Hrh3 (histamine receptor H3) - Rat Genome Database

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Gene: Hrh3 (histamine receptor H3) Rattus norvegicus
Analyze
Symbol: Hrh3
Name: histamine receptor H3
RGD ID: 620630
Description: Enables amine binding activity and heterocyclic compound binding activity. Involved in several processes, including learning or memory; negative regulation of adenylate cyclase activity; and regulation of secretion. Predicted to be active in dendrite; plasma membrane; and synapse. Used to study several diseases, including amnestic disorder; gastric ulcer; hyperglycemia; obesity; and sciatic neuropathy. Biomarker of status epilepticus. Orthologous to human HRH3 (histamine receptor H3); INTERACTS WITH 2-methylpyrrolidine; 3',5'-cyclic AMP; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: H3R; HH3R; histamine H3 receptor; MGC105370
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83187,569,174 - 187,575,263 (-)NCBIGRCr8
mRatBN7.23167,191,551 - 167,196,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,191,558 - 167,196,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3171,568,751 - 171,573,827 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03180,527,834 - 180,532,910 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,192,527 - 177,197,612 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03175,474,310 - 175,479,395 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,473,078 - 175,479,395 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03181,639,287 - 181,644,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,154,980 - 169,160,064 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13169,061,015 - 169,066,100 (-)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-methylpyrrolidine  (EXP,ISO)
3',5'-cyclic AMP  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-methylhistamine  (EXP,ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
clobenpropit  (EXP,ISO)
clozapine  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
dextran sulfate  (ISO)
diethylamine  (EXP,ISO)
dimethylamine  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
ethylparaben  (ISO)
furans  (ISO)
GTP  (EXP,ISO)
histamine  (EXP,ISO)
imetit  (EXP,ISO)
Immepip  (EXP,ISO)
ketamine  (EXP)
mercury dibromide  (ISO)
N(tele)-methylhistamine  (EXP)
N-alpha-Methylhistamine  (ISO)
N-methylethanolamine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctanoic acid  (EXP)
pyrrolidine  (EXP,ISO)
SB 431542  (ISO)
scopolamine  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Tesaglitazar  (EXP)
Thioperamide  (EXP,ISO)
thiophenes  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IBA)
membrane  (IEA)
plasma membrane  (IBA,IEA)
synapse  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression of mRNA encoding the H1, H2, and H3 histamine receptors in the rat cochlea. Azuma H, etal., Neuroreport 2003 Mar 3;14(3):423-5.
2. The H3 receptor protean agonist proxyfan enhances the expression of fear memory in the rat. Baldi E, etal., Neuropharmacology. 2005 Feb;48(2):246-51.
3. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. Dai H, etal., Eur J Pharmacol. 2007 Jun 1;563(1-3):117-23. Epub 2007 Feb 8.
4. Role of capsaicin-sensitive nerves and histamine H1, H2, and H3 receptors in the gastroprotective effect of histamine against stress ulcers in rats. Dembinski A, etal., Eur J Pharmacol. 2005 Jan 31;508(1-3):211-21. Epub 2004 Dec 30.
5. Presynaptic localization of histamine H3-receptors in rat brain. Fujimoto K, etal., Biochem Biophys Res Commun. 1991 Jun 28;177(3):907-12.
6. Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus. Garduno-Torres B, etal., Neuropharmacology. 2007 Feb;52(2):527-35. Epub 2006 Oct 5.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats. Godlewski G, etal., Naunyn Schmiedebergs Arch Pharmacol. 1997 Feb;355(2):261-6.
10. Epithelial cell proliferation is promoted by the histamine H(3) receptor agonist (R)-alpha-methylhistamine throughout the rat gastrointestinal tract. Grandi D, etal., Eur J Pharmacol. 2006 May 24;538(1-3):141-7. Epub 2006 Mar 27.
11. Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia. Harada C, etal., Methods Find Exp Clin Pharmacol. 2004 May;26(4):263-70.
