Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | PPP3CB (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | PPP3CB (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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# | Reference Title | Reference Citation |
1. | Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia. | Abe T, etal., Brain Res. 2004 May 29;1009(1-2):159-68. |
2. | Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction. | Bueno OF, etal., Circ Res. 2004 Jan 9;94(1):91-9. Epub 2003 Nov 13. |
3. | Calcineurin Agamma is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis. | Cottrell JR, etal., J Biol Chem. 2016 Jan 22;291(4):1948-56. doi: 10.1074/jbc.M115.705319. Epub 2015 Dec 1. |
4. | Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis. | Donelan MJ, etal., J Biol Chem. 2002 Jul 5;277(27):24232-42. Epub 2002 Apr 26. |
5. | Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathway. | Dupont-Versteegden EE, etal., Am J Physiol Cell Physiol 2002 Jun;282(6):C1387-95. |
6. | Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia. | Eastwood SL, etal., Biol Psychiatry. 2005 Apr 1;57(7):702-10. doi: 10.1016/j.biopsych.2004.12.029. |
7. | Differential expression of calcineurin A subunit mRNA isoforms during rat hippocampal and cerebellar development. | Eastwood SL, etal., Eur J Neurosci. 2005 Dec;22(12):3017-24. |
8. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
9. | Comparative Analysis of Gene Expression Profiles Involved in Calcium Signaling Pathways Using the NLVH Animal Model of Schizophrenia. | Genis-Mendoza A, etal., J Mol Neurosci. 2018 Jan;64(1):111-116. doi: 10.1007/s12031-017-1013-y. Epub 2017 Dec 6. |
10. | Calcineurin and matrix protein expression in cardiac hypertrophy : Evidence for calcineurin B to control excessive hypertrophic signaling. | Grammer JB, etal., Basic Res Cardiol. 2006 Jul;101(4):292-300. Epub 2006 May 10. |
11. | Direct association of the unique C-terminal tail of transmembrane AMPA receptor regulatory protein gamma-8 with calcineurin. | Itakura M, etal., FEBS J. 2014 Mar;281(5):1366-78. doi: 10.1111/febs.12708. Epub 2014 Jan 27. |
12. | Evidence for a second isoform of the catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A). | Kuno T, etal., Biochem Biophys Res Commun 1989 Dec 29;165(3):1352-8. |
13. | Distinct cellular expression of calcineurin A alpha and A beta in rat brain. | Kuno T, etal., J Neurochem. 1992 May;58(5):1643-51. |
14. | The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin. | Li J, etal., J Mol Cell Cardiol. 2010 Feb;48(2):387-94. Epub 2009 Oct 31. |
15. | Decreased calcineurin and increased phosphothreonine-DARPP-32 in the striatum of rats behaviorally sensitized to methamphetamine. | Lin XH, etal., Synapse 2002 Jun 1;44(3):181-7. |
16. | L-type calcium channel blocker suppresses calcineurin signal pathway and development of right ventricular hypertrophy. | Liu CZ, etal., J Formos Med Assoc. 2005 Nov;104(11):798-803. |
17. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
18. | A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. | Molkentin JD, etal., Cell. 1998 Apr 17;93(2):215-28. |
19. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
20. | Upregulation of myocardial estrogen receptors in human aortic stenosis. | Nordmeyer J, etal., Circulation. 2004 Nov 16;110(20):3270-5. Epub 2004 Nov 8. |
21. | Regulation of calcineurin through transcriptional induction of the calcineurin A beta promoter in vitro and in vivo. | Oka T, etal., Mol Cell Biol. 2005 Aug;25(15):6649-59. |
22. | The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. | Pare GC, etal., J Cell Sci. 2005 Dec 1;118(Pt 23):5637-46. |
23. | Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the alpha or beta catalytic subunit. | Perrino BA, etal., Eur J Biochem 2002 Jul;269(14):3540-8. |
24. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
25. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
26. | GOA pipeline | RGD automated data pipeline |
27. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
28. | Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. | Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91. |
29. | MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes. | Wu J, etal., J Clin Invest. 2015 Nov 2;125(11):4091-106. doi: 10.1172/JCI81061. Epub 2015 Oct 5. |
30. | DARPP-32, Jack of All Trades... Master of Which? | Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011. |
PMID:2174876 | PMID:2556704 | PMID:8524402 | PMID:9388246 | PMID:11005320 | PMID:11904392 | PMID:12091710 | PMID:15514034 | PMID:16648267 | PMID:17303652 | PMID:18097009 | PMID:18295934 |
PMID:19150448 | PMID:19154138 | PMID:19233846 | PMID:19287093 | PMID:20810903 | PMID:21423799 | PMID:21531385 | PMID:22305959 | PMID:22688515 | PMID:23382378 | PMID:23549689 | PMID:26794871 |
