RGD Reference Report - Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction.

Authors: Ju, H  Zhao, S  Tappia, PS  Panagia, V  Dixon, IM 
Citation: Ju H, etal., Circulation. 1998 Mar 10;97(9):892-9.
RGD ID: 2314514
Pubmed: PMID:9521338   (View Abstract at PubMed)

BACKGROUND: Large transmural myocardial infarction (MI) leads to maladaptive cardiac remodeling and places patients at increased risk of congestive heart failure. Angiotensin II, endothelin, and alpha1-adrenergic receptor agonists are implicated in the development of cardiac hypertrophy, interstitial fibrosis, and heart failure after MI. Because these agonists are coupled to and activate Gq alpha protein in the heart, the aim of the present study was to investigate Gq alpha expression and function in cardiac remodeling and heart failure after MI. METHODS AND RESULTS: MI was produced in rats by ligation of the left coronary artery, and Gq alpha protein concentration, localization, and mRNA abundance were noted in surviving left ventricle remote from the infarct and in border and scar tissues from 8-week post-MI hearts with moderate heart failure. Immunohistochemical staining localized elevated Gq alpha expression in the scar and border tissues. Western analysis confirmed significant upregulation of Gq alpha proteins in these regions versus controls. Furthermore, Northern analysis revealed that the ratios of Gq alpha/GAPDH mRNA abundance in both scar and viable tissues from experimental hearts were significantly increased versus controls. Increased expression of phospholipase C (PLC)-beta1 and PLC-beta3 proteins was apparent in the scar and viable tissues after MI versus controls and is associated with increased PLC-beta1 activity in experimental hearts. Furthermore, inositol 1,4,5-tris-phosphate is significantly increased in the border and scar tissues compared with control values. CONCLUSIONS: Upregulation of the Gq alpha/PLC-beta pathway was observed in the viable, border, and scar tissues in post-MI hearts. Gq alpha and PLC-beta may play important roles in scar remodeling as well as cardiac hypertrophy and fibrosis of the surviving tissue in post-MI rat heart. It is suggested that the Gq alpha/PLC-beta pathway may provide a possible novel target for altering postinfarct remodeling.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PLCB1Humanmyocardial infarction  ISOPlcb1 (Rattus norvegicus)protein:increased expression:heartRGD 
PLCB3Humanmyocardial infarction  ISOPlcb3 (Rattus norvegicus)protein:increased expression:heartRGD 
Plcb1Ratmyocardial infarction  IEP protein:increased expression:heartRGD 
Plcb1Mousemyocardial infarction  ISOPlcb1 (Rattus norvegicus)protein:increased expression:heartRGD 
Plcb3Ratmyocardial infarction  IEP protein:increased expression:heartRGD 
Plcb3Mousemyocardial infarction  ISOPlcb3 (Rattus norvegicus)protein:increased expression:heartRGD 

Objects Annotated

Genes (Rattus norvegicus)
Plcb1  (phospholipase C beta 1)
Plcb3  (phospholipase C beta 3)

Genes (Mus musculus)
Plcb1  (phospholipase C, beta 1)
Plcb3  (phospholipase C, beta 3)

Genes (Homo sapiens)
PLCB1  (phospholipase C beta 1)
PLCB3  (phospholipase C beta 3)


Additional Information