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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sotalol
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Accession:CHEBI:63622 term browser browse the term
Definition:A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Synonyms:exact_synonym: N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
 related_synonym: 4'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide;   Formula=C12H20N2O3S;   InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3;   InChIKey=ZBMZVLHSJCTVON-UHFFFAOYSA-N;   SMILES=CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1;   beta-cardone;   sotalolum
 alt_id: CHEBI:9206
 xref: CAS:3930-20-9;   DrugBank:DB00489;   Drug_Central:2464;   HMDB:HMDB0014632;   KEGG:C07309;   KEGG:D08525;   LINCS:LSM-1465
 xref_mesh: MESH:D013015
 xref: PMID:20562595;   PMID:21553267;   PMID:21854895;   Reaxys:2380820;   Wikipedia:Sotalol
 cyclic_relationship: is_conjugate_base_of CHEBI:63647


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sotalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport 		ISO valspodar inhibits the reaction [ABCB1 protein results in increased transport of Sotalol] CTD PMID:16671962 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Sotalol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:15060759 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237 		JBrowse link
G Adrb2 adrenoceptor beta 2 affects binding
multiple interactions 		ISO Sotalol binds to ADRB2 protein
[Sotalol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP 		CTD PMID:2169833 PMID:17925438 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Sotalol results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression
increases expression 		ISO Sotalol results in decreased expression of ASNS mRNA
Sotalol results in increased expression of ASNS mRNA 		CTD PMID:15342952 PMID:17175557 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Sotalol results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Sotalol results in increased expression of FNDC4 mRNA CTD PMID:17175557 NCBI chr 6:30,797,102...30,800,782
Ensembl chr 6:30,796,871...30,800,769 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression
decreases expression 		ISO Sotalol results in increased expression of GDPD3 mRNA
Sotalol results in decreased expression of GDPD3 mRNA 		CTD PMID:17175557 NCBI chr 1:190,804,053...190,813,609
Ensembl chr 1:190,803,993...190,813,606 		JBrowse link
G Inhbe inhibin subunit beta E decreases expression
increases expression 		ISO Sotalol results in decreased expression of INHBE mRNA
Sotalol results in increased expression of INHBE mRNA 		CTD PMID:17175557 NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases response to substance
affects binding
multiple interactions
decreases activity 		ISO KCNH2 gene mutant form results in decreased susceptibility to Sotalol
Sotalol analog binds to KCNH2 protein
Potassium inhibits the reaction [Sotalol results in decreased activity of KCNH2 protein] 		CTD PMID:15673388 PMID:16757186 PMID:16960444 PMID:18701618 PMID:24052561 More... NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Lss lanosterol synthase decreases expression ISO Sotalol results in decreased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
increases expression 		ISO Sotalol results in decreased expression of NR0B2 mRNA
Sotalol results in increased expression of NR0B2 mRNA 		CTD PMID:15342952 PMID:17175557 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Sotalol results in increased expression of NUPR1 mRNA CTD PMID:17175557 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Sotalol results in increased expression of PHYH mRNA CTD PMID:17567588 NCBI chr17:78,238,747...78,255,645
Ensembl chr17:78,238,747...78,255,645 		JBrowse link
G Plat plasminogen activator, tissue type increases expression EXP Sotalol results in increased expression of PLAT protein CTD PMID:9594410 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696 		JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Sotalol results in increased expression of SERPINA3 mRNA CTD PMID:17175557 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO Sotalol results in increased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Sotalol results in increased expression of WIPI1 mRNA CTD PMID:17175557 NCBI chr10:95,042,451...95,079,679
Ensembl chr10:95,042,441...95,079,293 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        xenobiotic 19528
          sotalol 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        amino alcohol 1084
                                          ethanolamines 829
                                            sotalol 18
paths to the root