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Gene: Plcb3 (phospholipase C beta 3) Rattus norvegicus

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Symbol:

Plcb3

Name:

phospholipase C beta 3

RGD ID:

61993

Description:

Enables phosphatidylinositol phospholipase C activity. Involved in several processes, including inositol trisphosphate metabolic process; phosphatidylinositol catabolic process; and post-Golgi vesicle-mediated transport. Located in cytosol and sarcolemma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to human PLCB3 (phospholipase C beta 3); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphaq family; protein kinase C (PKC) signaling pathway; INTERACTS WITH (R)-noradrenaline; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3; phosphoinositide phospholipase C-beta-3; phospholipase C, beta 3 (phosphatidylinositol-specific); phospholipase C-beta-3; PLC-beta-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PLCB3 (phospholipase C beta 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Plcb3 (phospholipase C, beta 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Plcb3 (phospholipase C beta 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PLCB3 (phospholipase C beta 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PLCB3 (phospholipase C beta 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Plcb3 (phospholipase C beta 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PLCB3 (phospholipase C beta 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PLCB3 (phospholipase C beta 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Plcb3 (phospholipase C beta 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Plcb3 (phospholipase C, beta 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PLCB3 (phospholipase C beta 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	plcb3 (phospholipase C, beta 3 (phosphatidylinositol-specific))	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PLC1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Plc21C	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	plcb3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

Plcb3^{Tn(sb-T2/Bart3)2.69Mcwi}

Genetic Models:

F344-Plcb3^{Tn(sb-T2/Bart3)2.69Mcwi}

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	213,572,499 - 213,589,585 (-)	NCBI		GRCr8
mRatBN7.2	1	204,143,257 - 204,160,384 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	204,144,956 - 204,160,228 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	212,495,137 - 212,510,459 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	219,590,221 - 219,605,490 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	212,281,275 - 212,296,544 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	222,207,887 - 222,224,993 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	222,209,575 - 222,224,910 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	229,198,739 - 229,215,831 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	209,628,425 - 209,643,694 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	209,786,729 - 209,802,063 (-)	NCBI
Celera	1	201,678,898 - 201,694,162 (-)	NCBI		Celera
RH 3.4 Map	1	1521.0	RGD
Cytogenetic Map	1	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chronic ulcer of skin (ISO)

Experimental Diabetes Mellitus (IEP)

Huntington's disease (ISO)

intellectual disability (ISO)

leukocyte adhesion deficiency 3 (ISO)

multiple endocrine neoplasia type 1 (ISO)

myocardial infarction (IEP)

spondylometaphyseal dysplasia with corneal dystrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-noradrenaline (EXP)

1,2-dimethylhydrazine (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-ethoxyethanol (EXP)

2-methoxyethanol (EXP)

3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

anthra[1,9-cd]pyrazol-6(2H)-one (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

caffeine (ISO)

calcitriol (EXP)

capsaicin (EXP)

carbon nanotube (ISO)

cobalt dichloride (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (ISO)

deguelin (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethanol (EXP,ISO)

fenamidone (ISO)

fenthion (ISO)

FR900359 (ISO)

hypochlorous acid (ISO)

inulin (ISO)

ivermectin (ISO)

lipopolysaccharide (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methidathion (ISO)

N-ethyl-N-nitrosourea (ISO)

N-methyl-4-phenylpyridinium (ISO)

oxytocin (ISO)

ozone (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenylephrine (EXP)

pirinixic acid (ISO)

prazosin (EXP)

pregnenolone 16alpha-carbonitrile (EXP)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (EXP,ISO)

sodium dichromate (ISO)

Soman (EXP)

sunitinib (ISO)

thifluzamide (ISO)

thiram (ISO)

Triptolide (EXP)

U-73122 (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IBA,IMP)

inositol trisphosphate metabolic process (IDA)

intracellular signal transduction (IEA)

lipid catabolic process (IEA)

lipid metabolic process (IEA)

phosphatidylinositol catabolic process (IDA)

phosphatidylinositol metabolic process (IBA,IEA,ISO)

phosphatidylinositol-mediated signaling (IBA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IEA,ISO,ISS,NAS)

phospholipase C-activating serotonin receptor signaling pathway (IEA,ISO)

post-Golgi vesicle-mediated transport (IDA)

regulation of systemic arterial blood pressure (IEA,ISO)

release of sequestered calcium ion into cytosol (IBA)

signal transduction (IEA)

Cellular Component

cytoplasm (IBA,IEA,ISO)

cytosol (IDA)

membrane (IEA)

nucleus (IEA)

postsynaptic cytosol (IEA,ISO)

protein-containing complex (IEA,ISO)

sarcolemma (IDA)

