Bcar1 (BCAR1 scaffold protein, Cas family member) - Rat Genome Database

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Gene: Bcar1 (BCAR1 scaffold protein, Cas family member) Rattus norvegicus
Analyze
Symbol: Bcar1
Name: BCAR1 scaffold protein, Cas family member
RGD ID: 2406
Description: Exhibits protein domain specific binding activity. Involved in several processes, including cellular response to endothelin; cellular response to nitric oxide; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to focal adhesion and plasma membrane. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member); PARTICIPATES IN endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-mevalonic acid; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: BCAR1, Cas family scaffold protein; BCAR1, Cas family scaffolding protein; breast cancer anti-estrogen resistance 1; breast cancer anti-estrogen resistance protein 1; Cas; CRK-associated substrate; Crkas; P130CAS; v-crk-associated tyrosine kinase substrate
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21939,679,218 - 39,713,952 (-)NCBI
Rnor_6.0 Ensembl1943,932,554 - 43,955,783 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01943,932,543 - 43,967,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01954,739,915 - 54,774,486 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,646,190 - 41,669,234 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11941,651,070 - 41,674,115 (-)NCBI
Celera1939,039,406 - 39,062,496 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R)-mevalonic acid  (EXP)
1,2-dimethylhydrazine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atropine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
blebbistatin  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
celecoxib  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
lovastatin  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
ML-7  (ISO)
N-Vinyl-2-pyrrolidone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitric oxide  (EXP)
oxotremorine M  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
potassium chloride  (EXP)
quercetin  (ISO)
reactive oxygen species  (ISO)
retinyl acetate  (ISO)
sodium arsenate  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
tetrahydropalmatine  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IEA,ISO)
axon  (IEA)
cytoplasm  (IBA,IEA,ISO,ISS)
focal adhesion  (IBA,IDA,IEA,ISO)
lamellipodium  (IEA,ISO)
membrane  (ISO)
plasma membrane  (IDA,IEA,ISO)
ruffle  (IEA,ISO,ISS)

Molecular Function

References

References - curated
1. Ballestrem C, etal., J Cell Sci. 2006 Mar 1;119(Pt 5):866-75. Epub 2006 Feb 14.
2. Dorssers LC, etal., Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6194-202.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Harte MT, etal., J Biol Chem. 1996 Jun 7;271(23):13649-55.
5. Honda H, etal., Nat Genet 1998 Aug;19(4):361-5.
6. Hoon Kim D, etal., Biochem Biophys Res Commun 2003 Jan 3;300(1):141-8.
7. Huang J, etal., J Biol Chem 2002 Jul 26;277(30):27265-72. Epub 2002 May 14.
8. Kodama H, etal., Hypertension. 2003 Jun;41(6):1372-9. Epub 2003 Apr 28.
9. Konrad RJ, etal., J Biol Chem 2003 Jul 25;278(30):28116-22. Epub 2003 May 12.
10. Lin Y, etal., Am J Physiol Heart Circ Physiol 2003 Aug;285(2):H710-21. Epub 2003 Apr 24.
11. Liu F, etal., J Biol Chem. 1996 Dec 6;271(49):31290-5.
12. MGD data from the GO Consortium
13. Nasertorabi F, etal., J Mol Recognit. 2006 Jan-Feb;19(1):30-8.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Oh MJ, etal., Biochem Biophys Res Commun. 2013 Nov 29;441(4):911-6. doi: 10.1016/j.bbrc.2013.10.161. Epub 2013 Nov 9.
16. Ojaniemi M and Vuori K, J Biol Chem. 1997 Oct 10;272(41):25993-8.
17. Pipeline to import KEGG annotations from KEGG into RGD
18. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. RGD automated import pipeline for gene-chemical interactions
20. Ribon V and Saltiel AR, J Biol Chem. 1996 Mar 29;271(13):7375-80.
21. Riggins RB, etal., Mol Cancer Res 2003 Apr;1(6):428-37.
22. Sakai R, etal., EMBO J 1994 Aug 15;13(16):3748-56.
23. Sanders MA and Basson MD, J Biol Chem. 2005 Jun 24;280(25):23516-22. Epub 2005 Apr 6.
24. Sorokin A, etal., Oncogene. 1998 May 14;16(19):2425-34.
25. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. van der Flier S, etal., Int J Biol Markers. 2001 Jul-Sep;16(3):172-8.
27. Yudin D, etal., Neuron. 2008 Jul 31;59(2):241-52. doi: 10.1016/j.neuron.2008.05.029.
Additional References at PubMed
PMID:8649368   PMID:9020138   PMID:9038154   PMID:9083073   PMID:9348226   PMID:9360983   PMID:9425168   PMID:9472046   PMID:9832615   PMID:9915838   PMID:10026197   PMID:10587647  
PMID:11146548   PMID:11181827   PMID:11864995   PMID:15272013   PMID:15485652   PMID:15728191   PMID:15795225   PMID:16105984   PMID:16354758   PMID:16861698   PMID:17129785   PMID:17615370  
PMID:17617061   PMID:19086031   PMID:20623582   PMID:21245381  


