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Gene: Bcar1 (BCAR1 scaffold protein, Cas family member) Rattus norvegicus
Symbol: Bcar1
Name: BCAR1 scaffold protein, Cas family member
RGD ID: 2406
Description: Exhibits protein domain specific binding activity. Involved in several processes, including cellular response to endothelin; cellular response to nitric oxide; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to focal adhesion and plasma membrane. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member); PARTICIPATES IN endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-mevalonic acid; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: BCAR1, Cas family scaffold protein; BCAR1, Cas family scaffolding protein; breast cancer anti-estrogen resistance 1; breast cancer anti-estrogen resistance protein 1; Cas; CRK-associated substrate; Crkas; P130CAS; v-crk-associated tyrosine kinase substrate
Homo sapiens (human) : BCAR1 (BCAR1 scaffold protein, Cas family member)  HGNC  Alliance
Mus musculus (house mouse) : Bcar1 (breast cancer anti-estrogen resistance 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bcar1 (BCAR1 scaffold protein, Cas family member)
Pan paniscus (bonobo/pygmy chimpanzee) : BCAR1 (BCAR1 scaffold protein, Cas family member)
Canis lupus familiaris (dog) : BCAR1 (BCAR1 scaffold protein, Cas family member)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bcar1 (BCAR1 scaffold protein, Cas family member)
Sus scrofa (pig) : BCAR1 (BCAR1 scaffold protein, Cas family member)
Chlorocebus sabaeus (African green monkey) : BCAR1 (BCAR1 scaffold protein, Cas family member)
Heterocephalus glaber (naked mole-rat) : Bcar1 (BCAR1 scaffold protein, Cas family member)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01943,932,543 - 43,967,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,932,554 - 43,955,783 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01954,739,915 - 54,774,486 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,646,190 - 41,669,234 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11941,651,070 - 41,674,115 (-)NCBI
Celera1939,039,406 - 39,062,496 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Bcar1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2406
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.