Fstl3 (follistatin like 3) - Rat Genome Database

Name: Fstl3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Fstl3 (follistatin like 3) Rattus norvegicus

Analyze

Symbol:

Fstl3

Name:

follistatin like 3

RGD ID:

621811

Description:

Predicted to enable activin binding activity and fibronectin binding activity. Involved in several processes, including adrenal gland development; male gonad development; and spermatogenesis. Located in extracellular space; neuron projection terminus; and secretory granule. Orthologous to human FSTL3 (follistatin like 3); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Flrg; follistatin-like 3; follistatin-like 3 (secreted glycoprotein); follistatin-like protein 3; follistatin-related gene protein; follistatin-related protein 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FSTL3 (follistatin like 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Fstl3 (follistatin-like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fstl3 (follistatin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FSTL3 (follistatin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FSTL3 (follistatin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fstl3 (follistatin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FSTL3 (follistatin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103233581 (follistatin-related protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fstl3 (follistatin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZNF668 (zinc finger protein 668)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Fstl3 (follistatin-like 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	FSTL3 (follistatin like 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fstl3 (follistatin-like 3 (secreted glycoprotein))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Fs	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector)
Xenopus tropicalis (tropical clawed frog):	fstl3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,574,195 - 10,579,844 (-)	NCBI		GRCr8
mRatBN7.2	7	9,923,574 - 9,929,223 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,923,576 - 9,939,639 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	12,805,686 - 12,810,209 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,683,767 - 14,688,290 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,543,082 - 12,547,606 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,806,031 - 12,810,556 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,804,919 - 12,810,570 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	12,976,235 - 12,980,760 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	11,438,360 - 11,442,885 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	11,437,263 - 11,442,906 (-)	NCBI
Celera	7	8,098,196 - 8,102,721 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cerebral creatine deficiency syndrome (ISO)

cyclic hematopoiesis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

butan-1-ol (ISO)

butanal (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

corticosterone (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dextran sulfate (ISO)

diethyl maleate (ISO)

dioxygen (EXP,ISO)

doxorubicin (ISO)

ethanol (ISO)

gentamycin (EXP)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

methimazole (EXP)

mifepristone (EXP,ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel dichloride (EXP)

nickel sulfate (ISO)

niclosamide (ISO)

paracetamol (EXP,ISO)

phenylephrine (EXP)

potassium chromate (ISO)

propanal (ISO)

quercetin (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

temozolomide (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adrenal gland development (IEP)

cell differentiation (IBA)

cellular response to metal ion (IEP)

hematopoietic progenitor cell differentiation (IEA,ISO)

kidney development (IEP)

lung development (IEP)

male gonad development (IEP)

negative regulation of activin receptor signaling pathway (IBA,IEA,ISO)

negative regulation of BMP signaling pathway (IEA,ISO)

negative regulation of osteoclast differentiation (IEA,ISO)

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (ISO)

ossification (IEA)

positive regulation of cell-cell adhesion (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of BMP signaling pathway (IBA)

regulation of transcription by RNA polymerase II (ISO)

spermatogenesis (IEP)

Cellular Component

extracellular region (IBA)

extracellular space (IBA,IDA,IEA,ISO)

neuron projection terminus (IDA)

nucleoplasm (IEA,ISO)

nucleus (ISO)

secretory granule (IDA)

Molecular Function

activin binding (IBA,IEA,ISO)

fibronectin binding (IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	Purification, cDNA cloning, and secretory properties of FLRG protein from PC12 cells and the distribution of FLRG mRNA and protein in rat tissues.	Ohsawa Y, etal., Arch Histol Cytol 2003 Oct;66(4):367-81.
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11010968	PMID:11739004	PMID:11948405	PMID:12493714	PMID:12697670	PMID:15451575	PMID:15574124	PMID:16150905	PMID:16336961	PMID:16935389	PMID:17868029	PMID:17878677
PMID:18781389	PMID:20103742	PMID:21245136	PMID:22915069	PMID:24006456	PMID:25937185	PMID:34723652

Genomics

Comparative Map Data

Fstl3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,574,195 - 10,579,844 (-)	NCBI		GRCr8
mRatBN7.2	7	9,923,574 - 9,929,223 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,923,576 - 9,939,639 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	12,805,686 - 12,810,209 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,683,767 - 14,688,290 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,543,082 - 12,547,606 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,806,031 - 12,810,556 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,804,919 - 12,810,570 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	12,976,235 - 12,980,760 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	11,438,360 - 11,442,885 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	11,437,263 - 11,442,906 (-)	NCBI
Celera	7	8,098,196 - 8,102,721 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