Genomics

Candidate Gene Status
Bcar1 is a candidate Gene for QTL Eau8
Comparative Map Data
Bcar1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21939,679,218 - 39,713,952 (-)NCBI
Rnor_6.0 Ensembl1943,932,554 - 43,955,783 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01943,932,543 - 43,967,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01954,739,915 - 54,774,486 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,646,190 - 41,669,234 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11941,651,070 - 41,674,115 (-)NCBI
Celera1939,039,406 - 39,062,496 (-)NCBICelera
Cytogenetic Map19q12NCBI
BCAR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1675,228,181 - 75,268,053 (-)EnsemblGRCh38hg38GRCh38
GRCh381675,228,181 - 75,268,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371675,262,079 - 75,301,905 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,820,429 - 73,843,004 (-)NCBINCBI36hg18NCBI36
Build 341673,820,429 - 73,843,004NCBI
Celera1659,556,476 - 59,596,268 (-)NCBI
Cytogenetic Map16q23.1NCBI
HuRef1661,013,718 - 61,052,474 (-)NCBIHuRef
CHM1_11676,675,047 - 76,714,069 (-)NCBICHM1_1
Bcar1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398112,437,106 - 112,470,481 (-)NCBIGRCm39mm39
GRCm39 Ensembl8112,437,106 - 112,470,441 (-)Ensembl
GRCm388111,710,474 - 111,743,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,710,474 - 111,743,809 (-)EnsemblGRCm38mm10GRCm38
MGSCv378114,234,374 - 114,267,709 (-)NCBIGRCm37mm9NCBIm37
MGSCv368114,597,147 - 114,630,482 (-)NCBImm8
Celera8115,938,849 - 115,972,131 (-)NCBICelera
Cytogenetic Map8E1NCBI
Bcar1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554842,227,337 - 2,260,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554842,223,306 - 2,258,444 (+)NCBIChiLan1.0ChiLan1.0
BCAR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11675,149,280 - 75,186,883 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1675,150,122 - 75,188,775 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01655,798,578 - 55,838,448 (-)NCBIMhudiblu_PPA_v0panPan3
BCAR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1575,463,906 - 75,499,557 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl575,463,926 - 75,512,476 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha575,439,949 - 75,476,374 (+)NCBI
ROS_Cfam_1.0575,819,916 - 75,856,356 (+)NCBI
UMICH_Zoey_3.1575,712,186 - 75,748,588 (+)NCBI
UNSW_CanFamBas_1.0575,547,221 - 75,583,635 (+)NCBI
UU_Cfam_GSD_1.0576,038,420 - 76,074,849 (+)NCBI
Bcar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934935,556,294 - 35,594,421 (+)NCBI
SpeTri2.0NW_00493647523,994,130 - 24,032,829 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCAR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl612,367,758 - 12,404,822 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1612,369,332 - 12,404,822 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2612,225,439 - 12,247,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCAR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,709,409 - 60,749,071 (-)NCBI
ChlSab1.1 Ensembl560,707,006 - 60,732,882 (-)Ensembl
Bcar1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474611,660,859 - 11,695,991 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19104464846044648Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19195770746957707Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19243296347217667Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19243296362275575Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)19370183548701835Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)19370183548701835Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19650676160220581Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19807254547318201Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191130392747879277Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191702800352538299Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191899398262275575Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191917749562275575Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)192140778762275575Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192481825762275575Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)193299439262275575Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193791679960220451Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193791679960220451Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:47
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000041815, ENSRNOT00000058891
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 49 41 6 41 1 74 35 41 11
Low 8 8 13 8 10 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000041815   ⟹   ENSRNOP00000039940
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1943,932,554 - 43,955,783 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000058891   ⟹   ENSRNOP00000055678
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1943,932,946 - 43,955,747 (-)Ensembl
