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Gene: Gzmb (granzyme B) Rattus norvegicus
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Symbol: Gzmb
Name: granzyme B
Description: Exhibits serine-type endopeptidase activity. Involved in positive regulation of necroptotic process. Localizes to the early endosome. Orthologous to human GZMB (granzyme B); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-chloro-2,4-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: fragmentin; GLP I; GLP III; GLP-1; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme-like protein 1; granzyme-like protein I; LOW QUALITY PROTEIN: granzyme-like protein 1; MGC156565; natural killer cell protease 1; RNKP-1
Orthologs:
Homo sapiens (human) : GZMB (granzyme B)  HGNC  Alliance
Mus musculus (house mouse) : Gzmb (granzyme B)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : GZMB (granzyme B)
Canis lupus familiaris (dog) : GZMB (granzyme B)
Sus scrofa (pig) : GZMB (granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1))
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01535,413,862 - 35,417,293 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01539,296,950 - 39,300,381 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41535,195,075 - 35,198,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11535,211,149 - 35,214,166 (-)NCBI
Celera1529,891,059 - 29,893,786 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gzmb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620018
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-09-17
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.