Molecular Function

calcium ion binding (IEA)

calmodulin binding (IBA,IEA,ISO)

hydrolase activity (IEA)

metal ion binding (IEA)

molecular adaptor activity (IEA,ISO)

molecular function activator activity (ISO)

phosphatidylinositol-4,5-bisphosphate phospholipase C activity (IBA,IDA,IEA,ISO)

phospholipase C activity (TAS)

phosphoric diester hydrolase activity (IEA)

protein binding (IPI,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

References

References - curated

#	Reference Title	Reference Citation
1.	Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport.	Diaz Anel AM Biochem J. 2007 Aug 15;406(1):157-65.
2.	Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding--how many ways can you activate an enzyme?	Drin G and Scarlata S, Cell Signal. 2007 Jul;19(7):1383-92. Epub 2007 Apr 29.
3.	Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases.	Friedrich B, etal., Brain Res. 2012 Oct 24;1481:37-48. doi: 10.1016/j.brainres.2012.08.005. Epub 2012 Aug 17.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal.	Hwang JI, etal., J Biol Chem. 2005 Apr 1;280(13):12467-73. Epub 2005 Jan 4.
6.	Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3.	Jhon DY, etal., J Biol Chem 1993 Mar 25;268(9):6654-61.
7.	Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction.	Ju H, etal., Circulation. 1998 Mar 10;97(9):892-9.
8.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
9.	G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner.	Kelley GG, etal., J Biol Chem. 2006 Feb 3;281(5):2639-48. Epub 2005 Nov 28.
10.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11.	Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction.	Li Z, etal., Science 2000 Feb 11;287(5455):1046-9.
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
14.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15.	GOA pipeline	RGD automated data pipeline
16.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
18.	Regulation of phosphoinositide-specific phospholipase C.	Rhee SG Annu Rev Biochem. 2001;70:281-312.
19.	Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits.	Smrcka AV and Sternweis PC, J Biol Chem. 1993 May 5;268(13):9667-74.
20.	Defective sarcolemmal phospholipase C signaling in diabetic cardiomyopathy.	Tappia PS, etal., Mol Cell Biochem. 2004 Jun;261(1-2):193-9.
21.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22.	Targeted disruption of the mouse phospholipase C beta3 gene results in early embryonic lethality.	Wang S, etal., FEBS Lett 1998 Dec 18;441(2):261-5.

Additional References at PubMed

PMID:9332346	PMID:12821674	PMID:17298601	PMID:18450967	PMID:18468998	PMID:19538471	PMID:25468996	PMID:30431106

Genomics

Comparative Map Data

Plcb3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	213,572,499 - 213,589,585 (-)	NCBI		GRCr8
mRatBN7.2	1	204,143,257 - 204,160,384 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	204,144,956 - 204,160,228 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	212,495,137 - 212,510,459 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	219,590,221 - 219,605,490 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	212,281,275 - 212,296,544 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	222,207,887 - 222,224,993 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	222,209,575 - 222,224,910 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	229,198,739 - 229,215,831 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	209,628,425 - 209,643,694 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	209,786,729 - 209,802,063 (-)	NCBI
Celera	1	201,678,898 - 201,694,162 (-)	NCBI		Celera
RH 3.4 Map	1	1521.0	RGD
Cytogenetic Map	1	q43	NCBI

PLCB3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	64,251,530 - 64,269,452 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	64,251,530 - 64,269,150 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	64,019,002 - 64,036,924 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	63,775,698 - 63,791,604 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	63,775,697 - 63,791,604	NCBI
Celera	11	61,345,878 - 61,363,808 (+)	NCBI		Celera
Cytogenetic Map	11	q13.1	NCBI
HuRef	11	60,321,780 - 60,364,717 (+)	NCBI		HuRef
CHM1_1	11	63,901,992 - 63,919,919 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	64,241,551 - 64,259,480 (+)	NCBI		T2T-CHM13v2.0

Plcb3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	6,931,081 - 6,951,738 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	6,929,693 - 6,953,838 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	6,953,708 - 6,975,006 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	6,952,325 - 6,976,470 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	7,028,203 - 7,044,242 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	7,020,757 - 7,036,796 (-)	NCBI		MGSCv36	mm8
Celera	19	6,730,717 - 6,746,754 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	5.1	NCBI

Plcb3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	20,810,544 - 20,827,267 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	20,810,871 - 20,827,267 (-)	NCBI	ChiLan1.0	ChiLan1.0

PLCB3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	65,478,680 - 65,496,608 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	66,523,825 - 66,542,014 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	59,608,651 - 59,626,289 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	62,953,587 - 62,971,393 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	62,953,587 - 62,971,393 (+)	Ensembl	panpan1.1		panPan2

PLCB3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	52,793,848 - 52,809,065 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	52,793,838 - 52,809,070 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	51,400,704 - 51,415,897 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	53,839,019 - 53,854,234 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	53,839,022 - 53,854,213 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	52,941,907 - 52,957,083 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	52,517,439 - 52,532,628 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	53,301,344 - 53,316,539 (-)	NCBI		UU_Cfam_GSD_1.0

Plcb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	8,491,781 - 8,508,215 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	4,934,060 - 4,950,570 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	4,934,123 - 4,950,564 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLCB3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	7,843,340 - 7,860,193 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	7,844,931 - 7,860,183 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	6,911,755 - 6,927,069 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PLCB3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	9,964,850 - 9,982,573 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	9,966,618 - 9,982,317 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	107,305,688 - 107,323,320 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Plcb3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	22,039,870 - 22,055,579 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	22,038,058 - 22,055,715 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Plcb3
25 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	34
Count of miRNA genes:	30
Interacting mature miRNAs:	33
Transcripts:	ENSRNOT00000028720
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	197814409	242814409	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
2302375	Bw83	Body weight QTL 83	4.87	0.0002	body mass (VT:0001259)	body weight (CMO:0000012)	1	197697768	242697768	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	201554356	246554356	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	167909849	212909849	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	180359209	210702199	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	184550676	229550676	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	201554356	246554356	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169537671	214537671	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	185145134	221264292	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	201554356	246554356	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	201554356	246554356	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	197814409	242814409	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	193113876	238113876	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	196248093	241248093	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	197814409	242814409	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	182623426	219932796	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	171310381	216310381	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	181759564	214537555	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	164747424	209747424	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	199368955	224569684	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	169537671	214537671	Rat
1331790	Bp201	Blood pressure QTL 201	3.127		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	198211513	225126682	Rat
10059587	Bw173	Body weight QTL 173	3.23	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	1	202069611	247069611	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	213533942	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	197697768	238755659	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	196248093	241248093	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	188377360	224054420	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
634338	Hcar4	Hepatocarcinoma resistance QTL 4	4.6		liver integrity trait (VT:0010547)	liver tumorous lesion number to liver area ratio (CMO:0001210)	1	193422268	214537671	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	180359209	218108781	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	197670404	242670404	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	203995416	244113296	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	192825253	243914732	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	201554356	246554356	Rat

