        amino alcohol 882
                                          ethanolamines 769
                                            sotalol 17
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