Cadps (calcium dependent secretion activator) - Rat Genome Database

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Gene: Cadps (calcium dependent secretion activator) Rattus norvegicus
Analyze
Symbol: Cadps
Name: calcium dependent secretion activator
RGD ID: 708573
Description: Enables calcium ion binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in positive regulation of calcium ion-dependent exocytosis. Located in dense core granule. Is active in glutamatergic synapse and presynapse. Is extrinsic component of neuronal dense core vesicle membrane. Orthologous to human CADPS (calcium dependent secretion activator); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ca++-dependent secretion activator; Ca2+ dependent secretion activator; Ca2+-dependent activator protein; Ca2+-dependent secretion activator; Ca<2+-dependent activator protein for secretion; calcium-dependent activator protein for secretion 1; calcium-dependent secretion activator 1; calcium-dependent secretion activator 1-like; Caps; CAPS-1; Caps1; Caps2; LOC103690082; rCAPS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Kidm51
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81514,719,078 - 15,173,218 (+)NCBIGRCr8
mRatBN7.21512,289,803 - 12,742,786 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1512,290,262 - 12,742,779 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1514,405,013 - 14,871,376 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01515,363,441 - 15,829,833 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01513,618,231 - 14,084,627 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01515,275,489 - 15,690,575 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1515,275,541 - 15,667,778 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01516,777,584 - 16,823,679 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01519,278,581 - 19,669,176 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41513,859,286 - 14,319,814 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11513,859,285 - 14,319,814 (+)NCBI
Celera1512,289,818 - 12,740,628 (+)NCBICelera
Cytogenetic Map15p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis. Ann K, etal., J Biol Chem 1997 Aug 8;272(32):19637-40.
2. CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis. Berwin B, etal., Neuron. 1998 Jul;21(1):137-45.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactions. James DJ, etal., Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17308-13. doi: 10.1073/pnas.0900755106. Epub 2009 Sep 29.
5. CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis. Kabachinski G, etal., Mol Biol Cell. 2014 Feb;25(4):508-21. doi: 10.1091/mbc.E12-11-0829. Epub 2013 Dec 19.
6. Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis. Loyet KM, etal., J Biol Chem. 1998 Apr 3;273(14):8337-43.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. Speidel D, etal., J Biol Chem. 2003 Dec 26;278(52):52802-9. doi: 10.1074/jbc.M304727200. Epub 2003 Oct 6.
12. A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells. Walent JH, etal., Cell 1992 Sep 4;70(5):765-75.
13. Role of CAPS in dense-core vesicle exocytosis. Wassenberg JJ and Martin TF, Ann N Y Acad Sci 2002 Oct;971:201-9.
Additional References at PubMed
PMID:9162085   PMID:9697859   PMID:10792045   PMID:11927595   PMID:15312653   PMID:15820695   PMID:15857609   PMID:15866726   PMID:17540763   PMID:18022372   PMID:19008227   PMID:19460754  
PMID:19896969   PMID:20826818   PMID:20921225   PMID:21040848   PMID:21307259   PMID:21803295   PMID:23801330   PMID:25374362   PMID:25719439   PMID:26700319   PMID:27528604   PMID:29476059  
PMID:30053369   PMID:33580180  


Genomics

Comparative Map Data
Cadps
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81514,719,078 - 15,173,218 (+)NCBIGRCr8