Markers in Region

D1Wox66

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	204,161,679 - 204,161,853 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	222,226,306 - 222,226,479	NCBI	Rnor6.0
Rnor_5.0	1	229,217,158 - 229,217,331	UniSTS	Rnor5.0
RGSC_v3.4	1	209,645,144 - 209,645,317	UniSTS	RGSC3.4
Celera	1	201,695,487 - 201,695,660	UniSTS
Cytogenetic Map	1	q43	UniSTS

RH133323

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	1	213,573,940 - 213,574,129 (+)	Marker Load Pipeline
mRatBN7.2	1	204,144,730 - 204,144,919 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	222,209,361 - 222,209,549	NCBI	Rnor6.0
Rnor_5.0	1	229,200,213 - 229,200,401	UniSTS	Rnor5.0
RGSC_v3.4	1	209,628,200 - 209,628,388	UniSTS	RGSC3.4
Celera	1	201,678,673 - 201,678,861	UniSTS
RH 3.4 Map	1	1520.9	UniSTS
Cytogenetic Map	1	q43	UniSTS

RH142215

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	204,161,822 - 204,162,012 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	222,226,449 - 222,226,638	NCBI	Rnor6.0
Rnor_5.0	1	229,217,301 - 229,217,490	UniSTS	Rnor5.0
RGSC_v3.4	1	209,645,287 - 209,645,476	UniSTS	RGSC3.4
Celera	1	201,695,630 - 201,695,819	UniSTS
RH 3.4 Map	1	1521.0	UniSTS
Cytogenetic Map	1	q43	UniSTS

Genetic Models

This gene Plcb3 is modified in the following models/strains:

F344-Plcb3^{Tn(sb-T2/Bart3)2.69Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_033350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006230711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106564	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC098622	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ120507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ120508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M99567	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U41411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028720 ⟹ ENSRNOP00000028720

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	204,144,956 - 204,160,228 (-)	Ensembl
Rnor_6.0 Ensembl	1	222,209,575 - 222,224,910 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098773 ⟹ ENSRNOP00000078628

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	204,144,956 - 204,160,216 (-)	Ensembl

RefSeq Acc Id:

NM_033350 ⟹ NP_203501

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	213,574,166 - 213,589,435 (-)	NCBI
mRatBN7.2	1	204,144,956 - 204,160,228 (-)	NCBI
Rnor_6.0	1	222,209,586 - 222,224,855 (-)	NCBI
Rnor_5.0	1	229,198,739 - 229,215,831 (-)	NCBI
RGSC_v3.4	1	209,628,425 - 209,643,694 (-)	RGD
Celera	1	201,678,898 - 201,694,162 (-)	RGD

Sequence:

