Advanced Search (OLGA)

Gene: Pacc1 (proton activated chloride channel 1) Rattus norvegicus

Analyze

Symbol:

Pacc1

Name:

proton activated chloride channel 1

RGD ID:

1359339

Description:

Predicted to enable pH-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human PACC1 (proton activated chloride channel 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC95217; PAC; proton-activated chloride channel; RGD1359339; similar to RIKEN cDNA 2310028N02; Tmem206; transmembrane protein 206

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	105,435,772 - 105,460,877 (+)	NCBI		GRCr8
mRatBN7.2	13	102,904,668 - 102,929,770 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	102,894,612 - 102,929,770 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	105,424,756 - 105,449,651 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	106,808,601 - 106,833,504 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	104,023,691 - 104,048,584 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	110,006,975 - 110,032,790 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,007,010 - 110,031,895 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	114,572,868 - 114,597,637 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	107,387,221 - 107,412,108 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	107,576,324 - 107,601,210 (+)	NCBI
Celera	13	102,343,772 - 102,368,659 (+)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-bromohexadecanoic acid (ISO)

2-palmitoylglycerol (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

choline (ISO)

copper(II) chloride (ISO)

coumarin (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

diuron (ISO)

doxorubicin (ISO)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

furan (EXP)

L-methionine (ISO)

lead diacetate (ISO)

methotrexate (ISO)

nickel atom (ISO)

nitrates (ISO)

perfluorohexanesulfonic acid (ISO)

phenobarbital (ISO)

phenylephrine (EXP)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

resveratrol (ISO)

rotenone (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulforaphane (ISO)

sunitinib (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

tributylstannane (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chloride transmembrane transport (IEA)

chloride transport (ISO,ISS)

Cellular Component

chloride channel complex (IEA)

plasma membrane (IEA,ISO,ISS)

Molecular Function

chloride channel activity (IEA)

pH-gated chloride channel activity (IEA,ISO,ISS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	GOA pipeline	RGD automated data pipeline
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
3.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:19581412	PMID:31023925	PMID:31318332

Genomics

Comparative Map Data

Pacc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	105,435,772 - 105,460,877 (+)	NCBI		GRCr8
mRatBN7.2	13	102,904,668 - 102,929,770 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	102,894,612 - 102,929,770 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	105,424,756 - 105,449,651 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	106,808,601 - 106,833,504 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	104,023,691 - 104,048,584 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	110,006,975 - 110,032,790 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,007,010 - 110,031,895 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	114,572,868 - 114,597,637 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	107,387,221 - 107,412,108 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	107,576,324 - 107,601,210 (+)	NCBI
Celera	13	102,343,772 - 102,368,659 (+)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

PACC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	212,363,928 - 212,414,886 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	212,363,928 - 212,414,901 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	212,537,270 - 212,588,228 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	210,604,439 - 210,654,890 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	185,763,548 - 185,813,983 (-)	NCBI		Celera
Cytogenetic Map	1	q32.3	NCBI
HuRef	1	183,214,097 - 183,264,414 (-)	NCBI		HuRef
CHM1_1	1	213,810,681 - 213,861,148 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	211,608,613 - 211,659,583 (-)	NCBI		T2T-CHM13v2.0

Pacc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	191,058,099 - 191,083,481 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	191,058,109 - 191,083,111 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	191,325,902 - 191,351,284 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	191,325,912 - 191,350,914 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	193,149,844 - 193,176,804 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	193,026,580 - 193,053,540 (+)	NCBI		MGSCv36	mm8
Celera	1	198,256,067 - 198,283,053 (+)	NCBI		Celera
Cytogenetic Map	1	H6	NCBI
cM Map	1	96.28	NCBI

Pacc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	5,035,745 - 5,058,189 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	5,036,167 - 5,058,189 (+)	NCBI	ChiLan1.0	ChiLan1.0

