Ppp3cb (protein phosphatase 3 catalytic subunit beta) - Rat Genome Database
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Gene: Ppp3cb (protein phosphatase 3 catalytic subunit beta) Rattus norvegicus
Analyze
Symbol: Ppp3cb
Name: protein phosphatase 3 catalytic subunit beta
RGD ID: 3383
Description: Exhibits calcium-dependent protein serine/threonine phosphatase activity and calmodulin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to amphetamine. Localizes to plasma membrane; protein-containing complex; and synapse. Biomarker of schizophrenia. Human ortholog(s) of this gene implicated in aortic valve stenosis. Orthologous to human PPP3CB (protein phosphatase 3 catalytic subunit beta); PARTICIPATES IN calcineurin signaling pathway; dopamine signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: calcineurin subunit A beta; calmodulin-dependent calcineurin A subunit beta isoform; Calna2; CAM-PRP catalytic subunit; CaN Abeta; CNA beta; protein phosphatase 3, catalytic subunit, beta isoform; protein phosphatase 3, catalytic subunit, beta isozyme; protein phosphatase-2Bb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
Rnor_6.0 Ensembl154,209,703 - 4,236,895 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0154,209,702 - 4,236,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0158,310,717 - 8,338,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,986,290 - 4,030,352 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X153,471,064 - 153,474,197 (+)NCBI
Celera15790,760 - 817,953 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
calcineurin complex  (IBA,IEA,ISO,ISS)
cytoplasm  (IBA,ISO)
cytosol  (TAS)
glutamatergic synapse  (IEA,ISO)
plasma membrane  (IDA,ISO)
protein-containing complex  (IDA)
synapse  (IDA)
T-tubule  (IEA,ISO)
Z disc  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Abe T, etal., Brain Res. 2004 May 29;1009(1-2):159-68.
2. Bueno OF, etal., Circ Res. 2004 Jan 9;94(1):91-9. Epub 2003 Nov 13.
3. Cottrell JR, etal., J Biol Chem. 2016 Jan 22;291(4):1948-56. doi: 10.1074/jbc.M115.705319. Epub 2015 Dec 1.
4. Donelan MJ, etal., J Biol Chem. 2002 Jul 5;277(27):24232-42. Epub 2002 Apr 26.
5. Dupont-Versteegden EE, etal., Am J Physiol Cell Physiol 2002 Jun;282(6):C1387-95.
6. Eastwood SL, etal., Biol Psychiatry. 2005 Apr 1;57(7):702-10. doi: 10.1016/j.biopsych.2004.12.029.
7. Eastwood SL, etal., Eur J Neurosci. 2005 Dec;22(12):3017-24.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Genis-Mendoza A, etal., J Mol Neurosci. 2018 Jan;64(1):111-116. doi: 10.1007/s12031-017-1013-y. Epub 2017 Dec 6.
10. Grammer JB, etal., Basic Res Cardiol. 2006 Jul;101(4):292-300. Epub 2006 May 10.
11. Itakura M, etal., FEBS J. 2014 Mar;281(5):1366-78. doi: 10.1111/febs.12708. Epub 2014 Jan 27.
12. Kuno T, etal., Biochem Biophys Res Commun 1989 Dec 29;165(3):1352-8.
13. Kuno T, etal., J Neurochem. 1992 May;58(5):1643-51.
14. Li J, etal., J Mol Cell Cardiol. 2010 Feb;48(2):387-94. Epub 2009 Oct 31.
15. Lin XH, etal., Synapse 2002 Jun 1;44(3):181-7.
16. Liu CZ, etal., J Formos Med Assoc. 2005 Nov;104(11):798-803.
17. MGD data from the GO Consortium
18. Molkentin JD, etal., Cell. 1998 Apr 17;93(2):215-28.
19. NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Nordmeyer J, etal., Circulation. 2004 Nov 16;110(20):3270-5. Epub 2004 Nov 8.