show sequence

CCTGGCTTGGCCATGGCGGGCGCGAGGCCCGGCGTCCACGCGCTGCAGCTGGAGCCGCCCACCG
TGGTGGAGACCCTGCGGCGCGGGAGTAAATTCATCAAATGGGACGAGGAGGCCTCCAGTCGGAA
CCTGGTGACCCTGCGAGTGGACCCCAATGGCTTCTTCTTGTACTGGACAGGACCCAACATGGAG
GTGGACACACTGGACATCAGCTCCATCAGGGACACAAGGACAGGTCGTTATGCCCGCCTGCCCA
AGGACCCCAAGATTCGAGAGGTACTGGGCTTTGGGGGTCCTGACACCCGGCTGGAGGAGAAACT
GATGACAGTGGTAGCAGGACCAGATCCAGTAAACACCACATTCTTGAACTTCATGGCCGTGCAA
GATGACACAGTCAAGGTCTGGTCAGAGGAGTTGTTTAAGCTGGCTATGAACATACTGGCTCAGA
ACGCCTCCCGGAACACGTTCCTTCGGAAAGCATACACGAAACTGAAGCTGCAGGTGAACCAGGA
TGGACGGATTCCAGTCAAGAACATTCTGAAGATGTTCTCCGCGGACAAGAAGCGGGTGGAGACT
GCACTGGAGTCCTGCGGCCTCAACTTCAACCGGAGTGAGTCCATTCGGCCTGATGAGTTTTCCT
TGGAAATCTTCGAGCGGTTCTTGAATAAGCTGTGTCTGCGACCGGATATTGACAAGATCCTGCT
GGAGATAGGTGCTAAGGGCAAGCCGTACCTCACTCTGGAGCAGCTCATGGACTTTATCAACCAG
AAGCAAAGAGACCCAAGACTCAACGAGGTGCTGTACCCACCGCTTCGCTCCTCACAGGCTCGGC
TGCTCATTGAGAAGTATGAGCCGAACAAACAGTTCCTGGAGCGCGACCAGATGTCTATGGAGGG
TTTCAGCCGCTATCTGGGAGGGGAGGAGAATGGCATCCTGCCCCTGGAGGCCCTGGATCTGAGC
ATGGACATGACGCAGCCACTGAGCGCATACTTCATCAATTCTTCACACAATACCTATCTCACTG
CGGGCCAGCTGGCTGGAACATCGTCAGTGGAGATGTACCGCCAGGCGCTGCTGTGGGGCTGCCG
TTGTGTGGAGCTGGATGTATGGAAGGGACGGCCACCGGAGGAAGAGCCCTTCATTACCCATGGT
TTCACCATGACCACTGAGGTGCCATTGCGTGATGTGTTAGAGGCCATCGCCGAGACAGCCTTCA
AGACCTCACCCTACCCTGTCATTCTCTCCTTCGAAAACCATGTGGACTCGGCAAAACAGCAGGC
CAAGATGGCAGAGTACTGCCGCTCTATCTTTGGGGAAGCGCTGCTCATTGACCCACTGGACAAG
TACCCGCTGTCTGCGGGCACCCCCCTTCCTAGTCCACAGGACCTGATGGGCCGTATCCTGGTGA
AGAATAAGAAGCGGCATCGGCCCAGCACAGGTGTCCCTGACAGCTCCGTGCGCAAGCGGCCTCT
GGAACAGAGCAATTCAGCCCTGAGTGAGAGCTCAGCTGCCACAGAGCCCTCCTCACCCCAGCTG
GGGTCCCCCAGCTCTGACAGCTGCCCTGGCCTAAGCAATGGGGAAGAGGTGGGACTTGAGAAGA
CCAGCCTGGAGCCTCAGAAGTCTCTAGGTGAGGAGGGCCTCAACCGAGGACCTAATGTTCTCAT
GCCTGACCGTGACCGAGAGGATGAGGAGGAAGATGAAGAAGAGGAGGAAACAACGGATCCAAAA
AAGCCCACCACCGATGAGGGCACAGCCAGCAGTGAGGTCAACGCCACAGAGGAGATGTCGACAC
TCGTCAATTACGTTGAGCCCGTCAAGTTCAAGTCCTTTGAGGCTGCTCGAAAAAGGAACAAGTG
CTTTGAGATGTCGTCCTTTGTGGAGACCAAGGCGATGGAGCAGCTGACCAAGAGCCCCATGGAG
TTCGTGGAATACAACAAACAGCAGCTTAGTCGCATCTACCCCAAGGGCACCCGTGTGGACTCCT
CCAACTACATGCCTCAGCTCTTCTGGAACGTGGGCTGTCAGCTTGTTGCCCTCAACTTCCAGAC
CTTGGATTTGCCAATGCAGCTCAACGCAGGCGTGTTTGAGTACAACGGGCGCAGTGGGTACTTG
CTCAAGCCTGAGTTTATGCGGCGGCCGGACAAGTCTTTTGACCCCTTCACTGAGGTCATCGTAG
ATGGCATAGTGGCCAACGCCTTGCGGGTCAAGGTGATTTCGGGGCAGTTTCTGTCTGACAGGAA
GGTGGGCATCTATGTCGAGGTGGACATGTTTGGTCTCCCAGTTGACACAAGACGCAAATATCGC
ACACGGACATCCCAGGGGAACTCATTCAACCCTGTGTGGGATGAAGAACCCTTTGACTTCCCCA
AGGTTGTGCTGCCCACGCTGGCCTCACTTCGCATTGCAGCCTTTGAGGAGGGTGGCAGATTTGT
TGGGCATCGTATCCTGCCTGTCTCTGCTATCCGCTCAGGATACCACTACGTCTGCCTGCGAAAT
GAGGCCAACCAACCGTTGTGCCTGCCTGCCCTGCTTATCTACACTGAAGCTTCTGACTACATCC
CAGATGACCACCAGGACTATGCGGAGGCCTTGATCAACCCCATCAAGCACGTCAGCCTAATGGA
CCAGCGGGCCAAGCAACTGGCTGCTCTCATTGGGGAGAGTGAGGCTCAGGCCAGTACAGAAATG
TGTCAGGAGACCCCGTCTCAACAGCAAGGCTCACAGCTCTCCTCCAACCCCGCACCTAACCCAC
TGGATGCCTCACCTCGATGGCCCCCAGGTCCTACCACCTCCCCCACTAGCACCTCCCTCAGTAG
CCCAGGGCAGCGAGATGATCTGATCGCCAGCATCCTTTCTGAGGTGACCCCAACACCCCTAGAG
GAGCTCCGAAGCCACAAGGCTATGGTGAAGCTCCGGAGCCGGCAGGATCGAGACCTGAGGGAAC
TGCATAAAAAACACCAGCGCAAGGCTGTGGCCCTCACCCGCCGCCTTCTGGATGGCCTGGCCCA
GGCCAGGGCTGAGGGGAAGTGCCGGCCCTCCTCCAGCGCCCTGAGCAGGGCCACCAATGTGGAA
GACGTGAAGGAGGAAGAAAAAGAGGCAGCCAGACAGTATCGAGAGTTCCAGAACCGACAAGTAC
AGAGCCTGCTGGAGCTGAGGGAGGCCCAGGCAGATGCAGAGACAGAACGGAGGCTGGAGCATCT
GAAACAGGCTCAGCAGCGGCTCAGGGAGGTTGTCCTGGACGCACATACGACTCAGTTCAAGAGG
CTGAAGGAGTTGAATGAAAGGGAGAAGAAGGAGCTTCAGAAGATCCTGGACAGGAAGCGCAACA
ACAGCATCTCAGAGGCCAAGACAAGGGAGAAACACAAGAAGGAGGTGGAACTGACAGAGATCAA
TCGGAGGCACATCACTGAGTCAGTGAACTCCATCAGGAGGCTGGAAGAGGCCCAGAAGCAGCGC
CACGAACGCCTCTTGGCAGGGCAACAGCAGGTCCTCCAGCAGCTAGTGGAAGAGGAGCCCAAGC
TGGTGGCCCAGCTGACCCAGGAGTGTCAGGAACAGCGAGAGAGGCTGCCCCAGGAGATCCGTCG
GTGCCTGCTGGGCGAGACATCAGAGGGATTGGGGGATGGCCCCCTGGTGGCCTGTGCCAGCAAT
GGTCATGCAGCTGGGAGTGGTGGGCACCAGTCCGGCGCTGACTCGGAGAGCCAGGAGGAAAACA
CCCAGCTTTGAACT

