CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: sotalol
Accession: CHEBI:63622
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Definition: A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Synonyms: exact_synonym: N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
related_synonym: 4'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide; Formula=C12H20N2O3S; InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3; InChIKey=ZBMZVLHSJCTVON-UHFFFAOYSA-N; SMILES=CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1; beta-cardone; sotalolum
alt_id: CHEBI:9206
xref: CAS:3930-20-9; DrugBank:DB00489; Drug_Central:2464; HMDB:HMDB0014632; KEGG:C07309; KEGG:D08525; LINCS:LSM-1465
xref_mesh: MESH:D013015
xref: PMID:20562595; PMID:21553267; PMID:21854895; Reaxys:2380820; Wikipedia:Sotalol
cyclic_relationship: is_conjugate_base_of CHEBI:63647
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions increases transport
ISO
valspodar inhibits the reaction [ABCB1 protein results in increased transport of Sotalol]
CTD
PMID:16671962
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Adrb1
adrenoceptor beta 1
multiple interactions
ISO
Sotalol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]
CTD
PMID:15060759
NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
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Adrb2
adrenoceptor beta 2
affects binding multiple interactions
ISO
Sotalol binds to ADRB2 protein [Sotalol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP
CTD
PMID:2169833 PMID:17925438
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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Asah1
N-acylsphingosine amidohydrolase 1
increases expression
ISO
Sotalol results in increased expression of ASAH1 mRNA
CTD
PMID:17175557
NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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Asns
asparagine synthetase (glutamine-hydrolyzing)
decreases expression increases expression
ISO
Sotalol results in decreased expression of ASNS mRNA Sotalol results in increased expression of ASNS mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Depp1
DEPP autophagy regulator 1
increases expression
ISO
Sotalol results in increased expression of DEPP1 mRNA
CTD
PMID:17175557
NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Sotalol results in increased expression of FNDC4 mRNA
CTD
PMID:17175557
NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
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Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
increases expression decreases expression
ISO
Sotalol results in increased expression of GDPD3 mRNA Sotalol results in decreased expression of GDPD3 mRNA
CTD
PMID:17175557
NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
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Inhbe
inhibin subunit beta E
decreases expression increases expression
ISO
Sotalol results in decreased expression of INHBE mRNA Sotalol results in increased expression of INHBE mRNA
CTD
PMID:17175557
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases response to substance affects binding multiple interactions decreases activity
ISO
KCNH2 gene mutant form results in decreased susceptibility to Sotalol Sotalol analog binds to KCNH2 protein Potassium inhibits the reaction [Sotalol results in decreased activity of KCNH2 protein]
CTD
PMID:15673388 PMID:16757186 PMID:16960444 PMID:18701618 PMID:24052561 PMID:30561737 More...
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Lss
lanosterol synthase
decreases expression
ISO
Sotalol results in decreased expression of LSS mRNA
CTD
PMID:15342952
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
decreases expression increases expression
ISO
Sotalol results in decreased expression of NR0B2 mRNA Sotalol results in increased expression of NR0B2 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Sotalol results in increased expression of NUPR1 mRNA
CTD
PMID:17175557
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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Phyh
phytanoyl-CoA 2-hydroxylase
increases expression
ISO
Sotalol results in increased expression of PHYH mRNA
CTD
PMID:17567588
NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
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Plat
plasminogen activator, tissue type
increases expression
EXP
Sotalol results in increased expression of PLAT protein
CTD
PMID:9594410
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
increases expression
ISO
Sotalol results in increased expression of SERPINA3 mRNA
CTD
PMID:17175557
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Slc2a3
solute carrier family 2 member 3
increases expression
ISO
Sotalol results in increased expression of SLC2A3 mRNA
CTD
PMID:15342952
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Sotalol results in increased expression of WIPI1 mRNA
CTD
PMID:17175557
NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
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