mRatBN7.21512,289,803 - 12,742,786 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1512,290,262 - 12,742,779 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1514,405,013 - 14,871,376 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01515,363,441 - 15,829,833 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01513,618,231 - 14,084,627 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01515,275,489 - 15,690,575 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1515,275,541 - 15,667,778 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01516,777,584 - 16,823,679 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01519,278,581 - 19,669,176 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41513,859,286 - 14,319,814 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11513,859,285 - 14,319,814 (+)NCBI
Celera1512,289,818 - 12,740,628 (+)NCBICelera
Cytogenetic Map15p15NCBI
CADPS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38362,398,348 - 62,875,416 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl362,398,346 - 62,875,416 (-)EnsemblGRCh38hg38GRCh38
GRCh37362,384,023 - 62,861,091 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36362,359,061 - 62,836,094 (-)NCBINCBI36Build 36hg18NCBI36
Build 34362,359,061 - 62,836,094NCBI
Celera362,401,123 - 62,879,063 (-)NCBICelera
Cytogenetic Map3p14.2NCBI
HuRef362,482,129 - 62,959,100 (-)NCBIHuRef
CHM1_1362,335,136 - 62,812,174 (-)NCBICHM1_1
T2T-CHM13v2.0362,441,892 - 62,919,090 (-)NCBIT2T-CHM13v2.0
Cadps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39149,646,424 - 10,097,203 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl149,646,684 - 10,097,200 (+)EnsemblGRCm39 Ensembl
GRCm381412,372,560 - 12,823,339 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1412,372,563 - 12,823,079 (-)EnsemblGRCm38mm10GRCm38
MGSCv371413,205,077 - 13,655,593 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361411,165,830 - 11,616,320 (-)NCBIMGSCv36mm8
Celera148,001,668 - 8,456,520 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map146.37NCBI
Cadps
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555172,965,471 - 3,420,183 (+)NCBIChiLan1.0ChiLan1.0
CADPS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2262,342,099 - 62,817,146 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1362,346,887 - 62,821,881 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0362,321,496 - 62,797,298 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1363,708,293 - 64,181,768 (-)NCBIpanpan1.1PanPan1.1panPan2
CADPS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12028,221,150 - 28,680,844 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2028,221,843 - 28,680,131 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2028,144,566 - 28,609,081 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02028,444,589 - 28,915,736 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2028,444,992 - 28,915,733 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12027,941,382 - 28,401,452 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02028,298,223 - 28,759,372 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02028,394,230 - 28,859,360 (+)NCBIUU_Cfam_GSD_1.0
Cadps
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118165,154,804 - 165,634,154 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366373,545,211 - 4,022,630 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366373,543,615 - 4,023,710 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CADPS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11343,979,694 - 44,482,985 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21348,085,695 - 48,367,520 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CADPS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12223,471,616 - 23,948,694 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041142,910,744 - 143,393,718 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cadps
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248882,985,966 - 3,443,542 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cadps
2163 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:170
Count of miRNA genes:123
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000012153
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15226636822711984Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat

Markers in Region
