Plcb3 (phospholipase C, beta 3) - Rat Genome Database

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Gene: Plcb3 (phospholipase C, beta 3) Mus musculus
Analyze
Symbol: Plcb3
Name: phospholipase C, beta 3
RGD ID: 62285
MGI Page MGI
Description: Predicted to enable several functions, including calmodulin binding activity; molecular function activator activity; and phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including inositol trisphosphate metabolic process; phosphatidylinositol catabolic process; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within regulation of systemic arterial blood pressure. Is active in postsynaptic cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to human PLCB3 (phospholipase C beta 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3; KIAA4098; mKIAA4098; phosphoinositide phospholipase C-beta-3; phospholipase C-beta-3; PLC-beta-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,931,081 - 6,951,738 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,929,693 - 6,953,838 (-)EnsemblGRCm39 Ensembl
GRCm38196,953,708 - 6,975,006 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,952,325 - 6,976,470 (-)EnsemblGRCm38mm10GRCm38
MGSCv37197,028,203 - 7,044,242 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,020,757 - 7,036,796 (-)NCBIMGSCv36mm8
Celera196,730,717 - 6,746,754 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-ethoxyethanol  (ISO)
2-methoxyethanol  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP,ISO)
Benoxacor  (EXP)
benzo[a]pyrene  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
cobalt dichloride  (ISO)
Cuprizon  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenamidone  (EXP)
fenthion  (EXP)
FR900359  (ISO)
hypochlorous acid  (EXP)
inulin  (EXP)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
methidathion  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
oxytocin  (EXP)
ozone  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylephrine  (ISO)
pirinixic acid  (EXP)
prazosin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (ISO)
sunitinib  (ISO)
thifluzamide  (ISO)
Triptolide  (ISO)
U-73122  (ISO)
valproic acid  (EXP,ISO)

References

References - curated
# Reference Title Reference Citation
1. Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding--how many ways can you activate an enzyme? Drin G and Scarlata S, Cell Signal. 2007 Jul;19(7):1383-92. Epub 2007 Apr 29.
2. Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases. Friedrich B, etal., Brain Res. 2012 Oct 24;1481:37-48. doi: 10.1016/j.brainres.2012.08.005. Epub 2012 Aug 17.
3. Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction. Ju H, etal., Circulation. 1998 Mar 10;97(9):892-9.
4. Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Li Z, etal., Science 2000 Feb 11;287(5455):1046-9.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Regulation of phosphoinositide-specific phospholipase C. Rhee SG Annu Rev Biochem. 2001;70:281-312.
15. Defective sarcolemmal phospholipase C signaling in diabetic cardiomyopathy. Tappia PS, etal., Mol Cell Biochem. 2004 Jun;261(1-2):193-9.
16. Targeted disruption of the mouse phospholipase C beta3 gene results in early embryonic lethality. Wang S, etal., FEBS Lett 1998 Dec 18;441(2):261-5.
Additional References at PubMed
PMID:2033248   PMID:7587389   PMID:8672127   PMID:8687404   PMID:8739298   PMID:8889548   PMID:9211987   PMID:9305844   PMID:9457670   PMID:9714794   PMID:9753089   PMID:10349636  
PMID:10468617   PMID:10501973   PMID:10609087   PMID:10748023   PMID:11042159   PMID:11076861   PMID:11145744   PMID:11217851   PMID:12477932   PMID:12823437   PMID:14610273   PMID:14681479  
PMID:15174099   PMID:15686869   PMID:15705797   PMID:15782199   PMID:15995354   PMID:16141072   PMID:16141073   PMID:16314422   PMID:16566000   PMID:17114052   PMID:17298601   PMID:17675482  
PMID:17921328   PMID:18079968   PMID:18287559   PMID:18411281   PMID:18468998   PMID:18799693   PMID:19020012   PMID:19564617   PMID:19647226   PMID:20579885   PMID:20858858   PMID:21683628  
PMID:21873635   PMID:22172670   PMID:22674805   PMID:22728827   PMID:23295235   PMID:24412367   PMID:25959047   PMID:26468229   PMID:28578927   PMID:28615442   PMID:30270038   PMID:30720883  
PMID:31040226   PMID:31268747   PMID:31898936   PMID:32325033   PMID:32360594   PMID:32790785   PMID:35236105   PMID:37657560   PMID:38183495  