PMID:30053369 | PMID:32357304 | PMID:37926341 |
Ppp3cb (Rattus norvegicus - Norway rat) |
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PPP3CB (Homo sapiens - human) |
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Ppp3cb (Mus musculus - house mouse) |
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Ppp3cb (Chinchilla lanigera - long-tailed chinchilla) |
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PPP3CB (Pan paniscus - bonobo/pygmy chimpanzee) |
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PPP3CB (Canis lupus familiaris - dog) |
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Ppp3cb (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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PPP3CB (Sus scrofa - pig) |
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PPP3CB (Chlorocebus sabaeus - green monkey) |
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Ppp3cb (Heterocephalus glaber - naked mole-rat) |
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Variants in Ppp3cb
138 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
AU022835 |
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RH131331 |
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RH143458 |
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RH140251 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 43 | 57 | 41 | 19 | 41 | 8 | 11 | 74 | 35 | 38 | 11 | 8 |
Low | 3 | ||||||||||||
Below cutoff |
RefSeq Transcripts | NM_017042 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_039092985 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039092986 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039092987 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039092988 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039092989 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039092990 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039092991 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC091344 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
CH474061 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D90036 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ213810 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ214219 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ214575 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000015 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M31809 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M58441 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000082236 ⟹ ENSRNOP00000074339 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000100861 ⟹ ENSRNOP00000090043 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000101580 ⟹ ENSRNOP00000090582 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000107965 ⟹ ENSRNOP00000096220 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000117871 ⟹ ENSRNOP00000086753 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_017042 ⟹ NP_058738 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039092985 ⟹ XP_038948913 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039092986 ⟹ XP_038948914 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039092987 ⟹ XP_038948915 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039092988 ⟹ XP_038948916 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039092989 ⟹ XP_038948917 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039092990 ⟹ XP_038948918 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039092991 ⟹ XP_038948919 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Protein RefSeqs | NP_058738 | (Get FASTA) | NCBI Sequence Viewer |
XP_038948913 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038948914 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038948915 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038948916 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038948917 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038948918 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038948919 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAA40848 | (Get FASTA) | NCBI Sequence Viewer |
AAA41915 | (Get FASTA) | NCBI Sequence Viewer | |
BAA14084 | (Get FASTA) | NCBI Sequence Viewer | |
EDL86229 | (Get FASTA) | NCBI Sequence Viewer | |
EDL86230 | (Get FASTA) | NCBI Sequence Viewer | |
EDL86231 | (Get FASTA) | NCBI Sequence Viewer | |
EDL86232 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000074339 | ||
ENSRNOP00000074339.2 | |||
ENSRNOP00000086753.1 | |||
ENSRNOP00000090043.1 | |||
ENSRNOP00000090582 | |||
ENSRNOP00000090582.1 | |||
ENSRNOP00000096220 | |||
ENSRNOP00000096220.1 | |||