D15Rat54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21512,496,141 - 12,496,364 (+)MAPPERmRatBN7.2
Rnor_6.01515,492,360 - 15,492,582NCBIRnor6.0
Rnor_5.01519,494,318 - 19,494,540UniSTSRnor5.0
RGSC_v3.41514,072,030 - 14,072,252UniSTSRGSC3.4
RGSC_v3.41514,072,029 - 14,072,252RGDRGSC3.4
RGSC_v3.11514,072,030 - 14,072,252RGD
Celera1512,495,261 - 12,495,483UniSTS
RH 3.4 Map15103.3RGD
RH 3.4 Map15103.3UniSTS
RH 2.0 Map1543.8RGD
SHRSP x BN Map159.5998RGD
FHH x ACI Map158.0199RGD
FHH x ACI Map158.0599UniSTS
Cytogenetic Map15p16UniSTS
D15Rat159  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01519,494,317 - 19,494,540NCBIRnor5.0
RGSC_v3.41514,072,030 - 14,072,252UniSTSRGSC3.4
RGSC_v3.11514,072,029 - 14,072,252RGD
Celera1512,495,261 - 12,495,483UniSTS
RH 3.4 Map15103.3UniSTS
FHH x ACI Map158.0599RGD
D15Rat137  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21512,345,430 - 12,345,585 (+)MAPPERmRatBN7.2
Rnor_6.01515,330,772 - 15,330,924NCBIRnor6.0
Rnor_5.01519,333,571 - 19,333,723UniSTSRnor5.0
RGSC_v3.41513,915,113 - 13,915,266RGDRGSC3.4
RGSC_v3.41513,915,114 - 13,915,266UniSTSRGSC3.4
RGSC_v3.11513,915,113 - 13,915,266RGD
Celera1512,344,951 - 12,345,103UniSTS
SHRSP x BN Map159.5698RGD
SHRSP x BN Map159.5698UniSTS
Cytogenetic Map15p16UniSTS
BF388496  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21512,624,913 - 12,625,084 (+)MAPPERmRatBN7.2
Rnor_6.01515,620,473 - 15,620,643NCBIRnor6.0
Rnor_5.01519,622,093 - 19,622,263UniSTSRnor5.0
RGSC_v3.41514,200,391 - 14,200,561UniSTSRGSC3.4
Celera1512,622,841 - 12,623,011UniSTS
RH 3.4 Map1595.4UniSTS
Cytogenetic Map15p16UniSTS
RH134048  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21512,372,228 - 12,372,410 (+)MAPPERmRatBN7.2
Rnor_6.01515,357,873 - 15,358,054NCBIRnor6.0
Rnor_5.01519,360,381 - 19,360,562UniSTSRnor5.0
RGSC_v3.41513,945,942 - 13,946,123UniSTSRGSC3.4
Celera1512,371,725 - 12,371,906UniSTS
RH 3.4 Map1596.6UniSTS
Cytogenetic Map15p16UniSTS
BF388503  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21512,720,057 - 12,720,192 (+)MAPPERmRatBN7.2
Rnor_6.01512,773,740 - 12,773,874NCBIRnor6.0
Rnor_5.01516,800,959 - 16,801,093UniSTSRnor5.0
RGSC_v3.41514,297,094 - 14,297,228UniSTSRGSC3.4
Celera1512,717,901 - 12,718,035UniSTS
RH 3.4 Map1595.8UniSTS
Cytogenetic Map15p16UniSTS
AU048310  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21512,527,434 - 12,527,551 (+)MAPPERmRatBN7.2
Rnor_6.01515,523,610 - 15,523,726NCBIRnor6.0
Rnor_5.01519,525,568 - 19,525,684UniSTSRnor5.0
RGSC_v3.41514,103,287 - 14,103,403UniSTSRGSC3.4
Celera1512,526,110 - 12,526,226UniSTS
Cytogenetic Map15p16UniSTS
RH135013  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21512,741,868 - 12,742,083 (+)MAPPERmRatBN7.2
Rnor_6.01512,795,550 - 12,795,764NCBIRnor6.0
Rnor_5.01516,822,769 - 16,822,983UniSTSRnor5.0
RGSC_v3.41514,318,904 - 14,319,118UniSTSRGSC3.4
Celera1512,739,718 - 12,739,932UniSTS
RH 3.4 Map1599.0UniSTS
Cytogenetic Map15p16UniSTS
RH136728  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21512,742,410 - 12,742,648 (+)MAPPERmRatBN7.2
Rnor_6.01512,796,092 - 12,796,329NCBIRnor6.0
Rnor_5.01516,823,311 - 16,823,548UniSTSRnor5.0
RGSC_v3.41514,319,446 - 14,319,683UniSTSRGSC3.4
Celera1512,740,260 - 12,740,497UniSTS
RH 3.4 Map15110.0UniSTS
Cytogenetic Map15p16UniSTS
RH138000  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21512,605,556 - 12,605,705 (+)MAPPERmRatBN7.2
Rnor_6.01515,601,116 - 15,601,264NCBIRnor6.0
Rnor_5.01519,602,736 - 19,602,884UniSTSRnor5.0
RGSC_v3.41514,181,034 - 14,181,182UniSTSRGSC3.4
Celera1512,603,472 - 12,603,620UniSTS
RH 3.4 Map1595.2UniSTS
Cytogenetic Map15p16UniSTS
AW531782  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21512,288,885 - 12,289,050 (+)MAPPERmRatBN7.2
Rnor_6.01515,274,113 - 15,274,277NCBIRnor6.0
Rnor_5.01519,277,205 - 19,277,369UniSTSRnor5.0
RGSC_v3.41513,857,907 - 13,858,071UniSTSRGSC3.4
Celera1512,288,442 - 12,288,606UniSTS
RH 3.4 Map1597.8UniSTS
Cytogenetic Map15p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 8 70 2
Low 3 35 17 11 17 11 3 3 4 34 33 10 3
Below cutoff 24 22 2 22 5 6 1 6 1 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000012153   ⟹   ENSRNOP00000012153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1512,290,262 - 12,742,779 (+)Ensembl
