Enables amine binding activity; heterocyclic compound binding activity; and organic cyclic compound binding activity. Involved in several processes, including cAMP metabolic process; learning or memory; and regulation of secretion. Predicted to be located in plasma membrane. Used to study several diseases, including gastric ulcer; hyperglycemia; obesity; sciatic neuropathy; and visual epilepsy. Biomarker of status epilepticus. Orthologous to human HRH3 (histamine receptor H3); INTERACTS WITH 2-methylpyrrolidine; 3',5'-cyclic AMP; 4,4'-sulfonyldiphenol.
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]] more ...
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]] more ...
[4-(1H-imidazol-4-ylmethyl)piperidine binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium more ...
[4-(1H-imidazol-4-ylmethyl)piperidine binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium more ...
clobenpropit binds to and results in decreased activity of HRH3 protein and clobenpropit inhibits the reaction [[Methylhistamines binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium]
[4-(1H-imidazol-4-ylmethyl)piperidine binds to and results in increased activity of HRH3 protein] which results in decreased susceptibility to clobenpropit more ...
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]] and alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]] and alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]
[Histamine binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium and Histamine binds to and results in increased activity of HRH3 protein
[imetit binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium and imetit binds to and results in increased activity of HRH3 protein
[4-(1H-imidazol-4-ylmethyl)piperidine binds to and results in increased activity of HRH3 protein] which results in decreased susceptibility to clobenpropit
4-(1H-imidazol-4-ylmethyl)piperidine binds to and results in increased activity of HRH3 protein and [4-(1H-imidazol-4-ylmethyl)piperidine binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium
[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRH3 mRNA
3-fluoro-3-(3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl)-N-(2-methylpropyl)cyclobutanecarboxamide inhibits the reaction [N-methylhistamine binds to HRH3 protein] and N-ethyl-3-fluoro-3-(3-fluoro-4-(pyrrolidinylmethyl)phenyl)cyclobutanecarboxamide inhibits the reaction [N-methylhistamine binds to HRH3 protein]
[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HRH3 mRNA
thioperamide binds to and results in decreased activity of HRH3 protein and thioperamide inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]
The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons.
GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models.
Histamine receptors influence blood-spinal cord barrier permeability, edema formation, and spinal cord blood flow following trauma to the rat spinal cord.