hide sequence

RefSeq Acc Id:

XM_006230711 ⟹ XP_006230773

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	213,572,499 - 213,589,583 (-)	NCBI
mRatBN7.2	1	204,143,257 - 204,160,383 (-)	NCBI
Rnor_6.0	1	222,207,887 - 222,224,993 (-)	NCBI
Rnor_5.0	1	229,198,739 - 229,215,831 (-)	NCBI

Sequence:

show sequence

GTCTCCCGTCCGTCCGGGACAGACTGGCTGGCGGGCGGGCGCTGACGCCGCGGGGCCAGAGCGG
GCCGCGCGGGAGCGTGTGGAGAAAGCAGTGGCACCGTCCGTTCCCGTCGGGGTTCCATAGGTCC
CCGAGCCGCCCCTGGCTTGGCCATGGCGGGCGCGAGGCCCGGCGTCCACGCGCTGCAGCTGGAG
CCGCCCACCGTGGTGGAGACCCTGCGGCGCGGGAGTAAATTCATCAAATGGGACGAGGAGGCCT
CCAGTCGGAACCTGGTGACCCTGCGAGTGGACCCCAATGGCTTCTTCTTGTACTGGACAGGACC
CAACATGGAGGTGGACACACTGGACATCAGCTCCATCAGGGACACAAGGACAGGTCGTTATGCC
CGCCTGCCCAAGGACCCCAAGATTCGAGAGGTACTGGGCTTTGGGGGTCCTGACACCCGGCTGG
AGGAGAAACTGATGACAGTGGTAGCAGGACCAGATCCAGTAAACACCACATTCTTGAACTTCAT
GGCCGTGCAAGATGACACAGTCAAGGTCTGGTCAGAGGAGTTGTTTAAGCTGGCTATGAACATA
CTGGCTCAGAACGCCTCCCGGAACACGTTCCTTCGGAAAGCATACACGAAACTGAAGCTGCAGG
TGAACCAGGATGGACGGATTCCAGTCAAGAACATTCTGAAGATGTTCTCCGCGGACAAGAAGCG
GGTGGAGACTGCACTGGAGTCCTGCGGCCTCAACTTCAACCGGAGTGAGTCCATTCGGCCTGAT
GAGTTTTCCTTGGAAATCTTCGAGCGGTTCTTGAATAAGCTGTGTCTGCGACCGGATATTGACA
AGATCCTGCTGGAGATAGGTGCTAAGGGCAAGCCGTACCTCACTCTGGAGCAGCTCATGGACTT
TATCAACCAGAAGCAAAGAGACCCAAGACTCAACGAGGTGCTGTACCCACCGCTTCGCTCCTCA
CAGGCTCGGCTGCTCATTGAGAAGTATGAGCCGAACAAACAGTTCCTGGAGCGCGACCAGATGT
CTATGGAGGGTTTCAGCCGCTATCTGGGAGGGGAGGAGAATGGCATCCTGCCCCTGGAGGCCCT
GGATCTGAGCATGGACATGACGCAGCCACTGAGCGCATACTTCATCAATTCTTCACACAATACC
TATCTCACTGCGGGCCAGCTGGCTGGAACATCGTCAGTGGAGATGTACCGCCAGGCGCTGCTGT
GGGGCTGCCGTTGTGTGGAGCTGGATGTATGGAAGGGACGGCCACCGGAGGAAGAGCCCTTCAT
TACCCATGGTTTCACCATGACCACTGAGGTGCCATTGCGTGATGTGTTAGAGGCCATCGCCGAG
ACAGCCTTCAAGACCTCACCCTACCCTGTCATTCTCTCCTTCGAAAACCATGTGGACTCGGCAA
AACAGCAGGCCAAGATGGCAGAGTACTGCCGCTCTATCTTTGGGGAAGCGCTGCTCATTGACCC
ACTGGACAAGTACCCGCTGTCTGCGGGCACCCCCCTTCCTAGTCCACAGGACCTGATGGGCCGT
ATCCTGGTGAAGAATAAGAAGCGGCATCGGCCCAGCACAGGTGTCCCTGACAGCTCCGTGCGCA
AGCGGCCTCTGGAACAGAGCAATTCAGCCCTGAGTGAGAGCTCAGCTGCCACAGAGCCCTCCTC
ACCCCAGCTGGGGTCCCCCAGCTCTGACAGCTGCCCTGGCCTAAGCAATGGGGAAGAGGTGGGA
CTTGAGAAGACCAGCCTGGAGCCTCAGAAGTCTCTAGGTGAGGAGGGCCTCAACCGAGGACCTA
ATGTTCTCATGCCTGACCGTGACCGAGAGGATGAGGAGGAAGATGAAGAAGAGGAGGAAACAAC
GGATCCAAAAAAGCCCACCACCGATGAGGGCACAGCCAGCAGTGAGGTCAACGCCACAGAGGAG
ATGTCGACACTCGTCAATTACGTTGAGCCCGTCAAGTTCAAGTCCTTTGAGGCTGCTCGAAAAA
GGAACAAGTGCTTTGAGATGTCGTCCTTTGTGGAGACCAAGGCGATGGAGCAGCTGACCAAGAG
CCCCATGGAGTTCGTGGAATACAACAAACAGCAGCTTAGTCGCATCTACCCCAAGGGCACCCGT
GTGGACTCCTCCAACTACATGCCTCAGCTCTTCTGGAACGTGGGCTGTCAGCTTGTTGCCCTCA
