Hrh3 (histamine receptor H3) - Rat Genome Database

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Gene: Hrh3 (histamine receptor H3) Rattus norvegicus
Analyze
Symbol: Hrh3
Name: histamine receptor H3
RGD ID: 620630
Description: Predicted to have G protein-coupled acetylcholine receptor activity and G protein-coupled serotonin receptor activity. Involved in several processes, including learning or memory; negative regulation of adenylate cyclase activity; and regulation of secretion. Localizes to myelin sheath; neuron projection; and plasma membrane. Used to study several diseases, including gastric ulcer; hyperglycemia; obesity; sciatic neuropathy; and visual epilepsy. Biomarker of status epilepticus. Orthologous to human HRH3 (histamine receptor H3); INTERACTS WITH 2-methylpyrrolidine; 3',5'-cyclic AMP; alpha-methylhistamine.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: H3R; HH3R; histamine H3 receptor; MGC105370
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23167,191,551 - 167,196,642 (-)NCBI
Rnor_6.0 Ensembl3175,473,078 - 175,479,395 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03175,474,310 - 175,479,395 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03181,639,287 - 181,644,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,154,980 - 169,160,064 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13169,061,015 - 169,066,100 (-)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Azuma H, etal., Neuroreport 2003 Mar 3;14(3):423-5.
2. Baldi E, etal., Neuropharmacology. 2005 Feb;48(2):246-51.
3. Dai H, etal., Eur J Pharmacol. 2007 Jun 1;563(1-3):117-23. Epub 2007 Feb 8.
4. Dembinski A, etal., Eur J Pharmacol. 2005 Jan 31;508(1-3):211-21. Epub 2004 Dec 30.
5. Fujimoto K, etal., Biochem Biophys Res Commun. 1991 Jun 28;177(3):907-12.
6. Garduno-Torres B, etal., Neuropharmacology. 2007 Feb;52(2):527-35. Epub 2006 Oct 5.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. GOA data from the GO Consortium
9. Godlewski G, etal., Naunyn Schmiedebergs Arch Pharmacol. 1997 Feb;355(2):261-6.
10. Grandi D, etal., Eur J Pharmacol. 2006 May 24;538(1-3):141-7. Epub 2006 Mar 27.
11. Harada C, etal., Methods Find Exp Clin Pharmacol. 2004 May;26(4):263-70.
12. Hiraga N, etal., Eur J Pharmacol. 2007 Feb 28;557(2-3):236-44. Epub 2006 Nov 14.
13. Huang L, etal., Reg Anesth Pain Med. 2007 Mar-Apr;32(2):124-9.
14. Ito S, etal., Eur J Pharmacol. 2006 Jan 4;529(1-3):40-6. Epub 2005 Nov 28.
15. Karlstedt K, etal., Mol Cell Neurosci. 2003 Nov;24(3):614-22.
16. Lintunen M, etal., Neurobiol Dis. 2005 Oct;20(1):155-69.
17. Lovenberg TW, etal., J Pharmacol Exp Ther 2000 Jun;293(3):771-8.
18. Malmlof K, etal., Obesity (Silver Spring). 2006 Dec;14(12):2154-62.
19. Medhurst AD, etal., Biochem Pharmacol. 2007 Apr 15;73(8):1182-94. Epub 2007 Jan 7.
20. Medhurst AD, etal., J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45. Epub 2007 Feb 27.
21. MGD data from the GO Consortium
22. NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Pawlik WW, etal., J Physiol Pharmacol. 2004 Sep;55(3):651-61.
24. RGD automated data pipeline
25. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. RGD automated import pipeline for gene-chemical interactions