GenBank Protein | P20651 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_058738 ⟸ NM_017042 |
- UniProtKB: | Q6LDJ7 (UniProtKB/Swiss-Prot), P20651 (UniProtKB/Swiss-Prot), A0A8I6A2X6 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000074339 ⟸ ENSRNOT00000082236 |
RefSeq Acc Id: | XP_038948913 ⟸ XM_039092985 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A8I6AAD3 (UniProtKB/TrEMBL), A0A8I6A2X6 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038948917 ⟸ XM_039092989 |
- Peptide Label: | isoform X5 |
- UniProtKB: | A0A8I6A2X6 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038948914 ⟸ XM_039092986 |
- Peptide Label: | isoform X2 |
- UniProtKB: | A0A8I6A2X6 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038948918 ⟸ XM_039092990 |
- Peptide Label: | isoform X6 |
- UniProtKB: | A0A8I6GLZ4 (UniProtKB/TrEMBL), A0A8I6A2X6 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038948916 ⟸ XM_039092988 |
- Peptide Label: | isoform X4 |
- UniProtKB: | A0A8I6A2X6 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038948919 ⟸ XM_039092991 |
- Peptide Label: | isoform X7 |
- UniProtKB: | A0A8I6A2X6 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038948915 ⟸ XM_039092987 |
- Peptide Label: | isoform X3 |
- UniProtKB: | A0A8I6A2X6 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | ENSRNOP00000090582 ⟸ ENSRNOT00000101580 |
RefSeq Acc Id: | ENSRNOP00000090043 ⟸ ENSRNOT00000100861 |
RefSeq Acc Id: | ENSRNOP00000096220 ⟸ ENSRNOT00000107965 |
RefSeq Acc Id: | ENSRNOP00000086753 ⟸ ENSRNOT00000117871 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P20651-F1-model_v2 | AlphaFold | P20651 | 1-525 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:3383 | AgrOrtholog |
BioCyc Gene | G2FUF-14541 | BioCyc |
Ensembl Genes | ENSRNOG00000054782 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000082236 | ENTREZGENE |
ENSRNOT00000082236.2 | UniProtKB/TrEMBL | |
ENSRNOT00000100861.1 | UniProtKB/TrEMBL | |
ENSRNOT00000101580 | ENTREZGENE | |
ENSRNOT00000101580.1 | UniProtKB/TrEMBL | |
ENSRNOT00000107965 | ENTREZGENE | |
ENSRNOT00000107965.1 | UniProtKB/TrEMBL | |
ENSRNOT00000117871.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 3.60.21.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
InterPro | Calcineurin-like_PHP_ApaH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Metallo-depent_PP-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
MPP_PP2B | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PP2B | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ser/Thr-sp_prot-phosphatase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:24675 | UniProtKB/Swiss-Prot |
NCBI Gene | 24675 | ENTREZGENE |
PANTHER | PTHR45673 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | Metallophos | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Ppp3cb | PhenoGen |
PRINTS | STPHPHTASE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | SER_THR_PHOSPHATASE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
RatGTEx | ENSRNOG00000054782 | RatGTEx |
SMART | PP2Ac | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Superfamily-SCOP | SSF56300 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A0A0G2K7T5_RAT | UniProtKB/TrEMBL |
A0A8I6A2X6 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6A8I8_RAT | UniProtKB/TrEMBL | |
A0A8I6AAD3 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6GLZ4 | ENTREZGENE, UniProtKB/TrEMBL | |
A6KKN5_RAT | UniProtKB/TrEMBL | |
A6KKN6_RAT | UniProtKB/TrEMBL | |
A6KKN7_RAT | UniProtKB/TrEMBL | |
A6KKN8_RAT | UniProtKB/TrEMBL | |
P20651 | ENTREZGENE, UniProtKB/Swiss-Prot | |
Q6LDJ7 | ENTREZGENE | |
UniProt Secondary | Q6LDJ7 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2016-02-17 | Ppp3cb | protein phosphatase 3 catalytic subunit beta | Ppp3cb | protein phosphatase 3, catalytic subunit, beta isozyme | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2012-01-26 | Ppp3cb | protein phosphatase 3, catalytic subunit, beta isozyme | Ppp3cb | protein phosphatase 3, catalytic subunit, beta isoform | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2001-10-24 | Ppp3cb | protein phosphatase 3, catalytic subunit, beta isoform | Name updated to reflect Human and Mouse nomenclature | 68913 | APPROVED |
Note Type | Note | Reference |
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gene_drugs | cyclosporin acts as a inhibitor partially blocking the muscle size | 628398 |
gene_process | calcium binding regulatory subunit which is activated by intracellular calcium anions | 628398 |
gene_process | mediates hypertropic response of muscle cells | 628398 |
gene_protein | 19 kDa in size | 628398 |
gene_regulation | activated by intracellular calcuim and dephosphorylates nuclear factors of activated T cells (NFATs) | 628398 |