ACTTCCAGACCTTGGATTTGCCAATGCAGCTCAACGCAGGCGTGTTTGAGTACAACGGGCGCAG
TGGGTACTTGCTCAAGCCTGAGTTTATGCGGCGGCCGGACAAGTCTTTTGACCCCTTCACTGAG
GTCATCGTAGATGGCATAGTGGCCAACGCCTTGCGGGTCAAGGTGATTTCGGGGCAGTTTCTGT
CTGACAGGAAGGTGGGCATCTATGTCGAGGTGGACATGTTTGGTCTCCCAGTTGACACAAGACG
CAAATATCGCACACGGACATCCCAGGGGAACTCATTCAACCCTGTGTGGGATGAAGAACCCTTT
GACTTCCCCAAGGTTGTGCTGCCCACGCTGGCCTCACTTCGCATTGCAGCCTTTGAGGAGGGTG
GCAGATTTGTTGGGCATCGTATCCTGCCTGTCTCTGCTATCCGCTCAGGATACCACTACGTCTG
CCTGCGAAATGAGGCCAACCAACCGTTGTGCCTGCCTGCCCTGCTTATCTACACTGAAGCTTCT
GACTACATCCCAGATGACCACCAGGACTATGCGGAGGCCTTGATCAACCCCATCAAGCACGTCA
GCCTAATGGACCAGCGGGCCAAGCAACTGGCTGCTCTCATTGGGGAGAGTGAGGCTCAGGCCAG
TACAGAAATGTGTCAGGAGACCCCGTCTCAACAGCAAGGCTCACAGCTCTCCTCCAACCCCGCA
CCTAACCCACTGGATGCCTCACCTCGATGGCCCCCAGGTCCTACCACCTCCCCCACTAGCACCT
CCCTCAGTAGCCCAGGGCAGCGAGATGATCTGATCGCCAGCATCCTTTCTGAGGTGACCCCAAC
ACCCCTAGAGGAGCTCCGAAGCCACAAGGCTATGGTGAAGCTCCGGAGCCGGCAGGATCGAGAC
CTGAGGGAACTGCATAAAAAACACCAGCGCAAGGCTGTGGCCCTCACCCGCCGCCTTCTGGATG
GCCTGGCCCAGGCCAGGGCTGAGGGGAAGTGCCGGCCCTCCTCCAGCGCCCTGAGCAGGGCCAC
CAATGTGGAAGACGTGAAGGAGGAAGAAAAAGAGGCAGCCAGACAGTATCGAGAGTTCCAGAAC
CGACAAGTACAGAGCCTGCTGGAGCTGAGGGAGGCCCAGGCAGATGCAGAGACAGAACGGAGGC
TGGAGCATCTGAAACAGGCTCAGCAGCGGCTCAGGGAGGTTGTCCTGGACGCACATACGACTCA
GTTCAAGAGGCTGAAGGAGTTGAATGAAAGGGAGAAGAAGGAGCTTCAGAAGATCCTGGACAGG
AAGCGCAACAACAGCATCTCAGAGGCCAAGACAAGGGAGAAACACAAGAAGGAGGTGGAACTGA
CAGAGATCAATCGGAGGCACATCACTGAGTCAGTGAACTCCATCAGGAGGCTGGAAGAGGCCCA
GAAGCAGCGCCACGAACGCCTCTTGGCAGGGCAACAGCAGGTCCTCCAGCAGCTAGTGGAAGAG
GAGCCCAAGCTGGTGGCCCAGCTGACCCAGGAGTGTCAGGAACAGCGAGAGAGGCTGCCCCAGG
AGATCCGTCGGTGCCTGCTGGGCGAGACATCAGAGGGATTGGGGGATGGCCCCCTGGTGGCCTG
TGCCAGCAATGGTCATGCAGCTGGGAGTGGTGGGCACCAGTCCGGCGCTGACTCGGAGAGCCAG
GAGGAAAACACCCAGCTTTGAACTGGCGGAGCAAGAGATGTGGAAGGAAACAGGTCCCGAATGG
AAGATGTCTGTACTGGGCCATAGCTAAGTGGAGACCTGTTGGAAGGCAGGATGGCCTACGTGCT
AGCTCTGTGCTGGATGGTCTTCACCAGCCTGGAGGACATGCTCTGAGCCTGGGACCAGCCAGGA
ACACCAGAGACCCTGTGGCAAGAGAACGGGCTAAGTTCTACAGCTGGGGCAGGCTGGCACTTCT
TCAAGGCCTCTCCCAGCTTCCTGGCCGTTGGGGACTGGCTGCTCCCTCCAGAGGAAGGCAGTCT
CTTATCTGGGCTTATCTCCTGCCAATGAAGTGTTTGCTTCGCTTTGTTTTTGTTGCAGCCCCAG
GCAAACAGATCGGGTAGGAAGGCCAGAGAAACTGGGTGGCCAGGGTTGGGCTTCCCAGGGCCTA
AGGCCTTAGCTCTCCCTGAGATTCCTACCATTGCCCAAGTCAACTTCTTCTGTAGTCAGTCCTT
GTCACGTTCCCAGCTCTGCCACTTTTCCATGTCCCAAGTCCTGTATCGCTGACTGGCTGACCTC
CATTTCCCGAACACTACATGTGGGCTGGGGTCCTCAAAAATAAGCTAAGTCCCAACATCCTGGT
GTGTCGGTCTGCAGAGTGTCAGTTCCAGACATAGCCTCACCTTCAAGACTGACCTACTCCTTGA
GGCCCTGTTGTGGGGGCCACCCCTCCCATGTTCCAGGAAGCAAAGTGGTGGCGCAACTTATCTG
CATATCCAGCGCAAAGCACTGGCCTGGGCTATAGGGGCGCCAATAAATCTCTGAACTGAGCTCT
GGGCCCTGCTCCAGGTCCCTGTGAGAA