Rnor_6.0 Ensembl1515,275,541 - 15,667,778 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094744   ⟹   ENSRNOP00000076873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1512,290,262 - 12,742,779 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094787   ⟹   ENSRNOP00000095628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1512,290,262 - 12,742,779 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098925   ⟹   ENSRNOP00000092113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1512,290,262 - 12,742,779 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099157   ⟹   ENSRNOP00000095354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1512,290,262 - 12,742,779 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105737   ⟹   ENSRNOP00000093742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1512,290,262 - 12,742,779 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115067   ⟹   ENSRNOP00000086566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1512,290,262 - 12,742,779 (+)Ensembl
RefSeq Acc Id: NM_013219   ⟹   NP_037351
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,720,726 - 15,173,211 (+)NCBI
mRatBN7.21512,290,262 - 12,742,779 (+)NCBI
Rnor_6.01515,275,489 - 15,690,575 (+)NCBI
Rnor_5.01516,777,584 - 16,823,679 (+)NCBI
Rnor_5.01519,278,581 - 19,669,176 (+)NCBI
RGSC_v3.41513,859,286 - 14,319,814 (+)RGD
Celera1512,289,818 - 12,740,628 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093050   ⟹   XP_038948978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
mRatBN7.21512,290,314 - 12,741,766 (+)NCBI
RefSeq Acc Id: XM_039093055   ⟹   XP_038948983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
mRatBN7.21512,290,314 - 12,741,766 (+)NCBI
RefSeq Acc Id: XM_039093060   ⟹   XP_038948988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
mRatBN7.21512,290,314 - 12,741,766 (+)NCBI
RefSeq Acc Id: XM_039093064   ⟹   XP_038948992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
mRatBN7.21512,290,314 - 12,741,766 (+)NCBI
RefSeq Acc Id: XM_039093067   ⟹   XP_038948995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
mRatBN7.21512,290,314 - 12,741,766 (+)NCBI
RefSeq Acc Id: XM_039093071   ⟹   XP_038948999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
mRatBN7.21512,289,803 - 12,742,786 (+)NCBI
RefSeq Acc Id: XM_063274046   ⟹   XP_063130116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
RefSeq Acc Id: XM_063274048   ⟹   XP_063130118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
RefSeq Acc Id: XM_063274049   ⟹   XP_063130119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
RefSeq Acc Id: XM_063274050   ⟹   XP_063130120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
RefSeq Acc Id: XM_063274051   ⟹   XP_063130121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
RefSeq Acc Id: XM_063274052   ⟹   XP_063130122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
RefSeq Acc Id: XM_063274054   ⟹   XP_063130124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,173,218 (+)NCBI
RefSeq Acc Id: XM_063274055   ⟹   XP_063130125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 15,032,985 (+)NCBI
RefSeq Acc Id: XM_063274056   ⟹   XP_063130126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81514,719,078 - 14,976,244 (+)NCBI
RefSeq Acc Id: NP_037351   ⟸   NM_013219
- UniProtKB: A0A8I5Y0W4 (UniProtKB/TrEMBL),   A6K086 (UniProtKB/TrEMBL),   F1LLX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012153   ⟸   ENSRNOT00000012153
RefSeq Acc Id: XP_038948999   ⟸   XM_039093071
- Peptide Label: isoform X15
- UniProtKB: F1LLX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948992   ⟸   XM_039093064
- Peptide Label: isoform X9
- UniProtKB: F1LLX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948978   ⟸   XM_039093050
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A5K7 (UniProtKB/TrEMBL),   A0A8I6AI45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948995   ⟸   XM_039093067
- Peptide Label: isoform X11
