Adora3 (adenosine A3 receptor) - Rat Genome Database

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Gene: Adora3 (adenosine A3 receptor) Rattus norvegicus
Analyze
Symbol: Adora3
Name: adenosine A3 receptor
RGD ID: 2051
Description: Enables G protein-coupled adenosine receptor activity. Involved in G protein-coupled receptor signaling pathway; presynaptic modulation of chemical synaptic transmission; and regulation of norepinephrine secretion. Located in presynaptic membrane. Is active in Schaffer collateral - CA1 synapse. Orthologous to human ADORA3 (adenosine A3 receptor); INTERACTS WITH 2,4-dinitrobenzenesulfonic acid; 3-iodobenzyl-5'-N-methylcarboxamidoadenosine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A3; Adenosine receptor A3; adenosine receptor A3-like; LOC100911796; putative G-protein coupled receptor; TGPCR1
RGD Orthologs
Human
Mouse
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22193,352,759 - 193,392,946 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,388,713 - 193,392,357 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2200,983,156 - 200,986,800 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02198,878,989 - 198,882,630 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02193,695,946 - 193,699,587 (+)NCBIRnor_WKY
Rnor_6.02208,492,231 - 208,536,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,530,864 - 208,534,506 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,373,154 - 208,376,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02227,900,059 - 227,955,985 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02227,743,778 - 227,796,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42201,157,782 - 201,161,425 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12201,120,535 - 201,124,179 (+)NCBI
Celera2186,090,081 - 186,093,723 (+)NCBICelera
RH 3.4 Map21369.2RGD
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. [Drug therapy of shock]. Bartels O, etal., Fortschr Med. 1978 Mar 30;96(12):653-60.
2. The role of adenosine A2A and A3 receptors on the differential modulation of norepinephrine and neuropeptide Y release from peripheral sympathetic nerve terminals. Donoso MV, etal., J Neurochem. 2006 Mar;96(6):1680-95.
3. Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus. Dunwiddie TV, etal., J Neurosci. 1997 Jan 15;17(2):607-14.
4. Subtype-specific regulation of receptor internalization and recycling by the carboxyl-terminal domains of the human A1 and rat A3 adenosine receptors: consequences for agonist-stimulated translocation of arrestin3. Ferguson G, etal., Biochemistry 2002 Dec 17;41(50):14748-61.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Adenosine A3 receptors are located in neurons of the rat hippocampus. Lopes LV, etal., Neuroreport. 2003 Aug 26;14(12):1645-8.
9. Adenosine A(3) receptor activation protects the myocardium from reperfusion/reoxygenation injury. Maddock HL, etal., Am J Physiol Heart Circ Physiol 2002 Oct;283(4):H1307-13.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. A role for the A3 adenosine receptor in determining tissue levels of cAMP and blood pressure: studies in knock-out mice. Zhao Z, etal., Biochim Biophys Acta 2000 Mar 17;1500(3):280-90.
15. Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor. Zhou QY, etal., Proc Natl Acad Sci U S A 1992 Aug 15;89(16):7432-6.
Additional References at PubMed
PMID:1647979   PMID:8612733   PMID:10660615   PMID:10692494   PMID:11214319   PMID:12477932   PMID:12817016   PMID:15240734   PMID:15632090   PMID:15681707   PMID:16943766   PMID:17519974  
PMID:17626785   PMID:19740086   PMID:21335481   PMID:21849555   PMID:24311446   PMID:24352876   PMID:24754634   PMID:26297614   PMID:27886186   PMID:31556103   PMID:32461578   PMID:33007835  
PMID:35775127  


Genomics

Comparative Map Data
Adora3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22193,352,759 - 193,392,946 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,388,713 - 193,392,357 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2200,983,156 - 200,986,800 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02198,878,989 - 198,882,630 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02193,695,946 - 193,699,587 (+)NCBIRnor_WKY
Rnor_6.02208,492,231 - 208,536,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,530,864 - 208,534,506 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,373,154 - 208,376,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02227,900,059 - 227,955,985 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02227,743,778 - 227,796,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42201,157,782 - 201,161,425 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12201,120,535 - 201,124,179 (+)NCBI
Celera2186,090,081 - 186,093,723 (+)NCBICelera
RH 3.4 Map21369.2RGD
Cytogenetic Map2q34NCBI
ADORA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,499,429 - 111,503,633 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1111,499,429 - 111,503,633 (-)EnsemblGRCh38hg38GRCh38
GRCh371112,042,051 - 112,046,255 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,827,493 - 111,908,120 (-)NCBINCBI36Build 36hg18NCBI36
Build 341111,754,096 - 111,758,785NCBI
Celera1110,272,892 - 110,353,227 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1109,897,418 - 109,977,884 (-)NCBIHuRef
CHM1_11112,140,977 - 112,221,562 (-)NCBICHM1_1
T2T-CHM13v2.01111,514,110 - 111,518,318 (-)NCBIT2T-CHM13v2.0
Adora3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393105,811,737 - 105,816,244 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3105,778,174 - 105,816,242 (+)EnsemblGRCm39 Ensembl
GRCm383105,904,421 - 105,908,928 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,870,858 - 105,908,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv373105,673,776 - 105,726,960 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363106,032,542 - 106,036,410 (+)NCBIMGSCv36mm8
Celera3108,059,748 - 108,112,932 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map346.45NCBI
ADORA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11763,895,408 - 63,898,666 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1763,895,408 - 63,898,666 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1763,408,938 - 63,412,242 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01765,066,829 - 65,070,166 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1765,066,642 - 65,071,049 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11763,801,857 - 63,805,119 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01763,860,662 - 63,863,924 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01764,658,761 - 64,662,034 (+)NCBIUU_Cfam_GSD_1.0
LOC101973578
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505817,309,039 - 17,325,264 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936690152,777 - 168,411 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADORA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4108,854,357 - 108,873,925 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14108,854,300 - 108,857,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24119,036,224 - 119,039,693 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103224223
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,043,367 - 22,127,103 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2022,106,190 - 22,123,629 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603836,352,015 - 36,375,319 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adora3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247727,229,093 - 7,232,837 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247727,189,381 - 7,232,919 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adora3
156 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:201
Count of miRNA genes:137
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000021236, ENSRNOT00000050538
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat

Markers in Region
ADORA3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,391,343 - 193,391,754 (+)MAPPERmRatBN7.2
Rnor_6.02208,533,494 - 208,533,904NCBIRnor6.0
Rnor_6.02208,375,791 - 208,376,201NCBIRnor6.0
Rnor_5.02227,795,692 - 227,796,102UniSTSRnor5.0
Rnor_5.02227,954,972 - 227,955,382UniSTSRnor5.0
RGSC_v3.42201,160,413 - 201,160,823UniSTSRGSC3.4
Celera2186,092,710 - 186,093,120UniSTS
Cytogenetic Map2q34UniSTS
RH94668  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,392,060 - 193,392,199 (+)MAPPERmRatBN7.2
Rnor_6.02208,534,211 - 208,534,349NCBIRnor6.0
Rnor_6.02208,376,508 - 208,376,646NCBIRnor6.0
Rnor_5.02227,955,689 - 227,955,827UniSTSRnor5.0
Rnor_5.02227,796,409 - 227,796,547UniSTSRnor5.0
RGSC_v3.42201,161,130 - 201,161,268UniSTSRGSC3.4
Celera2186,093,427 - 186,093,565UniSTS
RH 3.4 Map21369.2UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

reproductive system
High
Medium
Low
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021236   ⟹   ENSRNOP00000021236
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2193,388,713 - 193,392,357 (+)Ensembl
RefSeq Acc Id: NM_001302750   ⟹   NP_001289679
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22193,388,713 - 193,392,357 (+)NCBI
RefSeq Acc Id: NM_001302751   ⟹   NP_001289680
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22193,388,713 - 193,392,357 (+)NCBI
RefSeq Acc Id: XM_017590571   ⟹   XP_017446060
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22193,352,759 - 193,392,946 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_017446060   ⟸   XM_017590571
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001289679   ⟸   NM_001302750
- Peptide Label: isoform a
- UniProtKB: P28647 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001289680   ⟸   NM_001302751
- Peptide Label: isoform b
- UniProtKB: Q63792 (UniProtKB/Swiss-Prot),   P28647 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021236   ⟸   ENSRNOT00000021236
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28647-F1-model_v2 AlphaFold P28647 1-320 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2051 AgrOrtholog
Ensembl Genes ENSRNOG00000015788 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000050743 Ensembl
Ensembl Protein ENSRNOP00000021236 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021236 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7453330 IMAGE-MGC_LOAD
InterPro Adeno_A3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenosn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100911796 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114438 IMAGE-MGC_LOAD
NCBI Gene Adora3 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADORA3 RGD
PhenoGen Adora3 PhenoGen
PRINTS ADENOSINEA3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADENOSINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt AA3R_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63792 ENTREZGENE
  Q99P15_RAT UniProtKB/TrEMBL
UniProt Secondary Q63792 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-01 Adora3  adenosine A3 receptor  LOC100911796  adenosine receptor A3-like  Data Merged 737654 PROVISIONAL
2012-07-05 LOC100911796  adenosine receptor A3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Adora3  adenosine A3 receptor    Adenosine receptor A3  Name updated 625702 APPROVED
2002-06-10 Adora3  Adenosine receptor A3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains seven transmbembrane domain characteristic of G-protein coupled receptors 631810
gene_expression expressed in brain 631810
gene_expression mRNA expressed at high levels in testis 631810
gene_expression mRNA detected in lung, kidney, heart, brain cortex, striatum, and olfactory bulb  
gene_function binds adenosine with a non-A1, non-A2 receptor specificity 631810
gene_process may be involved in male reproduction 631810
gene_process may play a role in remodeling after myocardial cell injury 631763
gene_product member of the G-protein coupled receptor family 631810
gene_protein protein sequence contains 320 amino acid residues 631810