12. Suppression of inflammatory cell recruitment by histamine receptor stimulation in ischemic rat brains. Hiraga N, etal., Eur J Pharmacol. 2007 Feb 28;557(2-3):236-44. Epub 2006 Nov 14.
13. Histaminergic involvement in neuropathic pain produced by partial ligation of the sciatic nerve in rats. Huang L, etal., Reg Anesth Pain Med. 2007 Mar-Apr;32(2):124-9.
14. Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor. Ito S, etal., Eur J Pharmacol. 2006 Jan 4;529(1-3):40-6. Epub 2005 Nov 28.
15. Expression of the H3 receptor in the developing CNS and brown fat suggests novel roles for histamine. Karlstedt K, etal., Mol Cell Neurosci. 2003 Nov;24(3):614-22.
16. Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain. Ligneau X, etal., Br J Pharmacol. 2000 Dec;131(7):1247-50. doi: 10.1038/sj.bjp.0703712.
17. Transient changes in the limbic histaminergic system after systemic kainic acid-induced seizures. Lintunen M, etal., Neurobiol Dis. 2005 Oct;20(1):155-69.
18. Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles. Lovenberg TW, etal., J Pharmacol Exp Ther 2000 Jun;293(3):771-8.
19. Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides. Malmlof K, etal., Obesity (Silver Spring). 2006 Dec;14(12):2154-62.
20. Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats. Medhurst AD, etal., Biochem Pharmacol. 2007 Apr 15;73(8):1182-94. Epub 2007 Jan 7.
21. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. Medhurst AD, etal., J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45. Epub 2007 Feb 27.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. High constitutive activity of native H3 receptors regulates histamine neurons in brain. Morisset S, etal., Nature. 2000 Dec 14;408(6814):860-4. doi: 10.1038/35048583.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Histamine H3 receptors modulate reactive hyperemia in rat gut. Pawlik WW, etal., J Physiol Pharmacol. 2004 Sep;55(3):651-61.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Histamine receptors influence blood-spinal cord barrier permeability, edema formation, and spinal cord blood flow following trauma to the rat spinal cord. Sharma HS, etal., Acta Neurochir Suppl. 2006;96:316-21.
30. Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata. Threlfell S, etal., J Neurosci. 2004 Oct 6;24(40):8704-10.
31. Role of histamine H3 receptors during ischemia/reperfusion in isolated rat hearts. Yamamoto S, etal., J Cardiovasc Pharmacol. 2004 Mar;43(3):353-7.
32. Effect of L-carnosine on the hyperglycemia caused by intracranial injection of 2-deoxy-D-glucose in rats. Yamano T, etal., Neurosci Lett. 2001 Nov 2;313(1-2):78-82.
Additional References at PubMed
PMID:10347254   PMID:11125017   PMID:11162480   PMID:12477932   PMID:15465923   PMID:15899242   PMID:15928831   PMID:16181737   PMID:16415177   PMID:16436594   PMID:16715497   PMID:16797837  
PMID:17531160   PMID:17561422   PMID:17806162   PMID:17940197   PMID:17998102   PMID:18302930   PMID:18345490   PMID:18564330   PMID:19446035   PMID:19490084   PMID:19735700   PMID:21173143  
PMID:21272571   PMID:21839070   PMID:22050612   PMID:22277566   PMID:22356432   PMID:22870296   PMID:23488566   PMID:23896530   PMID:24432407   PMID:25745947   PMID:26169221   PMID:28964277  
PMID:29217157   PMID:32211996   PMID:33068216  


Genomics

Comparative Map Data
Hrh3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83187,569,174 - 187,575,263 (-)NCBIGRCr8
mRatBN7.23167,191,551 - 167,196,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,191,558 - 167,196,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3171,568,751 - 171,573,827 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03180,527,834 - 180,532,910 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,192,527 - 177,197,612 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03175,474,310 - 175,479,395 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,473,078 - 175,479,395 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03181,639,287 - 181,644,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,154,980 - 169,160,064 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13169,061,015 - 169,066,100 (-)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBICelera
Cytogenetic Map3q43NCBI
HRH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382062,214,960 - 62,220,278 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2062,214,960 - 62,220,278 (-)EnsemblGRCh38hg38GRCh38
GRCh372060,790,016 - 60,795,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362060,223,421 - 60,228,718 (-)NCBINCBI36Build 36hg18NCBI36
Build 342060,223,421 - 60,228,707NCBI
Celera2057,525,154 - 57,530,460 (-)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2057,566,507 - 57,570,202 (-)NCBIHuRef
CHM1_12060,690,583 - 60,695,889 (-)NCBICHM1_1
T2T-CHM13v2.02064,006,090 - 64,011,408 (-)NCBIT2T-CHM13v2.0
Hrh3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392179,741,258 - 179,746,264 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2179,741,258 - 179,746,281 (-)EnsemblGRCm39 Ensembl
GRCm382180,099,465 - 180,104,484 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,099,465 - 180,104,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv372179,834,178 - 179,838,927 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362180,028,881 - 180,033,632 (-)NCBIMGSCv36mm8
Celera2184,181,575 - 184,186,324 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2102.62NCBI
Hrh3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555281,819,247 - 1,826,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555281,819,247 - 1,826,707 (+)NCBIChiLan1.0ChiLan1.0
HRH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22167,996,962 - 68,002,333 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12067,990,084 - 67,995,449 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02058,581,228 - 58,586,585 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12059,900,919 - 59,905,858 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2059,901,327 - 59,909,901 (-)Ensemblpanpan1.1panPan2
HRH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12446,239,883 - 46,243,123 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2445,476,507 - 45,480,947 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02447,095,982 - 47,100,422 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2447,096,070 - 47,100,764 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12446,197,405 - 46,201,844 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02446,320,612 - 46,325,047 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,074,908 - 47,079,348 (-)NCBIUU_Cfam_GSD_1.0
Hrh3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640194,408,461 - 194,412,309 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365149,862,523 - 9,873,159 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365149,862,104 - 9,865,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HRH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1761,622,938 - 61,627,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11761,622,865 - 61,627,278 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HRH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.122,019,878 - 2,025,218 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl22,020,286 - 2,025,202 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605049,967,430 - 49,972,751 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hrh3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474128,080,965 - 28,085,428 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474128,080,957 - 28,086,312 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hrh3
5 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat

Markers in Region