Genomics

Comparative Map Data
Plcb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,931,081 - 6,951,738 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,929,693 - 6,953,838 (-)EnsemblGRCm39 Ensembl
GRCm38196,953,708 - 6,975,006 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,952,325 - 6,976,470 (-)EnsemblGRCm38mm10GRCm38
MGSCv37197,028,203 - 7,044,242 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,020,757 - 7,036,796 (-)NCBIMGSCv36mm8
Celera196,730,717 - 6,746,754 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.1NCBI
PLCB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,251,530 - 64,269,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1164,251,530 - 64,269,150 (+)EnsemblGRCh38hg38GRCh38
GRCh371164,019,002 - 64,036,924 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,775,698 - 63,791,604 (+)NCBINCBI36Build 36hg18NCBI36
Build 341163,775,697 - 63,791,604NCBI
Celera1161,345,878 - 61,363,808 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,321,780 - 60,364,717 (+)NCBIHuRef
CHM1_11163,901,992 - 63,919,919 (+)NCBICHM1_1
T2T-CHM13v2.01164,241,551 - 64,259,480 (+)NCBIT2T-CHM13v2.0
Plcb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,572,499 - 213,589,585 (-)NCBIGRCr8
mRatBN7.21204,143,257 - 204,160,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,144,956 - 204,160,228 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,495,137 - 212,510,459 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,590,221 - 219,605,490 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,281,275 - 212,296,544 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,207,887 - 222,224,993 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,209,575 - 222,224,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,198,739 - 229,215,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,628,425 - 209,643,694 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,786,729 - 209,802,063 (-)NCBI
Celera1201,678,898 - 201,694,162 (-)NCBICelera
RH 3.4 Map11521.0RGD
Cytogenetic Map1q43NCBI
Plcb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,810,544 - 20,827,267 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,810,871 - 20,827,267 (-)NCBIChiLan1.0ChiLan1.0
PLCB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,478,680 - 65,496,608 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,523,825 - 66,542,014 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,608,651 - 59,626,289 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,953,587 - 62,971,393 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,953,587 - 62,971,393 (+)Ensemblpanpan1.1panPan2
PLCB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,793,848 - 52,809,065 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,793,838 - 52,809,070 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,400,704 - 51,415,897 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,839,019 - 53,854,234 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,839,022 - 53,854,213 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,941,907 - 52,957,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,517,439 - 52,532,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,301,344 - 53,316,539 (-)NCBIUU_Cfam_GSD_1.0
Plcb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,491,781 - 8,508,215 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,934,060 - 4,950,570 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,934,123 - 4,950,564 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,843,340 - 7,860,193 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,844,931 - 7,860,183 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,911,755 - 6,927,069 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLCB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,964,850 - 9,982,573 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,966,618 - 9,982,317 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038107,305,688 - 107,323,320 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476722,039,870 - 22,055,579 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476722,038,058 - 22,055,715 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plcb3
495 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:119
Interacting mature miRNAs:134
Transcripts:ENSMUST00000025912
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
25394536Skmw86_mskeletal muscle weight 86, TA (mouse)1950648178957825Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse

Markers in Region
Plcb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19BUniSTS
cM Map192.5UniSTS
cM Map192.5UniSTS
PLCB3sts2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38196,954,263 - 6,954,730UniSTSGRCm38
MGSCv37197,028,753 - 7,029,220UniSTSGRCm37
Celera196,731,267 - 6,731,734UniSTS
Cytogenetic Map19BUniSTS
cM Map192.5UniSTS
Plcb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19BUniSTS
cM Map192.5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001290349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_177188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006526766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF022803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI851116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB527492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB877174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB895808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC934583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC953217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U43144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000025912   ⟹   ENSMUSP00000025912
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,931,081 - 6,947,182 (-)Ensembl
GRCm38.p6 Ensembl196,953,713 - 6,969,814 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235352   ⟹   ENSMUSP00000157584
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,939,279 - 6,953,838 (-)Ensembl
GRCm38.p6 Ensembl196,961,911 - 6,976,470 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235560
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,931,846 - 6,932,965 (-)Ensembl
GRCm38.p6 Ensembl196,954,478 - 6,955,597 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235832
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,939,592 - 6,940,859 (-)Ensembl
GRCm38.p6 Ensembl196,962,224 - 6,963,491 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236597
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,931,453 - 6,932,215 (-)Ensembl
GRCm38.p6 Ensembl196,954,085 - 6,954,847 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236961
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,939,395 - 6,941,291 (-)Ensembl
GRCm38.p6 Ensembl196,962,027 - 6,963,923 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237074   ⟹   ENSMUSP00000158236
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,942,056 - 6,947,076 (-)Ensembl
GRCm38.p6 Ensembl196,964,688 - 6,969,708 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237446
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,942,665 - 6,951,719 (-)Ensembl
GRCm38.p6 Ensembl196,965,297 - 6,974,351 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237726
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,931,082 - 6,947,128 (-)Ensembl
GRCm38.p6 Ensembl196,953,714 - 6,969,760 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237808   ⟹   ENSMUSP00000158254
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,929,693 - 6,935,081 (-)Ensembl
GRCm38.p6 Ensembl196,952,325 - 6,957,713 (-)Ensembl
RefSeq Acc Id: NM_001290349   ⟹   NP_001277278
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39196,931,081 - 6,947,182 (-)NCBI
GRCm38196,953,713 - 6,969,814 (-)NCBI
Celera196,730,717 - 6,746,816 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008874   ⟹   NP_032900
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39196,931,081 - 6,947,182 (-)NCBI
GRCm38196,953,713 - 6,969,814 (-)NCBI
MGSCv37197,028,203 - 7,044,242 (-)RGD
Celera196,730,717 - 6,746,816 (-)NCBI
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_177188
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39196,931,081 - 6,951,738 (-)NCBI
RefSeq Acc Id: XM_006526766   ⟹   XP_006526829
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39196,931,081 - 6,951,732 (-)NCBI
GRCm38196,953,708 - 6,974,217 (-)NCBI
Sequence:
RefSeq Acc Id: NP_032900   ⟸   NM_008874
- Peptide Label: isoform b
- UniProtKB: Q8CI86 (UniProtKB/TrEMBL),   Q3TWI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006526829   ⟸   XM_006526766
- Peptide Label: isoform X1
- UniProtKB: Q3TWI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277278   ⟸   NM_001290349
- Peptide Label: isoform a
- UniProtKB: Q3UIS0 (UniProtKB/Swiss-Prot),   P51432 (UniProtKB/Swiss-Prot),   Q3TWI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000158236   ⟸   ENSMUST00000237074
RefSeq Acc Id: ENSMUSP00000158254   ⟸   ENSMUST00000237808
RefSeq Acc Id: ENSMUSP00000025912   ⟸   ENSMUST00000025912
RefSeq Acc Id: ENSMUSP00000157584   ⟸   ENSMUST00000235352
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51432-F1-model_v2 AlphaFold P51432 1-1234 view protein structure

Promoters
RGD ID:13678710
Promoter ID:EPDNEW_M23504
Type:initiation region
Name:Plcb3_1
Description:Mus musculus phospholipase C, beta 3 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38196,969,789 - 6,969,849EPDNEW
RGD ID:6847578
Promoter ID:MM_ACW:25923
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung
Transcripts:PLCB3.DSEP07,   PLCB3.GSEP07,   PLCB3.ISEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36197,029,581 - 7,030,272 (-)MPROMDB
RGD ID:6830314
Promoter ID:MM_KWN:26226
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:UC008GJP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36197,032,836 - 7,033,336 (-)MPROMDB
RGD ID:6830313
Promoter ID:MM_KWN:26227
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_008874,   UC008GJR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36197,043,894 - 7,044,394 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104778 AgrOrtholog
Ensembl Genes ENSMUSG00000024960 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025912 ENTREZGENE
  ENSMUST00000025912.10 UniProtKB/Swiss-Prot
  ENSMUST00000235352.2 UniProtKB/TrEMBL
  ENSMUST00000237074.2 UniProtKB/TrEMBL
  ENSMUST00000237808.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1230.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC_EF-hand-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18797 UniProtKB/Swiss-Prot
MGD MGI:104778 ENTREZGENE
NCBI Gene 18797 ENTREZGENE
PANTHER 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plcb3 PhenoGen
PIRSF PLC-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PIPLC_X_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PLCXc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCYc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP C-terminal domain of PLC-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494B9C1_MOUSE UniProtKB/TrEMBL
  A0A494BAY4_MOUSE UniProtKB/TrEMBL
  P51432 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3TPL1_MOUSE UniProtKB/TrEMBL
  Q3TWI4 ENTREZGENE, UniProtKB/TrEMBL
  Q3UIS0 ENTREZGENE
  Q571K9_MOUSE UniProtKB/TrEMBL
  Q62076_MOUSE UniProtKB/TrEMBL
  Q8C8I0_MOUSE UniProtKB/TrEMBL
  Q8CI86 ENTREZGENE, UniProtKB/TrEMBL
  Q9R1Y4_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3UIS0 UniProtKB/Swiss-Prot