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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2830
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hrh1
Name: histamine receptor H 1
Acc ID: CHEBI:8430
Term: procaine
Definition: A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Chemical ID: MESH:D011343
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hrh1affects bindingISOHRH1 (Homo sapiens)6480464CTDHRH1 protein binds to ProcainePMID:32061592
Hrh1multiple interactionsISOHRH1 (Homo sapiens)6480464CTD[HRH1 protein binds to Procaine] which results in increased import of Calcium; HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]; HRH1 protein affects the reaction [Procaine results in increased transport of fluorescein isothiocyanate bovine serum albumin]PMID:32061592
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