21. Oka T, etal., Mol Cell Biol. 2005 Aug;25(15):6649-59.
22. Pare GC, etal., J Cell Sci. 2005 Dec 1;118(Pt 23):5637-46.
23. Perrino BA, etal., Eur J Biochem 2002 Jul;269(14):3540-8.
24. Pipeline to import KEGG annotations from KEGG into RGD
25. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. RGD automated data pipeline
27. RGD automated import pipeline for gene-chemical interactions
28. Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91.
29. Wu J, etal., J Clin Invest. 2015 Nov 2;125(11):4091-106. doi: 10.1172/JCI81061. Epub 2015 Oct 5.
30. Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:2174876   PMID:2556704   PMID:8524402   PMID:9388246   PMID:11005320   PMID:11904392   PMID:12091710   PMID:15514034   PMID:16648267   PMID:17303652   PMID:18097009   PMID:18295934  
PMID:19150448   PMID:19154138   PMID:19233846   PMID:19287093   PMID:20810903   PMID:21423799   PMID:21531385   PMID:22305959   PMID:22688515   PMID:23382378   PMID:23549689   PMID:26794871  
PMID:30053369  


Genomics

Comparative Map Data
Ppp3cb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
Rnor_6.0 Ensembl154,209,703 - 4,236,895 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0154,209,702 - 4,236,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0158,310,717 - 8,338,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,986,290 - 4,030,352 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X153,471,064 - 153,474,197 (+)NCBI
Celera15790,760 - 817,953 (-)NCBICelera
Cytogenetic Map15p16NCBI
PPP3CB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1073,436,428 - 73,496,024 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1073,436,433 - 73,496,024 (-)EnsemblGRCh38hg38GRCh38
GRCh381073,436,433 - 73,496,024 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371075,196,191 - 75,255,782 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,866,618 - 74,925,758 (-)NCBINCBI36hg18NCBI36
Build 341074,866,617 - 74,925,760NCBI
Celera1068,482,159 - 68,541,381 (-)NCBI
Cytogenetic Map10q22.2NCBI
HuRef1069,190,274 - 69,249,395 (-)NCBIHuRef
CHM1_11075,477,948 - 75,537,525 (-)NCBICHM1_1
Ppp3cb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,549,432 - 20,596,641 (-)NCBIGRCm39mm39
GRCm39 Ensembl1420,549,432 - 20,596,641 (-)Ensembl
GRCm381420,499,364 - 20,546,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,499,364 - 20,546,573 (-)EnsemblGRCm38mm10GRCm38
MGSCv371421,318,536 - 21,365,795 (-)NCBIGRCm37mm9NCBIm37
MGSCv361419,288,592 - 19,335,096 (-)NCBImm8
Celera1416,880,736 - 16,928,039 (-)NCBICelera
Cytogenetic Map14A3NCBI
Ppp3cb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,323,857 - 18,377,815 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543718,323,852 - 18,377,815 (+)NCBIChiLan1.0ChiLan1.0
PPP3CB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11072,443,051 - 72,501,752 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1072,443,051 - 72,501,752 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01069,984,241 - 70,043,352 (-)NCBIMhudiblu_PPA_v0panPan3
PPP3CB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl423,977,317 - 24,028,153 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1423,976,023 - 24,028,139 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ppp3cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365215,576,705 - 5,614,738 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP3CB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1476,248,849 - 76,305,328 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11476,239,497 - 76,305,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21482,376,144 - 82,430,833 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP3CB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1957,782,256 - 57,841,307 (+)NCBI
ChlSab1.1 Ensembl957,782,304 - 57,844,573 (+)Ensembl
Ppp3cb
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247547,045,532 - 7,097,658 (-)NCBI

Position Markers
AU022835  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera15797,890 - 798,036UniSTS
Cytogenetic Map15p16UniSTS
RH131331  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0154,237,291 - 4,237,504NCBIRnor6.0
Rnor_5.0158,338,548 - 8,338,761UniSTSRnor5.0
RGSC_v3.4154,030,748 - 4,030,961UniSTSRGSC3.4
Celera15790,151 - 790,364UniSTS
RH 3.4 Map1564.5UniSTS
Cytogenetic Map15p16UniSTS
RH143458  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X151,819,554 - 151,819,670NCBIRnor6.0
Rnor_5.0X151,809,605 - 151,809,721UniSTSRnor5.0
RGSC_v3.4X153,397,829 - 153,397,945UniSTSRGSC3.4
CeleraX141,796,043 - 141,796,159UniSTS
Cytogenetic Map15p16UniSTS
Cytogenetic Map15p11UniSTS
RH140251  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0154,207,794 - 4,207,974NCBIRnor6.0
Rnor_5.0158,308,807 - 8,308,987UniSTSRnor5.0