hide sequence

RefSeq Acc Id:

XM_039106564 ⟹ XP_038962492

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	213,579,302 - 213,589,585 (-)	NCBI
mRatBN7.2	1	204,150,095 - 204,160,384 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_203501	(Get FASTA)	NCBI Sequence Viewer
	XP_006230773	(Get FASTA)	NCBI Sequence Viewer
	XP_038962492	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC53366	(Get FASTA)	NCBI Sequence Viewer
	AAK14906	(Get FASTA)	NCBI Sequence Viewer
	AAZ23846	(Get FASTA)	NCBI Sequence Viewer
	AAZ23847	(Get FASTA)	NCBI Sequence Viewer
	EDM12633	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028720
GenBank Protein	Q99JE6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_203501 ⟸ NM_033350

- UniProtKB:

Q9QW29 (UniProtKB/Swiss-Prot), Q99JE6 (UniProtKB/Swiss-Prot), Q62887 (UniProtKB/Swiss-Prot), Q45QJ4 (UniProtKB/TrEMBL), F7FBZ0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNMEVDTL
DISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNFMAVQDDTV
KVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALES
CGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRD
PRLNEVLYPPLRSSQARLLIEKYEPNKQFLERDQMSMEGFSRYLGGEENGILPLEALDLSMDMT
QPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMT
TEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGEALLIDPLDKYPLS
AGTPLPSPQDLMGRILVKNKKRHRPSTGVPDSSVRKRPLEQSNSALSESSAATEPSSPQLGSPS
SDSCPGLSNGEEVGLEKTSLEPQKSLGEEGLNRGPNVLMPDRDREDEEEDEEEEETTDPKKPTT
DEGTASSEVNATEEMSTLVNYVEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEY
NKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPE
FMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTS
QGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGRFVGHRILPVSAIRSGYHYVCLRNEANQ
PLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTEMCQET
PSQQQGSQLSSNPAPNPLDASPRWPPGPTTSPTSTSLSSPGQRDDLIASILSEVTPTPLEELRS
HKAMVKLRSRQDRDLRELHKKHQRKAVALTRRLLDGLAQARAEGKCRPSSSALSRATNVEDVKE
EEKEAARQYREFQNRQVQSLLELREAQADAETERRLEHLKQAQQRLREVVLDAHTTQFKRLKEL
NEREKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHERL
LAGQQQVLQQLVEEEPKLVAQLTQECQEQRERLPQEIRRCLLGETSEGLGDGPLVACASNGHAA
GSGGHQSGADSESQEENTQL

hide sequence

RefSeq Acc Id:	XP_006230773 ⟸ XM_006230711
- Peptide Label:	isoform X1
- UniProtKB:	Q9QW29 (UniProtKB/Swiss-Prot), Q99JE6 (UniProtKB/Swiss-Prot), Q62887 (UniProtKB/Swiss-Prot), Q45QJ4 (UniProtKB/TrEMBL), F7FBZ0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNMEVDTL DISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNFMAVQDDTV KVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALES CGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRD PRLNEVLYPPLRSSQARLLIEKYEPNKQFLERDQMSMEGFSRYLGGEENGILPLEALDLSMDMT QPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMT TEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGEALLIDPLDKYPLS AGTPLPSPQDLMGRILVKNKKRHRPSTGVPDSSVRKRPLEQSNSALSESSAATEPSSPQLGSPS SDSCPGLSNGEEVGLEKTSLEPQKSLGEEGLNRGPNVLMPDRDREDEEEDEEEEETTDPKKPTT DEGTASSEVNATEEMSTLVNYVEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEY NKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPE FMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTS QGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGRFVGHRILPVSAIRSGYHYVCLRNEANQ PLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTEMCQET PSQQQGSQLSSNPAPNPLDASPRWPPGPTTSPTSTSLSSPGQRDDLIASILSEVTPTPLEELRS HKAMVKLRSRQDRDLRELHKKHQRKAVALTRRLLDGLAQARAEGKCRPSSSALSRATNVEDVKE EEKEAARQYREFQNRQVQSLLELREAQADAETERRLEHLKQAQQRLREVVLDAHTTQFKRLKEL NEREKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHERL LAGQQQVLQQLVEEEPKLVAQLTQECQEQRERLPQEIRRCLLGETSEGLGDGPLVACASNGHAA GSGGHQSGADSESQEENTQL hide sequence

