Gzmb (granzyme B) - Rat Genome Database

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Gene: Gzmb (granzyme B) Rattus norvegicus
Analyze
Symbol: Gzmb (Ensembl: Gzmbl2)
Name: granzyme B
RGD ID: 620018
Description: Enables serine-type endopeptidase activity. Involved in positive regulation of necroptotic process. Located in early endosome. Orthologous to human GZMB (granzyme B); PARTICIPATES IN interleukin-12 signaling pathway; allograft rejection pathway; autoimmune thyroiditis pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fragmentin; GLP I; GLP III; GLP-1; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme-like protein 1; granzyme-like protein I; MGC156565; natural killer cell protease 1; RNKP-1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21530,343,361 - 30,346,792 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,173,603 - 30,346,814 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1532,334,740 - 32,338,202 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01533,485,381 - 33,488,843 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01531,743,468 - 31,746,930 (-)NCBIRnor_WKY
Rnor_6.01535,413,862 - 35,417,293 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1535,413,793 - 35,417,316 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01539,296,950 - 39,300,381 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41535,195,075 - 35,198,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11535,211,149 - 35,214,166 (-)NCBI
Celera1529,891,059 - 29,893,786 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-tert-butylhydroquinone  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-azacytidine  (ISO)
acetamide  (EXP)
adenosine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium sulfate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
coformycin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
dichlorvos  (ISO)
ethambutol  (ISO)
ethanol  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
Fusarenone X  (ISO)
genistein  (ISO)
heparin  (EXP)
imiquimod  (ISO)
ionomycin  (ISO)
irinotecan  (EXP)
L-ascorbic acid  (ISO)
lipopolysaccharide  (EXP)
malathion  (ISO)
mercaptopurine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
nonanoic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
progesterone  (EXP,ISO)
purine-6-thiol  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
rifampicin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
tamoxifen  (ISO)
testosterone  (EXP)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trimellitic anhydride  (EXP,ISO)
valproic acid  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Identification, sequence analysis, and characterization of cDNA clones encoding two granzyme-like serine proteinases from rat duodenum. Amerik AYu, etal., FEBS Lett 1993 Jun 14;324(2):226-30.
2. Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice. Bem RA, etal., J Immunol. 2010 Jan 15;184(2):931-8. Epub 2009 Dec 16.
3. Multiple apoptogenic proteins are involved in the nuclear translocation of Apoptosis Inducing Factor during transient focal cerebral ischemia in rat. Chaitanya GV and Babu PP, Brain Res. 2008 Dec 30;1246:178-90. Epub 2008 Oct 9.
4. Differential PARP cleavage: an indication of heterogeneous forms of cell death and involvement of multiple proteases in the infarct of focal cerebral ischemia in rat. Chaitanya GV and Babu PP, Cell Mol Neurobiol. 2009 Jun;29(4):563-73. Epub 2009 Feb 19.
5. Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemia in rat model. Chaitanya GV, etal., Neuroscience. 2010 Feb 17;165(4):1203-16. Epub 2009 Nov 4.
6. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Cloning of cDNA for granzyme-like protein III, a novel serine proteinase from rat duodenum. Grigorenko VG, etal., FEBS Lett 1994 Apr 11;342(3):278-80.
9. Definition and redesign of the extended substrate specificity of granzyme B. Harris JL, etal., J Biol Chem. 1998 Oct 16;273(42):27364-73. doi: 10.1074/jbc.273.42.27364.
10. Increased levels of T cell granzyme b in bronchiolitis obliterans syndrome are not suppressed adequately by current immunosuppressive regimens. Hodge S, etal., Clin Exp Immunol. 2009 Nov;158(2):230-6. Epub 2009 Aug 3.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity. Ruggles SW, etal., J Biol Chem. 2004 Jul 16;279(29):30751-9. Epub 2004 May 3.
17. Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Thiery J, etal., Blood. 2010 Feb 25;115(8):1582-93. Epub 2009 Dec 28.
18. Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients. Urbanowicz RA, etal., Respir Res. 2010 Jun 11;11:76.
19. Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway. Vermijlen D, etal., J Leukoc Biol 2002 Oct;72(4):668-76.
20. RNKP-1, a novel natural killer-associated serine protease gene cloned from RNK-16 cytotoxic lymphocytes. Zunino SJ, etal., J Immunol 1990 Mar 1;144(5):2001-9.
Additional References at PubMed
PMID:1727874   PMID:1732416   PMID:11331782   PMID:12477932   PMID:14978081   PMID:15454490   PMID:15944262   PMID:16618603   PMID:18292522   PMID:19170890   PMID:19915045   PMID:19946888  
PMID:20450731   PMID:21426642   PMID:21795594   PMID:26432892   PMID:29107333   PMID:29445095   PMID:29669300  


Genomics

Comparative Map Data
Gzmb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21530,343,361 - 30,346,792 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,173,603 - 30,346,814 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1532,334,740 - 32,338,202 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01533,485,381 - 33,488,843 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01531,743,468 - 31,746,930 (-)NCBIRnor_WKY
Rnor_6.01535,413,862 - 35,417,293 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1535,413,793 - 35,417,316 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01539,296,950 - 39,300,381 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41535,195,075 - 35,198,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11535,211,149 - 35,214,166 (-)NCBI
Celera1529,891,059 - 29,893,786 (-)NCBICelera
Cytogenetic Map15p12NCBI
GZMB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,630,954 - 24,634,190 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1424,630,954 - 24,634,267 (-)EnsemblGRCh38hg38GRCh38
GRCh371425,100,160 - 25,103,396 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361424,170,000 - 24,173,272 (-)NCBINCBI36Build 36hg18NCBI36
Build 341424,170,003 - 24,173,272NCBI
Celera144,964,951 - 4,968,224 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef145,214,872 - 5,218,144 (-)NCBIHuRef
CHM1_11425,099,053 - 25,102,325 (-)NCBICHM1_1
T2T-CHM13v2.01418,829,837 - 18,833,074 (-)NCBIT2T-CHM13v2.0
Gzmb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,496,293 - 56,499,791 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,496,295 - 56,499,717 (-)EnsemblGRCm39 Ensembl
GRCm381456,258,836 - 56,262,334 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1456,258,838 - 56,262,260 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,877,693 - 56,881,097 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361455,212,927 - 55,216,331 (-)NCBIMGSCv36mm8
Celera1454,055,471 - 54,058,875 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
GZMB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11423,523,619 - 23,526,931 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,523,619 - 23,526,931 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0145,399,888 - 5,403,200 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GZMB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,508,718 - 4,511,824 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,470,577 - 4,512,628 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,430,126 - 4,433,251 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,620,020 - 4,623,146 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,601,184 - 4,623,149 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,309,346 - 4,312,469 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,371,938 - 4,375,062 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,634,356 - 4,637,481 (-)NCBIUU_Cfam_GSD_1.0
GZMB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,723,954 - 74,727,568 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1 Ensembl774,705,409 - 74,708,790 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1774,705,499 - 74,708,781 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2779,831,207 - 79,834,515 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GZMB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,574,452 - 1,577,861 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,574,453 - 1,577,798 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603613,270,472 - 13,273,777 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gzmb
154 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:52
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000041430
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
RH141566  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21530,343,613 - 30,343,803 (+)MAPPERmRatBN7.2
Rnor_6.01535,414,115 - 35,414,304NCBIRnor6.0
Rnor_5.01539,297,203 - 39,297,392UniSTSRnor5.0
RGSC_v3.41535,061,296 - 35,061,485UniSTSRGSC3.4
RGSC_v3.41535,195,328 - 35,195,517UniSTSRGSC3.4
Celera1530,064,847 - 30,065,036UniSTS
Celera1529,935,088 - 29,935,277UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 2
Low 2 6 7 3 10 3 1 5 7
Below cutoff 1 8 21 11 10 11 3 3 4 12 10 3 3

Sequence


Reference Sequences
RefSeq Acc Id: NM_138517   ⟹   NP_612526
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21530,343,361 - 30,346,792 (-)NCBI
Rnor_6.01535,413,862 - 35,417,293 (-)NCBI
Rnor_5.01539,296,950 - 39,300,381 (-)NCBI
RGSC_v3.41535,195,075 - 35,198,506 (-)RGD
Celera1530,064,594 - 30,068,025 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_612526 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI27476 (Get FASTA)   NCBI Sequence Viewer  
  EDM14323 (Get FASTA)   NCBI Sequence Viewer  
  P18291 (Get FASTA)   NCBI Sequence Viewer  
  Q06605 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_612526   ⟸   NM_138517
- Peptide Label: precursor
- UniProtKB: P18291 (UniProtKB/Swiss-Prot)
- Sequence:
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18291-F1-model_v2 AlphaFold P18291 1-248 view protein structure
AF-Q06605-F1-model_v2 AlphaFold Q06605 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699707
Promoter ID:EPDNEW_R10230
Type:single initiation site
Name:Gzmb_1
Description:granzyme B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01535,417,315 - 35,417,375EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620018 AgrOrtholog
BioCyc Gene G2FUF-13635 BioCyc
Ensembl Genes ENSRNOG00000049976 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000040429 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000043259.6 UniProtKB/TrEMBL
  ENSRNOP00000056412.4 UniProtKB/TrEMBL
  ENSRNOP00000064418.2 UniProtKB/TrEMBL
  ENSRNOP00000075556.1 UniProtKB/TrEMBL
  ENSRNOP00000082885.1 UniProtKB/TrEMBL
  ENSRNOP00000092778.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041430 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000045209.6 UniProtKB/TrEMBL
  ENSRNOT00000059660.5 UniProtKB/TrEMBL
  ENSRNOT00000071692.2 UniProtKB/TrEMBL
  ENSRNOT00000083961.2 UniProtKB/TrEMBL
  ENSRNOT00000110630.1 UniProtKB/TrEMBL
  ENSRNOT00000118970.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124652 IMAGE-MGC_LOAD
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171528 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156565 IMAGE-MGC_LOAD
NCBI Gene 171528 ENTREZGENE
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gzmb PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MY24_RAT UniProtKB/TrEMBL
  A0A8I5ZY48_RAT UniProtKB/TrEMBL
  A0A8I6AIL5_RAT UniProtKB/TrEMBL
  A0A8L2QRC7_RAT UniProtKB/TrEMBL
  A1L119_RAT UniProtKB/TrEMBL
  GRAB_RAT UniProtKB/Swiss-Prot
  M0R4W8_RAT UniProtKB/TrEMBL
  P18291 ENTREZGENE
  Q06605 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Gzmb  granzyme B  Gzmb  granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-22 Gzmb  granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)  Gzmb  granzyme B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gzmb  granzyme B      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Gzmb  granzyme B      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology shows 88.2% identity to GLP I and 50.6% identity to GLP II 632830
gene_protein 248 amino acid residues 632830