FSTL3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	676,392 - 683,385 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	676,392 - 683,392 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	676,392 - 683,385 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	627,389 - 634,392 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	627,416 - 634,389	NCBI
Celera	19	134,214 - 141,222 (-)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	446,191 - 453,199 (+)	NCBI		HuRef
CHM1_1	19	676,089 - 683,092 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	630,475 - 637,473 (+)	NCBI		T2T-CHM13v2.0

Fstl3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	79,613,108 - 79,618,464 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	79,613,106 - 79,618,464 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	79,777,274 - 79,782,630 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	79,777,272 - 79,782,630 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	79,240,019 - 79,245,375 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	79,180,424 - 79,185,451 (+)	NCBI		MGSCv36	mm8
Celera	10	80,791,969 - 80,797,325 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Fstl3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	7,078,427 - 7,082,717 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	7,077,424 - 7,082,768 (-)	NCBI	ChiLan1.0	ChiLan1.0

FSTL3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	5,001,470 - 5,008,587 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	4,239,588 - 4,246,692 (+)	NCBI		NHGRI_mPanPan1

FSTL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	57,878,623 - 57,884,240 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	57,879,722 - 57,884,172 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	57,680,806 - 57,686,436 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	58,621,365 - 58,627,006 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	58,621,362 - 58,626,955 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	57,675,541 - 57,681,139 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	58,155,035 - 58,160,630 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	58,358,373 - 58,363,941 (-)	NCBI		UU_Cfam_GSD_1.0

Fstl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	217,578,861 - 217,584,426 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	250,249 - 256,902 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	250,359 - 255,922 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FSTL3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	77,656,663 - 77,662,613 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	77,656,655 - 77,662,608 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LOC103233581
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	425,050 - 435,931 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	425,106 - 436,431 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	8,513,455 - 8,530,949 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fstl3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	7,843,906 - 7,848,134 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	7,842,903 - 7,848,181 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fstl3
9 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	366
Count of miRNA genes:	205
Interacting mature miRNAs:	227
Transcripts:	ENSRNOT00000012578
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	9462246	58265113	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat

Markers in Region

BE099290

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	9,923,878 - 9,924,047 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	12,805,240 - 12,805,408	NCBI	Rnor6.0
Rnor_5.0	7	12,975,444 - 12,975,612	UniSTS	Rnor5.0
RGSC_v3.4	7	11,437,569 - 11,437,737	UniSTS	RGSC3.4
Celera	7	8,097,405 - 8,097,573	UniSTS
RH 3.4 Map	7	46.9	UniSTS
Cytogenetic Map	7	q11	UniSTS

RH139332

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	9,924,674 - 9,924,899 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	12,806,036 - 12,806,260	NCBI	Rnor6.0
Rnor_5.0	7	12,976,240 - 12,976,464	UniSTS	Rnor5.0
RGSC_v3.4	7	11,438,365 - 11,438,589	UniSTS	RGSC3.4
Celera	7	8,098,201 - 8,098,425	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		14									25	11
Low	3	29	41	25	19	25	8	11	59	35	16		8
Below cutoff			16	16		16			15

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053629	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB021295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB071603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229809	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000012578 ⟹ ENSRNOP00000012578

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	9,923,576 - 9,929,216 (-)	Ensembl
Rnor_6.0 Ensembl	7	12,804,919 - 12,810,570 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109931 ⟹ ENSRNOP00000090726

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	9,923,576 - 9,939,639 (-)	Ensembl

RefSeq Acc Id:

NM_053629 ⟹ NP_446081

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	10,574,195 - 10,579,844 (-)	NCBI
mRatBN7.2	7	9,923,574 - 9,929,223 (-)	NCBI
Rnor_6.0	7	12,806,031 - 12,810,556 (-)	NCBI
Rnor_5.0	7	12,976,235 - 12,980,760 (-)	NCBI
RGSC_v3.4	7	11,438,360 - 11,442,885 (-)	RGD
Celera	7	8,098,196 - 8,102,721 (-)	RGD

Sequence:

show sequence

ATGCGTCCTGGGGCACTGTGGCCGCTGCTTTGGGGAGCCCTGGTCTGGGCGGTGGGATCCGTGG
GCGCCGTGATGGGCTCGGGGGATTCTGTGCCGGGTGGTGTGTGCTGGCTCCAGCAGGGCAAGGA
GGCCACCTGCAGTCTGGTGCTGAAGACACAGGTCAGCCGGGAGGAGTGCTGCGCTTCCGGCAAC
ATCAACACAGCCTGGTCCAACTTCACCCACCCGGGCAATAAAATCAGCCTGCTAGGATTCCTGG
GCCTTGTCCACTGCCTACCATGCAAAGATTCTTGCGACGGAGTGGAGTGCGGCCCCGGCAAGGC
GTGCCGCATGTTGGGGGGCCGTCCACACTGCGAGTGCGTGTCCAACTGCGAGGGGGTTCCCGCG
GGCTTCCAGGTCTGCGGCTCTGATGGCGCCACCTACCGGGACGAATGCGAACTGCGCACCGCGC
GCTGTCGCGGACACCCAGACCTGCGCGTCATGTACCGCGGCCGCTGCCAAAAGTCCTGCGCTCA
GGTAGTGTGCCCGCGCCCCCAGTCGTGCCTTGTGGATCAGACTGGCAGCGCACACTGCGTGGTG
TGTCGCGCTGCACCCTGCCCAGTACCTCCCAACCCTGGCCAAGAACTCTGCGGCAACAACAACG
TTACCTACATCTCGTCGTGTCACTTGCGCCAGGCCACTTGCTTTCTGGGCCGTTCCATTGGAGT
TCGGCACCCGGGCATCTGCACAGGTGGCCCCAAAGTACCAGCAGAGGAGGAAGAGAACTTCGTG
TGA