27. Sharma HS, etal., Acta Neurochir Suppl. 2006;96:316-21.
28. Threlfell S, etal., J Neurosci. 2004 Oct 6;24(40):8704-10.
29. Yamamoto S, etal., J Cardiovasc Pharmacol. 2004 Mar;43(3):353-7.
30. Yamano T, etal., Neurosci Lett. 2001 Nov 2;313(1-2):78-82.
Additional References at PubMed
PMID:10347254   PMID:11125017   PMID:11130725   PMID:11162480   PMID:12477932   PMID:15465923   PMID:15899242   PMID:15928831   PMID:16181737   PMID:16415177   PMID:16436594   PMID:16715497  
PMID:16797837   PMID:17531160   PMID:17561422   PMID:17806162   PMID:17940197   PMID:17998102   PMID:18302930   PMID:18345490   PMID:18564330   PMID:19446035   PMID:19490084   PMID:19735700  
PMID:21173143   PMID:21272571   PMID:21839070   PMID:22050612   PMID:22277566   PMID:22356432   PMID:22870296   PMID:23488566   PMID:23896530   PMID:24432407   PMID:25745947   PMID:26169221  
PMID:28964277   PMID:29217157  


Genomics

Comparative Map Data
Hrh3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23167,191,551 - 167,196,642 (-)NCBI
Rnor_6.0 Ensembl3175,473,078 - 175,479,395 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03175,474,310 - 175,479,395 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03181,639,287 - 181,644,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,154,980 - 169,160,064 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13169,061,015 - 169,066,100 (-)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBICelera
Cytogenetic Map3q43NCBI
HRH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2062,214,960 - 62,220,278 (-)EnsemblGRCh38hg38GRCh38
GRCh382062,213,845 - 62,220,278 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372060,790,016 - 60,795,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362060,223,421 - 60,228,718 (-)NCBINCBI36hg18NCBI36
Build 342060,223,421 - 60,228,707NCBI
Celera2057,525,154 - 57,530,460 (-)NCBI
Cytogenetic Map20q13.33NCBI
HuRef2057,566,507 - 57,570,202 (-)NCBIHuRef
CHM1_12060,690,583 - 60,695,889 (-)NCBICHM1_1
Hrh3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392179,741,258 - 179,746,293 (-)NCBIGRCm39mm39
GRCm39 Ensembl2179,741,258 - 179,746,281 (-)Ensembl
GRCm382180,099,465 - 180,104,484 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,099,465 - 180,104,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv372179,834,178 - 179,838,927 (-)NCBIGRCm37mm9NCBIm37
MGSCv362180,028,881 - 180,033,632 (-)NCBImm8
Celera2184,181,575 - 184,186,324 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2102.62NCBI
Hrh3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555281,819,247 - 1,826,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555281,819,247 - 1,826,707 (+)NCBIChiLan1.0ChiLan1.0
HRH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12059,900,919 - 59,905,858 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2059,901,327 - 59,909,901 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02058,581,228 - 58,586,585 (-)NCBIMhudiblu_PPA_v0panPan3
HRH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12446,239,883 - 46,243,123 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2445,476,507 - 45,480,947 (-)NCBI
ROS_Cfam_1.02447,095,982 - 47,100,422 (-)NCBI
UMICH_Zoey_3.12446,197,405 - 46,201,844 (-)NCBI
UNSW_CanFamBas_1.02446,320,612 - 46,325,047 (-)NCBI
UU_Cfam_GSD_1.02447,074,908 - 47,079,348 (-)NCBI
Hrh3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640194,408,461 - 194,412,309 (-)NCBI
SpeTri2.0NW_0049365149,862,104 - 9,865,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HRH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1761,622,703 - 61,627,633 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11761,622,865 - 61,627,278 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HRH3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.122,019,878 - 2,025,218 (+)NCBI
ChlSab1.1 Ensembl22,020,286 - 2,025,202 (+)Ensembl
Vero_WHO_p1.0NW_02366605049,967,430 - 49,972,751 (+)NCBI
Hrh3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474128,080,957 - 28,086,312 (-)NCBI

Position Markers
D3Wox40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23167,192,318 - 167,192,463 (+)MAPPER
Rnor_6.03175,475,072 - 175,475,216NCBIRnor6.0
Rnor_5.03181,643,466 - 181,643,610UniSTSRnor5.0
RGSC_v3.43169,155,741 - 169,155,885UniSTSRGSC3.4
Celera3165,387,654 - 165,387,788UniSTS
Cytogenetic Map3q43UniSTS
AA943666  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23167,191,632 - 167,191,754 (+)MAPPER
Rnor_6.03175,474,386 - 175,474,507NCBIRnor6.0
Rnor_5.03181,644,175 - 181,644,296UniSTSRnor5.0
RGSC_v3.43169,155,055 - 169,155,176UniSTSRGSC3.4
Celera3165,388,353 - 165,388,474UniSTS
RH 3.4 Map31524.0UniSTS
Cytogenetic Map3q43UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3129787213177699992Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3132875075176418101Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3138374177177699992Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3138374177177699992Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3139578365177699992Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3146232777177699992Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3148034701177699992Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3150368003177699992Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3153412455177699992Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3153918022177699992Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3156381661176418101Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3170428815177699992Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11
Low 15 17 61 6 2 5
Below cutoff 3 20 28 27 2 27 5 7 2 25 32 6 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB015646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF237919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY009370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY009371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB735595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ112342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ112343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000077308   ⟹   ENSRNOP00000071828
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3175,474,311 - 175,479,395 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086761   ⟹   ENSRNOP00000069003
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3175,473,078 - 175,479,034 (-)Ensembl
RefSeq Acc Id: NM_001270564   ⟹   NP_001257493
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270565   ⟹   NP_001257494
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270566   ⟹   NP_001257495
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270567   ⟹   NP_001257496
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270568   ⟹   NP_001257497
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270569   ⟹   NP_001257498
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270570   ⟹   NP_001257499
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_053506   ⟹   NP_445958
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
RGSC_v3.43169,154,980 - 169,160,064 (-)RGD
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NR_073042
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762548   ⟹   XP_008760770
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,191,551 - 167,194,873 (-)NCBI
Rnor_6.03175,474,310 - 175,478,438 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592083   ⟹   XP_017447572
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03175,474,310 - 175,478,896 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592084   ⟹   XP_017447573
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03175,474,310 - 175,477,728 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_445958   ⟸   NM_053506
- Peptide Label: isoform H3A
- UniProtKB: Q9QYN8 (UniProtKB/Swiss-Prot),   Q5PPG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257495   ⟸   NM_001270566
- Peptide Label: isoform H3D
- UniProtKB: Q2VJ18 (UniProtKB/TrEMBL),   Q5PPG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257493   ⟸   NM_001270564
- Peptide Label: isoform H3B
- UniProtKB: Q9QYN8 (UniProtKB/Swiss-Prot),   Q541U0 (UniProtKB/TrEMBL),   Q5PPG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257496   ⟸   NM_001270567
- Peptide Label: isoform H3E
- UniProtKB: Q2VJ17 (UniProtKB/TrEMBL),   Q5PPG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257498   ⟸   NM_001270569
- Peptide Label: isoform 7
- UniProtKB: Q541U0 (UniProtKB/TrEMBL),   Q5PPG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257494   ⟸   NM_001270565
- Peptide Label: isoform H3C
- UniProtKB: Q9QYN8 (UniProtKB/Swiss-Prot),   Q5PPG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257499   ⟸   NM_001270570
- Peptide Label: isoform 8
- UniProtKB: Q5PPG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257497   ⟸   NM_001270568
- Peptide Label: isoform H3F
- UniProtKB: Q9QYN8 (UniProtKB/Swiss-Prot),   Q5PPG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760770   ⟸   XM_008762548
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017447572   ⟸   XM_017592083
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017447573   ⟸   XM_017592084
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000071828   ⟸   ENSRNOT00000077308
RefSeq Acc Id: ENSRNOP00000069003   ⟸   ENSRNOT00000086761
Protein Domains
G_PROTEIN_RECEP_F1_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692729
Promoter ID:EPDNEW_R3254
Type:single initiation site
Name:Hrh3_1
Description:histamine receptor H3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03175,479,378 - 175,479,438EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620630 AgrOrtholog
Ensembl Genes ENSRNOG00000061153 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000069003 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000071828 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077308 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000086761 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7315203 IMAGE-MGC_LOAD
InterPro 7tmA_HRH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histamine_H3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85268 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105370 IMAGE-MGC_LOAD
NCBI Gene 85268 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hrh3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTAMINEH3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JU84_RAT UniProtKB/TrEMBL
  HRH3_RAT UniProtKB/Swiss-Prot
  Q2VJ17 ENTREZGENE, UniProtKB/TrEMBL
  Q2VJ18 ENTREZGENE, UniProtKB/TrEMBL
  Q541U0 ENTREZGENE, UniProtKB/TrEMBL
  Q5PPG3 ENTREZGENE, UniProtKB/TrEMBL
  Q9QYN8 ENTREZGENE
UniProt Secondary Q9QYN6 UniProtKB/Swiss-Prot
  Q9QYN7 UniProtKB/Swiss-Prot
  Q9QYN9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Hrh3  histamine receptor H3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Hrh3  histamine receptor H3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs binds antagonists thioperamide and clobenpropit with high affinity, in contrast to low affinity binding of thioperamide to the human homolog 632981
gene_expression expressed exclusively in brain 632981