Ensembl Acc Id:

ENSRNOP00000028720 ⟸ ENSRNOT00000028720

RefSeq Acc Id:	XP_038962492 ⟸ XM_039106564
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000078628 ⟸ ENSRNOT00000098773

Protein Domains

C2 PI-PLC X-box PI-PLC Y-box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99JE6-F1-model_v2	AlphaFold	Q99JE6	1-1234	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690710

Promoter ID:

EPDNEW_R1234

Type:

initiation region

Name:

Plcb3_1

Description:

phospholipase C beta 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	222,224,973 - 222,225,033	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61993	AgrOrtholog
BioCyc Gene	G2FUF-56576	BioCyc
BioCyc Pathway	PWY-6351 [D-myo-inositol (1,4,5)-trisphosphate biosynthesis]	BioCyc
	PWY-6367 [D-myo-inositol-5-phosphate metabolism]	BioCyc
	PWY-8052 [2-arachidonoylglycerol biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-6351	BioCyc
	PWY-6367	BioCyc
	PWY-8052	BioCyc
Ensembl Genes	ENSRNOG00000021150	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000028720	ENTREZGENE
Gene3D-CATH	1.20.1230.10	UniProtKB/Swiss-Prot
	2.30.29.240	UniProtKB/Swiss-Prot
	2.60.40.150	UniProtKB/Swiss-Prot
	3.20.20.190	UniProtKB/Swiss-Prot
	EF-hand	UniProtKB/Swiss-Prot
InterPro	C2_Ca-dep	UniProtKB/Swiss-Prot
	C2_domain_sf	UniProtKB/Swiss-Prot
	EF-hand-like_dom	UniProtKB/Swiss-Prot
	Phospholipase_C_Pinositol-sp_C	UniProtKB/Swiss-Prot
	Phospholipase_C_Pinositol-sp_Y	UniProtKB/Swiss-Prot
	PLC-beta	UniProtKB/Swiss-Prot
	PLC-beta_C	UniProtKB/Swiss-Prot
	PLC-beta_C_sf	UniProtKB/Swiss-Prot
	PLC-beta_PH	UniProtKB/Swiss-Prot
	PLC-like_Pdiesterase_TIM-brl	UniProtKB/Swiss-Prot
	PLCB1-4-like_EFh	UniProtKB/Swiss-Prot
	PLipase_C_PInositol-sp_X_dom	UniProtKB/Swiss-Prot
NCBI Gene	29322	ENTREZGENE
PANTHER	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3	UniProtKB/Swiss-Prot
	PTHR10336	UniProtKB/Swiss-Prot
Pfam	PF00168	UniProtKB/Swiss-Prot
	PH_14	UniProtKB/Swiss-Prot
	PI-PLC-X	UniProtKB/Swiss-Prot
	PI-PLC-Y	UniProtKB/Swiss-Prot
	PLC-beta_C	UniProtKB/Swiss-Prot
	PLCB1-4-like_EFh	UniProtKB/Swiss-Prot
PhenoGen	Plcb3	PhenoGen
PIRSF	PLC-beta	UniProtKB/Swiss-Prot
PRINTS	PHPHLIPASEC	UniProtKB/Swiss-Prot
PROSITE	PIPLC_X_DOMAIN	UniProtKB/Swiss-Prot
	PIPLC_Y_DOMAIN	UniProtKB/Swiss-Prot
	PS50004	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000021150	RatGTEx
SMART	PLCXc	UniProtKB/Swiss-Prot
	PLCYc	UniProtKB/Swiss-Prot
	SM00239	UniProtKB/Swiss-Prot
Superfamily-SCOP	C-terminal domain of PLC-beta	UniProtKB/Swiss-Prot
	PH domain-like	UniProtKB/Swiss-Prot
	PLC-like_Pdiesterase_TIM-brl	UniProtKB/Swiss-Prot
	SSF47473	UniProtKB/Swiss-Prot
	SSF49562	UniProtKB/Swiss-Prot
TIGR	TC207503
UniProt	A0A8I5ZLC4_RAT	UniProtKB/TrEMBL
	F7FBZ0	ENTREZGENE, UniProtKB/TrEMBL
	PLCB3_RAT	UniProtKB/Swiss-Prot
	Q45QJ4	ENTREZGENE, UniProtKB/TrEMBL
	Q62887	ENTREZGENE
	Q99JE6	ENTREZGENE
	Q9QW29	ENTREZGENE
UniProt Secondary	Q62887	UniProtKB/Swiss-Prot
	Q9QW29	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Plcb3	phospholipase C, beta 3			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

BioCyc Pathways

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

BioCyc Pathways