- UniProtKB: F1LLX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948983   ⟸   XM_039093055
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AGZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948988   ⟸   XM_039093060
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AI45 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000095628   ⟸   ENSRNOT00000094787
RefSeq Acc Id: ENSRNOP00000076873   ⟸   ENSRNOT00000094744
RefSeq Acc Id: ENSRNOP00000095354   ⟸   ENSRNOT00000099157
RefSeq Acc Id: ENSRNOP00000092113   ⟸   ENSRNOT00000098925
RefSeq Acc Id: ENSRNOP00000093742   ⟸   ENSRNOT00000105737
RefSeq Acc Id: ENSRNOP00000086566   ⟸   ENSRNOT00000115067
RefSeq Acc Id: XP_063130116   ⟸   XM_063274046
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063130119   ⟸   XM_063274049
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063130122   ⟸   XM_063274052
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063130118   ⟸   XM_063274048
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130120   ⟸   XM_063274050
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063130124   ⟸   XM_063274054
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063130121   ⟸   XM_063274051
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063130125   ⟸   XM_063274055
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063130126   ⟸   XM_063274056
- Peptide Label: isoform X14
Protein Domains
C2   MHD1   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62717-F1-model_v2 AlphaFold Q62717 1-1289 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708573 AgrOrtholog
BioCyc Gene G2FUF-14357 BioCyc
Ensembl Genes ENSRNOG00000008570 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012153.7 UniProtKB/TrEMBL
  ENSRNOT00000094744 ENTREZGENE
  ENSRNOT00000094744.1 UniProtKB/TrEMBL
  ENSRNOT00000094787.1 UniProtKB/TrEMBL
  ENSRNOT00000098925.1 UniProtKB/TrEMBL
  ENSRNOT00000099157.1 UniProtKB/TrEMBL
  ENSRNOT00000105737.1 UniProtKB/TrEMBL
  ENSRNOT00000115067.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.357.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAPS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Munc13_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26989 UniProtKB/Swiss-Prot
NCBI Gene 26989 ENTREZGENE
PANTHER CALCIUM-DEPENDENT SECRETION ACTIVATOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12166 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF1041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cadps PhenoGen
PROSITE MHD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008570 RatGTEx
SMART DUF1041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y0W4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5K7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AI45 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATV6_RAT UniProtKB/TrEMBL
  A0A8I6B2G7_RAT UniProtKB/TrEMBL
  A6K086 ENTREZGENE, UniProtKB/TrEMBL
  A6K087_RAT UniProtKB/TrEMBL
  CAPS1_RAT UniProtKB/Swiss-Prot
  F1LLX6 ENTREZGENE, UniProtKB/TrEMBL
  Q62717 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cadps  calcium dependent secretion activator  LOC103690082  calcium-dependent secretion activator 1-like  Data merged from RGD:9360488 737654 PROVISIONAL
2016-06-22 Cadps  calcium dependent secretion activator  Cadps  Ca2+ dependent secretion activator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Cadps  Ca2+ dependent secretion activator  Cadps  Ca++-dependent secretion activator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103690082  calcium-dependent secretion activator 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-29 Cadps  Ca++-dependent secretion activator  Cadps  Ca2+-dependent secretion activator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27     Cadps  Ca2+-dependent secretion activator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Cadps  Ca2+-dependent secretion activator    Ca<2+-dependent activator protein for secretion  Name updated 1299863 APPROVED
2004-12-14 Cadps  Ca<2+-dependent activator protein for secretion  Caps  Ca2+-dependent activator protein  Symbol and Name updated 1299863 APPROVED