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Gene: Kmt2e (lysine methyltransferase 2E) Rattus norvegicus
Symbol: Kmt2e
Name: lysine methyltransferase 2E
Description: Predicted to have enzyme binding activity and methylated histone binding activity. Predicted to be involved in several processes, including neutrophil activation; positive regulation of G1/S transition of mitotic cell cycle; and positive regulation of macromolecule metabolic process. Predicted to localize to the nucleus; protein-containing complex; and transcriptionally active chromatin. Human ortholog(s) of this gene implicated in autistic disorder and cervical cancer. Orthologous to human KMT2E (lysine methyltransferase 2E); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase MLL5; LOC311968; lysine (K)-specific methyltransferase 2E; Mll5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
Homo sapiens (human) : KMT2E (lysine methyltransferase 2E)  HGNC  Alliance
Mus musculus (house mouse) : Kmt2e (lysine (K)-specific methyltransferase 2E)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt2e (lysine methyltransferase 2E)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT2E (lysine methyltransferase 2E)
Canis lupus familiaris (dog) : KMT2E (lysine methyltransferase 2E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt2e (lysine methyltransferase 2E)
Sus scrofa (pig) : KMT2E (lysine methyltransferase 2E)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.048,187,751 - 8,255,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.048,193,464 - 8,261,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.447,042,012 - 7,111,851 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.147,042,856 - 7,111,933 (-)NCBI
Celera47,269,290 - 7,338,691 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Kmt2e
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309641
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.