hide sequence

RefSeq Acc Id:

XM_063262862 ⟹ XP_063118932

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	10,574,196 - 10,579,564 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446081	(Get FASTA)	NCBI Sequence Viewer
	XP_063118932	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAB32664	(Get FASTA)	NCBI Sequence Viewer
	BAC16229	(Get FASTA)	NCBI Sequence Viewer
	EDL89395	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012578
	ENSRNOP00000012578.3
	ENSRNOP00000090726.1
	ENSRNOP00055046916
	ENSRNOP00060038606
	ENSRNOP00065027648
GenBank Protein	Q99PW7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_446081 ⟸ NM_053629
- Peptide Label:	precursor
- UniProtKB:	Q54A93 (UniProtKB/Swiss-Prot), Q99PW7 (UniProtKB/Swiss-Prot), A6K8X5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRPGALWPLLWGALVWAVGSVGAVMGSGDSVPGGVCWLQQGKEATCSLVLKTQVSREECCASGN INTAWSNFTHPGNKISLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPHCECVSNCEGVPA GFQVCGSDGATYRDECELRTARCRGHPDLRVMYRGRCQKSCAQVVCPRPQSCLVDQTGSAHCVV CRAAPCPVPPNPGQELCGNNNVTYISSCHLRQATCFLGRSIGVRHPGICTGGPKVPAEEEENFV hide sequence

RefSeq Acc Id:

ENSRNOP00000012578 ⟸ ENSRNOT00000012578

RefSeq Acc Id:

ENSRNOP00000090726 ⟸ ENSRNOT00000109931

RefSeq Acc Id:	XP_063118932 ⟸ XM_063262862
- Peptide Label:	isoform X1

Protein Domains

Follistatin-like Kazal-like TB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99PW7-F1-model_v2	AlphaFold	Q99PW7	1-256	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695051

Promoter ID:

EPDNEW_R5576

Type:

multiple initiation site

Name:

Fstl3_1

Description:

follistatin like 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	12,810,584 - 12,810,644	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621811	AgrOrtholog
BioCyc Gene	G2FUF-34888	BioCyc
Ensembl Genes	ENSRNOG00000009311	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055032847	UniProtKB/Swiss-Prot
	ENSRNOG00060026817	UniProtKB/Swiss-Prot
	ENSRNOG00065020413	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000012578	ENTREZGENE
	ENSRNOT00000012578.6	UniProtKB/Swiss-Prot
	ENSRNOT00000109931.1	UniProtKB/TrEMBL
	ENSRNOT00055056815	UniProtKB/Swiss-Prot
	ENSRNOT00060046448	UniProtKB/Swiss-Prot
	ENSRNOT00065034502	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.60.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.90.290.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Fol_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Follistatin/Osteonectin_EGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kazal_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kazal_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TB_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TB_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:114031	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	114031	ENTREZGENE
PANTHER	FOLLISTATIN-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FOLLISTATIN-RELATED PROTEIN 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	FOLN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FST_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kazal_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Fstl3	PhenoGen
PROSITE	KAZAL_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PS51364	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009311	RatGTEx
	ENSRNOG00055032847	RatGTEx
	ENSRNOG00060026817	RatGTEx
	ENSRNOG00065020413	RatGTEx
SMART	FOLN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	KAZAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF100895	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57581	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AEC7_RAT	UniProtKB/TrEMBL
	A6K8X5	ENTREZGENE, UniProtKB/TrEMBL
	FSTL3_RAT	UniProtKB/Swiss-Prot
	Q54A93	ENTREZGENE
	Q99PW7	ENTREZGENE
UniProt Secondary	Q54A93	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-27	Fstl3	follistatin like 3	Fstl3	follistatin-like 3 (secreted glycoprotein)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Fstl3	follistatin-like 3 (secreted glycoprotein)	Fstl3	follistatin-like 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Fstl3	follistatin-like 3			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Fstl3	follistatin-like 3			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	abundantly expressed in the adrenal gland and testis	1302294

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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