Gene: Gzmb (granzyme B) Rattus norvegicus
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Symbol: Gzmb
Name: granzyme B
Description: ENCODES a protein that exhibits serine-type endopeptidase activity; serine-type peptidase activity (ortholog); INVOLVED IN positive regulation of cell death; positive regulation of necroptotic process; granzyme-mediated apoptotic signaling pathway (ortholog); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); autistic disorder (ortholog); Breast Neoplasms (ortholog); FOUND IN early endosome; cytolytic granule (ortholog); cytoplasm (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-chloro-2,4-dinitrobenzene; 17beta-estradiol
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: fragmentin; GLP I; GLP III; GLP-1; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme-like protein 1; granzyme-like protein I; LOW QUALITY PROTEIN: granzyme-like protein 1; MGC156565; natural killer cell protease 1; RNKP-1
Orthologs:
Homo sapiens (human) : GZMB (granzyme B)  HGNC  Alliance
Mus musculus (house mouse) : Gzmb (granzyme B)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : GZMB (granzyme B)
Canis lupus familiaris (dog) : GZMB (granzyme B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01535,413,862 - 35,417,293 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01539,296,950 - 39,300,381 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41535,195,075 - 35,198,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11535,211,149 - 35,214,166 (-)NCBI
Celera1529,891,059 - 29,893,786 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
  
More on Gzmb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620018
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2018-06-05
Status: ACTIVE



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