RefSeq Acc Id: NM_012931   ⟹   NP_037063
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21939,679,229 - 39,702,283 (-)NCBI
Rnor_6.01943,932,554 - 43,955,783 (-)NCBI
Rnor_5.01954,739,915 - 54,774,486 (-)NCBI
RGSC_v3.41941,646,190 - 41,669,234 (-)RGD
Celera1939,039,406 - 39,062,496 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255628   ⟹   XP_006255690
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21939,679,218 - 39,713,952 (-)NCBI
Rnor_6.01943,932,543 - 43,967,452 (-)NCBI
Rnor_5.01954,739,915 - 54,774,486 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255629   ⟹   XP_006255691
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21939,679,218 - 39,702,377 (-)NCBI
Rnor_6.01943,932,543 - 43,957,859 (-)NCBI
Rnor_5.01954,739,915 - 54,774,486 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097494   ⟹   XP_038953422
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21939,679,218 - 39,702,190 (-)NCBI
RefSeq Acc Id: XM_039097495   ⟹   XP_038953423
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21939,679,218 - 39,713,707 (-)NCBI
RefSeq Acc Id: XM_039097496   ⟹   XP_038953424
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21939,679,218 - 39,699,337 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037063   ⟸   NM_012931
- UniProtKB: Q63767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255690   ⟸   XM_006255628
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006255691   ⟸   XM_006255629
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000039940   ⟸   ENSRNOT00000041815
RefSeq Acc Id: ENSRNOP00000055678   ⟸   ENSRNOT00000058891
RefSeq Acc Id: XP_038953423   ⟸   XM_039097495
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038953422   ⟸   XM_039097494
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038953424   ⟸   XM_039097496
- Peptide Label: isoform X3
Protein Domains
SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701152
Promoter ID:EPDNEW_R11676
Type:multiple initiation site
Name:Bcar1_1
Description:BCAR1, Cas family scaffolding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01943,955,804 - 43,955,864EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2406 AgrOrtholog
Ensembl Genes ENSRNOG00000019253 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000039940 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000055678 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041815 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000058891 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.830 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BCAR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCAR1_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAS_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAS_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serine_rich_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serine_rich_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25414 UniProtKB/Swiss-Prot
NCBI Gene 25414 ENTREZGENE
PANTHER PTHR10654 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10654:SF15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CAS_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serine_rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB BCAR1 RGD
PhenoGen Bcar1 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205306
UniProt BCAR1_RAT UniProtKB/Swiss-Prot
  D3ZE30_RAT UniProtKB/TrEMBL
  F1LVA8_RAT UniProtKB/TrEMBL
  Q63767 ENTREZGENE
UniProt Secondary Q63766 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-27 Bcar1  BCAR1 scaffold protein, Cas family member  Bcar1  BCAR1, Cas family scaffold protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-03-13 Bcar1  BCAR1, Cas family scaffold protein  Bcar1  BCAR1, Cas family scaffolding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-27 Bcar1  BCAR1, Cas family scaffolding protein  Bcar1  breast cancer anti-estrogen resistance 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Bcar1  breast cancer anti-estrogen resistance 1  Crkas  v-crk-associated tyrosine kinase substrate  Symbol and Name updated 1299863 APPROVED
2002-06-10 Crkas  v-crk-associated tyrosine kinase substrate      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains an SH3 domain and a repetitive stretch of tyrosine-containing motifs 1298806
gene_physical_interaction tyrosine-phosphorylated protein forms stable interactions with v-Src and v-Crk kinases and serves as a substrate for both kinases 1298805
gene_process may serve to assemble signals from multiple SH2 domain-containing molecules 1298805
gene_process essential for oncogenesis, actin cytoskeleton organization and cellular migration 1298806
gene_protein tyrosine phosphorylated upon cellular transformation with p60v-src or v-Crk 1298805
gene_regulation degraded during apoptosis via cleavage by caspase following dephosphorylation 1298807
gene_regulation tyrosine phosphorylated in beta cells upon treatment with glucose 1298808