RGSC_v3.4154,001,251 - 4,001,431UniSTSRGSC3.4
Celera15819,681 - 819,861UniSTS
RH 3.4 Map1563.9UniSTS
Cytogenetic Map15p16UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300142Bp191Blood pressure QTL 1913.14arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)15112800829Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15130597196Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15137708474Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15137708474Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15137708474Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15142844179Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15143521446Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15110589015828368Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15232787726288802Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15232787726288802Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15388113148881131Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:276
Count of miRNA genes:184
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000010476
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 38 11 8
Low 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC091344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D90036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000082236   ⟹   ENSRNOP00000074339
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl154,209,703 - 4,236,895 (+)Ensembl
RefSeq Acc Id: NM_017042   ⟹   NP_058738
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2153,760,030 - 3,804,208 (+)NCBI
Rnor_6.0154,209,702 - 4,236,895 (+)NCBI
Rnor_5.0158,310,717 - 8,338,152 (+)NCBI
RGSC_v3.4153,986,290 - 4,030,352 (+)RGD
Celera15790,760 - 817,953 (-)RGD
Sequence:
RefSeq Acc Id: XM_039092985   ⟹   XP_038948913
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: XM_039092986   ⟹   XP_038948914
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: XM_039092987   ⟹   XP_038948915
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: XM_039092988   ⟹   XP_038948916
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: XM_039092989   ⟹   XP_038948917
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: XM_039092990   ⟹   XP_038948918
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: XM_039092991   ⟹   XP_038948919
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058738   ⟸   NM_017042
- UniProtKB: P20651 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074339   ⟸   ENSRNOT00000082236
RefSeq Acc Id: XP_038948913   ⟸   XM_039092985
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948917   ⟸   XM_039092989
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038948914   ⟸   XM_039092986
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948918   ⟸   XM_039092990
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038948916   ⟸   XM_039092988
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038948919   ⟸   XM_039092991
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038948915   ⟸   XM_039092987
- Peptide Label: isoform X3
Protein Domains
SER_THR_PHOSPHATASE

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3383 AgrOrtholog
Ensembl Genes ENSRNOG00000054782 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000074339 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082236 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MPP_PP2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24675 UniProtKB/Swiss-Prot
NCBI Gene 24675 ENTREZGENE
PANTHER PTHR45673 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp3cb PhenoGen
PRINTS STPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PP2Ac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K7T5_RAT UniProtKB/TrEMBL
  P20651 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6LDJ7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Ppp3cb  protein phosphatase 3 catalytic subunit beta  Ppp3cb  protein phosphatase 3, catalytic subunit, beta isozyme  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-26 Ppp3cb  protein phosphatase 3, catalytic subunit, beta isozyme  Ppp3cb  protein phosphatase 3, catalytic subunit, beta isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-24 Ppp3cb  protein phosphatase 3, catalytic subunit, beta isoform      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs cyclosporin acts as a inhibitor partially blocking the muscle size 628398
gene_process calcium binding regulatory subunit which is activated by intracellular calcium anions 628398
gene_process mediates hypertropic response of muscle cells 628398
gene_protein 19 kDa in size 628398
gene_regulation activated by intracellular calcuim and dephosphorylates nuclear factors of activated T cells (NFATs) 628398