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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Phyh
Name: phytanoyl-CoA 2-hydroxylase
Acc ID: CHEBI:63622
Term: sotalol
Definition: A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Chemical ID: MESH:D013015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Phyhincreases expressionISOPHYH (Homo sapiens)6480464CTDSotalol results in increased expression of PHYH mRNAPMID:17567588
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