D3Wox40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23167,192,318 - 167,192,463 (+)MAPPERmRatBN7.2
Rnor_6.03175,475,072 - 175,475,216NCBIRnor6.0
Rnor_5.03181,643,466 - 181,643,610UniSTSRnor5.0
RGSC_v3.43169,155,741 - 169,155,885UniSTSRGSC3.4
Celera3165,387,654 - 165,387,788UniSTS
Cytogenetic Map3q43UniSTS
AA943666  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23167,191,632 - 167,191,754 (+)MAPPERmRatBN7.2
Rnor_6.03175,474,386 - 175,474,507NCBIRnor6.0
Rnor_5.03181,644,175 - 181,644,296UniSTSRnor5.0
RGSC_v3.43169,155,055 - 169,155,176UniSTSRGSC3.4
Celera3165,388,353 - 165,388,474UniSTS
RH 3.4 Map31524.0UniSTS
Cytogenetic Map3q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 7 26 113 77 76 45 25 45 6 171 73 93 39 53 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB015646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF237919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY009370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY009371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB735595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ112342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ112343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000077308   ⟹   ENSRNOP00000071828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,191,558 - 167,196,642 (-)Ensembl
Rnor_6.0 Ensembl3175,474,311 - 175,479,395 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086761   ⟹   ENSRNOP00000069003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,191,558 - 167,196,642 (-)Ensembl
Rnor_6.0 Ensembl3175,473,078 - 175,479,034 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116829   ⟹   ENSRNOP00000090011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,191,558 - 167,196,642 (-)Ensembl
RefSeq Acc Id: NM_001270564   ⟹   NP_001257493
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,574,259 (-)NCBI
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270565   ⟹   NP_001257494
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,574,259 (-)NCBI
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270566   ⟹   NP_001257495
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,574,259 (-)NCBI
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270567   ⟹   NP_001257496
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,574,259 (-)NCBI
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270568   ⟹   NP_001257497
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,574,259 (-)NCBI
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270569   ⟹   NP_001257498
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,574,259 (-)NCBI
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270570   ⟹   NP_001257499
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,574,259 (-)NCBI
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NM_053506   ⟹   NP_445958
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,574,259 (-)NCBI
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
RGSC_v3.43169,154,980 - 169,160,064 (-)RGD
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: NR_073042
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,574,259 (-)NCBI
mRatBN7.23167,191,557 - 167,196,642 (-)NCBI
Rnor_6.03175,474,310 - 175,479,395 (-)NCBI
Rnor_5.03181,639,287 - 181,644,372 (+)NCBI
Celera3165,383,487 - 165,388,550 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762548   ⟹   XP_008760770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,573,301 (-)NCBI
mRatBN7.23167,191,551 - 167,194,873 (-)NCBI
Rnor_6.03175,474,310 - 175,478,438 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063284742   ⟹   XP_063140812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,574,584 (-)NCBI
RefSeq Acc Id: XM_063284743   ⟹   XP_063140813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,575,263 (-)NCBI
RefSeq Acc Id: XM_063284744   ⟹   XP_063140814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,573,301 (-)NCBI
RefSeq Acc Id: XM_063284745   ⟹   XP_063140815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,573,812 (-)NCBI
RefSeq Acc Id: XM_063284746   ⟹   XP_063140816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,573,301 (-)NCBI
RefSeq Acc Id: XM_063284747   ⟹   XP_063140817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,569,174 - 187,573,806 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001257493 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257494 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257495 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257496 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257497 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257498 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257499 (Get FASTA)   NCBI Sequence Viewer  
  NP_445958 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760770 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140812 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140813 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140814 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140815 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140816 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140817 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF82086 (Get FASTA)   NCBI Sequence Viewer  
  AAH87707 (Get FASTA)   NCBI Sequence Viewer  
  AAK02069 (Get FASTA)   NCBI Sequence Viewer  
  AAK02070 (Get FASTA)   NCBI Sequence Viewer  
  AAZ93637 (Get FASTA)   NCBI Sequence Viewer  
  AAZ93638 (Get FASTA)   NCBI Sequence Viewer  
  BAA88765 (Get FASTA)   NCBI Sequence Viewer  
  BAA88766 (Get FASTA)   NCBI Sequence Viewer  
  BAA88767 (Get FASTA)   NCBI Sequence Viewer  
  BAA88768 (Get FASTA)   NCBI Sequence Viewer  
  EDL88825 (Get FASTA)   NCBI Sequence Viewer  
  EDL88826 (Get FASTA)   NCBI Sequence Viewer  
  EDL88827 (Get FASTA)   NCBI Sequence Viewer  
  EDL88828 (Get FASTA)   NCBI Sequence Viewer  
  EDL88829 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069003
  ENSRNOP00000069003.2
  ENSRNOP00000071828
  ENSRNOP00000090011
  ENSRNOP00000090011.1
GenBank Protein Q9QYN8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445958   ⟸   NM_053506
- Peptide Label: isoform H3A
- UniProtKB: Q9QYN7 (UniProtKB/Swiss-Prot),   Q9QYN6 (UniProtKB/Swiss-Prot),   Q9QYN9 (UniProtKB/Swiss-Prot),   Q9QYN8 (UniProtKB/Swiss-Prot),   A6KMB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257495   ⟸   NM_001270566
- Peptide Label: isoform H3D
- UniProtKB: Q2VJ18 (UniProtKB/TrEMBL),   A0A0G2JU84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257493   ⟸   NM_001270564
- Peptide Label: isoform H3B
- UniProtKB: Q541U0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257496   ⟸   NM_001270567
- Peptide Label: isoform H3E
- UniProtKB: Q2VJ17 (UniProtKB/TrEMBL),   A0A0G2JU84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257498   ⟸   NM_001270569
- Peptide Label: isoform 7
- UniProtKB: Q541U0 (UniProtKB/TrEMBL),   Q5PPG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257494   ⟸   NM_001270565
- Peptide Label: isoform H3C
- UniProtKB: Q9QYN8 (UniProtKB/Swiss-Prot),   Q5PPG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257499   ⟸   NM_001270570
- Peptide Label: isoform 8
- UniProtKB: Q5PPG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257497   ⟸   NM_001270568
- Peptide Label: isoform H3F
- UniProtKB: A0A0G2JU84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760770   ⟸   XM_008762548
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000071828   ⟸   ENSRNOT00000077308
Ensembl Acc Id: ENSRNOP00000069003   ⟸   ENSRNOT00000086761
Ensembl Acc Id: ENSRNOP00000090011   ⟸   ENSRNOT00000116829
RefSeq Acc Id: XP_063140813   ⟸   XM_063284743
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140812   ⟸   XM_063284742
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140815   ⟸   XM_063284745
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140817   ⟸   XM_063284747
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140816   ⟸   XM_063284746
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140814   ⟸   XM_063284744
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYN8-F1-model_v2 AlphaFold Q9QYN8 1-445 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692729
Promoter ID:EPDNEW_R3254
Type:single initiation site
Name:Hrh3_1
Description:histamine receptor H3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03175,479,378 - 175,479,438EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620630 AgrOrtholog
BioCyc Gene G2FUF-46369 BioCyc
Ensembl Genes ENSRNOG00000061153 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000077308 ENTREZGENE
  ENSRNOT00000086761 ENTREZGENE
  ENSRNOT00000086761.2 UniProtKB/Swiss-Prot
  ENSRNOT00000116829 ENTREZGENE
  ENSRNOT00000116829.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7315203 IMAGE-MGC_LOAD
InterPro 7tmA_HRH3 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Histamine_H3_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:85268 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105370 IMAGE-MGC_LOAD
NCBI Gene 85268 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot
  HISTAMINE H3 RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Hrh3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  HISTAMINEH3R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000061153 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A0G2JU84 ENTREZGENE, UniProtKB/TrEMBL
  A6KMB7 ENTREZGENE, UniProtKB/TrEMBL
  A6KMB9_RAT UniProtKB/TrEMBL
  A6KMC0_RAT UniProtKB/TrEMBL
  HRH3_RAT UniProtKB/Swiss-Prot
  Q2VJ17 ENTREZGENE, UniProtKB/TrEMBL
  Q2VJ18 ENTREZGENE, UniProtKB/TrEMBL
  Q541U0 ENTREZGENE, UniProtKB/TrEMBL
  Q5PPG3 ENTREZGENE, UniProtKB/TrEMBL
  Q9QYN6 ENTREZGENE
  Q9QYN7 ENTREZGENE
  Q9QYN8 ENTREZGENE
  Q9QYN9 ENTREZGENE
UniProt Secondary Q9QYN6 UniProtKB/Swiss-Prot
  Q9QYN7 UniProtKB/Swiss-Prot
  Q9QYN9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Hrh3  histamine receptor H3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Hrh3  histamine receptor H3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs binds antagonists thioperamide and clobenpropit with high affinity, in contrast to low affinity binding of thioperamide to the human homolog 632981
gene_expression expressed exclusively in brain 632981