PACC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	36,990,596 - 37,042,132 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	36,955,055 - 37,007,697 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	187,928,923 - 187,980,274 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	192,790,932 - 192,843,577 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	192,790,932 - 192,843,577 (-)	Ensembl	panpan1.1		panPan2

PACC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	10,568,030 - 10,606,672 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	10,568,026 - 10,610,578 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	10,143,342 - 10,181,979 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	10,273,755 - 10,312,411 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	10,273,755 - 10,312,420 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	10,196,568 - 10,235,194 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	10,297,886 - 10,336,505 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	10,421,365 - 10,460,215 (-)	NCBI		UU_Cfam_GSD_1.0

Pacc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	63,868,253 - 63,901,887 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	1,108,511 - 1,142,291 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	1,108,556 - 1,142,844 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PACC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	130,835,317 - 131,001,479 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	130,968,208 - 131,001,491 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	144,015,830 - 144,048,093 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PACC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	17,116,762 - 17,160,851 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	17,116,852 - 17,161,760 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	17,617,246 - 17,661,350 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pacc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	17,863,411 - 17,900,353 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624771	17,863,411 - 17,900,222 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pacc1
125 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	232
Count of miRNA genes:	154
Interacting mature miRNAs:	168
Transcripts:	ENSRNOT00000005387
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	66451204	106807694	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat

Markers in Region

RH78888

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	102,919,124 - 102,919,277 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	110,021,411 - 110,021,563	NCBI	Rnor6.0
Rnor_5.0	13	114,586,992 - 114,587,144	UniSTS	Rnor5.0
RGSC_v3.4	13	107,401,622 - 107,401,774	UniSTS	RGSC3.4
Celera	13	102,358,173 - 102,358,325	UniSTS
Cytogenetic Map	13	q27	UniSTS

RH134564

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	102,929,368 - 102,929,550 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	110,031,655 - 110,031,836	NCBI	Rnor6.0
Rnor_5.0	13	114,597,236 - 114,597,417	UniSTS	Rnor5.0
RGSC_v3.4	13	107,411,866 - 107,412,047	UniSTS	RGSC3.4
Celera	13	102,368,417 - 102,368,598	UniSTS
RH 3.4 Map	13	727.8	UniSTS
Cytogenetic Map	13	q27	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007679	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC125873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC082061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225543	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005387 ⟹ ENSRNOP00000005387

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	102,904,682 - 102,929,769 (+)	Ensembl
Rnor_6.0 Ensembl	13	110,007,010 - 110,031,895 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105057 ⟹ ENSRNOP00000078608

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	102,906,701 - 102,929,770 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114123 ⟹ ENSRNOP00000085237

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	102,894,612 - 102,929,770 (+)	Ensembl

RefSeq Acc Id:

NM_001007679 ⟹ NP_001007680

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,435,831 - 105,460,718 (+)	NCBI
mRatBN7.2	13	102,904,724 - 102,929,611 (+)	NCBI
Rnor_6.0	13	110,007,010 - 110,031,897 (+)	NCBI
Rnor_5.0	13	114,572,868 - 114,597,637 (+)	NCBI
RGSC_v3.4	13	107,387,221 - 107,412,108 (+)	RGD
Celera	13	102,343,772 - 102,368,659 (+)	RGD

Sequence:

show sequence

GGTAGACCTCGGAGCTCCTACCTCCCGCAGCGTCGCGGTCCCTAGTGAGCCGCAGCCGGCCAGT
GCCATGATCCGACAAGACCTCTCCACATCCTACCAGGAGCTCAGTGAAGAGTTGGAGCAGGTGG
TTGAGAACTCGGAGCAGGCAGATGAACGGGACAAGGAGCTGGTCCAAGTTCAAGGTCCAGGTGT
TGTGCCAGGTGTGGACAATGAGTCTGCATCCAGCAGCATCCGCTTCAGCAAGGCCTGCCTGAAG
AATGTCTTCTCGGTCCTCCTCATTCTCATCTACCTGCTGCTCATGGCAGTGGCCGTCTTCCTGG
TCTACCAGACCATCACGGACTTCCGAGAAAAGCTCAAGCACCCTGTCATGTCTGTGTCTTACAA
GGAGGTGGATCGCTACGATGCTCCAGGGATTGCCTTATACCCCGGTCAGGCTCAGCTGCTCAGC
TGTAAGCACCACTATGAGGTCATCCCACCTCTTGCCAGCCCTGGCCAGCCCGGAGACAGGAACT
GCACCACTCAGAGGATCAATTACACCCACCCCTTCTCCAATCACACCATGCAGTCAGCCCTGAT
TGTCCAGGGGCCCCAGGAAGTGAAGAAGCGGGAGCTGGTGTTCCTCCAGTTCCGCCTGAACCAG
AGCGACGAGGACTTCAGTGCCATTGACTATCTCCTCTTCTCCTCTTTCCGGGAGTTCATGCAAA
GCCCGGACAAGGCGGGCTTCATGCAGGCCTGTGAGAGTGCCTACTCCAGCTGGAAGTTCTCCGG
AGGCTTCCGCACCTGGGTCAAGATGTCACTGGTGAAGACCAAAGAAGAGGATGGGCGAGAAGCC
GTTGAGTTCCGGCAAGAGACCAGCGTGGTCAATTATATTGACCAGAGGCCGGCAGCCGAGAAGA
GTACTCAGTTGTTCTTTGTGGTCTTTGAATGGAAGGATCCCTTCATCCAGAAAGTCCAGGATAT
AATCACGGCCAATCCTTGGAACACCATCGCCCTACTCTGCGGGGCGTTCCTGGCATTATTTAAA
GCAGCAGAGTTTGCCAAACTAAGTGTGAAATGGATGATCAAAATCAGGAAACGATACCTTAAAC
GGAGAGGCCAGGCGACAAACCACATAAGCTGAAGTGCCTGTGCCCCAGCACTCCGACAAACCGA
GCCACCAGCACTCCTGTACTCACTTGAAGGGACCTCGCAGGGAAGGACGGCCTGTCGCATTGGA
TGCTCAACCCTGGCCCAGGAGGACACTGTCCTGGGCCCAAAGGGAAACACCCAGTGGATAACCC
GAAACTTATTTAAGTACTTAAATTATTAACGGACATTTGCAGAGCTGCCTAGTGCCTTGGAGAG
GTTTGCGGAAGGCGGCTTCCTCCTATTTGGTCATTAAATAGTTAAGCTCCAAAAAAAAAAAAAA
AAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006250481 ⟹ XP_006250543

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,435,772 - 105,460,877 (+)	NCBI
mRatBN7.2	13	102,904,668 - 102,929,770 (+)	NCBI
Rnor_6.0	13	110,006,980 - 110,032,790 (+)	NCBI
Rnor_5.0	13	114,572,868 - 114,597,637 (+)	NCBI

Sequence:

show sequence

AGACTAGAGCGGGTCTCACTTAGTAGAGCGGGTAGACCTCGGAGCTCCTACCTCCCGCAGCGTC
GCGGTCCCTAGTGAGCCGCAGCCGGCCAGTGCCATGATCCGACAAGACCTCTCCACATCCTACC
AGGAGCTCAGTGAAGAGTTGGAGCAGGTGGTTGAGAACTCGGAGCAGGCAGATGAACGGGACAA
GGAGCTGGTCCAAGTTCAAGGTCCAGGTGTTGTGCCAGGGATTGCCTTATACCCCGGTCAGGCT
CAGCTGCTCAGCTGTAAGCACCACTATGAGGTCATCCCACCTCTTGCCAGCCCTGGCCAGCCCG
GAGACAGGAACTGCACCACTCAGAGGATCAATTACACCCACCCCTTCTCCAATCACACCATGCA
GTCAGCCCTGATTGTCCAGGGGCCCCAGGAAGTGAAGAAGCGGGAGCTGGTGTTCCTCCAGTTC
CGCCTGAACCAGAGCGACGAGGACTTCAGTGCCATTGACTATCTCCTCTTCTCCTCTTTCCGGG
AGTTCATGCAAAGCCCGGACAAGGCGGGCTTCATGCAGGCCTGTGAGAGTGCCTACTCCAGCTG
GAAGTTCTCCGGAGGCTTCCGCACCTGGGTCAAGATGTCACTGGTGAAGACCAAAGAAGAGGAT
GGGCGAGAAGCCGTTGAGTTCCGGCAAGAGACCAGCGTGGTCAATTATATTGACCAGAGGCCGG
CAGCCGAGAAGAGTACTCAGTTGTTCTTTGTGGTCTTTGAATGGAAGGATCCCTTCATCCAGAA
AGTCCAGGATATAATCACGGCCAATCCTTGGAACACCATCGCCCTACTCTGCGGGGCGTTCCTG
GCATTATTTAAAGCAGCAGAGTTTGCCAAACTAAGTGTGAAATGGATGATCAAAATCAGGAAAC
GATACCTTAAACGGAGAGGCCAGGCGACAAACCACATAAGCTGAAGTGCCTGTGCCCCAGCACT
CCGACAAACCGAGCCACCAGCACTCCTGTACTCACTTGAAGGGACCTCGCAGGGAAGGACGGCC
TGTCGCATTGGATGCTCAACCCTGGCCCAGGAGGACACTGTCCTGGGCCCAAAGGGAAACACCC
AGTGGATAACCCGAAACTTATTTAAGTACTTAAATTATTAACGGACATTTGCAGAGCTGCCTAG
TGCCTTGGAGAGGTTTGCGGAAGGCGGCTTCCTCCTATTTGGTCATTAAATAGTTAAGCTCCAA
GTTAAGGTTTCTTCTTTACCTTAGGATATTTTTTTCCTTTTAAGTGGACTGATGTGCTCTGTAT
ACAAAACTCCTTTTATACCATCTACTGTTACTTAACAAGAACTAGATCAGAATTTTTGTTTTTT
AATAAAATGTAGCCCTAGCGGAATCACTGTAGACCAGGCTTGCCTCTGCCTTCCCATTGCTGGG
AATAAGAGCCTACATCACCCCCCACCCCCACCCCCACCCCACCCGGCTTTACATGAGACCTTAA
AGGCTACTAGAAACCCGTGACCATTTCTGATGCACTAGAAGTGCTAGCACAGACGTACACAGTA
GGCGCCTACTTAGCGTATCTTGATTTCATTAACAGGTAAATAAAGTTGGGCTAGCACAAAAGGG
ATGAGTGTGGCCACCCAGTAAACCGGCAGGCAGCAACACCGGACGTGGATGCTGTGACCAGCAG
ACCCCGAGGGTAGTGTGAGTCTGGACCGCAGCACAATGGCTCCGACCCAGCATAAGTCGCTGCT
CCCAGGGAGGTAAGCTGGGAATGACAGGTGGCCAGGAGGGACACACCACACAAGCTCGTCACCG
TGACCTACAGAAACACACACCTGAAAGGGTGGCCTTTGGGGCTTTGACAAACAGTACCTGCATG
AAACATGTGGCCAGAGGGAACACAGTAACACCGAAGAATTCGTAATTAGGCCTTAGAGACTCTG
AAGGGAACTACTCACAGGTGTAAGGAAGACGTTTTTTATCTCTAAATTAGCAGCAAGAAGCTCT
GTTTTGCCCAAATCCCTAGAGATAAACTTGGATAGTGAAAATATTCCTGCTACCTCTGTCTCAG
ATATACAAGAATTTAGATTTTAGCCTAGATCTTTTATTATAAAACACCATTTTAGCACAAA

hide sequence

RefSeq Acc Id:

XM_063272397 ⟹ XP_063128467

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,435,772 - 105,459,286 (+)	NCBI

RefSeq Acc Id:

XR_010056921

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	105,435,772 - 105,459,282 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001007680	(Get FASTA)	NCBI Sequence Viewer
	XP_006250543	(Get FASTA)	NCBI Sequence Viewer
	XP_063128467	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH82061	(Get FASTA)	NCBI Sequence Viewer
	EDL95002	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005387.4
	ENSRNOP00000078608.1
	ENSRNOP00000085237.1
GenBank Protein	Q66H28	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001007680 ⟸ NM_001007679

- UniProtKB:

Q66H28 (UniProtKB/Swiss-Prot), A6JGZ6 (UniProtKB/TrEMBL), A0A8I5ZNJ7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MIRQDLSTSYQELSEELEQVVENSEQADERDKELVQVQGPGVVPGVDNESASSSIRFSKACLKN
VFSVLLILIYLLLMAVAVFLVYQTITDFREKLKHPVMSVSYKEVDRYDAPGIALYPGQAQLLSC
KHHYEVIPPLASPGQPGDRNCTTQRINYTHPFSNHTMQSALIVQGPQEVKKRELVFLQFRLNQS
DEDFSAIDYLLFSSFREFMQSPDKAGFMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAV
EFRQETSVVNYIDQRPAAEKSTQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKA
AEFAKLSVKWMIKIRKRYLKRRGQATNHIS

hide sequence

RefSeq Acc Id:

XP_006250543 ⟸ XM_006250481

- Peptide Label:

isoform X1

- Sequence:

show sequence

MIRQDLSTSYQELSEELEQVVENSEQADERDKELVQVQGPGVVPGIALYPGQAQLLSCKHHYEV
IPPLASPGQPGDRNCTTQRINYTHPFSNHTMQSALIVQGPQEVKKRELVFLQFRLNQSDEDFSA
IDYLLFSSFREFMQSPDKAGFMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQET
SVVNYIDQRPAAEKSTQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKL
SVKWMIKIRKRYLKRRGQATNHIS

hide sequence

Ensembl Acc Id:

ENSRNOP00000005387 ⟸ ENSRNOT00000005387

Ensembl Acc Id:

ENSRNOP00000085237 ⟸ ENSRNOT00000114123

Ensembl Acc Id:

ENSRNOP00000078608 ⟸ ENSRNOT00000105057

RefSeq Acc Id:	XP_063128467 ⟸ XM_063272397
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66H28-F1-model_v2	AlphaFold	Q66H28	1-350	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699115

Promoter ID:

EPDNEW_R9640

Type:

initiation region

Name:

Tmem206_1

Description:

transmembrane protein 206

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	110,006,968 - 110,007,028	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359339	AgrOrtholog
BioCyc Gene	G2FUF-16846	BioCyc
Ensembl Genes	ENSRNOG00000003915	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005387.7	UniProtKB/Swiss-Prot
	ENSRNOT00000105057.1	UniProtKB/TrEMBL
	ENSRNOT00000114123.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7132483	IMAGE-MGC_LOAD
InterPro	TMEM206	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:305070	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:95217	IMAGE-MGC_LOAD
NCBI Gene	305070	ENTREZGENE
PANTHER	PROTON-ACTIVATED CHLORIDE CHANNEL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR16087	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	TMEM206	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pacc1	PhenoGen
RatGTEx	ENSRNOG00000003915	RatGTEx
UniProt	A0A8I5ZNJ7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A2U8_RAT	UniProtKB/TrEMBL
	A6JGZ6	ENTREZGENE, UniProtKB/TrEMBL
	Q66H28	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-05	Pacc1	proton activated chloride channel 1	Tmem206	transmembrane protein 206	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-02	Tmem206	transmembrane protein 206	RGD1359339	similar to RIKEN cDNA 2310028N02	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	RGD1359339	similar to RIKEN cDNA 2310028N02	MGC95217		Symbol updated	1299863	APPROVED
2005-07-29	MGC95217	similar to RIKEN cDNA 2310028N02			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar